The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Regulation of AMPA receptor lateral movements
Abstract
An essential feature in the modulation of the efficacy of synaptic transmission is rapid changes in the number of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors at post-synaptic sites on neurons. Regulation of receptor endo- and exocytosis has been shown to be involved in this process. Whether regulated lateral diffusion of receptors in the plasma membrane also participates in receptor exchange to and from post-synaptic sites remains unknown. We analysed the lateral mobility of native AMPA receptors containing the glutamate receptor subunit GluR2 in rat cultured hippocampal neurons, using single-particle tracking and video microscopy. Here we show that AMPA receptors alternate within seconds between rapid diffusive and stationary behaviour. During maturation of neurons, stationary periods increase in frequency and length, often in spatial correlation with synaptic sites. Raising intracellular calcium, a central element in synaptic plasticity, triggers rapid receptor immobilization and local accumulation on the neuronal surface. We suggest that calcium influx prevents AMPA receptors from diffusing, and that lateral receptor diffusion to and from synaptic sites acts in the rapid and controlled regulation of receptor numbers at synapses.
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In the citing paper
“Calcium elevations were shown to generally slow diffusion and locally accumulate AMPA receptors (Borgdorff and Choquet, 2002).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
In the citing paper
“although their respective contributions have remained unresolved (Passafaro et al., 2001; Borgdorff and Choquet, 2002; Adesnik et al., 2005; Ashby et al., 2006; Park et al., 2006; Ehlers et al., 2007; Heine et al., 2008; Newpher and Ehlers, 2008; Yang et al., 2008; Kennedy et al., 2010; Opazo and Choquet, 2011; Czöndör et al., 2012; Czöndör and Thoumine, 2013).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
In the citing paper
“Lateral diffusion of receptors through the plasma membrane and activity-triggered exocytosis of receptors from internal endosomal compartments have become generally accepted regulation mechanisms for synaptic plasticity, although their respective contributions have remained unresolved”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Borgdorff and Choquet, 2002
In the citing paper
“These studies show that many synaptic proteins are remarkably dynamic, including AMPARs (237, 249, 327, 328), NMDARs (329), CaMKII (330), and scaffolding proteins, such as PSD-95 (331).”
From Synaptic memory and CaMKII (2023) · cites this paper as [327]
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Cites
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences
Ghosh, A., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.7716515 · Cited by 1,411
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094
Lu, W.-Y., Man, H., Ju, W. H., Trimble, W. S., MacDonald, J. F., & Wang, Y. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00194-5 · Cited by 935
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 711
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 562
Selective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation
Yang, S.-N., Tang, Y.-G., & Zucker, R. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.781 · Cited by 534
Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis
Wang, Y. T., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81066-1 · Cited by 484
Carroll, R. C., Lissin, D., von Zastrow, M., Nicoll, R. A., & Malenka, R. C. (1999) · Nature Neuroscience · doi:10.1038/8123 · Cited by 472
Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
Liu, S. J., & Cull-Candy, S. G. (2000) · Nature · doi:10.1038/35013064 · Cited by 452
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
LTP mechanisms: from silence to four-lane traffic
Malinow, R., Mainen, Z. F., & Hayashi, Y. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00099-4 · Cited by 386
Noël, J., Ralph, G. S., Pickard, L., Williams, J., Molnár, E., Uney, J. B., Collingridge, G. L., & Henley, J. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80786-2 · Cited by 298
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 298
Fast and reversible trapping of surface glycine receptors by gephyrin
Meier, J. C., Vannier, C., Sergé, A., Triller, A., & Choquet, D. (2001) · Nature Neuroscience · doi:10.1038/85099 · Cited by 257
Self-citationSimson, R., Sheets, E. D., & Jacobson, K. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)79972-6 · Cited by 254
Pickard, L., Noël, J., Henley, J. M., Collingridge, G. L., & Molnár, E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07922.2000 · Cited by 250
Fletcher, T., Camilli, P. V. D., & Banker, G. A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06695.1994 · Cited by 204
AMPA Receptor Trafficking and the Control of Synaptic Transmission
Sheng, M., & Lee, S. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00406-8 · Cited by 196
Sergé, A., Fourgeaud, L., Hémar, A., & Choquet, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03910.2002 · Cited by 175
Self-citationContribution of the Neural Cell Adhesion Molecule to Neuronal and Synaptic Plasticity
Kiss, J. Z., & Müller, D. (2001) · Reviews in the Neurosciences · doi:10.1515/revneuro.2001.12.4.297 · Cited by 167
Structural Mosaicism on the Submicron Scale in the Plasma Membrane
Simson, R., Yang, B., Moore, S. E., Doherty, P., Walsh, F. S., & Jacobson, K. A. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77787-2 · Cited by 162
AMPA amd NMDA receptors: similarities and differences in their synaptic distribution
Nusser, Z. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00086-6 · Cited by 108
Mapping of Eps15 Domains Involved in Its Targeting to Clathrin-coated Pits
Benmerah, A., Poupon, V., Cerf–Bensussan, N., & Dautry‐Varsat, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3288 · Cited by 104
Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons
Hémar, A., Olivo, J.-C., Williamson, E., Saffrich, R., & Dotti, C. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09026.1997 · Cited by 61
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Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
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Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
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Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042
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Metadata
- Authors
- Borgdorff, A. J., & Choquet, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Choquet, Daniel
- ORCID
- Choquet, Daniel
- Venue
- Nature
- Published
- 2002-06
- Volume
- 417
- Issue
- 6889
- Pages
- 649-653
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1965202553
- Cited by
- 542
- References
- 29
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 15 · 2023: 13 · 2022: 12 · 2021: 26 · 2020: 17 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 18 · 2015: 19 · 2014: 23 · 2013: 32 · 2012: 28
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- AMPA receptors, GluR2, receptor lateral diffusion, synaptic plasticity, intracellular calcium, receptor immobilization, synaptic transmission, hippocampal neurons, single-particle tracking
- MeSH terms
- Animals, Calcium, Cell Differentiation, Cells, Cultured, Diffusion, Hippocampus, Kinetics, Neurons, Photolysis, Synapses, Receptors, AMPA, Microscopy, Video, Protein Subunits, Protein Transport, Rats
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