Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Cited by (1,063)

Items 1,001–1,063 of 1,063

1. Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner
   Chatterjee, Samit, Dwivedi, Ved Prakash, Singh, Yogesh, Siddiqui, Imran, Sharma, Pawan, Van Kaer, Luc, Chattopadhyay, Debprasad, Das, Gobardhan · 2011 · PLoS Pathogens
2. Role of Interleukin-6 in Vascular Health and Disease
   Villar-Fincheira, Paulina, Sanhueza-Olivares, Fernanda, Norambuena-Soto, Ignacio, Cancino-Arenas, Nicole, Hernandez-Vargas, Felipe, Troncoso, Rodrigo, Gabrielli, Luigi, Chiong, Mario · 2021 · Frontiers in Molecular Biosciences
3. T _H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity
   Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon A., Hatton, Robin D., Weaver, Casey T. · 2020 · Science Immunology
4. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system
   Larochelle, Catherine, Cayrol, Romain, Kebir, Hania, Alvarez, Jorge Ivan, Lécuyer, Marc-André, Ifergan, Igal, Viel, Émilie, Bourbonnière, Lyne, Beauseigle, Diane, Terouz, Simone et al. · 2012 · Brain
5. Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis
   MILLER, STEPHEN D., McMAHON, EILEEN J., SCHREINER, BETTINA, BAILEY, SAMANTHA L. · 2007 · Annals of the New York Academy of Sciences
6. The correlation between the Th17/Treg cell balance and bone health
   Zhu, Lei, Hua, Fei, Ding, Wenge, Ding, Kai, Zhang, Yige, Xu, Chenyang · 2020 · Immunity & Ageing
7. Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways
   Dull, Ana-Maria, Moga, Marius Alexandru, Dimienescu, Oana Gabriela, Sechel, Gabriela, Burtea, Victoria, Anastasiu, Costin Vlad · 2019 · Molecules
8. Ipilimumab and nivolumab/pembrolizumab in advanced hepatocellular carcinoma refractory to prior immune checkpoint inhibitors
   Wong, Jeffrey Sum Lung, Kwok, Gerry Gin Wai, Tang, Vikki, Li, Bryan Cho Wing, Leung, Roland, Chiu, Joanne, Ma, Ka Wing, She, Wong Hoi, Tsang, Josephine, Lo, Chung Mau et al. · 2021 · Journal for ImmunoTherapy of Cancer
9. Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway
   Parker-Athill, E. Carla, Tan, Jun · 2010 · Neurosignals
10. IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19
    Kishimoto, Tadamitsu, Kang, Sujin · 2022 · Annual Review of Immunology
11. Hepatic Stellate Cells Function as Regulatory Bystanders
    Ichikawa, Shintaro, Mucida, Daniel, Tyznik, Aaron J, Kronenberg, Mitchell, Cheroutre, Hilde · 2011 · The Journal of Immunology
12. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
    Gupta, Shipra, Thornley, Thomas B., Gao, Wenda, Larocca, Rafael, Turka, Laurence A., Kuchroo, Vijay K., Strom, Terry B. · 2012 · Journal of Clinical Investigation
13. How bile acids and the microbiota interact to shape host immunity
    Lee, Michael H., Nuccio, Sean-Paul, Mohanty, Ipsita, Hagey, Lee R., Dorrestein, Pieter C., Chu, Hiutung, Raffatellu, Manuela · 2024 · Nature Reviews Immunology
14. Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    Schulze-Topphoff, Ulf, Prat, Alexandre, Prozorovski, Timour, Siffrin, Volker, Paterka, Magdalena, Herz, Josephine, Bendix, Ivo, Ifergan, Igal, Schadock, Ines, Mori, Marcelo A et al. · 2009 · Nature Medicine
15. The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
    Hanna, Bola S., Wang, Gang, Galván-Peña, Silvia, Mann, Alexander O., Ramirez, Ricardo N., Muñoz-Rojas, Andrés R., Smith, Kathleen, Wan, Min, Benoist, Christophe, Mathis, Diane · 2023 · Immunity
16. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation
    Barnett, Lisa G, Simkins, Helen M A, Barnett, Burton E, Korn, Lisa L, Johnson, Andy L, Wherry, E John, Wu, Gregory F, Laufer, Terri M · 2014 · The Journal of Immunology
17. Targeting dendritic cell signaling to regulate the response to immunization
    Escors, David, Lopes, Luciene, Lin, Rongtuan, Hiscott, John, Akira, Shizuo, Davis, Roger J., Collins, Mary K. · 2008 · Blood
18. Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory t cells
    Yun, Tae Jin, Lee, Jun Seong, Machmach, Kawthar, Shim, Dahee, Choi, Junhee, Wi, Young Jin, Jang, Hyung Seok, Jung, In-Hyuk, Kim, Kyeongdae, Yoon, Won Kee et al. · 2016 · Cell Metabolism
19. Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22
    Hyvärinen, Kati, Holopainen, Minna, Skirdenko, Vita, Ruhanen, Hanna, Lehenkari, Petri, Korhonen, Matti, Käkelä, Reijo, Laitinen, Saara, Kerkelä, Erja · 2018 · Frontiers in Immunology
20. An interferon-γ-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis
    Suryani, Santi, Sutton, Ian · 2007 · Journal of Neuroimmunology
21. Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
    Apostolidis, Sokratis A., Rauen, Thomas, Hedrich, Christian M., Tsokos, George C., Crispín, José C. · 2013 · Journal of Biological Chemistry
22. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
    Zhang, Huiyuan, Madi, Asaf, Yosef, Nir, Chihara, Norio, Awasthi, Amit, Pot, Caroline, Lambden, Conner, Srivastava, Amitabh, Burkett, Patrick R., Nyman, Jackson et al. · 2020 · Cell Reports
23. Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Rao, Deepak A., Eid, Raymond E., Qin, Lingfeng, Yi, Tai, Kirkiles-Smith, Nancy C., Tellides, George, Pober, Jordan S. · 2008 · The Journal of Experimental Medicine
24. Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.
    Reed, M, Morris, S H, Owczarczyk, A B, Lukacs, N W · 2015 · Mucosal Immunology
25. Commensal gut flora and brain autoimmunity: a love or hate affair?
    Berer, Kerstin, Krishnamoorthy, Gurumoorthy · 2012 · Acta Neuropathologica
26. Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?
    Wesselingh, Robb, Butzkueven, Helmut, Buzzard, Katherine, Tarlinton, David, O'Brien, Terence J., Monif, Mastura · 2019 · Frontiers in Immunology
27. A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy
    Horisberger, Alice, La Rosa, Stefano, Zurcher, Jean-Philippe, Zimmermann, Stefan, Spertini, Francois, Coukos, George, Obeid, Michel · 2018 · Journal for ImmunoTherapy of Cancer
28. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells
    Nakatsukasa, Hiroko, Zhang, Dunfang, Maruyama, Takashi, Chen, Hua, Cui, Kairong, Ishikawa, Masaki, Deng, Lisa, Zanvit, Peter, Tu, Eric, Jin, Wenwen et al. · 2015 · Nature Immunology
29. Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice
    Chen, Ying, Li, Cuiying, Weng, Dong, Song, Laiyu, Tang, Wen, Dai, Wujing, Yu, Ye, Liu, Fangwei, Zhao, Ming, Lu, Chunwei et al. · 2014 · Toxicology and Applied Pharmacology
30. ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease
    Zanin-Zhorov, Alexandra, Blazar, Bruce R. · 2021 · Clinical Immunology
31. Toll-like receptors in the respiratory system: Their roles in inflammation
    Iwamura, Chiaki, Nakayama, Toshinori · 2008 · Current Allergy and Asthma Reports
32. Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis
    Saito, Masafumi, Fujinami, Yoshihisa, Ono, Yuko, Ohyama, Shohei, Fujioka, Kazumichi, Yamashita, Kimihiro, Inoue, Shigeaki, Kotani, Joji · 2021 · Brain, Behavior, and Immunity
33. Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
    Chan, Yvonne R., Chen, Kong, Duncan, Steven R., Lathrop, Kira L., Latoche, Joseph D., Logar, Alison J., Pociask, Derek A., Wahlberg, Brendon J., Ray, Prabir, Ray, Anuradha et al. · 2013 · Journal of Allergy and Clinical Immunology
34. Signal transduction and Th17 cell differentiation
    O'Shea, John J., Steward-Tharp, Scott M., Laurence, Arian, Watford, Wendy T., Wei, Lai, Adamson, Adewole S., Fan, Samuel · 2009 · Microbes and Infection
35. Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies
    Naseem, Sidrah, Hussain, Tabinda, Manzoor, Sobia · 2018 · Cytokine & Growth Factor Reviews
36. Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
    Freuchet, Antoine, Roy, Payel, Armstrong, Sujit Silas, Oliaeimotlagh, Mohammad, Kumar, Sunil, Orecchioni, Marco, Ali, Amal J., Khan, Amir, Makings, Jeffrey, Lyu, Qingkang et al. · 2023 · Nature Immunology
37. Th17 cell pathogenicity in autoimmune disease
    Park, Eunchong, Ciofani, Maria · 2025 · Experimental & Molecular Medicine
38. The role of CD4⁺FoxP3⁺ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment
    Wang, Yifei, Zheng, Jingbin, Islam, Md Sahidul, Yang, Yang, Hu, Yuanjia, Chen, Xin · 2021 · International Journal of Biological Sciences
39. HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis
    Higashiyama, Masaaki, Hokari, Ryota, Hozumi, Hideaki, Kurihara, Chie, Ueda, Toshihide, Watanabe, Chikako, Tomita, Kengo, Nakamura, Mitsuyasu, Komoto, Shunsuke, Okada, Yoshikiyo et al. · 2012 · Journal of Leukocyte Biology
40. Galectin-3 Modulates Th17 Responses by Regulating Dendritic Cell Cytokines
    Fermin Lee, Agnes, Chen, Huan-Yuan, Wan, Lei, Wu, Sheng-Yang, Yu, Jhang-Sian, Huang, Annie C., Miaw, Shi-Chuen, Hsu, Daniel K., Wu-Hsieh, Betty A., Liu, Fu-Tong · 2013 · The American Journal of Pathology
41. Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity
    Janelsins, Brian M., Lu, Mingfang, Datta, Sandip K. · 2014 · Proceedings of the National Academy of Sciences
42. Protein Kinase C-θ Promotes Th17 Differentiation via Upregulation of Stat3
    Kwon, Myung-Ja, Ma, Jian, Ding, Yan, Wang, Ruiqing, Sun, Zuoming · 2012 · The Journal of Immunology
43. The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states
    Thakore, Pratiksha I., Schnell, Alexandra, Zhao, Maryann, Huang, Linglin, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Ma, Sai et al. · 2022
44. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation
    Hernandez, Jeniffer B., Chang, Christina, LeBlanc, Mathias, Grimm, David, Le Lay, John, Kaestner, Klaus H., Zheng, Ye, Montminy, Marc · 2015 · Nature Communications
45. Detection of IL-17 and IL-23 in Plasma Samples of Children with Autism
    Enstrom, Amanda, Onore, Charity, Hertz-Picc, Irva, Hansen, Robin, Croen, Lisa, Water, Judy Van de, Ashwood, Paul · 2008 · American Journal of Biochemistry and Biotechnology
46. Interleukin-17 as a key player in neuroimmunometabolism
    Douglas, Aaron, Stevens, Brenneth, Lynch, Lydia · 2023 · Nature Metabolism
47. Th17/Treg balance in children with obstructive sleep apnea syndrome and the relationship with allergic rhinitis
    Ni, Kun, Zhao, Limin, Wu, Jiali, Chen, Wei, HongyaYang, Li, Xiaoyan · 2015 · International Journal of Pediatric Otorhinolaryngology
48. Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation
    Hwang, Joonsung, Kita, Ryosuke, Kwon, Hyouk-Soo, Choi, Eung Ho, Lee, Seung Hun, Udey, Mark C., Morasso, Maria I. · 2011 · Proceedings of the National Academy of Sciences
49. TGF-beta: a master switch in tumor immunity
    Gigante, Margherita, Gesualdo, Loreto, Ranieri, Elena · 2012 · Current Pharmaceutical Design
50. Perspectives on Hypoxia Signaling in Tumor Stroma
    Zhang, Yuqing, Coleman, Morgan, Brekken, Rolf A. · 2021 · Cancers
51. Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity
    Doss, Prenitha Mercy Ignatius Arokia, Umair, Muhammad, Baillargeon, Joanie, Fazazi, Reda, Fudge, Neva, Akbar, Irshad, Yeola, Asmita Pradeep, Williams, John B., Leclercq, Mickael, Joly-Beauparlant, Charles et al. · 2021 · Cell Reports
52. IL6 fuels durable memory for Th17 cell–mediated responses to tumors
    Knochelmann, Hannah M., Dwyer, Connor J., Smith, Aubrey S., Bowers, Jacob S., Wyatt, Megan M., Nelson, Michelle H., Rangel Rivera, Guillermo O., Horton, Joshua D., Krieg, Carsten, Armeson, Kent et al. · 2020 · Cancer Research
53. Update on the role of Interleukin 17 in rheumatologic autoimmune diseases
    Konya, Christine, Paz, Ziv, Apostolidis, Sokratis A., Tsokos, George C. · 2015 · Cytokine
54. Neutralization of Interleukin‐17 Attenuates Cholestatic Liver Fibrosis in Mice
    Zhang, S., Huang, D., Weng, J., Huang, Y., Liu, S., Zhang, Q., Li, N., Wen, M., Zhu, G., Lin, F. et al. · 2016 · Scandinavian Journal of Immunology
55. Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p
    Xu, Qian-Fei, Peng, Hui-Ping, Lu, Xi-Rong, Hu, Yun, Xu, Zou-Hua, Xu, Jin-Kang · 2021 · Cytokine
56. Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases
    Jeffery, Hannah C, Hunter, Stuart, Humphreys, Elizabeth H, Bhogal, Ricky, Wawman, Rebecca E, Birtwistle, Jane, Atif, Muhammad, Bagnal, Christopher J, Rodriguez Blanco, Giovanny, Richardson, Naomi et al. · 2019 · The Journal of Immunology
57. Targeting PKC in Human T Cells Using Sotrastaurin (AEB071) Preserves Regulatory T Cells and Prevents IL-17 Production
    He, Xuehui, Koenen, Hans J.P.M., Smeets, Ruben L., Keijsers, Romy, van Rijssen, Esther, Koerber, Andreas, van de Kerkhof, Peter C., Boots, Annemieke M.H., Joosten, Irma · 2014 · Journal of Investigative Dermatology
58. The imbalance between regulatory and IL-17-secreting CD4+T cells in multiple-trauma rat
    Dai, Heling, Sun, Tiansheng, Liu, Zhi, Zhang, Jianzheng, Zhou, Meng · 2013 · Injury
59. The role of the adaptive immune system in the initiation and persistence of multiple sclerosis
    Afzali, Ali Maisam, Korn, Thomas · 2025 · Seminars in Immunology
60. Human IL-6R hi TIGIT − CD4 + CD127 low CD25 + T cells display potent in vitro suppressive capacity and a distinct Th17 profile
    Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A. · 2017 · Clinical Immunology
61. Targeting interleukin-17 as a novel treatment option for fibrotic diseases
    Sisto, Margherita, Lisi, Sabrina · 2023 · Journal of Clinical Medicine
62. A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs
    Fowler, Kevin D., Kuchroo, Vijay K., Chakraborty, Arup K. · 2012 · PLoS ONE
63. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis
    Hanna, Bola S., Langston, P. Kent, Marin-Rodero, Miguel, Ramirez, Ricardo N., Wan, Min, Benoist, Christophe, Mathis, Diane · 2026 · Proceedings of the National Academy of Sciences