The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Exposing murine whole bone marrow in vitro to a long acting derivative of prostaglandin E2 (dmPGE2) prior to transplantation resulted in a 3-fold increase of day-12 spleen colony forming units, indicative of an increase in HSC, and a 2.3-fold increase in long term engraftment in competitive limiting –dilution transplantation assays in the mouse[94].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [94]
In the citing paper
“Similarly, North et al. has recently identified chemicals that enhance prostaglandin (PG) E2 synthesis which appear to preserve or expand HSC in a screening assay utilizing the zebra fish system[94].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [94]
In the citing paper
“Exposing murine whole bone marrow in vitro to a long acting derivative of prostaglandin E2 (dmPGE2) prior to transplantation resulted in a 3-fold increase of day-12 spleen colony forming units, indicative of an increase in HSC, and a 2.3-fold increase in long term engraftment in competitive limiting –dilution transplantation assays in the mouse[94].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [94]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Langenbach, R., Loftin, C., Lee, C., & Tiano, H. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00158-6 · Cited by 230
Research works printed but not linked: 29
- Dzierzak, E. The emergence of definitive hematopoietic stem cells in the mammal. Curr. Opin. Hematol. 12, 197–202 (2005) · DOI
- Galloway, J. L. & Zon, L. I. Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr. Top. Dev. Biol. 53, 139–158 (2003) · DOI
- North, T. E. et al. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity 16, 661–672 (2002) · DOI
- Mukouyama, Y. et al. Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb. Curr. Biol. 9, 833–836 (1999) · DOI · Paper page
- Kalev-Zylinska, M. L. et al. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1–CBF2T1 transgene advances a model for studies of leukemogenesis. Development 129, 2015–2030 (2002) · DOI
- Grosser, T., Yusuff, S., Cheskis, E., Pack, M. A. & FitzGerald, G. A. Developmental expression of functional cyclooxygenases in zebrafish. Proc. Natl Acad. Sci. USA 99, 8418–8423 (2002) · DOI
- Cha, Y. I., Kim, S. H., Solnica-Krezel, L. & Dubois, R. N. Cyclooxygenase-1 signaling is required for vascular tube formation during development. Dev. Biol. 282, 274–283 (2005) · DOI
- Cha, Y. I. et al. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 20, 77–86 (2006) · DOI
- Burns, C. E., Traver, D., Mayhall, E., Shepard, J. L. & Zon, L. I. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 19, 2331–2342 (2005) · DOI · Paper page
- Nakano, T., Kodama, H. & Honjo, T. In vitro development of primitive and definitive erythrocytes from different precursors. Science 272, 722–724 (1996) · DOI
- Ivanova, N. B. et al. A stem cell molecular signature. Science 298, 601–604 (2002) · DOI
- Akashi, K. et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101, 383–389 (2003) · DOI
- Venezia, T. A. et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2, e301 (2004) · DOI
- Zhang, C. C. & Lodish, H. F. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood 103, 2513–2521 (2004) · DOI
- Boer, A. K., Drayer, A. L., Rui, H. & Vellenga, E. Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Blood 100, 467–473 (2002) · DOI
- Rocca, B. et al. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc. Natl Acad. Sci. USA 99, 7634–7639 (2002) · DOI
- Feher, I. & Gidali, J. Prostaglandin E2 as stimulator of haemopoietic stem cell proliferation. Nature 247, 550–551 (1974) · DOI
- Langenbach, R. et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83, 483–492 (1995) · DOI
- Lorenz, M. et al. Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil-induced myelotoxicity in mice. Exp. Hematol. 27, 1494–1502 (1999) · DOI
- Cayeux, S. J., Beverley, P. C., Schulz, R. & Dorken, B. Elevated plasma prostaglandin E2 levels found in 14 patients undergoing autologous bone marrow or stem cell transplantation. Bone Marrow Transplant. 12, 603–608 (1993)
- Talosi, G. et al. Prostaglandin E1 treatment in patent ductus arteriosus dependent congenital heart defects. J. Perinat. Med. 32, 368–374 (2004) · DOI
- Thanopoulos, B. D., Andreou, A. & Frimas, C. Prostaglandin E2 administration in infants with ductus-dependent cyanotic congenital heart disease. Eur. J. Pediatr. 146, 279–282 (1987) · DOI
- Hertelendy, F., Woods, R. & Jaffe, B. M. Prostaglandin E levels in peripheral blood during labor. Prostaglandins 3, 223–227 (1973) · DOI
- Zhu, H. et al. Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev. Biol. 281, 256–269 (2005) · DOI
- Weber, G. J. et al. Mutant-specific gene programs in the zebrafish. Blood 106, 521–530 (2005) · DOI
- Pini, B. et al. Prostaglandin E synthases in zebrafish. Arterioscler. Thromb. Vasc. Biol. 25, 315–320 (2005) · DOI
- Traver, D. et al. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood 104, 1298–1305 (2004) · DOI
- Kyba, M. et al. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Proc. Natl Acad. Sci. USA 100 (Suppl 1). 11904–11910 (2003) · DOI
- Wang, Y., Yates, F., Naveiras, O., Ernst, P. & Daley, G. Q. Embryonic stem cell-derived hematopoietic stem cells. Proc. Natl Acad. Sci. USA 102, 19081–19086 (2005) · DOI
Cited by
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570
Self-citationGreenhough, A., Smartt, H. J. M., Moore, A. E., Roberts, H. R., Williams, A. C., Paraskeva, C., & Kaidi, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp014 · Cited by 1,220
Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy
Huang, Q., Li, F., Liu, X., Li, W., Shi, W., Liu, F.-F., O'Sullivan, B., He, Z., Peng, Y., Tan, A.-C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2385 · Cited by 886
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Targeted genome editing in human repopulating haematopoietic stem cells
Genovese, P., Schiroli, G., Escobar, G., Di Tomaso, T., Firrito, C., Calabria, A., Moi, D., Mazzieri, R., Bonini, C., Holmes, M. C., et al. (2014) · Nature · doi:10.1038/nature13420 · Cited by 555
Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.018 · Cited by 454
Tissue homeostasis and inflammation
Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053734 · Cited by 364
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Shan, J., Schwartz, R. E., Ross, N. T., Logan, D. J., Thomas, D., Duncan, S. A., North, T. E., Goessling, W., Carpenter, A. E., & Bhatia, S. N. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1270 · Cited by 254
Self-citationInhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
Hoban, M. D., Orkin, S. H., & Bauer, D. E. (2016) · Blood · doi:10.1182/blood-2015-09-618587 · Cited by 194
Self-citationZebrafish as a model for the study of neutrophil biology
Henry, K. M., Loynes, C. A., Whyte, M. K. B., & Renshaw, S. A. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1112594 · Cited by 143
Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion
Isern, J., Martín-Antonio, B., Ghazanfari, R., Martín, A. M., López, J. A., del Toro, R., Sánchez-Aguilera, A., Arranz, L., Martín-Pérez, D., Suárez-Lledó, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.041 · Cited by 141
Zimmerman, M. A., Huang, Q., Li, F., Liu, X., & Li, C.-Y. (2013) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2013.05.003 · Cited by 59
Wojtowicz, E. E., Lechman, E. R., Hermans, K. G., Schoof, E. M., Wienholds, E., Isserlin, R., van Veelen, P. A., Broekhuis, M. J. C., Janssen, G. M. C., Trotman-Grant, A., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.008 · Cited by 60
“Recently, promising HSC expansion protocols have employed small molecules such as prostaglandin E2, SR1, UM171, or UM729, although clinical efficacy remains elusive (Boitano et al., 2010; Fares et al., 2014; North et al., 2007).”
Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J.-I., Raftopoulou, C., Murphey, R. D., Bayliss, P. E., Imai, Y., Burns, C. E., Masutomi, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003364 · Cited by 58
Self-citationNfix is a novel regulator of murine hematopoietic stem and progenitor cell survival
Holmfeldt, P., Pardieck, J., Saulsberry, A. C., Nandakumar, S. K., Finkelstein, D., Gray, J. T., Persons, D. A., & McKinney-Freeman, S. (2013) · Blood · doi:10.1182/blood-2013-04-493973 · Cited by 55
Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52
Self-citationFinding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia
Müller, L. U. W., & Williams, D. A. (2009) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2009.03.010 · Cited by 31
Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
Martin, C. S., Moriyama, A., & Zon, L. I. (2011) · Genome Medicine · doi:10.1186/gm299 · Cited by 29
Self-citationStrategies for elevating hematopoietic stem cells expansion and engraftment capacity
Derakhshani, M., Abbaszadeh, H., Movassaghpour, A. A., Mehdizadeh, A., Ebrahimi-Warkiani, M., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116598 · Cited by 28
Using the Zebrafish as a Genetic Model to Study Erythropoiesis
Zhang, Y., Chen, M., & Chen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910475 · Cited by 25
A chemical screen identifies small molecules that regulate hepcidin expression
Gaun, V., Patchen, B., Volovetz, J., Zhen, A. W., Andreev, A., Pollastri, M. P., & Fraenkel, P. G. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.06.002 · Cited by 22
A comparative study of bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia
Cheung, A. M. S., Chow, H. C. H., Liang, R., & Leung, A. Y. H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07431.x · Cited by 13
Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer
Caronni, N., Montaldo, E., Mezzanzanica, L., Cilenti, F., Genua, M., & Ostuni, R. (2021) · Immunological Reviews · doi:10.1111/imr.12944 · Cited by 6
Metadata
- Authors
- North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I.-H., Grosser, T., FitzGerald, G. A., Daley, G. Q., Orkin, S. H., & Zon, L. I.
- Venue
- Nature
- Published
- 2007-06
- Volume
- 447
- Issue
- 7147
- Pages
- 1007-1011
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 1,029
- References
- 1
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review