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Cited by 1,139

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Open access
Ding, Li, Ellis, Matthew J., Li, Shunqiang, Larson, David E., Chen, Ken, Wallis, John W., Harris, Christopher C., McLellan, Michael D., Fulton, Robert S., Fulton, Lucinda L., Abbott, Rachel M., Hoog, Jeremy, Dooling, David J., Koboldt, Daniel C., Schmidt, Heather, Kalicki, Joelle, Zhang, Qunyuan, Chen, Lei, Lin, Ling, Wendl, Michael C., McMichael, Joshua F., Magrini, Vincent J., Cook, Lisa, McGrath, Sean D., Vickery, Tammi L., Appelbaum, Elizabeth, DeSchryver, Katherine, Davies, Sherri, Guintoli, Therese, Lin, Li, Crowder, Robert, Tao, Yu, Snider, Jacqueline E., Smith, Scott M., Dukes, Adam F., Sanderson, Gabriel E., Pohl, Craig S., Delehaunty, Kim D., Fronick, Catrina C., Pape, Kimberley A., Reed, Jerry S., Robinson, Jody S., Hodges, Jennifer S., Schierding, William, Dees, Nathan D., Shen, Dong, Locke, Devin P., Wiechert, Madeline E., Eldred, James M., Peck, Josh B., Oberkfell, Benjamin J., Lolofie, Justin T., Du, Feiyu, Hawkins, Amy E., O’Laughlin, Michelle D., Bernard, Kelly E., Cunningham, Mark, Elliott, Glendoria, Mason, Mark D., Thompson Jr, Dominic M., Ivanovich, Jennifer L., Goodfellow, Paul J., Perou, Charles M., Weinstock, George M., Aft, Rebecca, Watson, Mark, Ley, Timothy J., Wilson, Richard K., Mardis, Elaine R.·2010·Nature
DOI 10.1038/nature08989
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Abstract

Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer: peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The metastasis contained two de novo mutations and a large deletion not present in the primary tumour, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumour mutations and displayed a mutation enrichment pattern that resembled the metastasis. Two overlapping large deletions, encompassing CTNNA1, were present in all three tumour samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour.

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Authors
Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L. L., Abbott, R. M., Hoog, J., Dooling, D. J., Koboldt, D. C., Schmidt, H., Kalicki, J., Zhang, Q., Chen, L., Lin, L., Wendl, M. C., McMichael, J. F., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Appelbaum, E., DeSchryver, K., Davies, S., Guintoli, T., Lin, L., Crowder, R., Tao, Y., Snider, J. E., Smith, S. M., Dukes, A. F., Sanderson, G. E., Pohl, C. S., Delehaunty, K. D., Fronick, C. C., Pape, K. A., Reed, J. S., Robinson, J. S., Hodges, J. S., Schierding, W., Dees, N. D., Shen, D., Locke, D. P., Wiechert, M. E., Eldred, J. M., Peck, J. B., Oberkfell, B. J., Lolofie, J. T., Du, F., Hawkins, A. E., O’Laughlin, M. D., Bernard, K. E., Cunningham, M., Elliott, G., Mason, M. D., Thompson Jr, D. M., Ivanovich, J. L., Goodfellow, P. J., Perou, C. M., Weinstock, G. M., Aft, R., Watson, M., Ley, T. J., Wilson, R. K., & Mardis, E. R.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2010-04
Volume
464
Issue
7291
Pages
999-1005
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature08989
OpenAlex
W2147354890
Cited by
1,139
References
3
FWCI
44.89
Type
journal article
Language
en
Open access
bronze

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