Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323

Environmental risk factors for multiple sclerosis. Part I: The role of infection

Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21117 · Cited by 1,036

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H., & Miller, S. D. (2005) · Nature Medicine · doi:10.1038/nm1202 · Cited by 694

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

Goverman, J. M., Woods, A., Larson, L., Weiner, L. P., Hood, L., & Zaller, D. M. (1993) · Cell · doi:10.1016/0092-8674(93)90074-z · Cited by 684

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

Hill, D. A., & Artis, D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101330 · Cited by 600

Investigation of probiotics in multiple sclerosis

Tankou, S. K., Regev, K., Healy, B. C., Cox, L. M., Tjon, E., Kivisakk, P., Vanande, I. P., Cook, S., Gandhi, R., Glanz, B., et al. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517737390 · Cited by 156

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

Ben‐Nun, A., Kaushansky, N., Kawakami, N., Krishnamoorthy, G., Berer, K., Liblau, R., Hohlfeld, R., & Wekerle, H. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.06.004 · Cited by 165

Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis

Riccio, P., & Rossano, R. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0581-4 · Cited by 164

Intestinal microbiota: Shaping local and systemic immune responses

Molloy, M. J., Bouladoux, N. J., & Belkaid, Y. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.11.008 · Cited by 159

The fecal microbiome of ALS patients

Brenner, D., Hiergeist, A., Adis, C. I., Mayer, B., Gessner, A., Ludolph, A. C., & Weishaupt, J. H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.023 · Cited by 156

The aryl hydrocarbon receptor and the gut–brain axis

Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00585-5 · Cited by 152

Environmental factors in autoimmune diseases and their role in multiple sclerosis

Haase, S., Grohme, D. A., Erzler, M., Binsfeld, M., Haghikia, A., Müller, D. N., Linker, R. A., & Kleinewietfeld, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2311-1 · Cited by 156

Schizophrenia and the gut–brain axis

Nemani, K., Hosseini Ghomi, R., McCormick, B., & Fan, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.018 · Cited by 151

Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment

Huynh, J. L., & Casaccia, P. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70309-5 · Cited by 162

Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

Pluznick, J. L. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.033 · Cited by 153

Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury

Cheng, S., Ma, X., Geng, S., Jiang, X., Li, Y., Hu, L., Lǐ, J., Wang, Y., & Han, X. (2018) · mSystems · doi:10.1128/msystems.00137-18 · Cited by 153

Microbial view of central nervous system autoimmunity

Berer, K., & Krishnamoorthy, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.007 · Cited by 153

Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

Sécher, T., Kassem, S., Benamar, M., Bernard, I., Boury, M., Barreau, F., Oswald, É., & Saoudi, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01096 · Cited by 148

Cross talk between neutrophils and the microbiota

Zhang, D., & Frenette, P. S. (2019) · Blood · doi:10.1182/blood-2018-11-844555 · Cited by 153

Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study

Buscarinu, M. C., Cerasoli, B., Annibali, V., Policano, C., Lionetto, L., Capi, M., Mechelli, R., Romano, S., Fornasiero, A., Mattei, G., et al. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516652498 · Cited by 149

Microbiota and neurologic diseases: potential effects of probiotics

Umbrello, G., & Esposito, S. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1058-7 · Cited by 147

Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment

Dolpady, J., Sorini, C., Pietro, C. D., Cosorich, I., Ferrarese, R., Saita, D., Clementi, M., Canducci, F., & Falcone, M. (2015) · Journal of Diabetes Research · doi:10.1155/2016/7569431 · Cited by 147

Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome

Al-Ghezi, Z. Z., Busbee, P. B., Alghetaa, H., Nagarkatti, P. S., & Nagarkatti, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.028 · Cited by 149

Diet, gut microbiota and cognition

Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144

Fecal microbiota transplantation associated with 10 years of stability in a patient with SPMS

Makkawi, S., Camara-Lemarroy, C. R., & Metz, L. M. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000459 · Cited by 144

Air Pollution and Children: Neural and Tight Junction Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in Neurodegeneration

Calderón‐Garcidueñas, L., Vojdani, A., Blaurock-Busch, E., Busch, Y. M., Friedle, A., Franco-Lira, M., Mukherjee, P. S., Martínez-Aguirre, X., Park, S., Torres‐Jardón, R., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141365 · Cited by 148

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

Amato, M. P., Derfuss, T. J., Hemmer, B., Liblau, R., Montalbán, X., Sørensen, P. S., Miller, D. H., For the 2016 ECTRIMS Focused Workshop Group, Alfredsson, L. S., Aloisi, F., et al. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458516686847 · Cited by 152

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

Mu, Q., Zhang, H., & Luo, X. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00608 · Cited by 147

Connection between gut microbiome and brain development in preterm infants

Lu, J. N., & Claud, E. C. (2018) · Developmental Psychobiology · doi:10.1002/dev.21806 · Cited by 152

A clinical update on the significance of the gut microbiota in systemic autoimmunity

Rosser, E. C., & Mauri, C. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.06.009 · Cited by 142

The Gut Microbiome and Multiple SclerosisPreprint

Ochoa‐Repáraz, J., Kirby, T. O., & Kasper, L. H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029017 · Cited by 143

Clostridium Difficile Infection

Lübbert, C., John, E., & von Müller, L. (2014) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2014.0723 · Cited by 147

Pro-Angiogenic Activity of TLRs and NLRs: A Novel Link Between Gut Microbiota and Intestinal Angiogenesis

Schirbel, A., Kessler, S. P., Rieder, F., West, G. A., Rebert, N. A., Asosingh, K., McDonald, C., & Fiocchi, C. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.005 · Cited by 142

Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis

Ferolla, S. M., Couto, C. A., Costa‐Silva, L., Armiliato, G. N. D. A., Pereira, C., Martins, F. S., Ferrari, M. L., Vilela, E. G., Tôrres, H. O. D. G., da Cunha, A. S., et al. (2016) · Nutrients · doi:10.3390/nu8070397 · Cited by 136

The microbiota and autoimmunity: Their role in thyroid autoimmune diseases

Köhling, H.-L., Plummer, S. F., Marchesi, J. R., Davidge, K. S., & Ludgate, M. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.07.001 · Cited by 139

Animal models of multiple sclerosis: From rodents to zebrafish

Burrows, D. J., McGown, A., Jain, S. A., De Felice, M., Ramesh, T. M., Sharrack, B., & Majid, A. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458518805246 · Cited by 135

Lymphotoxin signalling in immune homeostasis and the control of microorganisms

Upadhyay, V., & Fu, Y. (2013) · Nature reviews. Immunology · doi:10.1038/nri3406 · Cited by 136

Brain-Reactive Antibodies and Disease

Diamond, B., Honig, G., Mader, S., Brimberg, L., & Volpe, B. T. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075041 · Cited by 138

The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Ochoa‐Repáraz, J., & Kasper, L. H. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0191-1 · Cited by 141

The role of gut microbiota in T cell immunity and immune mediated disorders

Shim, J. A., Ryu, J. H., Jo, Y., & Hong, C. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79430 · Cited by 140

Technological strategies ensuring the safe arrival of beneficial microorganisms to the gut: From food processing and storage to their passage through the gastrointestinal tract

Cassani, L., Gomez-Zavaglia, A., & Simal-Gandara, J. (2020) · Food Research International · doi:10.1016/j.foodres.2019.108852 · Cited by 133

IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments

Luchtman, D. W., Ellwardt, E., Larochelle, C., & Zipp, F. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.013 · Cited by 137

Microbial metaproteomics for characterizing the range of metabolic functions and activities of human gut microbiota

Xiong, W., Abraham, P. E., Li, Z., Pan, C., & Hettich, R. L. (2015) · PROTEOMICS · doi:10.1002/pmic.201400571 · Cited by 136

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

Koutrolos, M., Berer, K., Kawakami, N., Wekerle, H., & Krishnamoorthy, G. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0163-1 · Cited by 139

Regulatory T Cells and Immune Tolerance in the IntestinePreprint

Harrison, O. B., & Powrie, F. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018341 · Cited by 137

Gut Microbiome and Multiple Sclerosis

Bhargava, P., & Mowry, E. M. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0492-2 · Cited by 129

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

Li, C., Chen, W., Lin, F., Li, W., Wang, P., Liao, G., & Zhang, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01238-z · Cited by 129

The Gut-Microglia Connection: Implications for Central Nervous System Diseases

Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 130

Microbiome and immunological interactions

Kelly, D., & Mulder, I. E. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00498.x · Cited by 131

The role of short-chain fatty acid on blood pressure regulation

Miyamoto, J., Kasubuchi, M., Nakajima, A., Irie, J., Itoh, H., & Kimura, I. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000246 · Cited by 128

Myasthenia Gravis: Paradox versus paradigm in autoimmunity

Berrih‐Aknin, S. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.05.001 · Cited by 129

Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation

Steelman, A. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00520 · Cited by 131

Functional immune cell–astrocyte interactions

Sanmarco, L. M., Polonio, C. M., Wheeler, M. A., & Quintana, F. J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202715 · Cited by 134

Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome

Marietta, E. V., Gomez, A. M., Yeoman, C. J., Tilahun, A. Y., Clark, C. R., Luckey, D. H., Murray, J. A., White, B. A., Kudva, Y. C., & Rajagopalan, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078687 · Cited by 125

Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury

Kigerl, K. A., Mostacada, K., & Popovich, P. G. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0583-2 · Cited by 126

Age-related changes in intestinal immunity and the microbiome

Walrath, T., Dyamenahalli, K. U., Hulsebus, H. J., McCullough, R. L., Idrovo, J., Boe, D. M., McMahan, R. H., & Kovacs, E. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0620-405rr · Cited by 129

The gut microbiota in multiple sclerosis varies with disease activity

Thirion, F., Sellebjerg, F. T., Fan, Y., Lyu, L., Hansen, T. H., Pons, N., Levenez, F., Quinquis, B., Stankevič, E., Søndergaard, H. B., et al. (2023) · Genome Medicine · doi:10.1186/s13073-022-01148-1 · Cited by 133

The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168870 · Cited by 123

Autoimmune host–microbiota interactions at barrier sites and beyond

Ruff, W. E., & Kriegel, M. A. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.006 · Cited by 122

Short-chain fatty acids and gut microbiota in multiple sclerosis

Melbye, P., Olsson, A., Hansen, T. H., Søndergaard, H. B., & Oturai, A. B. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13045 · Cited by 125

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20200895 · Cited by 120

Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders

Gilbert, J. A., Krajmalnik‐Brown, R., Porazinska, D. L., Weiss, S. J., & Knight, R. D. (2013) · Cell · doi:10.1016/j.cell.2013.11.035 · Cited by 124

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Papotto, P. H., Reinhardt, A., Prinz, I., & Silva‐Santos, B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.11.006 · Cited by 123

Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma

Gong, H., Zhang, S., Li, Q., Zuo, C., Gao, X., Zheng, B., & Lin, M. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.107921 · Cited by 121

Microglia in neurodegenerative diseases

Xu, Y., Jin, M.-Z., Yang, Z., & Jin, M.-Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290881 · Cited by 121

Gut microbiome-mediated regulation of neuroinflammation

Bostick, J. W., Schonhoff, A. M., & Mazmanian, S. K. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102177 · Cited by 120

Multiple Sclerosis Risk Factors and Pathogenesis

Nourbakhsh, B., & Mowry, E. M. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000725 · Cited by 126

Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview

Ilchmann-Diounou, H., & Ménard, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01823 · Cited by 125

Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases

Riedhammer, C., & Weissert, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00322 · Cited by 124

The immune system and stroke: from current targets to future therapy

Malone, K., Amu, S., Moore, A., & Waeber, C. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12191 · Cited by 116

Gut feelings about smoking and coffee in Parkinson's disease

Derkinderen, P., Shannon, K. M., & Brundin, P. (2014) · Movement Disorders · doi:10.1002/mds.25882 · Cited by 115

Ultrahigh-throughput functional profiling of microbiota communities

Terekhov, S. S., Smirnov, I. V., Malakhova, M. V., Samoilov, A. E., Manolov, A. I., Nazarov, A. S., Danilov, D. V., Dubiley, S. A., Osterman, I. А., Rubtsova, M. P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811250115 · Cited by 115

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J., Spencer, C. M., Lynch, S. V., Zamvil, S. S., & Waubant, E. L. (2016) · BMC Neurology · doi:10.1186/s12883-016-0703-3 · Cited by 117

IFN‐γ promotes transendothelial migration of CD4+ T cells across the blood–brain barrier

Sonar, S. A., Shaikh, S., Joshi, N., Atre, A. N., & Lal, G. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.56 · Cited by 121

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

Brevi, A., Cogrossi, L. L., Grazia, G., Masciovecchio, D., Impellizzieri, D., Lacanfora, L., Grioni, M., & Bellone, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565470 · Cited by 114

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Vasconcelos, A. R., dos Santos, N. B., Scavone, C., & Munhoz, C. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00033 · Cited by 113

Effects of gut microbiota on the microRNA and mRNA expression in the hippocampus of mice

Chen, J.-J., Zeng, B.-H., Li, W.-W., Zhou, C.-J., Fan, S.-H., Cheng, K., Zeng, L., Zheng, P., Fang, L., Wei, H., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.021 · Cited by 111

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Regen, T., Isaac, S., Amorim, A., Núñez, N. G., Hauptmann, J., Shanmugavadivu, A., Klein, M., Sankowski, R., Mufazalov, I. A., Yogev, N., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.aaz6563 · Cited by 111

The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression : Towards Characterization of the “MS Microbiome.”

Pröbstel, A.-K., & Baranzini, S. E. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0587-y · Cited by 110

A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection

Zhu, C. S., Grandhi, R., Patterson, T. F., & Nicholson, S. E. (2018) · Brain Sciences · doi:10.3390/brainsci8060113 · Cited by 112

Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021

Xu, J., Moore, B. N., & Pluznick, J. L. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.18558 · Cited by 119

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Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 116

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

Li, L., Rao, S., Cheng, Y., Zhuo, X., Deng, C., Xu, N., Zhang, H., & Yang, L. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.810 · Cited by 109

Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease

Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109

Invited Review: From nose to gut – the role of the microbiome in neurological disease

Bell, J. S., Spencer, J. I., Yates, R. L., Yee, S. A., Jacobs, B. M., & DeLuca, G. C. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12520 · Cited by 111

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Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108

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Wekerle, H. (2017) · Autoimmunity · doi:10.1080/08916934.2017.1281914 · Cited by 108

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Zundler, S., Günther, C., Kremer, A. E., Zaiss, M. M., Rothhammer, V., & Neurath, M. F. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00663-1 · Cited by 112

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Brown, J. M., & Hazen, S. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.765388 · Cited by 108

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Seo, D.-O., & Holtzman, D. M. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz262 · Cited by 109

Microbiota-brain interactions: Moving toward mechanisms in model organisms

Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 110

Disease-modifying therapies alter gut microbial composition in MS

Sand, I. K., Zhu, Y., Ntranos, A., Clemente, J. C., Cekanaviciute, E., Brandstadter, R., Crabtree‐Hartman, E., Singh, S., Bencosme, Y., Debelius, J. W., et al. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000517 · Cited by 106

Gut Microbiota Interaction with the Central Nervous System throughout Life

Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 112

Apoptosis in response to microbial infection induces autoreactive TH17 cells

Campisi, L., Barbet, G., Ding, Y., Esplugues, E., Flavell, R. A., & Blander, J. M. (2016) · Nature Immunology · doi:10.1038/ni.3512 · Cited by 105

The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue

Kirby, T. O., & Ochoa‐Repáraz, J. (2018) · Medical Sciences · doi:10.3390/medsci6030069 · Cited by 114

Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells

Ding, W., You, Z., Chen, Q., Yang, L., Doheny, J. T., Zhou, X. P., Li, N., Wang, S., Hu, K., Chen, L. L., et al. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005155 · Cited by 105

The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?

Parodi, B., & de Rosbo, N. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718220 · Cited by 114

Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

Pellegrino, A., Coppola, G., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Nutrients · doi:10.3390/nu15081815 · Cited by 107

Dysregulation of immune homeostasis in autoimmune diseases

Kuchroo, V. K., Ohashi, P. S., Sartor, R. B., & Vinuesa, C. G. (2012) · Nature Medicine · doi:10.1038/nm.2621 · Cited by 105

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

Branton, W. G., Lu, J., Surette, M. G., Holt, R. A., Lind, J. C., Laman, J. D., & Power, C. (2016) · Scientific Reports · doi:10.1038/srep37344 · Cited by 104

Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye

Kim, J., Choi, S. H., Kim, Y., Jeong, H. J., Ryu, J. J., Lee, H. J., Kim, T., Im, S., Oh, J. Y., & Kim, M. (2017) · Nutrients · doi:10.3390/nu9111166 · Cited by 104

Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course

Ventura, R. E., Iizumi, T., Battaglia, T., Liu, M., Perez-Perez, G. I., Herbert, J., & Blaser, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-52894-z · Cited by 106

Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice

Yu, X., Zhou, G., Shao, B., Zhou, H., Xu, C., Yan, F., Wang, L., Chen, G., Li, J., & Fu, X. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.647304 · Cited by 104

The Gut Microbiome in Multiple Sclerosis

Mielcarz, D. W., & Kasper, L. H. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0344-7 · Cited by 109

Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis

Duc, D., Vigne, S., Bernier‐Latmani, J., Yersin, Y., Ruiz, F., Gaïa, N., Léo, S., Lazarević, V., Schrenzel, J., Petrova, T. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.002 · Cited by 110

Does multiple sclerosis originate in the gut?

Yates, D. M. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3150

The gut–brain connection: triggering of brain autoimmune disease by commensal gut bacteria

Wekerle, H. (2016) · Rheumatology · doi:10.1093/rheumatology/kew353 · Cited by 41

Gut Microbiota in Multiple Sclerosis

Wekerle, H., & Hohlfeld, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801914-6.00009-x · Cited by 17

Commensal gut flora and brain autoimmunity: a love or hate affair?

Berer, K., & Krishnamoorthy, G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0949-9 · Cited by 82

Gut microorganisms act together to exacerbate inflammation in spinal cords

Miyauchi, E., Kim, S.-W., Suda, W., Kawasumi, M., Onawa, S., Taguchi-Atarashi, N., Morita, H., Taylor, T. D., Hattori, M., & Ohno, H. (2020) · Nature · doi:10.1038/s41586-020-2634-9 · Cited by 268