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Cited by 384

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

Open access
Aragona, Mariaceleste, Dekoninck, Sophie, Rulands, Steffen, Lenglez, Sandrine, Mascré, Guilhem, Simons, Benjamin D., Blanpain, Cédric·2017·Nature Communications
DOI 10.1038/ncomms14684
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Abstract

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitors that expand and repair the wound. These results have important implications for tissue regeneration, acute and chronic wound disorders.

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Crossref · 10.1038/ncomms14684

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Metadata

Authors
Aragona, M., Dekoninck, S., Rulands, S., Lenglez, S., Mascré, G., Simons, B. D., & Blanpain, C.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2017-03-01
Volume
8
Issue
1
Pages
14684-14684
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms14684
OpenAlex
W2593620662
Cited by
384
References
71
FWCI
28.78
Type
journal article
Language
en
Open access
gold

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