The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Open accessAbstract
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin--a hormone best known for its role in lactation, parturition and social behaviours--is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“As demonstrated in Figure 2, old human serum strongly reduced myogenic cell proliferation (which is consistent with the effects of the old mouse serum [1, 2, 6, 7, 13]).”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [13]
In the citing paper
“Intriguingly, at least part of the ‘rejuvenating’ effect of a young systemic environment appears related to the higher levels of circulating growth differentiation factor 11 (GDF11) and oxytocin present in young blood as compared to aged38,166,168,169.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Self-citationThe ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Self-citationOxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948 · cited 1×
“While the rejuvenating effects of heterochronic parabiosis have been observed in several tissues such as muscle, brain, liver, pancreas, and heart 4-9 the molecular mechanisms are not fully understood and only a few potential systemic factors responsible for this phenomena have been identified.”
Walston, J. D. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328358d59b · Cited by 756
Research works printed but not linked: 1
- Conboy, I. M., Yousef, H. & Conboy, M. J. Embryonic anti-ageing niche. ageing (Albany NY) 3, 555–563 (2011).
Cited by
Sorted by citations
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437
Cognitive frailty, a novel target for the prevention of elderly dependency
Ruan, Q., Yu, Z., Ma, C., Bao, Z., Li, J., & He, W. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.004 · Cited by 392
Self-citationLukjanenko, L., Karaz, S., Stuelsatz, P., Gurriaran-Rodriguez, U., Michaud, J., Dammone, G., Sizzano, F., Mashinchian, O., Ancel, S., Migliavacca, E., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2018.12.014 · Cited by 374
Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease
Almada, A. E., & Wagers, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.7 · Cited by 322
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
Rebo, J., Mehdipour, M., Gathwala, R., Causey, K., Liu, Y., Conboy, M. J., & Conboy, I. M. (2016) · Nature Communications · doi:10.1038/ncomms13363 · Cited by 291
Self-citationCellular and epigenetic drivers of stem cell ageing
Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage
Fafián-Labora, J. A., Rodríguez-Navarro, J. A., & O’Loghlen, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.004 · Cited by 203
Stenvinkel, P., Carrero, J. J., von Walden, F., Ikizler, T. A., & Nader, G. A. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv122 · Cited by 193
Translational strategies and challenges in regenerative medicine
Dimmeler, S., Ding, S., Rando, T. A., & Trounson, A. (2014) · Nature Medicine · doi:10.1038/nm.3627 · Cited by 179
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Yamakawa, H., Kusumoto, D., Hashimoto, H., & Yuasa, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051830 · Cited by 187
The ins and outs of muscle stem cell aging
Brack, A. S., & Muñoz-Cánoves, P. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0072-z · Cited by 166
Blue Journal Conference. Aging and Susceptibility to Lung Disease
Thannickal, V. J., Murthy, M., Balch, W. E., Chandel, N. S., Meiners, S., Eickelberg, O., Selman, M., Pardo, A., White, E. S., Levy, B. D., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1876pp · Cited by 164
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163
Farup, J., Madaro, L., Puri, P., & Mikkelsen, U. R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.198 · Cited by 162
Turning back time with emerging rejuvenation strategies
Mahmoudi, S., Xu, L., & Brunet, A. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0206-0 · Cited by 168
Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Neves, J., Sousa‐Victor, P., & Jasper, H. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.01.008 · Cited by 160
Microbial lysate upregulates host oxytocin
Varian, B. J., Poutahidis, T., DiBenedictis, B. T., Levkovich, T., Ibrahim, Y., Didyk, E., Shikhman, L., Cheung, H. K., Hardas, A., Ricciardi, C. E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.002 · Cited by 153
Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?
Kob, R., Bollheimer, L. C., Bertsch, T., Fellner, C., Djukic, M., Sieber, C. C., & Fischer, B. E. (2015) · Biogerontology · doi:10.1007/s10522-014-9539-7 · Cited by 151
Regenerative decline of stem cells in sarcopenia
Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147
Beneficial bacteria inhibit cachexia
Varian, B. J., Goureshetti, S., Poutahidis, T., Lakritz, J. R., Levkovich, T., Kwok, C., Teliousis, K., Ibrahim, Y. M., Mirabal, S., & Erdman, S. E. (2016) · Oncotarget · doi:10.18632/oncotarget.7730 · Cited by 146
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 148
Approaches Mediating Oxytocin Regulation of the Immune System
Li, T., Wang, P., Wang, S. C., & Wang, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00693 · Cited by 140
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Baig, M. H., Ahmad, K., Moon, J. S., Park, S.-Y., Ho Lim, J., Chun, H. J., Qadri, A. F., Hwang, Y. C., Jan, A. T., Ahmad, S. S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876078 · Cited by 135
Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation
Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00451-9 · Cited by 134
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage
Sousa‐Victor, P., Neves, J., Cedron-Craft, W., Ventura, P. B., Liao, C., Riley, R. R., Soifer, I., van Bruggen, N., Kolumam, G. A., Villeda, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0023-6 · Cited by 129
Regenerative function of immune system: Modulation of muscle stem cells
Saini, J., McPhee, J. S., Al-Dabbagh, S., Stewart, C. E., & Al‐Shanti, N. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.03.006 · Cited by 131
Yousef, H., Conboy, M. J., Morgenthaler, A., Schlesinger, C., Bugaj, L., Paliwal, P., Greer, C., Conboy, I. M., & Schaffer, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3851 · Cited by 113
Self-citationSatellite cells in ageing: use it or lose it
Chen, W., Datzkiw, D., & Rudnicki, M. A. (2020) · Open Biology · doi:10.1098/rsob.200048 · Cited by 120
The physiology and pharmacology of oxytocin in labor and in the peripartum period
Uvnäs-Moberg, K. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.04.011 · Cited by 118
Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 117
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Mehdipour, M., Skinner, C., Wong, N., Lieb, M., Liu, C., Etienne, J., Kato, C., Kiprov, D., Conboy, M. J., & Conboy, I. M. (2020) · Aging · doi:10.18632/aging.103418 · Cited by 115
Self-citationOxytocin in metabolic homeostasis: implications for obesity and diabetes management
Ding, C., Leow, M. K., & Magkos, F. (2018) · Obesity Reviews · doi:10.1111/obr.12757 · Cited by 115
Regulation of inflammation as an anti‐aging intervention
Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15061 · Cited by 110
Lefevre, A., Mottolese, R., Dirheimer, M., Mottolese, C., Duhamel, J.-R., & Sirigu, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17674-7 · Cited by 105
Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies
Lev, R., & Seliktar, D. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0380 · Cited by 105
Aging of the endocrine system and its potential impact on sarcopenia
Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 109
The clinical impact and biological mechanisms of skeletal muscle aging
Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R., & LeBrasseur, N. K. (2019) · Bone · doi:10.1016/j.bone.2019.05.021 · Cited by 112
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 103
Extracellular vesicles and aging
Robbins, P. D. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.12.03 · Cited by 93
Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps
Anderson, S. E., Han, W. M., Srinivasa, V., Mohiuddin, M., Ruehle, M. A., Moon, J. Y., Shin, E.-J., Emeterio, C. L. S., Ogle, M. E., Botchwey, E. A., et al. (2019) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2018.0324 · Cited by 91
Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases
Otto, E., Knapstein, P., Jahn, D., Appelt, J., Frosch, K., Tsitsilonis, S., & Keller, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144946 · Cited by 88
Aging and brain rejuvenation as systemic events
Bouchard, J. J., & Villeda, S. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12969 · Cited by 89
Plasencia, G., Luedicke, J., Pournajafi‐Nazarloo, H., Carter, C. S., & Ebner, N. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104419 · Cited by 87
Husarova, V. M., Lakatošová, S., Pivovarciova, A., Babinská, K., Bakoš, J., Durdiaková, J., Kubranská, A., Ondrejka, I., & Ostatníková, D. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.2.174 · Cited by 82
Hwang, A. B., & Brack, A. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.008 · Cited by 83
Contribution of muscle satellite cells to sarcopenia
Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74
Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
Yin, J., Yang, L., Xie, Y., Liu, Y., Li, S., Yang, W., Xu, B., Ji, H., Ding, L., Wang, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04038-6 · Cited by 72
Ageing research: Blood to blood
Scudellari, M. (2015) · Nature · doi:10.1038/517426a · Cited by 76
The wonder exerkines—novel insights: a critical state-of-the-art review
Magliulo, L., Bondi, D., Pini, N., Marramiero, L., & Filippo, E. S. D. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04264-5 · Cited by 77
Kiss, T., Tarantini, S., Csípő, T., Balasubramanian, P., Nyúl‐Tóth, Á., Yabluchanskiy, A., Wren, J. D., Garman, L., Huffman, D. M., Csiszár, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00180-6 · Cited by 74
Wang, P., Wang, S. C., Yang, H.-P., Lv, C., Jia, S., Liu, X., Wang, X., Meng, D., Qin, D., Zhu, H. F., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00454 · Cited by 73
Das, J. K., Banskota, N., Candia, J., Griswold, M., Orenduff, M. C., de Cabo, R., Corcoran, D. L., Das, S. K., De, S., Huffman, K. M., et al. (2023) · Aging Cell · doi:10.1111/acel.13963 · Cited by 73
Gheller, B. J. F., Blum, J., Lim, E. W., Handzlik, M. K., Fong, E. H. H., Ko, A. C., Khanna, S., Gheller, M. E., Bender, E. L., Alexander, M. S., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101106 · Cited by 71
Sannino, S., Chini, B., & Grinevich, V. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22450 · Cited by 72
Haines, M. S., Marengi, D. A., Pulumo, R., Yu, E. W.-Y., Eddy, K. T., Klibanski, A., Miller, K. K., & Lawson, E. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3963 · Cited by 68
Geroconversion of aged muscle stem cells under regenerative pressure
Sousa-Victor, P., Perdiguero, E., & Muñoz-Cánoves, P. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965072 · Cited by 68
The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 69
Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 68
Stem cell aging in the skeletal muscle: The importance of communication
Hong, X., Campanario, S., Ramírez‐Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz‐Cánoves, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101528 · Cited by 71
Zhang, R., Chen, H., & Liu, D. (2015) · Cell Systems · doi:10.1016/j.cels.2015.09.002 · Cited by 70
Buemann, B., & Uvnäs-Moberg, K. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109597 · Cited by 66
Systemic problems: a perspective on stem cell aging and rejuvenation.
Conboy, I. M., Conboy, M. J., & Rebo, J. (2015) · Aging · doi:10.18632/aging.100819 · Cited by 58
Self-citationAltirriba, J., Poher, A.-L., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00119 · Cited by 63
Liu, Y., Conboy, M. J., Mehdipour, M., Liu, Y., Tran, T. P., Blotnick, A., Rajan, P., Santos, T. C., & Conboy, I. M. (2017) · Nature Communications · doi:10.1038/s41467-017-00698-y · Cited by 59
Self-citationThe Fountain of Youth: A tale of parabiosis, stem cells, and rejuvenation
Conese, M., Carbone, A., Beccia, E., & Angiolillo, A. (2017) · Open Medicine · doi:10.1515/med-2017-0053 · Cited by 65
The nematode Caenorhabditis elegans as a model for aging research
Mack, H. I. D., Heimbucher, T., & Murphy, C. T. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2018.11.001 · Cited by 68
Molecular pathology endpoints useful for aging studies
Niedernhofer, L. J., Kirkland, J. L., & Ladiges, W. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.012 · Cited by 59
Gabery, S., Ahmed, R. M., Caga, J., Kiernan, M. C., Halliday, G. M., & Petersén, Å. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12709 · Cited by 60
Maeda, Y., Yonemochi, Y., Nakajyo, Y., Hidaka, H., Ikeda, T., & Ando, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-02928-1 · Cited by 60
Zhang, L., & Liu, L. (2019) · Nanoscale · doi:10.1039/c8nr08760a · Cited by 59
Age-Specific Functional Epigenetic Changes in p21 and p16 in Injury-Activated Satellite Cells
Li, J., Han, S., Cousin, W., & Conboy, I. M. (2014) · Stem Cells · doi:10.1002/stem.1908 · Cited by 56
Self-citationReversibility of irreversible aging
Galkin, F., Zhang, B., Dmitriev, S. E., & Gladyshev, V. N. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.008 · Cited by 55
Emerging rejuvenation strategies—Reducing the biological age
Zhang, B., Trapp, A., Kerepesi, C., & Gladyshev, V. N. (2021) · Aging Cell · doi:10.1111/acel.13538 · Cited by 53
Spliced genes in muscle from Nelore Cattle and their association with carcass and meat quality
Silva, D. B. D. S., Fonseca, L. F. S., Pinheiro, D. G., Magalhães, A. F. B., Muniz, M. M. M., Ferro, J. A., Baldi, F. S., Chardulo, L. A. L., Schnabel, R. D., Taylor, J. F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71783-4 · Cited by 54
Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 53
Invited review: Stem cells and muscle diseases: advances in cell therapy strategies
Négroni, E., Gidaro, T., Bigot, A., Butler-Browne, G. S., Mouly, V., & Trollet, C. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12198 · Cited by 49
Oxytocin: Potential to mitigate cardiovascular risk
Reiss, A. B., Glass, D. S., Lam, E., Glass, A. D., Leon, J. D., & Kasselman, L. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.05.001 · Cited by 45
Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation
Etienne, J., Liu, C., Skinner, C. M., Conboy, M. J., & Conboy, I. M. (2020) · Skeletal Muscle · doi:10.1186/s13395-020-0222-1 · Cited by 53
Self-citationEnhancer selection dictates gene expression responses in remote organs during tissue regeneration
Sun, F., Ou, J., Shoffner, A. R., Luan, Y., Yang, H., Song, L., Safi, A., Cao, J., Yue, F., Crawford, G. E., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00906-y · Cited by 49
Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
Faraji, J., Karimi, M., Soltanpour, N., Moharrerie, A., Rouhzadeh, Z., Lotfi, H., Hosseini, S. A., Jafari, S. Y., Roudaki, S., Moeeini, R., et al. (2018) · eLife · doi:10.7554/elife.40262 · Cited by 46
Jaeggi, A. V., Trumble, B. C., Kaplan, H. S., & Gurven, M. (2015) · Biology Letters · doi:10.1098/rsbl.2015.0058 · Cited by 44
Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis
Mehdi, S. F., Pusapati, S., Khenhrani, R. R., Farooqi, M. S., Sarwar, S., Alnasarat, A., Mathur, N., Metz, C. N., LeRoith, D., Tracey, K. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864007 · Cited by 46
Blood-Based Therapies to Combat Aging
Castellano, J. M. (2018) · Gerontology · doi:10.1159/000492573 · Cited by 46
Espinoza, S. E., Lee, J. L., Wang, C.-P., Ganapathy, V., MacCarthy, D., Pascucci, C., Musi, N., & Volpi, E. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.04.015 · Cited by 44
Engineered matrices for skeletal muscle satellite cell engraftment and function
Han, W. M., Jang, Y. C., & Garcı́a, A. J. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.06.001 · Cited by 43
Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma
Mu, X., Agarwal, R., March, D., Rothenberg, A. C., Voigt, C., Tebbets, J. C., Huard, J., & Weiss, K. R. (2016) · Sarcoma · doi:10.1155/2016/3758162 · Cited by 43
Ling, Y., Zheng, Q., Sui, M., Zhu, L., Xu, L., Zhang, Y., Liu, Y., Fang, F., Chu, M., Ma, Y., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163950 · Cited by 43
Muscle Dysfunction in Patients with Lung Diseases. A Growing Epidemic
Barreiro, E., Sznajder, J. I., Nader, G. A., & Budinger, G. R. S. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2189oe · Cited by 42
Restoring aged stem cell functionality: Current progress and future directions
Spehar, K., Pan, A., & Beerman, I. (2020) · Stem Cells · doi:10.1002/stem.3234 · Cited by 46
Mehdipour, M., Etienne, J., Chen, C.-C., Gathwala, R., Rehman, M., Kato, C., Liu, C., Liu, Y., Zuo, Y., Conboy, M. J., et al. (2019) · Aging · doi:10.18632/aging.102148 · Cited by 39
Self-citationOxytocin and vasopressin signaling in health and disease
Perisic, M., Woolcock, K., Hering, A., Mendel, H. C., & Muttenthaler, M. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.01.010 · Cited by 42
Perspectives on the evolution of animal dancing: a case study of manakins
Fuxjager, M. J., & Schlinger, B. A. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.06.007 · Cited by 40
Oxytocin Reverses Osteoporosis in a Sex-Dependent Manner
Béranger, G. E., Djedaini, M., Battaglia, S., Roux, C. H., Scheideler, M., Heymann, D., Amri, E., & Pisani, D. F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00081 · Cited by 39
Ikemoto‐Uezumi, M., Uezumi, A., Tsuchida, K., Fukada, S., Yamamoto, H., Yamamoto, N., Shiomi, K., & Hashimoto, N. (2015) · Stem Cells · doi:10.1002/stem.2045 · Cited by 39
Metadata
- Authors
- Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M.
- Affiliations
- QB3 (US)
- Corresponding author
- Cousin, Wendy
- Conboy, Irina M.
- Venue
- Nature Communications
- Published
- 2014-06-10
- Volume
- 5
- Issue
- 1
- Pages
- 4082-4082
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4512838
- OpenAlex
- W2169617007
- Cited by
- 411
- References
- 52
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 29 · 2023: 30 · 2022: 33 · 2021: 56 · 2020: 37 · 2019: 44 · 2018: 30 · 2017: 30 · 2016: 28 · 2015: 30 · 2014: 13
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- SENS Research Foundation
- Siebel Stem Cell Institute
- National Institutes of Health (TG2-01164)
- National Institute on Aging (AG027252, R01AG027252)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- oxytocin, skeletal muscle aging, muscle regeneration, muscle stem cells, sarcopenia, plasma hormone levels, ERK signaling, muscle homeostasis
- MeSH terms
- Aging, Animals, Homeostasis, Oxytocin, Regeneration, Stem Cells, Muscle, Skeletal, Muscle Fibers, Skeletal, Cell Culture Techniques, MAP Kinase Signaling System, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
