Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898

‘Actively Acquired Tolerance’ of Foreign Cells

BILLINGHAM, R. E., BRENT, L., & MEDAWAR, P. B. (1953) · Nature · doi:10.1038/172603a0 · Cited by 3,136

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

Bach, J.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,687

Latest Advances in Understanding Preeclampsia

Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607

Incidence of early loss of pregnancy

Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354

Stress-induced immune dysfunction: implications for health

Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., et al. (2006) · Nature Medicine · doi:10.1038/nm1452 · Cited by 1,681

Regulatory T cells mediate maternal tolerance to the fetus

Aluvihare, V. R., Kallikourdis, M., & Betz, A. G. (2004) · Nature Immunology · doi:10.1038/ni1037 · Cited by 1,657

Rate of Pregnancy-Related Relapse in Multiple Sclerosis

Confavreux, C., Hutchinson, M., Hours, M. M., Cortinovis-Tourniaire, P., & Moreau, T. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390501 · Cited by 1,559

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

Kovats, S., Main, E. K., Librach, C., Stubblebine, M., Fisher, S. J., & DeMars, R. (1990) · Science · doi:10.1126/science.2326636 · Cited by 1,407

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

Owen, R. D. (1945) · Science · doi:10.1126/science.102.2651.400 · Cited by 1,368

Decisions About Dendritic Cells: Past, Present, and Future

Steinman, R. M. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100311-102839 · Cited by 1,274

Implantation and the Survival of Early Pregnancy

Norwitz, E. R., Schust, D. J., & Fisher, S. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmra000763 · Cited by 1,264

Natural killer cells and pregnancy

Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235

Recurrent miscarriage

Rai, R., & Regan, L. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69204-0 · Cited by 1,227

The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies

Pijnenborg, R., Vercruysse, L., & Hanssens, M. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,205

MHC class I molecules and kirs in human history, health and survival

Parham, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1570 · Cited by 1,203

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,177

Human Diversity in Killer Cell Inhibitory Receptor Genes

Uhrberg, M., Valiante, N. M., Shum, B. P., Shilling, H. G., Lienert-Weidenbach, K., Corliss, B., Tyan, D., Lanier, L. L., & Parham, P. (1997) · Immunity · doi:10.1016/s1074-7613(00)80394-5 · Cited by 1,059

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

Curotto de Lafaille, M. A., & Lafaille, J. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.002 · Cited by 1,055

Adult Consequences of Fetal Growth Restriction

BARKER, D. J. P. (2006) · Clinical Obstetrics and Gynecology · doi:10.1097/00003081-200606000-00009 · Cited by 930

Synthesis of T helper 2-type cytokines at the maternal-fetal interface.

Lin, H., Mosmann, T. R., Guilbert, L., Tuntipopipat, S., & Wegmann, T. G. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4562 · Cited by 899

Immunology of placentation in eutherian mammals

Moffett, A., & Loke, C. (2006) · Nature Reviews Immunology · doi:10.1038/nri1897 · Cited by 836

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K. P., Busch, M. P., Lee, T.-H., Nixon, D. F., & McCune, J. M. (2008) · Science · doi:10.1126/science.1164511 · Cited by 836

Some immunological and endocrinological problems raised by the evolution of viviparity in verte- brates

Medawar, P. B., & Medawar, P. B. (1953) · Symposia of the Society for Experimental Biology · Cited by 833

Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases

Sasaki, Y. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah044 · Cited by 746

Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis

Van Kerkhove, M. D., Vandemaele, K. A. H., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., Carlino, L. O., Owen, R., Paterson, B., Pelletier, L., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001053 · Cited by 706

A Systematic Review and Meta-Analysis of Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus and Lupus Nephritis

Smyth, A., Oliveira, G. H. M., Lahr, B. D., Bailey, K. R., Norby, S. M., & Garovic, V. D. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00240110 · Cited by 660

Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post‐partum relapse

Vukusic, S., Hutchinson, M., Hours, M., Moreau, T., Cortinovis‐Tourniaire, P., Adeleine, P., & Confavreux, C. (2004) · Brain · doi:10.1093/brain/awh152 · Cited by 656

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

Samstein, R. M., Josefowicz, S. Z., Arvey, A., Treuting, P. M., & Rudensky, A. Y. (2012) · Cell · doi:10.1016/j.cell.2012.05.031 · Cited by 623

Estimates of human fertility and pregnancy loss

Zinaman, M. J., Clegg, E. D., Brown, C. C., O’Connor, J., & Selevan, S. G. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58144-8 · Cited by 604

Orchestrating the orchestrators: chemokines in control of T cell traffic

Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 593

The trafficking of natural killer cells

Grégoire, C., Chasson, L., Luci, C., Tomasello, E., Geissmann, F., Vivier, E., & Walzer, T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00563.x · Cited by 569

Disease activity of rheumatoid arthritis during pregnancy: Results from a nationwide prospective study

de Man, Y. A., Dolhain, R. J. E. M., van de Geijn, F. E., Willemsen, S. P., & Hazes, J. M. W. (2008) · Arthritis Care & Research · doi:10.1002/art.24003 · Cited by 531

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

Rowe, J. H., Ertelt, J. M., Xin, L., & Way, S. S. (2012) · Nature · doi:10.1038/nature11462 · Cited by 523

A pivotal role for galectin-1 in fetomaternal tolerance

Blois, S. M., Ilarregui, J. M., Tometten, M., Garcia, M., Orsal, A. S., Cordo-Russo, R., Toscano, M. A., Bianco, G. A., Kobelt, P., Handjiski, B., et al. (2007) · Nature Medicine · doi:10.1038/nm1680 · Cited by 491

Identification of Fetal DNA and Cells in Skin Lesions from Women with Systemic Sclerosis

Artlett, C. M., Smith, J. B., & Jimenez, S. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804233381704 · Cited by 480

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

Ilarregui, J. M., Croci, D. O., Bianco, G. A., Toscano, M. A., Salatino, M., Vermeulen, M. E., Geffner, J. R., & Rabinovich, G. A. (2009) · Nature Immunology · doi:10.1038/ni.1772 · Cited by 476

A critical role for the programmed death ligand 1 in fetomaternal tolerance

Guleria, I., Khosroshahi, A., Ansari, M. J., Habicht, A., Azuma, M., Yagita, H., Noelle, R. J., Coyle, A., Mellor, A. L., Khoury, S. J., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050019 · Cited by 439

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

Nancy, P., Tagliani, E., Tay, C.-S., Asp, P., Levy, D. E., & Erlebacher, A. (2012) · Science · doi:10.1126/science.1220030 · Cited by 429

TGFβ promotes conversion of CD16 + peripheral blood NK cells into CD16 − NK cells with similarities to decidual NK cells

Keskin, D. B., Allan, D. S. J., Rybalov, B., Andzelm, M. M., Stern, J. N. H., Kopcow, H. D., Koopman, L. A., & Strominger, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611098104 · Cited by 370

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti‐HLA antibodies

Apps, R., Murphy, S. P., Fernando, R., Gardner, L., Ahad, T., & Moffett, A. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03019.x · Cited by 360

1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells

Penna, G., Amuchastegui, S., Giarratana, N., Daniel, K. C., Vulcano, M., Sozzani, S., & Adorini, L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.145 · Cited by 355

CXCL12 expression by invasive trophoblasts induces the specific migration of CD16– human natural killer cells

Hanna, J., Wald, O., Goldman-Wohl, D., Prus, D., Markel, G., Gazit, R., Katz, G., Haimov-Kochman, R., Fujii, N., Yagel, S., et al. (2003) · Blood · doi:10.1182/blood-2003-02-0517 · Cited by 346

Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage

Hiby, S. E., Regan, L., Lo, W., Farrell, L., Carrington, M., & Moffett, A. (2008) · Human Reproduction · doi:10.1093/humrep/den011 · Cited by 334

HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+T cells

LeMaoult, J., Krawice-Radanne, I., Dausset, J., & Carosella, E. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401922101 · Cited by 314

Oxidative stress, inflamm-aging and immunosenescence

Cannizzo, E. S., Clement, C. C., Sahu, R., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 299

Unique Appearance of Proliferating Antigen-Presenting Cells Expressing DC-SIGN (CD209) in the Decidua of Early Human Pregnancy

Kämmerer, U., Eggert, A. O., Kapp, M., McLellan, A. D., Geijtenbeek, T. B. H., Dietl, J., van Kooyk, Y., & Kämpgen, E. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63884-9 · Cited by 296

Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus

Hunt, J. S., Vassmer, D., Ferguson, T. A., & Miller, L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4122 · Cited by 282

FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

Mjösberg, J., Berg, G., Jenmalm, M. C., & Ernerudh, J. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.109.081208 · Cited by 280

An immunohistochemical study of human endometrial extracellular matrix during the menstrual cycle and first trimester of pregnancy

Aplin, J. D., Charlton, A. K., & Ayad, S. (1988) · Cell and Tissue Research · doi:10.1007/bf00221758 · Cited by 279

Surface Expression of HLA-C Antigen by Human Extravillous Trophoblast

King, A., Burrows, T. D., Hiby, S. E., Bowen, J. M., Joseph, S., Verma, S., Lim, P. B., Gardner, L., Le Bouteiller, P., Ziegler, A., et al. (2000) · Placenta · doi:10.1053/plac.1999.0496 · Cited by 279

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

Baban, B., Chandler, P., McCool, D., Marshall, B., Munn, D. H., & Mellor, A. L. (2004) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2003.11.003 · Cited by 274

Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones

Anne Croy, B., Van Den Heuvel, M. J., Borzychowski, A. M., & Tayade, C. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00447.x · Cited by 274

Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia

Redman, C. W. G., Tannetta, D. S., Dragovic, R. A., Gardiner, C., Southcombe, J. H., Collett, G. P., & Sargent, I. L. (2012) · Placenta · doi:10.1016/j.placenta.2011.12.006 · Cited by 257

Crosstalk between decidual NK and CD14 + myelomonocytic cells results in induction of Tregs and immunosuppression

Vacca, P., Cantoni, C., Vitale, M., Prato, C., Canegallo, F., Fenoglio, D., Ragni, N., Moretta, L., & Mingari, M. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001749107 · Cited by 256

Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice

Collins, M. K., Tay, C.-S., & Erlebacher, A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38714 · Cited by 248

Decidualization of the human endometrial stromal cell: an enigmatic transformation

Dunn, C. L., Kelly, R. W., & Critchley, H. O. (2003) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61745-2 · Cited by 244

Suppression of B lymphopoiesis during normal pregnancy.

Medina, K. L., Smithson, G., & Kincade, P. W. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.5.1507 · Cited by 241

Intra-uterine insemination for unexplained subfertility

Veltman-Verhulst, S. M., Cohlen, B. J., Hughes, E., & Heineman, M. J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001838.pub3 · Cited by 241

Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy

Tilburgs, T., Roelen, D. L., van der Mast, B. J., van Schip, J. J., Kleijburg, C., de Groot-Swings, G. M., Kanhai, H. H. H., Claas, F. H. J., & Scherjon, S. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.11.008 · Cited by 239

The Th1/Th2 paradigm: still important in pregnancy?

Chaouat, G. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0069-0 · Cited by 232

Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus

Erlebacher, A., Vencato, D., Price, K. A., Zhang, D., & Glimcher, L. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28214 · Cited by 232

Oxidative Stress, Inflammaging, and Immunosenescence

Bauer, M. E., & De la Fuente, M. (2014) · Inflammation, Advancing Age and Nutrition · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229

CD34 + hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells

Vacca, P., Vitale, C., Montaldo, E., Conte, R., Cantoni, C., Fulcheri, E., Darretta, V., Moretta, L., & Mingari, M. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016257108 · Cited by 226

Early risk factors for miscarriage: a prospective cohort study in pregnant women

Arck, P. C., Rücke, M., Rose, M., Szekeres-Bartho, J., Douglas, A. J., Pritsch, M., Blois, S. M., Pincus, M. K., Bärenstrauch, N., Dudenhausen, J. W., et al. (2008) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60300-8 · Cited by 219

Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature

Haddad, R., Tromp, G., Kuivaniemi, H., Chaiworapongsa, T., Kim, Y. M., Mazor, M., & Romero, R. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.08.057 · Cited by 218

Human Decidua Contains Potent Immunostimulatory CD83+ Dendritic Cells

Kämmerer, U., Schoppet, M., McLellan, A. D., Kapp, M., Huppertz, H.-I., Kämpgen, E., & Dietl, J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64527-0 · Cited by 200

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

Li, C., Houser, B. L., Nicotra, M. L., & Strominger, J. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901173106 · Cited by 192

Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice

Gonzalez, J. M., Franzke, C.-W., Yang, F., Romero, R., & Girardi, G. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.024 · Cited by 189

Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet β cell microchimerism

Nelson, J. L., Gillespie, K. M., Lambert, N. C., Stevens, A. M., Loubiere, L. S., Rutledge, J. C., Leisenring, W. M., Erickson, T. D., Yan, Z., Mullarkey, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606169104 · Cited by 185

Human First-Trimester Trophoblast Cells Recruit CD56brightCD16− NK Cells into Decidua by Way of Expressing and Secreting of CXCL12/Stromal Cell-Derived Factor 1

Wu, X., Jin, L.-P., Yuan, M.-M., Zhu, Y., Wang, M.-Y., & Li, D.-J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.61 · Cited by 178

Depletion of CD8+ Cells Abolishes the Pregnancy Protective Effect of Progesterone Substitution with Dydrogesterone in Mice by Altering the Th1/Th2 Cytokine Profile

Blois, S. M., Joachim, R., Kandil, J., Margni, R., Tometten, M., Klapp, B. F., & Arck, P. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5893 · Cited by 174

Activating T regulatory cells for tolerance in early pregnancy — the contribution of seminal fluid

Robertson, S. A., Guerin, L. R., Moldenhauer, L. M., & Hayball, J. D. (2009) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.08.003 · Cited by 171

Progesterone Increases Systemic and Local Uterine Proportions of CD4+CD25+ Treg Cells during Midterm Pregnancy in Mice

Mao, G., Wang, J., Kang, Y., Tai, P., Wen, J., Zou, Q., Li, G., Ouyang, H., Xia, G., & Wang, B. (2010) · Endocrinology · doi:10.1210/en.2010-0426 · Cited by 171

Lineage, Maturity, and Phenotype of Uterine Murine Dendritic Cells Throughout Gestation Indicate a Protective Role in Maintaining Pregnancy1

Blois, S. M., Soto, C. D. A., Tometten, M., Klapp, B. F., Margni, R. A., & Arck, P. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.022640 · Cited by 170

CXCR3 Chemokine Receptor Distribution in Normal and Inflamed Tissues: Expression on Activated Lymphocytes, Endothelial Cells, and Dendritic Cells

García-López, M. Á., Sánchez-Madrid, F., Rodríguez-Frade, J. M., Mellado, M., Acevedo, A., García, M. I., Albar, J. P., Martínez-A, C., & Marazuela, M. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780248 · Cited by 169

Evidence of Fetal Microchimerism in Hashimoto's Thyroiditis

Klintschar, M. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.6.2494 · Cited by 169

Maternal KIR and fetal HLA-C: a fine balance

Chazara, O., Xiong, S., & Moffett, A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0511227 · Cited by 168

Fetal alloantigen is responsible for the expansion of the CD4+CD25+ regulatory T cell pool during pregnancy

Zhao, J.-X., Zeng, Y.-Y., & Liu, Y. (2007) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2007.06.052 · Cited by 163

Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

Madeja, Z., Yadi, H., Apps, R., Boulenouar, S., Roper, S. J., Gardner, L., Moffett, A., Colucci, F., & Hemberger, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005342108 · Cited by 163

11 Frequency of implantation and early pregnancy loss in natural cycles

Chard, T. (1991) · Baillière's Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80077-x · Cited by 161

A short history of HLA

Thorsby, E. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01291.x · Cited by 158

Killer Ig-Like Receptor Expression in Uterine NK Cells Is Biased toward Recognition of HLA-C and Alters with Gestational Age

Sharkey, A., Gardner, L., Hiby, S. E., Farrell, L. E., Apps, R., Masters, L. M., Goodridge, J. P., Lathbury, L. J., Stewart, C. A., Verma, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.39 · Cited by 155

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation

Red‐Horse, K., Rivera, J., Schanz, A., Zhou, Y., Winn, V., Kapidzic, M., Maltepe, E., Okazaki, K., Kochman, R., Vo, K. C., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27306 · Cited by 155

Chemokine Ligand and Receptor Expression in the Pregnant Uterus

Red‐Horse, K., Drake, P. M., Gunn, M. D., & Fisher, S. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63071-4 · Cited by 151

The CD4+CD25bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage

Jin, L., Chen, Q., Zhang, T., Guo, P.-F., & Li, D. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.08.009 · Cited by 151

Systemic Reduction of Functionally Suppressive CD4dimCD25highFoxp3+ Tregs in Human Second Trimester Pregnancy Is Induced by Progesterone and 17β-Estradiol

Mjösberg, J., Svensson‐Arvelund, J., Johansson, E., Hellström, L., Casas, R., Jenmalm, M. C., Boij, R., Matthiesen, L., Jönsson, J., Berg, G. E., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803654 · Cited by 149

Alloantigen-enhanced accumulation of CCR5 + ‘effector’ regulatory T cells in the gravid uterus

Kallikourdis, M., Andersen, K. G., Welch, K. A., & Betz, A. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604268104 · Cited by 138

Offspring number, pregnancy, and risk of a first clinical demyelinating event: The AusImmune Study

Ponsonby, A., Lucas, R. M., van der Mei, I. A. F., Dear, K. B. G., Valery, P. C., Pender, M. P., Taylor, B. V., Kilpatrick, T. J., Coulthard, A., Chapman, C., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31824c4648 · Cited by 132

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Liu, A., Jin, F., Zhang, W.-W., et al. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.049379 · Cited by 131

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Dotan, I., Werner, L., Vigodman, S., Weiss, S., Brazowski, E., Maharshak, N., Chen, O., Tulchinsky, H., Halpern, Z., & Guzner‐Gur, H. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21106 · Cited by 127

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Lim, H. J., & Wang, H. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41210 · Cited by 126

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Ferreira, G. B., Kleijwegt, F. S., Waelkens, E., Lage, K., Nikolić, T., Hansen, D. A., Workman, C. T., Roep, B. O., Overbergh, L., & Mathieu, C. (2011) · Journal of Proteome Research · doi:10.1021/pr200724e · Cited by 121

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Erlebacher, A., Zhang, D., Parlow, A. F., & Glimcher, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20645 · Cited by 118

T cell apoptosis at the maternal–fetal interface in early human pregnancy, involvement of galectin-1

Kopcow, H. D., Rosetti, F., Leung, Y., Allan, D., Kutok, J. L., & Strominger, J. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809233105 · Cited by 117

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Shao, L., Jacobs, A. R., Johnson, V. V., & Mayer, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7539 · Cited by 111

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Dutta, P., Dart, M. L., Bobadilla, J. L., Roenneburg, D. A., Yan, Z., Torrealba, J. R., & Burlingham, W. J. (2009) · Blood · doi:10.1182/blood-2009-03-213561 · Cited by 111

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Rieger, L., Segerer, S. E., Bernar, T., Kapp, M., Majic, M., Morr, A.-K., Dietl, J., & Kämmerer, U. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-132 · Cited by 109

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Huang, Y., Zhu, X., Du, M., & Li, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2367 · Cited by 108

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Thiele, K., Keßler, T., Arck, P., Erhardt, A., & Tiegs, G. (2013) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2012.10.014 · Cited by 105

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Kim, M. R., Park, D. W., Lee, J. H., Choi, D. S., Hwang, K. J., Ryu, H., & Min, C. K. (2005) · Molecular Human Reproduction · doi:10.1093/molehr/gah240 · Cited by 104

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Lyall, F., Bulmer, J. N., Kelly, H., Duffie, E., & Robson, S. C. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65363-1 · Cited by 103

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Clark, D. A. (2008) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00580.x · Cited by 81

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Taglauer, E. S., Yankee, T. M., & Petroff, M. G. (2009) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2008.12.001 · Cited by 72

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Kuroki, M., Okayama, A., Nakamura, S., Sasaki, T., Murai, K., Shiba, R., Shinohara, M., & Tsubouchi, H. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.12.1041 · Cited by 58

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Marleau, A. M., Greenwood, J. D., Wei, Q., et al. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000067500.85003.32 · Cited by 53

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Muñoz-Suano, A., Kallikourdis, M., Sarris, M., & Betz, A. G. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.09.007 · Cited by 51

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Shimada, S., Nishida, R., Takeda, M., Iwabuchi, K., Kishi, R., Onoé, K., Minakami, H., & Yamada, H. (2006) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00417.x · Cited by 47

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Bai, X., Williams, J., Greenwood, S. L., Baker, P. N., Aplin, J., & Crocker, I. P. (2009) · Placenta · doi:10.1016/j.placenta.2009.07.006 · Cited by 46

Evidence that CD8 T‐cell homeostasis and function remain intact during murine pregnancy

Norton, M. T., Fortner, K. A., Oppenheimer, K. H., & Bonney, E. A. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03316.x · Cited by 46

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Hartwig, I., Pincus, M., Diemert, A., Hecher, K., & Arck, P. (2012) · Human Reproduction · doi:10.1093/humrep/des367 · Cited by 44

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Moldenhauer, L. M., Hayball, J. D., & Robertson, S. A. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2010.05.007 · Cited by 42

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Lockwood, C. J., Krikun, G., Caze, R., Rahman, M. M., Buchwalder, L. F., & Schatz, F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1434.013 · Cited by 42

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Scherjon, S. A., Lashley, L., van der Hoorn, M., & Claas, F. H. J. (2011) · Placenta · doi:10.1016/j.placenta.2011.03.014 · Cited by 41

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Ernest, J. M., Marshburn, P. B., & Kutteh, W. H. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1293206 · Cited by 40

Glycoprotein and carbohydrate binding protein expression in the placenta in early pregnancy loss

Jeschke, U., Tóth, B., Scholz, C., Friese, K., & Makrigiannakis, A. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.10.012 · Cited by 40

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Karimi, K., & Arck, P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.015 · Cited by 35

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Aït‐Azzouzene, D., Caucheteux, S. M., Tchang, F., Wantyghem, J., Moutier, R., Langkopf, A., Gendron, M., & Kanellopoulos‐Langevin, C. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.2.337 · Cited by 35

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Chaouat, G., & Clark, D. A. (2001) · American Journal of Reproductive Immunology · doi:10.1111/j.8755-8920.2001.450208.x · Cited by 34

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Chan, W. F. N., Atkins, C. J., Naysmith, D., van der Westhuizen, N., Woo, J., & Nelson, J. L. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33358 · Cited by 33

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Cavanagh, P. C., Dunk, C., Pampillo, M., Szereszewski, J. M., Taylor, J. E., Kahiri, C., Han, V. K. M., Lye, S. J., Bhattacharya, M. M., & Babwah, A. V. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00013.2009 · Cited by 32

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Wienecke, J., Hebel, K., Hegel, K. J., Pierau, M., Brune, T., Reinhold, D., Pethe, A., & Brunner-Weinzierl, M. C. (2011) · Placenta · doi:10.1016/j.placenta.2011.10.014 · Cited by 29

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Solano, M. E., Jago, C. A., Pincus, M., & Arck, P. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.01.023 · Cited by 28

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Ye, Y., van Zyl, B., Varsani, H., Wedderburn, L. R., Ramanan, A. V., & Gillespie, K. M. (2012) · Rheumatology · doi:10.1093/rheumatology/ker430 · Cited by 25

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Zhang, J., Chen, Z., Fritz, J. H., Rochman, Y., Leonard, W. J., Gommerman, J. L., Plumb, A. W., Abraham, N. B., & Croy, B. A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011501 · Cited by 22

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

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Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

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He, C., Zheng, S., Luo, Y., & Wang, B. (2018) · Theranostics · doi:10.7150/thno.21945 · Cited by 1,249

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Deuse, T., Hu, X., Gravina, A., Wang, D., Tediashvili, G., De, C., Thayer, W. O., Wahl, A., Garcia, J. V., Reichenspurner, H., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0016-3 · Cited by 758

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Arora, N., Sadovsky, Y., Dermody, T. S., & Coyne, C. B. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.007 · Cited by 382

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Leone Roberti Maggiore, U., Ferrero, S., Mangili, G., Bergamini, A., Inversetti, A., Giorgione, V., Viganò, P., & Candiani, M. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv045 · Cited by 321