Cited by 306Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Input normalization by global feedforward inhibition expands cortical dynamic range

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Pouille, Frédéric, Marin-Burgin, Antonia, Adesnik, Hillel, Atallah, Bassam V, Scanziani, Massimo·2009·Nature Neuroscience

DOI 10.1038/nn.2441

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Abstract

The cortex is sensitive to weak stimuli, but responds to stronger inputs without saturating. The mechanisms that enable this wide range of operation are not fully understood. We found that the amplitude of excitatory synaptic currents necessary to fire rodent pyramidal cells, the threshold excitatory current, increased with stimulus strength. Consequently, the relative contribution of individual afferents in firing a neuron was inversely proportional to the total number of active afferents. Feedforward inhibition, acting homogeneously across pyramidal cells, ensured that threshold excitatory currents increased with stimulus strength. In contrast, heterogeneities in the distribution of excitatory currents in the neuronal population determined the specific set of pyramidal cells recruited. Together, these mechanisms expand the range of afferent input strengths that neuronal populations can represent.

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Authors: Pouille, F., Marin-Burgin, A., Adesnik, H., Atallah, B. V., & Scanziani, M.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Scanziani, Massimo
ORCID: Adesnik, Hillel
Atallah, Bassam V
Scanziani, Massimo
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-11-01
Volume: 12
Issue: 12
Pages: 1577-1585
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2441
OpenAlex: W2124909604
Cited by: 306
References: 45
Citations by year: 2026: 8 · 2025: 17 · 2024: 15 · 2023: 28 · 2022: 16 · 2021: 11 · 2020: 18 · 2019: 19 · 2018: 16 · 2017: 18 · 2016: 21 · 2015: 19 · 2014: 22 · 2013: 22 · 2012: 24
FWCI: 9.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of Mental Health (MH71401, R01MH071401)
National Institute of Neurological Disorders and Stroke (F31NS061521, NS061521)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: feedforward inhibition, input normalization, pyramidal neurons, stimulus sensitivity, population coding, rodent cortex
MeSH terms: Action Potentials, Animals, Interneurons, Models, Neurological, Neural Inhibition, Neural Pathways, Rodentia, Somatosensory Cortex, Synapses, Pyramidal Cells, Excitatory Postsynaptic Potentials, Feedback, Physiological, CA1 Region, Hippocampal

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Input normalization by global feedforward inhibition expands cortical dynamic range

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