Three-dimensional chromatin organization in brain function and dysfunction
Open accessAbstract
The three-dimensional (3D) organization of chromatin within the nucleus is now recognized as a bona fide epigenetic property influencing genome function, replication, and maintenance. In the recent years, several studies have revealed how 3D chromatin organization is associated with brain function and its emerging role in disorders of the brain. 3D chromatin organization plays a crucial role in the development of different cell types of the nervous system and some neuronal cell types have adapted unique modifications to this organization that deviates from all other cell types. In post-mitotic neurons, dynamic changes in chromatin interactions in response to neuronal activity underlie learning and memory formation. Finally, new evidence directly links 3D chromatin organization to several disorders of the brain. These recent findings position 3D chromatin organization as a fundamental regulatory mechanism poised to reveal the etiology of brain function and dysfunctions.
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The 3D genome is actively regulated during learning and memory formation.
“There is now emerging evidence that the 3D genome is actively regulated during learning and memory formation”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [40]
The 3D genome plays an important role in neuronal gene expression and function.
“The 3D genome plays an important role in neuronal gene expression and function”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [40]
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Phase separation drives heterochromatin domain formation
Strom, A. R., Emelyanov, A. V., Mir, M., Fyodorov, D. V., Darzacq, X., & Karpen, G. H. (2017) · Nature · doi:10.1038/nature22989 · Cited by 1,813 · see citing works
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Larson, A. G., Elnatan, D., Keenen, M. M., Trnka, M., Johnston, J. B., Burlingame, A., Agard, D., Redding, S., & Narlikar, G. J. (2017) · Nature · doi:10.1038/nature22822 · Cited by 1,554 · see citing works
Multiscale 3D Genome Rewiring during Mouse Neural Development
Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G. L., Lubling, Y., Xu, X., Lv, X., Hugnot, J.-P., Tanay, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.043 · Cited by 1,338 · see citing works
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
van Steensel, B., & Belmont, A. S. (2017) · Cell · doi:10.1016/j.cell.2017.04.022 · Cited by 1,140 · see citing works
Long-range enhancer–promoter contacts in gene expression control
Schoenfelder, S., & Fraser, P. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0128-0 · Cited by 1,102 · see citing works
Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087 · see citing works
Javierre, B. M., Burren, O. S., Wilder, S. P., Kreuzhuber, R., Hill, S. M., Sewitz, S., Cairns, J., Wingett, S. W., Várnai, C., Thiecke, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.037 · Cited by 1,046 · see citing works
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, A. S., Li, C. H., Zamudio, A. V., Sigova, A. A., Hannett, N. M., Day, D. S., Abraham, B. J., Cohen, M. A., Nabet, B., Buckley, D. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.008 · Cited by 992 · see citing works
Brain cell type–specific enhancer–promoter interactome maps and disease <b>-</b> risk association
Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., et al. (2019) · Science · doi:10.1126/science.aay0793 · Cited by 823 · see citing works
Solovei, I., Wang, A. S., Thanisch, K., Schmidt, C. S., Krebs, S., Zwerger, M., Cohen, T. V., Devys, D., Foisner, R., Peichl, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.009 · Cited by 809 · see citing works
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
Solovei, I. V., Kreysing, M., Lanctôt, C., Kösem, S., Peichl, L., Cremer, T. J., Guck, J. R., & Joffe, B. I. (2009) · Cell · doi:10.1016/j.cell.2009.01.052 · Cited by 785 · see citing works
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740 · see citing works
Guenthner, C. J., Miyamichi, K., Yang, H. H., Heller, H. C., & Luo, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.025 · Cited by 705 · see citing works
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700 · see citing works
Heterochromatin drives compartmentalization of inverted and conventional nuclei
Falk, M., Feodorova, Y., Naumova, N., Imakaev, M., Lajoie, B. R., Leonhardt, H., Joffe, B., Dekker, J., Fudenberg, G., Solovei, I., et al. (2019) · Nature · doi:10.1038/s41586-019-1275-3 · Cited by 646 · see citing works
Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior
Yap, E.-L., & Greenberg, M. E. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.013 · Cited by 626 · see citing works
Chromosome conformation elucidates regulatory relationships in developing human brain
Won, H., de la Torre-Ubieta, L., Stein, J. L., Parikshak, N. N., Huang, J., Opland, C. K., Gandal, M. J., Sutton, G. J., Hormozdiari, F., Lu, D., et al. (2016) · Nature · doi:10.1038/nature19847 · Cited by 584 · see citing works
Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations
Zhang, Y., McCord, R. P., Ho, Y.-J., Lajoie, B. R., Hildebrand, D. G., Simon, A. C., Becker, M. S., Alt, F. W., & Dekker, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.002 · Cited by 545 · see citing works
Methods for mapping 3D chromosome architecture
Kempfer, R., & Pombo, A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0195-2 · Cited by 502 · see citing works
Suberbielle, E., Sanchez, P. E., Kravitz, A. V., Wang, X., Ho, K., Eilertson, K., Devidze, N., Kreitzer, A. C., & Mucke, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3356 · Cited by 487 · see citing works
Integrative detection and analysis of structural variation in cancer genomes
Dixon, J. R., Xu, J., Dileep, V., Zhan, Y., Song, F., Le, V. T., Yardımcı, G. G., Chakraborty, A., Bann, D. V., Wang, Y., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0195-8 · Cited by 452 · see citing works
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Tyssowski, K. M., DeStefino, N. R., Cho, J.-H., Dunn, C. J., Poston, R. G., Carty, C. E., Jones, R. D., Chang, S. M., Romeo, P., Wurzelmann, M. K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.001 · Cited by 390 · see citing works
Genome Organization Drives Chromosome Fragility
Canela, A., Maman, Y., Jung, S., Wong, N., Callen, E., Day, A., Kieffer-Kwon, K.-R., Pekowska, A., Zhang, H., Rao, S. S. P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.034 · Cited by 383 · see citing works
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works
The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis
de la Torre-Ubieta, L., Stein, J. L., Won, H., Opland, C. K., Liang, D., Lu, D., & Geschwind, D. H. (2018) · Cell · doi:10.1016/j.cell.2017.12.014 · Cited by 353 · see citing works
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment
Beagan, J. A., Duong, M. T., Titus, K. R., Zhou, L., Cao, Z., Ma, J., Lachanski, C. V., Gillis, D. R., & Phillips-Cremins, J. E. (2017) · Genome Research · doi:10.1101/gr.215160.116 · Cited by 299 · see citing works
Evolutionary changes in promoter and enhancer activity during human corticogenesis
Reilly, S. K., Yin, J., Ayoub, A. E., Emera, D., Leng, J., Cotney, J., Sarro, R., Rakic, P., & Noonan, J. P. (2015) · Science · doi:10.1126/science.1260943 · Cited by 297 · see citing works
Control of DNA replication timing in the 3D genome
Marchal, C., Sima, J., & Gilbert, D. M. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0162-y · Cited by 287 · see citing works
Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
Morgan, S. L., Mariano, N. C., Bermudez, A., Arruda, N. L., Wu, F., Luo, Y., Shankar, G., Jia, L., Chen, H., Hu, J.-F., et al. (2017) · Nature Communications · doi:10.1038/ncomms15993 · Cited by 279 · see citing works
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
Joo, J.-Y., Schaukowitch, K., Farbiak, L., Kilaru, G., & Kim, T.-K. (2016) · Nature Neuroscience · doi:10.1038/nn.4170 · Cited by 271 · see citing works
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Zhang, H., Emerson, D. J., Gilgenast, T. G., Titus, K. R., Lan, Y., Huang, P., Zhang, D., Wang, H., Keller, C. A., Giardine, B., et al. (2019) · Nature · doi:10.1038/s41586-019-1778-y · Cited by 271 · see citing works
Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries
Sun, J. H., Zhou, L., Emerson, D. J., Phyo, S. A., Titus, K. R., Gong, W., Gilgenast, T. G., Beagan, J. A., Davidson, B. L., Tassone, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.005 · Cited by 249 · see citing works
Lhx2/Ldb1-mediated trans interactions regulate olfactory receptor choice
Monahan, K., Horta, A., & Lomvardas, S. (2019) · Nature · doi:10.1038/s41586-018-0845-0 · Cited by 245 · see citing works
Neuronal activity modifies the chromatin accessibility landscape in the adult brain
Su, Y., Shin, J., Zhong, C., Wang, S. Z., Roychowdhury, P., Lim, J., Kim, D. S., Ming, G., & Song, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4494 · Cited by 234 · see citing works
Lamin Dysfunction Mediates Neurodegeneration in Tauopathies
Frost, B., Bardai, F. H., & Feany, M. B. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.039 · Cited by 226 · see citing works
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casiño, C., Powell, S., Yashaswini, C., LaMarca, E. A., Kassim, B., et al. (2018) · Science · doi:10.1126/science.aat4311 · Cited by 219 · see citing works
A chromosome folding intermediate at the condensin-to-cohesin transition during telophase
Abramo, K., Valton, A.-L., Venev, S. V., Özadam, H., Fox, A. N., & Dekker, J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0406-2 · Cited by 196 · see citing works
Tan, L., Ma, W., Wu, H., Zheng, Y., Xing, D., Chen, R., Li, X., Daley, N., Deisseroth, K. A., & Xie, X. S. (2021) · Cell · doi:10.1016/j.cell.2020.12.032 · Cited by 190 · see citing works
Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus
Fernandez-Albert, J., Lipinski, M., Lopez-Cascales, M. T., Rowley, M. J., Martin-Gonzalez, A. M., del Blanco, B., Corces, V. G., & Barco, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0476-2 · Cited by 166 · see citing works
Loop extrusion: theory meets single-molecule experiments
Banigan, E. J., & Mirny, L. A. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.04.011 · Cited by 160 · see citing works
Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00717-0 · Cited by 159 · see citing works
Self-citationBeagan, J. A., Pastuzyn, E. D., Fernandez, L. R., Guo, M. H., Feng, K., Titus, K. R., Chandrashekar, H., Shepherd, J. D., & Phillips-Cremins, J. E. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0634-6 · Cited by 143 · see citing works
LADL: light-activated dynamic looping for endogenous gene expression control
Kim, J. H., Rege, M., Valeri, J., Dunagin, M. C., Metzger, A., Titus, K. R., Gilgenast, T. G., Gong, W., Beagan, J. A., Raj, A., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0436-5 · Cited by 135 · see citing works
Gros, M. A. L., Clowney, E. J., Magklara, A., Yen, A., Markenscoff-Papadimitriou, E., Colquitt, B. M., Myllys, M., Kellis, M., Lomvardas, S., & Larabell, C. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.060 · Cited by 124 · see citing works
Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems
Tan, L., Xing, D., Daley, N., & Xie, X. S. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0205-2 · Cited by 115 · see citing works
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
Ba, Z., Lou, J., Ye, A. Y., Dai, H., Dring, E. W., Lin, S. G., Jain, S., Kyritsis, N., Kieffer-Kwon, K.-R., Casellas, R. C., et al. (2020) · Nature · doi:10.1038/s41586-020-2578-0 · Cited by 115 · see citing works
MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
Boxer, L. D., Renthal, W. R., Greben, A. W., Whitwam, T., Silberfeld, A., Stroud, H., Li, E., Yang, M. G., Kinde, B., Griffith, E. C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.032 · Cited by 111 · see citing works
Nucleome Dynamics during Retinal Development
Norrie, J. L., Lupo, M. S., Xu, B., Aldiri, I., Valentine, M. B., Putnam, D. K., Griffiths, L. M., Zhang, J., Johnson, D. A., Easton, J. B., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.002 · Cited by 87 · see citing works
Sensory experience remodels genome architecture in neural circuit to drive motor learning
Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1190-7 · Cited by 83 · see citing works
MeCP2 represses enhancers through chromosome topology-associated DNA methylation
Clemens, A. W., Wu, D. Y., Moore, J., Christian, D. L., Zhao, G., & Gabel, H. W. (2019) · Molecules and Cells · doi:10.1016/j.molcel.2019.10.033 · Cited by 80 · see citing works
Changes in Chromatin Structure Associated with Alzheimer’s Disease
Lewis, P. N., Lukiw, W. J., De Boni, U., & Crapper McLachlan, D. R. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb04670.x · Cited by 78 · see citing works
Olfactory receptor genes make the case for inter-chromosomal interactions
Bashkirova, E., & Lomvardas, S. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.07.004 · Cited by 76 · see citing works
Understanding the 3D genome: Emerging impacts on human disease
Krumm, A., & Duan, Z. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.004 · Cited by 75 · see citing works
Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin looping
Kikuchi, M., Hara, N., Hasegawa, M., Miyashita, A., Kuwano, R., Ikeuchi, T., & Nakaya, A. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0574-8 · Cited by 74 · see citing works
Nuclear compartmentalization of odorant receptor genes
Armelin‐Correa, L., Gutiyama, L. M., Brandt, D. Y. C., & Malnic, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317036111 · Cited by 60 · see citing works
The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
Goodman, J. V., Yamada, T., Yang, Y., Kong, L., Wu, D. Y., Zhao, G.-Y., Gabel, H. W., & Bonni, A. (2020) · Nature Communications · doi:10.1038/s41467-020-17065-z · Cited by 55 · see citing works
Chromatin architecture reorganization during neuronal cell differentiation in Drosophila genomePreprint
Chathoth, K. T., & Zabet, N. R. (2019) · Genome Research · doi:10.1101/gr.246710.118 · Cited by 54 · see citing works
Gaspar, N., Zambito, G., Dautzenberg, I. J. C., Cramer, S. J., Hoeben, R. C., Lowik, C., Walker, J. R., Kirkland, T. A., Smith, T. P., van Weerden, W. M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165863 · Cited by 54 · see citing works
Rhie, S., Schreiner, S., Witt, H., Armoskus, C., Lay, F. D., Camarena, A., Spitsyna, V. N., Guo, Y., Berman, B. P., Evgrafov, O., et al. (2018) · Science Advances · doi:10.1126/sciadv.aav8550 · Cited by 50 · see citing works
Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis
Mahajani, S. U., Giacomini, C., Marinaro, F., Tonelli, D. D. P., Contestabile, A., & Gasparini, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-05078-6 · Cited by 43 · see citing works
Ito, S., Magalska, A., Alcaraz-Iborra, M., López-Atalaya, J., Rovira, V., Contreras-Moreira, B., Lipiński, M., Olivares, R., Martínez-Hernández, J., Ruszczycki, B., et al. (2014) · Nature Communications · doi:10.1038/ncomms5450 · Cited by 40 · see citing works
Gigante, C. M., Dibattista, M., Dong, F. N., Zheng, X., Yue, S., Young, S. G., Reisert, J., Zheng, Y., & Zhao, H. (2017) · Nature Communications · doi:10.1038/ncomms15098 · Cited by 32 · see citing works
DNA Double-Strand Breaks Are a Critical Regulator of Fear Memory Reconsolidation
Navabpour, S., Rogers, J. M., McFadden, T., & Jarome, T. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238995 · Cited by 20 · see citing works
Kwak, J., Kim, S., Yu, N., Seo, H., Choi, J. E., Kim, J., Choi, D. I., Kim, M. W., Kwak, C., Lee, K., et al. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12701 · Cited by 9 · see citing works
Differential involvement of caspase-6 in amyloid-β-induced fragmentation of lamin A and B
Islam, M. R., Hossain, M. S., & Park, I. (2020) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2020.100839 · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 67 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.038 · Cited by 130 · see citing works
Self-citationChromatin compaction precedes apoptosis in developing neurons
Rose, R., Peschke, N., Nigi, E., Gelléri, M., Ritz, S., Cremer, C. G., Luhmann, H. J., & Sinning, A. (2022) · Communications Biology · doi:10.1038/s42003-022-03704-2 · Cited by 39 · see citing works
Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review
Mir, F. A., Amanullah, A., Jain, B. P., Hyderi, Z., & Gautam, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102067 · Cited by 28 · see citing works
Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer’s agents
Ordoñez, W. O. C., Cajas‐Salazar, N., & Velasco-Reyes, M. A. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382232 · Cited by 26 · see citing works
Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior
Xia, J., Zhao, J. Z., Strom, A. R., & Brangwynne, C. P. (2025) · Nature Communications · doi:10.1038/s41467-025-60771-9 · Cited by 24 · see citing works
Kyung, J., Jeon, M., & Lee, I. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.964931 · Cited by 22 · see citing works
Pumo, G., Kitazawa, T., & Rijli, F. M. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.911023 · Cited by 21 · see citing works
Three‐dimensional genome structure and function
Liu, H., Tsai, H., Yang, M., Li, G., Bian, Q., Ding, G., Wu, D., & Dai, J. (2023) · MedComm · doi:10.1002/mco2.326 · Cited by 18 · see citing works
The cap epitranscriptome: Early directions to a complex life as mRNA
Anreiter, I., Tian, Y. W., & Soller, M. (2022) · BioEssays · doi:10.1002/bies.202200198 · Cited by 9 · see citing works
Evaluation of chromatin mesoscale organization
Lorber, D., & Volk, T. (2022) · APL Bioengineering · doi:10.1063/5.0069286 · Cited by 6 · see citing works
On the origin and nature of nongenetic information in eumetazoans
Cabej, N. R. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15001 · Cited by 5 · see citing works
Deciphering the dynamical chromosome structural reorganizations in human neural development
Chu, X., Feng, C., & Wang, J. (2024) · Physical Review Research · doi:10.1103/physrevresearch.6.023309 · Cited by 3 · see citing works
A computational framework for epigenetic plasticity in memory
Delamare, G., Wagle, S., Gräff, J., & Claudia Clopath, A. (2026) · Brain · doi:10.1093/brain/awag094 · Cited by 1 · see citing works
Nongenetic Mechanisms of Animal Evolution
Cabej, N. R. (2026) · Springer eBooks · doi:10.1007/978-3-032-24295-2_27
- Authors
- Dileep, V., & Tsai, L.-H.
- Affiliations
- Massachusetts Institute of Technology (US)
- Broad Institute (US)
- Corresponding author
- Tsai, Li-Huei
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 69
- Pages
- 214-221
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W3168632767
- Cited by
- 14
- References
- 67
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Neurological Disorders and Stroke
- Alzheimer's Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- 3D genome organization, nuclear organization, epigenetics, brain development, neuronal cell types, neuronal activity, learning and memory, chromatin interactions, brain disorders
- MeSH terms
- Brain, Cell Nucleus, Chromatin, Chromosomes, Genome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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