Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

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Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953

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Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667

Neurobiology of relapse to heroin and cocaine seeking: a review

Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880

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Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340

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Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

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Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397

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Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350

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Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108

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Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,015

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Samuni, Y., Goldstein, S., Dean, O. M., & Berk, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.016 · Cited by 876

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Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863

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Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 763

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Peters, J., Kalivas, P. W., & Quirk, G. J. (2009) · Learning & Memory · doi:10.1101/lm.1041309 · Cited by 736

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Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584

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Bridges, R. J., Natale, N. R., & Patel, S. A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01480.x · Cited by 538

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Dean, O., Giorlando, F., & Berk, M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100057 · Cited by 494

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Aoyama, K., Suh, S. W., Hamby, A. M., Liu, J., Chan, W. Y., Chen, Y., & Swanson, R. A. (2006) · Nature Neuroscience · doi:10.1038/nn1609 · Cited by 484

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Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.015 · Cited by 463

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Berk, M., Malhi, G. S., Gray, L. J., & Dean, O. M. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.01.001 · Cited by 434

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Dodd, S., Dean, O., Copolov, D. L., Malhi, G. S., & Berk, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14728220802517901 · Cited by 413

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Weiss, F. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.001 · Cited by 411

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Lo, M., Wang, Y., & Gout, P. W. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21366 · Cited by 399

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Shippenberg, T. S., Zapata, A., & Chefer, V. I. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.011 · Cited by 387

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Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369

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Root, D. H., Melendez, R. I., Zaborszky, L., & Napier, T. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.005 · Cited by 353

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Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G., Marie, H., Liu, W., Yan, Z., Sorg, B. A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.007 · Cited by 289

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Wolf, M. E., & Ferrario, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.013 · Cited by 271

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Madayag, A., Lobner, D., Kau, K. S., Mantsch, J. R., Abdulhameed, O., Hearing, M., Grier, M. D., & Baker, D. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2808-07.2007 · Cited by 225

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Bridges, R., Lutgen, V., Lobner, D., & Baker, D. A. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003889 · Cited by 205

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Scofield, M. D., Boger, H. A., Smith, R. J., Li, H., Haydon, P. G., & Kalivas, P. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.016 · Cited by 197

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Self, D. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.005 · Cited by 189

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Moussawi, K., Riegel, A., Nair, S., & Kalivas, P. W. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00094 · Cited by 184

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Gray, K. M., Sonne, S. C., McClure, E. A., Ghitza, U. E., Matthews, A. G., McRae-Clark, A. L., Carroll, K. M., Potter, J. S., Wiest, K., Mooney, L. J., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.04.020 · Cited by 157

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Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148

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Bull, C., Freitas, K. C., Zou, S., Poland, R. S., Syed, W. A., Urban, D. J., Minter, S. C., Shelton, K. L., Hauser, K. F., Negus, S. S., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.135 · Cited by 145

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Rao, P. S. S., Bell, R. L., Engleman, E. A., & Sari, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00144 · Cited by 136

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Pierce, R. C., & Vanderschuren, L. J. M. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.007 · Cited by 115

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Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.05.003 · Cited by 112

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Schmaal, L., Berk, L., Hulstijn, K. P., Cousijn, J., Wiers, R. W., & van den Brink, W. (2011) · European Addiction Research · doi:10.1159/000327682 · Cited by 93

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Garcia‐Keller, C., Martinez, S. A., Esparza, M. A., Bollati, F., Kalivas, P. W., & Cancela, L. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12121 · Cited by 92

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Koob, G. F. (2011) · Focus · doi:10.1176/foc.9.1.foc55 · Cited by 79

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Namba, M. D., Leyrer-Jackson, J. M., Nagy, E. K., Olive, M. F., & Neisewander, J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.650785 · Cited by 76

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Spencer, S., & Kalivas, P. W. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx050 · Cited by 71

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Price, K. L., McRae-Clark, A. L., Saladin, M. E., Maria, M. M. M.-S., DeSantis, S. M., Back, S. E., & Brady, K. T. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990903384332 · Cited by 54

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Keramati, M., Durand, A., Girardeau, P., Gutkin, B., & Ahmed, S. H. (2017) · Psychological Review · doi:10.1037/rev0000046 · Cited by 44

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Niehaus, J. L., Cruz‐Bermúdez, N. D., & Kauer, J. A. (2009) · The American Journal on Addictions · doi:10.1080/10550490902925946 · Cited by 42

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Rich, M. T., & Torregrossa, M. M. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.09.003 · Cited by 27

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Peng, S., Peng, Z., Qin, M., Huang, L., Zhao, B., Wei, L., Ning, J., Tuo, Q.-H., Yuan, T.-F., Shi, Z., et al. (2021) · Nutrition · doi:10.1016/j.nut.2020.111058 · Cited by 18