The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
The neurobiology of pair bonding.
Abstract
A neurobiological model for pair-bond formation has emerged from studies in monogamous rodents. The neuropeptides oxytocin and vasopressin contribute to the processing of social cues necessary for individual recognition. Mesolimbic dopamine is involved in reinforcement and reward learning. Concurrent activation of neuropeptide and dopamine receptors in the reward centers of the brain during mating results in a conditioned partner preference, observed as a pair bond. Differential regulation of neuropeptide receptor expression may explain species differences in the ability to form pair bonds. These and other studies discussed here have intriguing implications for the neurobiology of social attachment in our own species.
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In the citing paper
“Meta-analyses and systematic reviews indicate that a range of common therapies can indeed be effective in relieving couple distress in many situations [26, 27].”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [26]
In the citing paper
“The hypothalamic peptide oxytocin (OXT) has been identified as a key modulator of pair-bonding in men, but its effects in women are still elusive.”
From Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face (2016) · cites this paper as Young and Wang, 2004
In the citing paper
“A study injecting 3H-leucine into the SON found multiple extrahypothalamic projections, including olfactory bulb, amygdala, cingulum, and locus coeruleus [140].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [140]
In the citing paper
“which suggests that species-specific differences in neural distributions of OXTR can reflect the social organisation of the species (20,21).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [20]
In the citing paper
“OXTR signaling in the NAcc is required for mating-induced partner preference formation, a laboratory proxy of pair bonding (6).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“In a socially monogamous rodent, the prairie vole (Microtus ochrogaster), OXTR is enriched in important MLR regions such as the nucleus accumbens (NAcc) and prefrontal cortex (PFC) that constitute part of a neural network for pair bonding (6, 8, 34).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“OXTR density is much higher in the NAcc of prairie voles than promiscuous vole species”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“It is thought that the interface between oxytocin and the dopaminergic reward system may contribute to the success of mother-infant and pair-bonding processes [18,[75][76][77].”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [76]
In the citing paper
“Our first studies of the role of the AVPR1a gene in social cognition exemplified by a simple laboratory paradigm converges with a wide range of both animal and human experimentation showing that arginine vasopressin (AVP) and the closely related oxytocin (OT) are key neuropeptides that facilitate social communication, affiliative behaviors and social cognition across mammals [6], [7] .”
From The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task (2009) · cites this paper as [7]
In the citing paper
“By contrast, other related vole species such as the meadow vole (M. pennsylvanicus) and the montane vole (M. montanus) are relatively asocial and do not readily form social bonds, providing a useful point of comparison for identifying neurobiological and genetic systems leading to diversity in social behaviors [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“By contrast, other related vole species such as the meadow vole (M. pennsylvanicus) and the montane vole (M. montanus) are relatively asocial and do not readily form social bonds, providing a useful point of comparison for identifying neurobiological and genetic systems leading to diversity in social behaviors [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“For example, socially monogamous male prairie voles have high densities of AVPR1A binding in the ventral pallidum, a major output of the NAcc, while non-mongamous vole species do not [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“One of these socially monogamous mammals that has provided remarkable insights into the neural and neurogenetic mechanisms of social attachments is the prairie vole (Microtus ochrogaster)”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Young and Wang 2004
In the citing paper
“V1aR signaling in the ventral pallidum and LS promote partner preferences (149), while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus (43,150).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [149]
In the citing paper
“Because animal research has documented that OT is primarily a social bonding hormone that activates socio-emotional neural pathways in the brain 22,23 , we would also expect the effect of OT in humans to be limited to social situations where initiating or establishing partnership is important to realize synergy.”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [23]
In the citing paper
“this finding fits with the crucial function of OT as a female hormone in labor, bonding and parenting both in human- [54], [4] and non-human mammals [55]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [55]
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“…63regulate, including social approach (Goodson et al., 2009; Lukas 64et al., 2011), social recognition (Bielsky and Young, 2004), social 65bonding (Young and Wang, 2004; Ross and Young, 2009; Q4Insel and 66Young, 2001; Q5Klatt and Goodson, 2012), social cognition (Donaldson 67and Young, 2008), as…”
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“OXTR in the nucleus accumbens and medial prefrontal cortex, and AVPR1a in the ventral pallidum and lateral septum regulate pair bonding in female and male prairie voles, respectively (Johnson and Young 2015; Lim et al. 2004b; Young and Wang 2004; Young et al. 2001).”
BackgroundHelping behavior in prairie voles: a model of empathy and the importance of oxytocin
Kitano, K., Yamagishi, A., Horie, K., Nishimori, K., & Sato, N. (2022) · iScience · doi:10.1016/j.isci.2022.103991 · Cited by 31
“Oxytocin works as a hormone and as a neurotransmitter, which is involved in a variety of sociality, such as nurturing, familiarity, empathy, and social attachment (Bosch and Neumann, 2012; Decety et al., 2016; Insel, 2010; King et al., 2016; Rodrigues et al., 2009; Young and Wang, 2004).”
Oxytocin and the social brain: beware the complexity
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“Recent studies have demonstrated dramatic effects of these neuropeptides in animals: a single dose of OT can induce a life-long pair-bond in prairie voles, or bring about the strong attachment of a mother to its child in virgin females to stranger pups (Young and Wang, 2004).”
BackgroundInfluentialRomantic love evolved by co-opting mother-infant bonding
Bode, A. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1176067 · Cited by 32
“These studies are summarized in multiple reviews (e.g., Carter, 1998; Carter and Keverne, 2002; Young and Wang, 2004; Broad et al., 2006; Numan and Young, 2016; Walum and Young, 2018) and tend to focus on mammals, notably rodents.”
BackgroundInoue, K., Burkett, J. P., & Young, L. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.035 · Cited by 33
“Conversely, literature on pair bond formation has implicated the indirect pathway (Young and Wang, 2004; Burkett et al., 2012), including MOR in the dorsal striatum, whose endogenous ligand, enkephalin, is expressed in indirect pathway neurons, which also express D2 dopamine receptors (Steiner and…”
BackgroundInfluentialArginine vasotocin reduces levels of cooperative behaviour in a cleaner fish
Cardoso, S. C., Paitio, J. R., Oliveira, R. F., Bshary, R., & Soares, M. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.052 · Cited by 31
“In rodents, AVP is crucial for the enhancement of social recognition and social memory [56–58] while in humans it seems to affect social communication, demonstrating biassed effects between genders [16–18].”
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“Animal studies have also demonstrated that oxytocin interacts with dopaminergic neurons in the nucleus accumbens and ventral tegmental areas to regulate complex social information processing and responses (Young & Wang, 2004).”
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“Specifically, the evolutionarily highly conserved nonapeptide hormone oxytocin (OXT) has a well-established role in human sociality, including altruistic behavior (Young and Wang, 2004; Israel et al., 2012; Hurlemann and Marsh, 2016).”
BackgroundWeitekamp, C. A., Nguyen, J. M., & Hofmann, H. A. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12389 · Cited by 35
“The D2 receptor (D2R) pathway in particular plays an intriguing role in modulating motivation related to social context (Choleris et al. 2011; Young & Wang 2004).”
BackgroundSocial recognition in paired, but not single, male prairie voles
Blocker, T. D., & Ophir, A. G. (2015) · Animal Behaviour · doi:10.1016/j.anbehav.2015.07.003 · Cited by 30
van Anders, S. M., & Gray, P. B. (2007) · Annual Review of Sex Research · doi:10.1080/10532528.2007.10559847 · Cited by 32
The utility of behavioral models and modules in molecular analyses of social behavior
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“The first clue came from the observation that V1aR and OTR are both expressed in brain regions commonly associated with the 262 Genes, Brain and Behavior (2008) 7: 257–265 vertebrate dopaminergic reward-processing system (Young & Wang 2004; Young et al. 2001).”
BackgroundInfluentialRío, R. T.-D., Tecamachaltzi-Silvarán, M. B., Díaz-Estrada, V. X., Herrera‐Covarrubias, D., Corona-Morales, A. A., Pfaus, J. G., & Coria‐Ávila, G. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.019 · Cited by 33
Moscovice, L. R., & Ziegler, T. E. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.08.011 · Cited by 31
“In addition to the established relationship between OT and affiliative pair-bonds in monogamous species (Snowdon et al., 2010; Young and Wang, 2004), this preliminary study suggests that peripheral OT is related to the maintenance of short-term, exclusive consortships in a promiscuous species.”
Ophir, A. G., Sorochman, G., Evans, B. L., & Prounis, G. S. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12049 · Cited by 32
The role of orgasm in the development and shaping of partner preferences
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“This occurs mainly as a result of D1-type receptor upregulation in the NAc after the first pair bond (Aragona et al., 2006; Young & Wang, 2004).”
BackgroundUlloa, M., Portillo, W., Díaz, N. F., Young, L. J., Camacho, F. J., Rodríguez, V. M., & Paredes, R. G. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.10.015 · Cited by 31
“The partner-specific characteristics (olfactory visual or auditory cues) can be associated with the sexual reward, which in turn will allow the vole to recognize and choose a partner and exclude other potential mates (Coria-Avila et al., 2016; Johnson et al., 2017; Johnson and Young, 2015; Young and Wang, 2004).”
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“While the voles have similar distributions of OXT and AVP in the brain, they differ markedly in distribution of receptors that respond to the peptides, OXTR and AVPR1a, respectively (Young and Wang, 2004).”
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“The neuromodulator oxytocin has been implicated in mediating a wide variety of social behaviors, including the facilitation of social bonds, trust, and affiliative behavior (Bartz et al, 2011; Carter, 2013; Feifel, 2012; Feldman, 2012; Guastella et al, 2013; Harris and Carter, 2013; Heinrichs and Domes, 2008; Hollande…”
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“OXTRs in the nucleus accumbens (NAc) are implicated in social phenotypes including alloparental behaviour, mating-induced partnerpreference formation and male monogamy-related behaviour (Young & Wang, 2004; Olazabal & Young, 2006).”
BackgroundSadino, J. M., Bradeen, X., Kelly, C. J., Brusman, L. E., Walker, D. M., & Donaldson, Z. R. (2023) · eLife · doi:10.7554/elife.80517 · Cited by 29
“Similarly, in prairie voles, pair bond-associated behavioral changes are under-written by several known neuromolecular changes within the NAc which maintain and reinforce pair bonds over time ( Insel and Young, 2001 ; Aragona and Wang, 2004 ; Young and Wang, 2004 ).”
BackgroundRamsey, M. E., Maginnis, T. L., Wong, R. Y., Brock, C. D., & Cummings, M. E. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00062 · Cited by 30
“The neuropeptides vasopressin and oxytocin have been well-studied in mediating pair bonding in voles (Young and Wang, 2004), and the fish homologs vasotocin and isotocin have been implicated in social approach and reproductive behavior in fish (Goodson and Bass, 2000; Thompson and Walton, 2004).”
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“This is despite considerable evidence suggesting that oxytocin and vasopressin's effects on social behaviour are sexually differentiated (Young and Wang, 2004) and it iswidely known thatwomen are over-representedwith respect to the prevalence of mood disorders such as depression and anxiety (Weissman and Olfson, 1995).”
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“The social functions of OT are not restricted to reproductive behaviors such as pair bonding and parental care.”
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Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles
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“Young and Wang (2004) proposed that pair bonding in prairie voles involves AVP-V1a binding in the ventral pallidum that regulates partner preference.”
The Timing of Brain Maturation, Early Experience, and the Human Social Niche
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“Sexual activity and pair bonding enjoyed by the breeding pair, but not by the non-breeders, is expected to result in surge of diverse hormones and neurotransmitters, particularly oxytocin, arginine vasopressin, sexual hormones, prolactin, dehydroepiandrostone, and dopamine (cf. Young and Wang 2004 ).”
BackgroundFrom affiliative behaviors to romantic feelings: A role of nanopeptides
Dębiec, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.095 · Cited by 30
“The concurrent activation of peptidergic social learning pathways and dopaminergic reward pathways reinforces partner approach behavior and pair bonds [11,32]; OT, oxytocin, AVP, vasopressin, DA, dopamine.”
BackgroundInfluentialIwata, E., & Manbo, J. (2013) · acta ethologica · doi:10.1007/s10211-012-0142-0 · Cited by 29
“It is clear that mammals and birds exhibit social recognition and partner preference (Adkins-Regan 2011; Ferguson et al. 2002; Young and Wang 2004); recent studies have revealed these traits in several species of teleost fishes as well (Yabuta 2007; Sogabe and Yanagisawa 2008; Ward et al.”
BackgroundRío, R. T.-D., Montero-Domínguez, F. Á., Llanderal, T. C., Tecamachaltzi-Silvarán, M. B., García, L. I., Manzo, J., Hernández‐Aguilar, M. E., & Coria‐Ávila, G. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.006 · Cited by 31
Viewing Loved Faces Inhibits Defense Reactions: A Health-Promotion Mechanism?
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“This effect was enhanced by intranasal oxytocin administration, the neuropeptide implicated in both parent-child bonding and prosocial behaviors [10].”
BackgroundRivera, D. S., Inestrosa, N. C., & Bozinovic, F. (2016) · Biological Research · doi:10.1186/s40659-016-0074-7 · Cited by 31
“Recent advances in neuroscience, endocrinology, and molecular genetics offer the opportunity to incorporate predictions for how these factors upon which selection can act to shape social systems and allows understand proximate mechanisms of social behavior still in an ecological context [4, 22].”
BackgroundAggression: Perspectives from social and systems neuroscience
Kelly, A. M., & Wilson, L. C. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.010 · Cited by 29
“The ventral-striato pallidum is part of a neural ‘pairbonding circuit,’ which has been studied extensively in prairie voles (Young and Wang, 2004; Young et al., 2008; Young et al., 2011).”
Medina, L. M., Abellán, A., & Desfilis, E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00894 · Cited by 30
“The nucleus accumbens, the ventral pallidum, the prefrontal cortex, and the amygdala are among the areas showing higher receptor density in monogamous compared to non-monogamous voles (Insel et al., 1994; Young and Wang, 2004).”
BackgroundSocial recognition is context dependent in single male prairie voles
Zheng, D., Foley, L., Rehman, A., & Ophir, A. G. (2013) · Animal Behaviour · doi:10.1016/j.anbehav.2013.09.015 · Cited by 28
Anestis, S. F., Webster, T. H., Kamilar, J. M., Fontenot, M. B., Watts, D. P., & Bradley, B. J. (2014) · International Journal of Primatology · doi:10.1007/s10764-013-9747-z · Cited by 30
“Closely related montane and prairie voles have promiscuous (nonmonogamous) and monogamous mating systems, respectively, and show corresponding differences in vasopressin receptor expression: prairie voles have higher vasopressin receptor expression in the ventral pallidum and other brain regions than montane voles (Yo…”
BackgroundResultInfluentialInvestigation of an F-18 oxytocin receptor selective ligand via PET imaging
Smith, A. L., Freeman, S. M., Voll, R. J., Young, L. J., & Goodman, M. M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.07.045 · Cited by 28
Friend of the Devil: Negative Social Influences Driving Substance Use Disorders
Pomrenze, M. B., Paliarin, F., & Maiya, R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.836996 · Cited by 29
“Early investigations spanning multiple animal models of sociability implicate an important role for DA release in the nucleus accumbens (NAc) in affiliative interactions (Robinson et al., 2002, 2011; Young and Wang, 2004).”
BackgroundStoesz, B. M., Hare, J. F., & Snow, W. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.007 · Cited by 28
How does individual variation in sociality influence fitness in prairie voles?
Sabol, A. C., Lambert, C. T., Keane, B., Solomon, N. G., & Dantzer, B. (2020) · Animal Behaviour · doi:10.1016/j.anbehav.2020.02.009 · Cited by 28
Behavioral, hormonal, and neural alterations induced by social contagion for pain in mice
Baptista‐de‐Souza, D., Tavares, L. R. R., Canto‐de‐Souza, L., Nunes‐de‐Souza, R. L., & Canto‐de‐Souza, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108878 · Cited by 30
Prior, N. H., Bentz, E. J., & Ophir, A. G. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12781 · Cited by 31
“of the specific chemical signature of each partner's respective mate.(26,60) This concurrent activation of reward systems with facilitated sensory learning results in a conditioned partner preference, that is, a”
BackgroundInfluentialAdrian, O., Kaiser, S., Sachser, N., Jandewerth, P., Löttker, P., Epplen, J. T., & Hennessy, M. B. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.009 · Cited by 28
Llanderal, T. C., Rosas-Aguilar, V., Río, R. T.-D., Pérez-Estudillo, C. A., Manzo, J., García, L. I., & Coria‐Ávila, G. A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.04.007 · Cited by 29
“As in previous studies, social partner preference was inferred when a male spent more time in close contact with the stimulus partners (Aragona et al., 2003; Carter et al., 1992; DeVries et al., 1996; Lim et al., 2004; Wang and Aragona, 2004; Wang et al., 1999; Young and Wang, 2004).”
Pharmacology of Economic and Social Decision Making
Crockett, M. J., & Fehr, E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416008-8.00014-0 · Cited by 29
Søvik, E., Perry, C. J., & Barron, A. B. (2015) · Advances in insect physiology · doi:10.1016/bs.aiip.2014.12.006 · Cited by 29
Social experience influences hypothalamic oxytocin in the WHHL rabbit
Paredes, J., Szeto, A., Levine, J. E., Zaias, J., Gonzales, J. A., Mendez, A. J., Llabre, M. M., Schneiderman, N., & McCabe, P. M. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.06.007 · Cited by 28
“Basic research has established that OT is associated with the emergence of social bonding, affiliative behavior, parental care, pair-bond formation, social recognition and attachment (Insel, 1992; Insel et al., 1997; Carter, 1998; Cho et al., 1999; Insel and Young, 2000; Young and Wang, 2004).”
BackgroundLove and Attachment: The Psychobiology of Social Bonding
Stein, D. J., & Vythilingum, B. (2009) · CNS Spectrums · doi:10.1017/s1092852900025384 · Cited by 28
Oldfield, R. G., Harris, R. M., & Hofmann, H. A. (2015) · Frontiers in Zoology · doi:10.1186/1742-9994-12-s1-s16 · Cited by 28
“Wang ZX, Young LJ, Liu Y, Insel TR: Species differences in vasopressin receptor binding are evident early in development: Comparative anatomic studies in prairie and montane voles.”
BackgroundInfluentialAhern, T. H., Olsen, S., Tudino, R., & Beery, A. K. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105209 · Cited by 27
Day, N. F., Saxon, D., Robbins, A., Harris, L., Nee, E., Shroff-Mehta, N., Stout, K., Sun, J., Lillie, N., Burns, M., et al. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.191510 · Cited by 27
Konno, A., Inoue‐Murayama, M., Yabuta, S., Tonoike, A., Nagasawa, M., Mogi, K., & Kikusui, T. (2018) · Journal of Heredity · doi:10.1093/jhered/esy012 · Cited by 26
“Oxytocin and its receptor have been highly conserved during the evolutionary process of mammalian species and have been shown to play a key role in mediating pair bonding between parent and offspring as well as between sexual partners in monogamous species (Young and Wang 2004; Ross and Young 2009).”
BackgroundNagano, M., Takumi, T., & Suzuki, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-32042-9 · Cited by 30
Dissecting neural mechanisms of prosocial behaviors
Walsh, J. J., Christoffel, D. J., Wu, X., Pomrenze, M. B., & Malenka, R. C. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.006 · Cited by 30
Mean Girls: Social Stress Models for Female Rodents
Kuske, J. X., & Trainor, B. C. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_247 · Cited by 27
Almeida, D. M., Fiori, L. M., Chen, G. G., Aouabed, Z., Lutz, P.-É., Zhang, T., Mechawar, N., Meaney, M. J., & Turecki, G. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105600 · Cited by 28
Mitchell, I., Gillespie, S. M., & Abu-Akel, A. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.018 · Cited by 27
DNA Methylation and Hydroxymethylation and Behavior
Rustad, S. R., Papale, L. A., & Alisch, R. S. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_104 · Cited by 26
Cacioppo, J. T., & Cacioppo, S. (2013) · Perspectives on Psychological Science · doi:10.1177/1745691613507456 · Cited by 32
“…1999; cf. Decety & Cacioppo, 2011); cellular and molecular techniques in genetics and epigenetics (e.g., Cole, Hawkley, Arevalo, & Cacioppo, 2011; Young & Wang, 2004); twin studies and molecular techniques (e.g., Abdellaoui et al., in press); and high performance computing and meta-analytic…”
Alcohol preference in mice lacking the Avpr1a vasopressin receptor
Sanbe, A., Takagi, N., Fujiwara, Y., Yamauchi, J., Endo, T., Mizutani, R., Takeo, S., Tsujimoto, G., & Tanoue, A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00708.2007 · Cited by 27
“known as a regulator of aggression (7), pair bonding ( 54 ), and anxiety-related behaviors”
BackgroundGrebe, N. M., Sharma, A., Freeman, S. M., Palumbo, M. C., Patisaul, H. B., Bales, K. L., & Drea, C. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-83342-6 · Cited by 26
Sakamoto, T., Sugimoto, S., & Uekita, T. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112701 · Cited by 27
Prior, N. H. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01370 · Cited by 27
Abreu, J. A. G., Rosenberg, A. E., Fricker, B. A., Wallace, K. J., Seifert, A. W., & Kelly, A. M. (2022) · iScience · doi:10.1016/j.isci.2022.104230 · Cited by 26
“OT receptors in the nucleus accumbens (NAc) are crucial for pair-bonding in the monogamous prairie vole (Young and Wang, 2004) and OT activity in the NAc facilitates the rewarding properties associated with performance in a social conditioned place preference (CPP) assay in mice (Dolen et al.,…”
Genetics of Aggression in Voles
Gobrogge, K. L., & Wang, Z. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380858-5.00003-4 · Cited by 26
Ophir, A. G., Crino, O. L., Wilkerson-Vidal, Q. C., Wolff, J. O., & Phelps, S. M. (2007) · Brain Behavior and Evolution · doi:10.1159/000108609 · Cited by 26
“Although vasopressin’s action on V1aR does play an important role in pairbonding and paternal care, there are other proximate influences on how such social behaviors manifest themselves [e.g., oxytocin and dopamine, Young and Wang, 2004, and estrogen receptor alpha, Cushing and WynneEdwards, 2006].”
BackgroundInfluentialFisher‐Phelps, M., Mendoza, S. P., Serna, S. N., Griffin, L. L., Schaefer, T. J., Jarcho, M. R., Ragen, B., Goetze, L. R., & Bales, K. L. (2015) · American Journal of Primatology · doi:10.1002/ajp.22483 · Cited by 26
Birnbaum, G. E., Mizrahi, M., Kaplan, A., Kadosh, D., Kariv, D., Tabib, D., Ziv, D., Sadeh, L., & Burban, D. (2017) · Personality and Social Psychology Bulletin · doi:10.1177/0146167217695556 · Cited by 27
“Still, because humans, unlike most mammals, do not limit their sexual interactions to the few days surrounding ovulation, they are more likely to experience an extended exposure to these neuropeptides and feel their beneficial long-lasting effects on attachment processes (L. J. Young & Wang, 2004).”
BackgroundKatayama, M., Hirayama, T., Horie, K., Kiyono, T., Donai, K., Takeda, S., Nishimori, K., & Fukuda, T. (2016) · Cell Transplantation · doi:10.3727/096368916x690502 · Cited by 26
Evolutionary diversity as a catalyst for biological discovery
JOHNSON, Z. V., & YOUNG, L. J. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12339 · Cited by 25
“…V1aR, dopamine receptors, and other neuromodulatory receptors play causal roles in regulating pair bonding behavior (Aragona et al, 2003; Burkett et al, 2011; Curtis & Wang, 2005; Gingrich et al, 2000; Keebaugh et al, 2015; Lim et al, 2007; Lim & Young, 2004; Liu & Wang, 2003; Young et al, 2001).”
BackgroundTranscriptomic analysis of instinctive and learned reward-related behaviors in honey bees
Naeger, N. L., & Robinson, G. E. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.144311 · Cited by 25
“KEY WORDS: Brain, Gene expression, Mushroom bodies, Neuroethology, Social insects”
BackgroundDemarchi, L., Pawluski, J. L., & Bosch, O. J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170593 · Cited by 26
Social zebrafish: Danio rerio as an emerging model in social neuroendocrinology
Kareklas, K., Teles, M. C., Nunes, A. R., & Oliveira, R. F. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13280 · Cited by 24
The Obsidian Evidence for the Scale of Social Life during the Palaeolithic
Moutsiou, T. (2014) · University of Michigan Press eBooks · doi:10.30861/9781407312446 · Cited by 25
Beysard, M., Krebs-Wheaton, R., & Heckel, G. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0455-5 · Cited by 26
“This measure has been shown to be the most sensitive indicator of a partner preference in Microtus species [57, 60, 61].”
BackgroundBeloate, L. N., & Coolen, L. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.024 · Cited by 26
“The neural mechanisms that control pair bonding have been extensively studied (Young and Wang, 2004; Young et al., 2008, 2011; Gobrogge, 2013).”
Martin, M. M., Liu, Y., & Wang, Z. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.015 · Cited by 26
“Studies have also shown that male and female prairie voles form long lasting pair bonds following mating [79-81] and that these behaviors are regulated by a variety of neurochemicals including OT [81, 82], arginine vasopressin (AVP) [79, 83, 84], dopamine (DA) [85] and 5-HT [86].”
BackgroundInfluentialOut of touch? How trauma shapes the experience of social touch – Neural and endocrine pathways
Stevens, L., Bregulla, M., & Scheele, D. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105595 · Cited by 28
Personality is tightly coupled to vasopressin-oxytocin neuron activity in a gregarious finch
Kelly, A. M., & Goodson, J. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00055 · Cited by 24
“In humans, personality profoundly impacts the neural processing of social stimuli (Kennis et al., 2013), but to our knowledge, mechanisms of similarly complex behavioral phenotypes have not been examined at high resolution (i.e., at a cellular level) in nonhuman species.”
BackgroundOxytocin and positive couple interaction affect the perception of wound pain in everyday life
Pfeifer, A.-C., Schröder‐Pfeifer, P., Schneider, E., Schick, M., Heinrichs, M., Bodenmann, G., Ehlert, U., Herpertz, S. C., Läuchli, S., Eckstein, M., et al. (2020) · Molecular Pain · doi:10.1177/1744806920918692 · Cited by 25
Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
Medina, L. M., Abellán, A., Morales, L., Pross, A., Metwalli, A. H., González‐Alonso, A., Freixes, J., & Desfilis, E. (2022) · Brain Behavior and Evolution · doi:10.1159/000527512 · Cited by 26
“…BST (BSTM), forming together the medial extended amygdala (EAme) [Alheid et al., 1995; McDonald et al., 1999; Dong et al., 2001; Bienkowski et al., 2013], which plays a key role in social behavior and cognition [De Vries and Miller, 1998; Newman, 1999; Young and Wang, 2004; Choi et al., 2005].”
BackgroundHeteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes
Amato, S., Averna, M., Guidolin, D., Ceccoli, C., Gatta, E., Candiani, S., Pedrazzi, M., Capraro, M., Maura, G., Agnati, L. F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054677 · Cited by 24
“The OT-mediated social affiliative behaviors seem linked to regulation of the dopaminergic reward system [49,50].”
BackgroundMonogamy: dopamine ties the knot
Edwards, S., & Self, D. W. (2005) · Nature Neuroscience · doi:10.1038/nn0106-7 · Cited by 24
Social experience organizes parallel networks in sensory and limbic forebrain
Yang, E., & Wilczynski, W. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20347 · Cited by 24
“Dopamine release in NACC and POA is implicated in reinforcement of social behavior (Hull et al., 2002; Young and Wang, 2004), and it has been observed that dopaminergic activities in mesolimbic brain regions are downregulated with chronic stress (Lucas et al.”
BackgroundThe role of conditioning on heterosexual and homosexual partner preferences in rats
Coria‐Ávila, G. A. (2012) · Socioaffective Neuroscience & Psychology · doi:10.3402/snp.v2i0.17340 · Cited by 24
“Infusions of AVP antagonist into the ventral pallidum disrupts the development of pair bonds induced by sex (Young & Wang, 2004).”
BackgroundInfluential
Metadata
- Authors
- Young, L. J., & Wang, Z.
- Affiliations
- Emory University (US)
- Florida State University (US)
- Corresponding author
- Young, Larry J
- Venue
- Nature Neuroscience
- Published
- 2004-09-26
- Volume
- 7
- Issue
- 10
- Pages
- 1048-1054
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2055445652
- Cited by
- 1,523
- References
- 76
- Citations by year
- 2026: 42 · 2025: 63 · 2024: 54 · 2023: 64 · 2022: 62 · 2021: 65 · 2020: 73 · 2019: 60 · 2018: 83 · 2017: 85 · 2016: 99 · 2015: 96 · 2014: 86 · 2013: 106 · 2012: 85
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- pair bonding, monogamy, oxytocin, vasopressin, mesolimbic dopamine system, reward learning, social attachment, individual recognition, social behavior
- MeSH terms
- Animals, Brain, Dopamine, Humans, Neural Pathways, Neuropeptides, Pair Bond, Reward, Receptors, Neuropeptide, Models, Animal
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