The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
The neurobiology of pair bonding.
Abstract
A neurobiological model for pair-bond formation has emerged from studies in monogamous rodents. The neuropeptides oxytocin and vasopressin contribute to the processing of social cues necessary for individual recognition. Mesolimbic dopamine is involved in reinforcement and reward learning. Concurrent activation of neuropeptide and dopamine receptors in the reward centers of the brain during mating results in a conditioned partner preference, observed as a pair bond. Differential regulation of neuropeptide receptor expression may explain species differences in the ability to form pair bonds. These and other studies discussed here have intriguing implications for the neurobiology of social attachment in our own species.
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In the citing paper
“Meta-analyses and systematic reviews indicate that a range of common therapies can indeed be effective in relieving couple distress in many situations [26, 27].”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [26]
In the citing paper
“The hypothalamic peptide oxytocin (OXT) has been identified as a key modulator of pair-bonding in men, but its effects in women are still elusive.”
From Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face (2016) · cites this paper as Young and Wang, 2004
In the citing paper
“A study injecting 3H-leucine into the SON found multiple extrahypothalamic projections, including olfactory bulb, amygdala, cingulum, and locus coeruleus [140].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [140]
In the citing paper
“which suggests that species-specific differences in neural distributions of OXTR can reflect the social organisation of the species (20,21).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [20]
In the citing paper
“OXTR signaling in the NAcc is required for mating-induced partner preference formation, a laboratory proxy of pair bonding (6).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“In a socially monogamous rodent, the prairie vole (Microtus ochrogaster), OXTR is enriched in important MLR regions such as the nucleus accumbens (NAcc) and prefrontal cortex (PFC) that constitute part of a neural network for pair bonding (6, 8, 34).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“OXTR density is much higher in the NAcc of prairie voles than promiscuous vole species”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [6]
In the citing paper
“It is thought that the interface between oxytocin and the dopaminergic reward system may contribute to the success of mother-infant and pair-bonding processes [18,[75][76][77].”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [76]
In the citing paper
“Our first studies of the role of the AVPR1a gene in social cognition exemplified by a simple laboratory paradigm converges with a wide range of both animal and human experimentation showing that arginine vasopressin (AVP) and the closely related oxytocin (OT) are key neuropeptides that facilitate social communication, affiliative behaviors and social cognition across mammals [6], [7] .”
From The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task (2009) · cites this paper as [7]
In the citing paper
“By contrast, other related vole species such as the meadow vole (M. pennsylvanicus) and the montane vole (M. montanus) are relatively asocial and do not readily form social bonds, providing a useful point of comparison for identifying neurobiological and genetic systems leading to diversity in social behaviors [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“By contrast, other related vole species such as the meadow vole (M. pennsylvanicus) and the montane vole (M. montanus) are relatively asocial and do not readily form social bonds, providing a useful point of comparison for identifying neurobiological and genetic systems leading to diversity in social behaviors [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“For example, socially monogamous male prairie voles have high densities of AVPR1A binding in the ventral pallidum, a major output of the NAcc, while non-mongamous vole species do not [2].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [2]
In the citing paper
“One of these socially monogamous mammals that has provided remarkable insights into the neural and neurogenetic mechanisms of social attachments is the prairie vole (Microtus ochrogaster)”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Young and Wang 2004
In the citing paper
“V1aR signaling in the ventral pallidum and LS promote partner preferences (149), while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus (43,150).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [149]
In the citing paper
“Because animal research has documented that OT is primarily a social bonding hormone that activates socio-emotional neural pathways in the brain 22,23 , we would also expect the effect of OT in humans to be limited to social situations where initiating or establishing partnership is important to realize synergy.”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [23]
In the citing paper
“this finding fits with the crucial function of OT as a female hormone in labor, bonding and parenting both in human- [54], [4] and non-human mammals [55]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [55]
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“Central OT has been implicated in activation of social attachments, such as maternal behavior in rats and sheep (Pedersen, 1997; Kendrick, 2000) and pair-bonding in monogamous prairie voles (Insel et al 1997; Young and Wang, 2004).”
BackgroundVasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression
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“These rodents form monogamous social bonds between males and females, live in extended families, and engage in biparental and allo-parental care of offspring, similar to human social systems (Getz et al., 1981; Carter, 2001; Cushing et al., 2001; Young and Wang, 2004).”
A registered replication study on oxytocin and trust
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“Previous studies in female prairie voles have focused on the NAS as the striatal component of the pair bonding circuitry (Young and Wang, 2004).”
BackgroundSelf-citationDissecting the Role of Oxytocin in the Formation and Loss of Social Relationships
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“, the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus) (9,10).”
BackgroundA psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
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Hormonal correlates of human paternal interactions: A hospital-based investigation in urban Jamaica
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“parturition, and pair bonding [30] whereas the TRHR signaling Figure 2.”
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“Microtine rodents, or voles, are one such model that have been particularly useful in providing insight into the nature and diversity of social behavior (Carter, DeVries, & Getz, 1995; Young & Wang, 2004).”
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“Indeed , the prairie vole pair bond has emerged as a model for human love (Carter 1998; Young & Wang 2004).”
Sex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin
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“Oxytocin (OT) has diverse effects on social behaviors and behavioral responses to threat (1) by facilitating aspects of social bonding and cognition (2,3) and by exerting anxiolytic effects (4–9).”
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“The neuropeptide OT (see Glossary), an evolutionarily ancient and conserved hormone, has been implicated in important reproductive and adaptive functions in animal models [2–4], including sexual behavior [5], facilitation of birth [3,6], pair bonding [7], and maternal behavior [8,9].”
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“D2-oxytocinR Heteroreceptor Complexes In classical studies it was shown by Insel and Young (2001) and his group that striatal oxytocin receptors play a key role in inducing the pair bonding found in the monogamous prairie vole female and that the D2Rs play an important role in the social attachment process (Gingrich e…”
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Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior
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“…neuropeptide vasopressin contributes to the regulation of behaviors such as learning and memory, stress and anxiety, and social behaviors, through its action at the vasopressin 1a receptor (V1aR) (Bielsky et al. 2004; Egashira et al. 2004; Mishima et al. 2001; Wang et al. 1998; Young & Wang 2004).”
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“…behaviors throughout the vertebrate lineage (reviewed in Goodson and Bass, 2001; Goodson, 2005), work in rodents has highlighted the species- and often sex-specific roles of AVP and OT in coordinating sociosexual and parental behaviors (reviewed in Young and Wang, 2004; Donaldson and Young, 2008).”
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“Specifically, oxytocin and vasopressin “contribute to the processing of social cues necessary for individual recognition,” while dopamine plays a reinforcing role by signaling reward (Young and Wang 2004, 1048).”
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“…pleasant feelings (Rolls et al. 2008), pleasantness felt when eating chocolate (Small et al. 2001) and seeing the face of the person we love (Xu et al. 2011) or our own babies (Bartels and Zeki 2004), affiliative reward mechanisms (Young and Wang 2004), and charitable donations (Moll et al. 2006).”
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“This has been demonstrated in female prairie voles, where administration of an oxytocin receptor antagonist blocks partner preference induced by D2 activation, whereas blockade of D2 receptors in the nucleus accumbens prevents partner preference formation induced by oxytocin (Young and Wang, 2004; Liu and Wang, 2003).”
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“DA and social behaviors DA plays an important role in the modulation of social behavior, including display of social status (Miczek and Gold, 1983), defensive/submissive behavior (Puglisi-Allegra and Cabib, 1997), and mating behavior (Young and Wang, 2004).”
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Positive maternal mental health, parenting, and child development
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“Here, we describe how the use of one such model system, the socially monogamous prairie vole (Microtus ochrogaster), has signifi cantly advanced our understanding of the neural regulation of social choice behavior (Carter et al., 1995; Dewsbury, 1987; Getz and Carter, 1996; Young and Wang, 2004).”
BackgroundMethodInfluentialA relationship between oxytocin and anxiety of romantic attachment
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“Fax: reiburg.de (G. Domes). as pair bonding and parental care (e.g. Insel and Young, 2001; Young and Wang, 2004).”
BackgroundKisspeptin modulates sexual and emotional brain processing in humans
Comninos, A. N., Wall, M. B., Demetriou, L., Shah, A., Clarke, S. A., Narayanaswamy, S., Nesbitt, A., Izzi‐Engbeaya, C. N., Prague, J., Abbara, A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89519 · Cited by 123
“Likewise, the amygdala is implicated in bonding (18), and we observed that kisspeptin’s enhanced activation of the amygdala in response to bonding images related to improvements in positive mood (r = 0.”
Overview of human oxytocin research
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When Sex Primes Love: Subliminal Sexual Priming Motivates Relationship Goal Pursuit
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“Young and Wang (2004) suggested that specific aspects of human sexuality are “designed” to increase the release of oxytocin and opioids into the blood stream, causing partners to become more attached to each other.”
BackgroundInfluentialOxytocin and social functioning
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“, 2011) and non-human animals (Donaldson and Young, 2008), enabling pair bonding (Young and Wang, 2004) and maternal attachment (Insel and Young, 2001).”
BackgroundNeural mechanisms underlying the evolvability of behaviour
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Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
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“Multiple lines of evidence suggest that the hypothalamic peptide oxytocin (OXT) is a key factor modulating pair-bonding behaviors (Young and Wang, 2004; Hurlemann and Scheele, 2016).”
Backgroundκ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance
Resendez, S. L., Kuhnmuench, M., Krzywosinski, T., & Aragona, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5779-11.2012 · Cited by 110
“The socially monogamous prairie vole (Microtus ochrogaster) is an excellent model system to study the neurobiology of social attachment (Young and Wang, 2004; Young et al., 2005; Aragona and Wang, 2009).”
BackgroundDynamic corticostriatal activity biases social bonding in monogamous female prairie voles
Amadei, E. A., Johnson, Z. V., Jun Kwon, Y., Shpiner, A. C., Saravanan, V., Mays, W. D., Ryan, S. J., Walum, H., Rainnie, D. G., Young, L. J., et al. (2017) · Nature · doi:10.1038/nature22381 · Cited by 115
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Mogil, J. S., Sorge, R. E., LaCroix‐Fralish, M. L., Smith, S. B., Fortin, A., Sotocinal, S. G., Ritchie, J., Austin, J., Schorscher-Petcu, A., Melmed, K. R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2941 · Cited by 115
“, and its involvement in affiliation and social communication in microtine rodent”
Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis
Borland, J. M., Rilling, J. K., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0129-2 · Cited by 116
Ahern, T. H., Hammock, E. A. D., & Young, L. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20498 · Cited by 113
“…prairie vole pups are variably reared by large communal families, lone breeder-pairs, and single-mothers (SMs); there are also variations in the levels of maternal, paternal, and alloparental investment (Carter et al., 1995; Getz & Carter, 1996; Lonstein & De Vries, 2000; Young & Wang, 2004).”
BackgroundInfluentialOlfactory Conditioned Partner Preference in the Female Rat.
Coria‐Ávila, G. A., Ouimet, A. J., Pacheco, P., Manzo, J. G., & Pfaus, J. G. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.3.716 · Cited by 115
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113
Schorscher-Petcu, A., Dupré, A., & Tribollet, E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.016 · Cited by 111
Attachment between humans and dogs
Nagasawa, M., Mogi, K., & Kikusui, T. (2009) · Japanese Psychological Research · doi:10.1111/j.1468-5884.2009.00402.x · Cited by 112
Plasticity and constraints on social evolution in African mole-rats: ultimate and proximate factors
Faulkes, C. G., & Bennett, N. C. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0347 · Cited by 112
“Furthermore, there is a remarkable correspondence between the OXT receptor levels in some areas of the brain in the eusocial naked mole-rat and the monogamous and pair-bonding prairie vole at one end of the spectrum, and the asocial Cape mole-rat and the solitary, non-pair-bonding and promiscuous voles at the other [2…”
BackgroundInfluentialGoodson, J., Kabelik, D., Kelly, A. M., Rinaldi, J. M., & Klatt, J. D. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0811821106 · Cited by 115
“, mating system and sociality) and individual differences in affiliation (3, 4).”
BackgroundSteinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105
“Previous reviews highlighted the importance of OT–dopamine interactions within the PVN-NAc circuit in modulating pair bonding behavior in prairie voles (49,50).”
Neuroplasticity in the Mesolimbic System Induced by Natural Reward and Subsequent Reward Abstinence
Pitchers, K. K., Balfour, M. E., Lehman, M. N., Richtand, N. M., Yu, L., & Coolen, L. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.036 · Cited by 117
Oxytocin and Autism Spectrum Disorders
Yamasue, H., & Domes, G. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_24 · Cited by 109
Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial
Colloca, L., Pine, D. S., Ernst, M., Miller, F. G., & Grillon, C. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.019 · Cited by 110
Gervai, J., Novák, A., Lakatos, K., Tóth, I., Danis, I., Rónai, Z., Nemoda, Z., Sasvári‐Székely, M., Bureau, J.-F., Bronfman, E. T., et al. (2007) · Social Neuroscience · doi:10.1080/17470910701391893 · Cited by 113
“It has also been shown that administration of a D2 receptor antagonist in prairie voles blocks male female bonding by removing the hedonic value of stimuli associated with the sexual partner (Young & Wang, 2004), congruent with the hypothesis that dopamine plays a role in attachment processes.”
BackgroundJankowski, K. F., & Takahashi, H. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12182 · Cited by 115
Oxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies
A, T. R. D. J., Veening, J. G., Olivier, B., & Waldinger, M. D. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00394.x · Cited by 108
“Although highly speculative, the involvement of oxytocin in social behavior and pair bonding [ 157 ,158] might perhaps explain the remarkable clinical phenomenon that many men with complaints of lifelong premature ejaculation report rapid ejaculation only during intravaginal contact and less so during masturbation (un…”
BackgroundSpontaneous object recognition: a promising approach to the comparative study of memory
Blaser, R. E., & Heyser, C. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00183 · Cited by 104
“The study of hormones involved in pair-bonding and parenting in voles is one example of this approach applied successfully to neuroscience (e.g., Young and Wang, 2004).”
MethodNeurobiology of social attachments
Coria‐Ávila, G. A., Manzo, J., García, L. I., Carrillo, P., Miquel, M., & Pfaus, J. G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.004 · Cited by 108
“…that although DA is sufficient to induce attachments in voles, it should not be considered “the neurotransmitter” for attachments in other species (Insel, 2003; Young and Wang, 2004; Aragona et al., 2006), although rats indeed form strong partner preferences after a process of conditioning.”
Primate Ecology and Conservation
(2013) · doi:10.1093/acprof:oso/9780199659449.001.0001 · Cited by 107
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103
“The role of oxytocin (OT) in formation of pair bonds is well established in non-human mammalian species (Carter, 1998; Young and Wang, 2004).”
Distribution of oxytocin in the brain of a eusocial rodent
Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.039 · Cited by 102
“Some social behaviors exhibited by naked mole-rats are modulated by VP in other species, such as vocal communication, pair-bonding, parental behavior, dominance-subordinance, and social memory (reviewed in de Wied et al., 1993; Goodson and Bass, 2001; Young and Wang, 2004).”
An affective neuroscience model of boosting resilience in adults
Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 115
Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S. (2010) · Endocrinology · doi:10.1210/en.2010-0151 · Cited by 104
Liu, Y., Aragona, B. J., Young, K. A., Dietz, D. M., Kabbaj, M., Mazei-Robison, M., Nestler, E. J., & Wang, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911998107 · Cited by 101
Overview of cellular electrophysiological actions of vasopressin
Raggenbass, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.074 · Cited by 107
Barrett, C. E., Keebaugh, A. C., Ahern, T. H., Bass, C. E., Terwilliger, E. F., & Young, L. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.005 · Cited by 100
“…is believed to arise from neuropeptide-mediated coding of socially-relevant cues of a partner (e.g. olfactory signatures) converging with dopaminergic and opioid mediated reward and reinforcement pathways activated during mating or social interaction (Young and Wang, 2004; Burkett and Young, 2012).”
Self-citationCRF receptors in the nucleus accumbens modulate partner preference in prairie voles
Lim, M. M., Liu, Y., Ryabinin, A. E., Bai, Y., Wang, Z., & Young, L. J. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.01.006 · Cited by 99
“Microtine rodents exhibit diverse social organizations and thus offer an excellent comparative approach in the study of the neurobiology of social behavior (Young and Wang, 2004).”
BackgroundNephew, B. C., & Bridges, R. S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.013 · Cited by 101
“Oxytocin seems to be more important in the control of female partner preference, whereas AVP is the significant neuropeptide in males (Young and Wang, 2004).”
BackgroundPark, S. M. (2013) · State University of New York Press eBooks · doi:10.1353/book22396 · Cited by 102
Different Perspectives on the Sex-Attachment Link: Towards an Emotion-Motivational Account
Dewitte, M. D. (2011) · The Journal of Sex Research · doi:10.1080/00224499.2011.576351 · Cited by 122
“Fostering a conditioned link between sexual reward and a specific partner, oxytocin is, thus, clearly implicated in the formation of pair-bonds (eg, Young & Wang, 2004 ).”
BackgroundTodeschin, A. S., Duarte, E. C. W., Jacob, M., Aranda, B. C. C., Jacobs, S., Fernandes, M. D. C., Ribeiro, M. F. M., Sanvitto, G. L., & Lucion, A. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.006 · Cited by 103
Vrangalova, Z. (2014) · Archives of Sexual Behavior · doi:10.1007/s10508-013-0255-1 · Cited by 100
“…disproportionally more affected by negative reproductive outcomes (e.g., unwanted pregnancy) and may be more susceptible to forming attachment bonds following casual sex (de Graaf & Sandfort, 2004; Townsend & Wasserman, 2011), perhaps due to differential effects of oxytocin (Young & Wang, 2004).”
CD38 and its role in oxytocin secretion and social behavior
Higashida, H., Yokoyama, S., Kikuchi, M., & Munesue, T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.011 · Cited by 98
“In rodents, OXT is highly involved in social interactions, social recognition, pair-bonding, and maternal behavior (Winslow 5 and Insel, 2004; Insel and Fernald, 2004; Young and Wang, 2004; Young, 2007; Neumann, 2008; Donaldson and Young, 2008; Insel, 2010; Higashida et al., 2010).”
BackgroundHigashida, H., Lopatina, O., Yoshihara, T., Pichugina, Y. A., Soumarokov, A. A., Munesue, T., Minabe, Y., Kikuchi, M., Ono, Y., Korshunova, N., et al. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01976.x · Cited by 98
Baracz, S. J., Rourke, P. I., Pardey, M. C., Hunt, G. E., McGregor, I. S., & Cornish, J. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.038 · Cited by 100
Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand
Cox, B. M., Bentzley, B. S., Regen-Tuero, H. C., See, R. E., Reichel, C. M., & Aston‐Jones, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.011 · Cited by 98
“Introduction Oxytocin, an endogenous neuropeptide well known for its role in social behaviors and childbirth, is a potential pharmacotherapy for addiction (1-9).”
The Arts are More than Aesthetics: Neuroaesthetics as Narrow Aesthetics
Brown, S., & Dissanayake, E. (2018) · Routledge eBooks · doi:10.4324/9781315224091-4 · Cited by 100
“…contains a high concentration of receptors for vasopressin and oxytocin—both of which are implicated in the experience of affiliation in animals (Nelson & Panksepp, 1998; Young & Wang, 2004; see also papers in Pedersen, Caldwell, Jirikowski, & Insel, 1992)—and projects to the orbitofrontal cortex.”
BackgroundLim, M. M., Nair, H. P., & Young, L. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20532 · Cited by 95
Self-citationVolume transmission and its different forms in the central nervous system
Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Zhang, W., & Agnati, L. F. (2013) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-013-1455-1 · Cited by 103
Insular function in autism: Update and future directions in neuroimaging and interventions
Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 98
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95
Peptide therapeutics for CNS indications
McGonigle, P. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.10.014 · Cited by 95
The physiology of moral sentiments
Zak, P. J. (2010) · Journal of Economic Behavior & Organization · doi:10.1016/j.jebo.2009.11.009 · Cited by 97
“Behaviorally, AVP rises when offspring are born and is causally associated with mate- and nest-guarding (Young et al., 1999; Young and Wang, 2004; Bester-Meredith et al., 2005).”
Yokoi, S., Okuyama, T., Kamei, Y., Naruse, K., Taniguchi, Y., Ansai, S., Kinoshita, M., Young, L. J., Takemori, N., Kubo, T., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005009 · Cited by 95
“In mammalian species, the socially monogamous prairie vole (Microtus ochrogaster) has been used as a model organism for investigating the neurobiology of this type of complex social behavior, such as pair-bonding, which involves both intersexual and intrasexual interactions [56–58].”
BackgroundMethodSelf-citationBirnbaum, G. E., & Reis, H. T. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.02.005 · Cited by 109
Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder
Li, X., Zhang, K., He, X., Zhou, J., Jin, C., Shen, L., Gao, Y., Tian, M., & Zhang, H. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00673-0 · Cited by 94
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94
“Infusion of an OXT-A into the prefrontal cortex and nucleus accumbens, but only in females, decreased mating-induced partner preference [59].”
BackgroundKalamatianos, T., Faulkes, C. G., Oosthuizen, M. K., Poorun, R., Bennett, N. C., & Coen, C. W. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22302 · Cited by 92
“…studies indicate that telencephalic oxytocin receptors, particularly those in the nucleus accumbens, contribute not only to the formation and maintenance of monogamous attachments (Young and Wang, 2004) but also to the regulation of maternal and allomaternal behavior (Olazabal and Young, 2006a,b).”
BackgroundO’Connell, L. A., & Hofmann, H. A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22401 · Cited by 93
“The midbrain dopaminergic system consists of the ventral tegmental area, which projects to many forebrain nuclei in what has been described as the ‘‘reward’’ system and is important for reinforcing learned behavior (Young and Wang, 2004).”
Background
Metadata
- Authors
- Young, L. J., & Wang, Z.
- Affiliations
- Emory University (US)
- Florida State University (US)
- Corresponding author
- Young, Larry J
- Venue
- Nature Neuroscience
- Published
- 2004-09-26
- Volume
- 7
- Issue
- 10
- Pages
- 1048-1054
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2055445652
- Cited by
- 1,523
- References
- 76
- Citations by year
- 2026: 42 · 2025: 63 · 2024: 54 · 2023: 64 · 2022: 62 · 2021: 65 · 2020: 73 · 2019: 60 · 2018: 83 · 2017: 85 · 2016: 99 · 2015: 96 · 2014: 86 · 2013: 106 · 2012: 85
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- pair bonding, monogamy, oxytocin, vasopressin, mesolimbic dopamine system, reward learning, social attachment, individual recognition, social behavior
- MeSH terms
- Animals, Brain, Dopamine, Humans, Neural Pathways, Neuropeptides, Pair Bond, Reward, Receptors, Neuropeptide, Models, Animal
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