Fundamental contribution by the basolateral amygdala to different forms of decision making
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Impairments in decision making about risks and rewards have been observed in patients with amygdala damage. Similarly, lesions of the basolateral amygdala (BLA) in rodents disrupts cost/benefit decision making, reducing preference for larger rewards obtainable after a delay or considerable physical effort. We assessed the effects of inactivation of the BLA on risk- and effort-based decision making, using discounting tasks conducted in an operant chamber. Separate groups of rats were trained on either a risk- or effort-discounting task, consisting of four blocks of 10 free-choice trials. Selection of one lever always delivered a smaller reward (one or two pellets), whereas responding on the other delivered a larger, four pellet reward. For risk discounting, the probability of receiving the larger reward decreased across trial blocks (100-12.5%), whereas on the effort task, the larger reward was delivered after a ratio of presses that increased across blocks (2-20). Infusions of GABA agonists baclofen/muscimol into the BLA disrupted risk discounting, inducing a risk-averse pattern of choice, and increased response latencies and trial omissions, most prominently during trial blocks that provided the greatest uncertainty about the most beneficial course of action. Similar inactivations also increased effort discounting, reducing the preference for larger yet more costly rewards, even when the relative delays to reward delivery were equalized across response options. These findings point to a fundamental role for the BLA in different forms of cost/benefit decision making, facilitating an organism's ability to overcome a variety of costs (work, uncertainty, delays) to promote actions that may yield larger rewards.
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Amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task that were different from those in physical effort tasks.
“Specifically, amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task [27] that were different to those in physical effort tasks [2, 25, 26].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [26]
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- Authors
- Ghods-Sharifi, S., St. Onge, J. R., & Floresco, S. B.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Floresco, Stan B.
- ORCID
- Floresco, Stan B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-04-22
- Volume
- 29
- Issue
- 16
- Pages
- 5251-5259
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6665478
- OpenAlex
- W2037643842
- Cited by
- 257
- References
- 47
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 84 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 12 · 2018: 13 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 13 · 2013: 8 · 2012: 14
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Michael Smith Health Research BC
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- basolateral amygdala, decision-making, risk discounting, effort discounting, reward magnitude, baclofen, muscimol, risk aversion, response latency, delay discounting, rats
- MeSH terms
- Amygdala, Animals, Choice Behavior, Decision Making, Male, Psychomotor Performance, Random Allocation, Rats, Long-Evans, Rats
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