HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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Blinded by the Light: The Growing Complexity of p53

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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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Recent progress in the biology and physiology of sirtuins

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HIF-1: upstream and downstream of cancer metabolism

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Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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The impact of O2 availability on human cancer

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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

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Hypoxia requires Notch signaling to maintain the undifferentiated cell state

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Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

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Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

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The role of oxygen availability in embryonic development and stem cell function

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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

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Stabilization of wild-type p53 by hypoxia-inducible factor 1α

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The role of hypoxia-inducible factors in tumorigenesis

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p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

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HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

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Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

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The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

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Making a tumour's bed: glioblastoma stem cells and the vascular niche

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

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Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation

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Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway

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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

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HIF-1α induces cell cycle arrest by functionally counteracting Myc

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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasisPreprint

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SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

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The interplay between MYC and HIF in cancer

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Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

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Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

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Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

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Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia

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Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

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HIF-2α, but not HIF-1α, promotes iron absorption in mice

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

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HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

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Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

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Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1

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O2 regulates stem cells through Wnt/β-catenin signalling

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Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

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The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling

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Acute postnatal ablation of Hif-2 α results in anemia

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Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells

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Regulation of HIF-1α Stability through S-Nitrosylation

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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

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The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

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Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells

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Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

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Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

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Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus

Makino, Y., Kanopka, A., Wilson, W. J., Tanaka, H., & Poellinger, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200328200 · Cited by 376

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

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HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

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Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

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The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355

The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

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HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression

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Common corruption of the mTOR signaling network in human tumors

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Hypoxia-Inducible Factor-1α Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

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Direct Interactions between HIF-1α and Mdm2 Modulate p53 Function

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Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth

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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

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RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia

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Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

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Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1α

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Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

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Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

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Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency

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Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex

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cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix-Loop-Helix/PAS Factor (Arnt2) with Close Sequence Similarity to the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt)

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Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

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Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α

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mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

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Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis

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Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α

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The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

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Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Purdue, M. P., Johansson, M., Zélénika, D., Toro, J. R., Scélo, G., Moore, L. E., Prokhortchouk, E., Wu, X., Kiemeney, L. A. L. M., Gaborieau, V., et al. (2010) · Nature Genetics · doi:10.1038/ng.723 · Cited by 238

The SirT3 Divining Rod Points to Oxidative Stress

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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A., & Semenza, G. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068577 · Cited by 232

HLF/HIF‐2α is a key factor in retinopathy of prematurity in association with erythropoietin

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Sumoylation increases HIF-1α stability and its transcriptional activity

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Hypoxia-Inducible Factor 1? Expression Correlates with Angiogenesis and Unfavorable Prognosis in Bladder Cancer

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Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1α and HIF-2α Stabilization and Transactivation in a Graded Oxygen Environment

Bracken, C. P., Fedele, A. O., Linke, S., Balrak, W., Lisy, K., Whitelaw, M. L., & Peet, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600288200 · Cited by 222

SENP3 is responsible for HIF‐1 transactivation under mild oxidative stress via p300 de‐SUMOylation

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Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

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Metastasis‐associated protein 1 enhances stability of hypoxia‐inducible factor‐1α protein by recruiting histone deacetylase 1

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HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

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Hypoxia Inducible Factor Activates the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells

Gunaratnam, L., Morley, M., Franovic, A., de Paulsen, N., Mekhail, K., Parolin, D. A. E., Nakamura, E., Lorimer, I. A. J., & Lee, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305502200 · Cited by 195

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

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Hypoxia-Inducible Factor 1α in Clear Cell Renal Cell Carcinoma

Klatte, T., Seligson, D. B., Riggs, S. B., Leppert, J. T., Berkman, M. K., Kleid, M. D., Yu, H., Kabbinavar, F. F., Pantuck, A. J., & Belldegrun, A. S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0411 · Cited by 187

Genetic evidence for a tumor suppressor role of HIF-2α

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Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

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EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

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The HIF pathway and erythrocytosis

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ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus

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Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients

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Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 ( Arnt2 ) gene reveals partial redundancy with Arnt

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Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer

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Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α

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Hypoxia-inducible factors 1?? and 2?? are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

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Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner

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Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer

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The Expression of Hypoxia-Inducible Factor 1α Is a Favorable Independent Prognostic Factor in Renal Cell Carcinoma

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Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

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HIF2α cooperates with RAS to promote lung tumorigenesis in mice

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The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma.

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Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer.

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Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia

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Hypoxia-Inducible Factor-2α Correlates to Distant Recurrence and Poor Outcome in Invasive Breast Cancer

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HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

Pietras, A., Hansford, L. M., Johnsson, A. S., Bridges, E., Sjölund, J., Gisselsson, D., Rehn, M., Beckman, S., Noguera, R., Navarro, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904606106 · Cited by 135

HIF-2α deletion promotes Kras-driven lung tumor development

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The human HIF (hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

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Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis

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Mxi1 is induced by hypoxia in a HIF-1–dependent manner and protects cells from c-Myc-induced apoptosis

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SWI/SNF Regulates the Cellular Response to Hypoxia

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The phosphorylation status of PAS‐B distinguishes HIF‐1α from HIF‐2α in NBS1 repression

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Expression of hypoxia-inducible factor 1α, hypoxia-inducible factor 2α, and von Hippel–Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1α is an independent prognostic factor in ovarian carcinoma

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Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer

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Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas

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Binding of Natively Unfolded HIF-1α ODD Domain to p53

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Prognostic significance of HIF-2α/EPAS1 expression in hepatocellular carcinoma

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The role of HIF prolyl hydroxylases in tumour growth

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Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

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Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF

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p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment

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Hypoxia‐inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis

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The relation between hypoxia‐inducible factor (HIF)‐1α and HIF‐2α expression with anemia and outcome in surgically treated head and neck cancer

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