Cited by 456Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

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AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, Neil, Prentki, Marc·2004·Nature Reviews Drug Discovery

DOI 10.1038/nrd1344

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Kraegen, E. W. et al. Insulin resistance induced by glucose infusion is associated temporally with reduced muscle and liver AMPK activity. Diabetes 52, A330 (2003).
Ido, Y. et al. The AMP-kinase (AMPK) activator, AICAR, inhibits the increase in oxidative stress induced by hyperglycemia and palmitate. Diabetes 51, A396 (2002).
Ido, Y., Yagihashi, N., Cacicedo, J. M., Ruderman, N. B. AMP-kinase activation prevents TNF-α induced ICAM expression by inhibiting NF-κB transactivation but not by inhibiting their translocation or DNA-binding. Diabetes 51, A458 (2002).
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Authors: Ruderman, N., & Prentki, M.
Affiliations: Boston University (US)
Centre Hospitalier de l’Université de Montréal (CA)
ORCID: Ruderman, Neil
Prentki, Marc
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2004-04-01
Volume: 3
Issue: 4
Pages: 340-351
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1344
OpenAlex: W1983336199
Semantic Scholar: ff013aa7272ad9b1a90aa52d7a0383e343b6f8ec
Cited by: 451
References: 168
Citations by year: 2026: 4 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 23 · 2021: 17 · 2020: 19 · 2019: 21 · 2018: 13 · 2017: 22 · 2016: 19 · 2015: 14 · 2014: 27 · 2013: 22 · 2012: 21
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
www.springer.com/tdm (unspecified)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: AMPK, malonyl-CoA, metabolic syndrome, insulin resistance, obesity, fatty acid metabolism, ectopic fat deposition, AMPK activators, therapeutic target, type 2 diabetes, atherosclerosis
MeSH terms: Adenylate Kinase, Animals, Fatty Acids, Humans, Malonyl Coenzyme A, Signal Transduction, Metabolic Syndrome

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