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Emerging patterns of somatic mutations in cancer

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Watson, Ian R., Takahashi, Koichi, Futreal, P. Andrew, Chin, Lynda·2013·Nature Reviews Genetics
DOI 10.1038/nrg3539
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Abstract

Recent advances in technological tools for massively parallel, high-throughput sequencing of DNA have enabled the comprehensive characterization of somatic mutations in a large number of tumour samples. In this Review, we describe recent cancer genomic studies that have assembled emerging views of the landscapes of somatic mutations through deep-sequencing analyses of the coding exomes and whole genomes in various cancer types. We discuss the comparative genomics of different cancers, including mutation rates and spectra, as well as the roles of environmental insults that influence these processes. We highlight the developing statistical approaches that are used to identify significantly mutated genes, and discuss the emerging biological and clinical insights from such analyses, as well as the future challenges of translating these genomic data into clinical impacts.

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Metadata

Authors
Watson, I. R., Takahashi, K., Futreal, P. A., & Chin, L.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-09-11
Volume
14
Issue
10
Pages
703-718
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/nrg3539
OpenAlex
W2011941471
Cited by
491
References
49
FWCI
4.39
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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Watson, I. R., Takahashi, K., Futreal, P. A., & Chin, L. (2013). Emerging patterns of somatic mutations in cancer. Nature Reviews Genetics. https://doi.org/10.1038/nrg3539

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