Cited by 281interferon and immune responsesNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

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Illuminating viral infections in the nervous system

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McGavern, Dorian B., Kang, Silvia S.·2011·Nature Reviews Immunology

DOI 10.1038/nri2971PMC PMC5001841

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Abstract

Viral infections are a major cause of human disease. Although most viruses replicate in peripheral tissues, some have developed unique strategies to move into the nervous system, where they establish acute or persistent infections. Viral infections in the central nervous system (CNS) can alter homeostasis, induce neurological dysfunction and result in serious, potentially life-threatening inflammatory diseases. This Review focuses on the strategies used by neurotropic viruses to cross the barrier systems of the CNS and on how the immune system detects and responds to viral infections in the CNS. A special emphasis is placed on immune surveillance of persistent and latent viral infections and on recent insights gained from imaging both protective and pathogenic antiviral immune responses.

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Authors: McGavern, D. B., & Kang, S. S.
Affiliations: National Institutes of Health (US)
Corresponding author: McGavern, Dorian B.
ORCID: McGavern, Dorian B.
Kang, Silvia S.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-04-21
Volume: 11
Issue: 5
Pages: 318-329
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2971
PMC: PMC5001841
OpenAlex: W2059369279
Cited by: 281
References: 119
Citations by year: 2026: 11 · 2025: 11 · 2024: 16 · 2023: 22 · 2022: 27 · 2021: 27 · 2020: 28 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 12 · 2013: 24 · 2012: 17
FWCI: 1.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS 061447-01, F32NS061447, ZIANS003111)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: neurotropic viruses, viral persistence, viral latency, antiviral immunity, immune surveillance, neuroinflammation, viral neuroinfection
MeSH terms: Animals, Blood-Brain Barrier, Capillary Permeability, Central Nervous System, Endothelium, Vascular, Humans, Viruses, Virus Latency, Peripheral Nervous System, Central Nervous System Viral Diseases, Blood-Nerve Barrier, Virus Internalization

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