mTOR: from growth signal integration to cancer, diabetes and ageing

Cited by (147)

Items 101–147 of 147

1. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
   Hirota, Yasushi, Cha, Jeeyeon, Yoshie, Mikihiro, Daikoku, Takiko, Dey, Sudhansu K. · 2011 · Proceedings of the National Academy of Sciences
2. Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction
   Long, Yan, Tsai, Wen-Bin, Wangpaichitr, Medhi, Tsukamoto, Takashi, Savaraj, Niramol, Feun, Lynn G., Kuo, Macus Tien · 2013 · Molecular Cancer Therapeutics
3. Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes
   Yasuda, Mako, Tanaka, Yuki, Kume, Shinji, Morita, Yoshikata, Chin-Kanasaki, Masami, Araki, Hisazumi, Isshiki, Keiji, Araki, Shin-ichi, Koya, Daisuke, Haneda, Masakazu et al. · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
4. mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse
   Neasta, Jeremie, Barak, Segev, Hamida, Sami Ben, Ron, Dorit · 2014 · Journal of Neurochemistry
5. p53 induces transcriptional and translational programs to suppress cell proliferation and growth
   Loayza-Puch, Fabricio, Drost, Jarno, Rooijers, Koos, Lopes, Rui, Elkon, Ran, Agami, Reuven · 2013 · Genome Biology
6. Macropinocytosis, mTORC1 and cellular growth control
   Yoshida, Sei, Pacitto, Regina, Inoki, Ken, Swanson, Joel · 2018 · Cellular and Molecular Life Sciences
7. Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle
   Møller, Andreas Buch, Vendelbo, Mikkel Holm, Christensen, Britt, Clasen, Berthil Forrest, Bak, Ann Mosegaard, Jørgensen, Jens O. L., Møller, Niels, Jessen, Niels · 2015 · Journal of Applied Physiology
8. Regulation of TOR by small GTPases
   Durán, Raúl V, Hall, Michael N · 2012 · The EMBO Reports
9. Growth factor signaling to mTORC1 by amino acid–laden macropinosomes
   Yoshida, Sei, Pacitto, Regina, Yao, Yao, Inoki, Ken, Swanson, Joel A. · 2015 · Journal of Cell Biology
10. Cellular senescence and tumor promotion: Is aging the key?
    Loaiza, Natalia, Demaria, Marco · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
11. Rheb and Rags come together at the lysosome to activate mTORC1
    Groenewoud, Marlous J., Zwartkruis, Fried J.T. · 2013 · Biochemical Society Transactions
12. Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome-autophagosome fusion
    Mohan, Nitin, Sorokina, Elena M., Verdeny, Ione Vilanova, Alvarez, Angel Sandoval, Lakadamyali, Melike · 2019 · Journal of Cell Biology
13. Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy
    Farkas, Thomas, Daugaard, Mads, Jäättelä, Marja · 2011 · Journal of Biological Chemistry
14. Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi–lysosome contact site
    Hao, Feike, Kondo, Kazuhiko, Itoh, Takashi, Ikari, Sumiko, Nada, Shigeyuki, Okada, Masato, Noda, Takeshi · 2018 · Journal of Cell Science
15. TOR kinase complexes and cell migration
    Liu, Lunhua, Parent, Carole A. · 2011 · Journal of Cell Biology
16. mTOR-Dependent Cell Proliferation in the Brain
    Ryskalin, Larisa, Lazzeri, Gloria, Flaibani, Marina, Biagioni, Francesca, Gambardella, Stefano, Frati, Alessandro, Fornai, Francesco · 2017 · BioMed Research International
17. mTOR and neuronal cell cycle reentry: how impaired brain insulin signaling promotes Alzheimer's disease
    Norambuena, Andrés, Wallrabe, Horst, McMahon, Lloyd, Silva, Antonia, Swanson, Eric, Khan, Shahzad S., Baerthlein, Daniel, Kodis, Erin, Oddo, Salvatore, Mandell, James W. et al. · 2017 · Alzheimer's & Dementia
18. Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1
    Gaccioli, Francesca, White, Veronica, Capobianco, Evangelina, Powell, Theresa L., Jawerbaum, Alicia, Jansson, Thomas · 2013 · Biology of Reproduction
19. Fasting and rapamycin: diabetes versus benevolent glucose intolerance
    Blagosklonny, Mikhail V. · 2019 · Cell Death & Disease
20. Retinal ganglion cell dendrite pathology and synapse loss
    Agostinone, Jessica, Di Polo, Adriana · 2015 · Progress in Brain Research
21. Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle
    Ogasawara, Riki, Sato, Koji, Higashida, Kazuhiko, Nakazato, Koichi, Fujita, Satoshi · 2013 · American Journal of Physiology-Endocrinology and Metabolism
22. The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications
    Xu, Yichen, Ruggero, Davide · 2020 · Annual Review of Cancer Biology
23. Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
    Affourtit, Charles · 2016 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
24. MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
    Fawal, Mohamad-Ali, Brandt, Marta, Djouder, Nabil · 2015 · Developmental Cell
25. Community-wide genome sequencing reveals 30 years of Darwin’s finch evolution
    Enbody, Erik D., Sendell-Price, Ashley T., Sprehn, C. Grace, Rubin, Carl-Johan, Visscher, Peter M., Grant, B. Rosemary, Grant, Peter R., Andersson, Leif · 2023 · Science
26. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
    Zhang, Ya-Kun, Qu, Yuan-Yuan, Lin, Yan, Wu, Xiao-Hui, Chen, Hou-Zao, Wang, Xu, Zhou, Kai-Qiang, Wei, Yun, Guo, Fushen, Yao, Cui-Fang et al. · 2017 · Nature Communications
27. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress
    Chau, Gia Cac, Im, Dong Uk, Kang, Tong Mook, Bae, Jeong Mo, Kim, Won, Pyo, Suhkneung, Moon, Eun-Yi, Um, Sung Hee · 2017 · Journal of Cell Biology
28. Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis
    Johnson, Mark A., Vidoni, Sara, Durigon, Romina, Pearce, Sarah F., Rorbach, Joanna, He, Jiuya, Brea-Calvo, Gloria, Minczuk, Michal, Reyes, Aurelio, Holt, Ian J. et al. · 2014 · PLoS ONE
29. Autophagy Is Involved in the Reduction of Myelinating Schwann Cell Cytoplasm during Myelin Maturation of the Peripheral Nerve
    Jang, So Young, Shin, Yoon Kyung, Park, So Young, Park, Joo Youn, Rha, Seo-Hee, Kim, Jong Kuk, Lee, Hye Jeong, Park, Hwan Tae · 2015 · PLOS ONE
30. Mitochondrial stress-dependent regulation of cellular protein synthesis
    Topf, Ulrike, Uszczynska-Ratajczak, Barbara, Chacinska, Agnieszka · 2019 · Journal of Cell Science
31. Rapamycin-Induced Glucose Intolerance: Hunger or Starvation Diabetes
    Blagosklonny, Mikhail V · 2011 · Cell Cycle
32. Novel Insights into the Anti-Aging Role of Mitophagy
    2018 · International Review of Cell and Molecular Biology
33. CCCP induces autophagy in an AMPK-independent manner
    Kwon, Kyum-Yil, Viollet, Benoit, Yoo, Ook Joon · 2011 · Biochemical and Biophysical Research Communications
34. The mTOR pathway negatively controls ATM by up-regulating miRNAs
    Shen, Changxian, Houghton, Peter J. · 2013 · Proceedings of the National Academy of Sciences
35. Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges
    Viana, Sofia D., Reis, Flávio, Alves, Rui · 2018 · Oxidative Medicine and Cellular Longevity
36. Lost in translation: regulation of skeletal muscle protein synthesis
    Weigl, Lukas G · 2012 · Current Opinion in Pharmacology
37. Senescence regulation by mTOR
    Dulic, Vjekoslav · 2013 · Methods in Molecular Biology
38. TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae
    Alfatah, Mohammad, Wong, Jin Huei, Krishnan, Vidhya Gomathi, Lee, Yong Cheow, Sin, Quan Feng, Goh, Corinna Jie Hui, Kong, Kiat Whye, Lee, Wei Ting, Lewis, Jacqueline, Hoon, Shawn et al. · 2021 · BMC Biology
39. PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer
    Kari, Suresh, Vasko, Vasyl V., Priya, Shivam, Kirschner, Lawrence S. · 2019 · Frontiers in Endocrinology
40. MERTK interactions with SH2-domain proteins in the retinal pigment epithelium
    Shelby, Shameka J., Colwill, Karen, Dhe-Paganon, Sirano, Pawson, Tony, Thompson, Debra A. · 2013 · PLoS ONE
41. New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft‐versus‐host disease
    Lutz, Mathias, Mielke, Stephan · 2016 · British Journal of Clinical Pharmacology
42. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas
    Bi, Chengfeng, Zhang, Xuan, Lu, Ting, Zhang, Xiaoyan, Wang, Xianhuo, Meng, Bin, Zhang, Huilai, Wang, Ping, Vose, Julie M., Chan, Wing C. et al. · 2017 · Haematologica
43. Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis
    Zech, Reinhard, Kiontke, Stephan, Mueller, Uwe, Oeckinghaus, Andrea, Kümmel, Daniel · 2016 · Journal of Biological Chemistry
44. Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels
    Jang, Hyun-Jin, Yang, Kyeong Eun, Oh, Won Keun, Lee, Song-I, Hwang, In-Hu, Ban, Kyung-Tae, Yoo, Hwa-Seung, Choi, Jong-Soon, Yeo, Eui-Ju, Jang, Ik-Soon · 2019 · Aging
45. Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses
    Kroczynska, Barbara, Rafidi, Robert L., Majchrzak-Kita, Beata, Kosciuczuk, Ewa M., Blyth, Gavin T., Jemielity, Jacek, Warminska, Zofia, Saleiro, Diana, Mehrotra, Swarna, Arslan, Ahmet Dirim et al. · 2016 · Journal of Biological Chemistry
46. The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex
    Deng, Yilun, Qin, Yuejuan, Srikantan, Subramanya, Luo, Anqi, Cheng, Zi-Ming, Flores, Shahida K, Vogel, Kris S, Wang, Exing, Dahia, Patricia L M · 2018 · Human Molecular Genetics
47. NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors
    Sharma, Nutan, Singh, Lakhwinder, Sharma, Aditya, Kumar, Ajay, Mahajan, Dinesh · 2024 · Pharmacological Research