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Cited by 573

The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.

Open chromatin in pluripotency and reprogramming

Open access
Gaspar-Maia, Alexandre, Alajem, Adi, Meshorer, Eran, Ramalho-Santos, Miguel·2011·Nature Reviews Molecular Cell Biology

Abstract

Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.

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Crossref · 10.1038/nrm3036

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Metadata

Authors
Gaspar-Maia, A., Alajem, A., Meshorer, E., & Ramalho-Santos, M.
Venue
Nature Reviews Molecular Cell Biology
Published
2010-12-22
Volume
12
Issue
1
Pages
36-47
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2095491090
Cited by
573
References
142
FWCI
2.03
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.