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Open chromatin in pluripotency and reprogramming
Open accessAbstract
Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a particularly 'open' chromatin state contributes to maintenance of pluripotency. Two principles are emerging: specific factors maintain a globally open chromatin state that is accessible for transcriptional activation; and other chromatin regulators contribute locally to the silencing of lineage-specific genes until differentiation is triggered. These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer.
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,926
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Establishment in culture of pluripotential cells from mouse embryos
Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,607
Martin, G. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7634 · Cited by 5,746
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,824
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
Ben-Porath, I., Thomson, M. W., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,523
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,514
Chen, X., Xu, H., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.043 · Cited by 2,501
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Reprogramming of human somatic cells to pluripotency with defined factors
Park, I.-H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., & Daley, G. Q. (2008) · Nature · doi:10.1038/nature06534 · Cited by 2,436
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,380
The Biology of Chromatin Remodeling Complexes
Clapier, C. R., & Cairns, B. R. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062706.153223 · Cited by 2,380
Epigenetic memory in induced pluripotent stem cells
Kim, K., Doi, A., Wen, B., Ng, K., Zhao, R., Cahan, P., Kim, J., Aryee, M. J., Ji, H., Ehrlich, L. I. R., et al. (2010) · Nature · doi:10.1038/nature09342 · Cited by 2,313
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R. M., Chevalier, B., Johnstone, S. E., Cole, M. F., Isono, K.-I., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,268
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., & Melton, D. A. (2008) · Nature Biotechnology · doi:10.1038/nbt1418 · Cited by 1,606
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
Ooi, S. K. T., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument-Bromage, H., Tempst, P., Lin, S.-P., Allis, C. D., et al. (2007) · Nature · doi:10.1038/nature05987 · Cited by 1,567
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
Bradley, A., Evans, M., Kaufman, M. H., & Robertson, E. (1984) · Nature · doi:10.1038/309255a0 · Cited by 1,525
Dissecting direct reprogramming through integrative genomic analysis
Mikkelsen, T. S., Hanna, J., Zhang, X., Ku, M., Wernig, M., Schorderet, P., Bernstein, B. E., Jaenisch, R., Lander, E. S., & Meissner, A. (2008) · Nature · doi:10.1038/nature07056 · Cited by 1,480
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,427
Chromatin signatures of pluripotent cell lines
Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H. F., John, R. M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1403 · Cited by 1,353
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., & Melton, D. A. (2008) · Nature Biotechnology · doi:10.1038/nbt.1502 · Cited by 1,341
Tagami, H., Ray-Gallet, D., Almouzni, G., & Nakatani, Y. (2004) · Cell · doi:10.1016/s0092-8674(03)01064-x · Cited by 1,295
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Goldberg, A. D., Banaszynski, L. A., Noh, K.-M., Lewis, P. W., Elsaesser, S. J., Stadler, S., Dewell, S., Law, M., Guo, X., Li, X., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.003 · Cited by 1,280
Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
Matsui, Y., Zsebo, K., & Hogan, B. L. M. (1992) · Cell · doi:10.1016/0092-8674(92)90317-6 · Cited by 1,214
Polo, J. M., Liu, S., Figueroa, M. E., Kulalert, W., Eminli, S., Tan, K. Y., Apostolou, E., Stadtfeld, M., Li, Y., Shioda, T., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1667 · Cited by 1,198
Epigenetic stem cell signature in cancer
Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143
Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130
FUNDAMENTALS OF PLANARIAN REGENERATION
Reddien, P. W., & Alvarado, A. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.095114 · Cited by 1,101
Generation of human induced pluripotent stem cells from dermal fibroblasts
Lowry, W. E., Richter, L., Yachechko, R., Pyle, A. D., Tchieu, J., Sridharan, R., Clark, A. T., & Plath, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711983105 · Cited by 1,041
Chin, M. H., Mason, M. J., Xie, W., Volinia, S., Singer, M., Peterson, C., Ambartsumyan, G., Aimiuwu, O., Richter, L., Zhang, J., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.06.008 · Cited by 1,035
Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E., Yellajoshula, D., George, E., Scambler, P. J., Brown, D. T., & Misteli, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.10.017 · Cited by 1,008
Self-citationSystematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells
Filion, G. J., van Bemmel, J. G., Braunschweig, U., Talhout, W., Kind, J., Ward, L. D., Brugman, W., de Castro, I. J., Kerkhoven, R. M., Bussemaker, H. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.009 · Cited by 964
Direct cell reprogramming is a stochastic process amenable to acceleration
Hanna, J., Saha, K., Pando, B., van Zon, J., Lengner, C. J., Creyghton, M. P., van Oudenaarden, A., & Jaenisch, R. (2009) · Nature · doi:10.1038/nature08592 · Cited by 938
Long-term proliferation of mouse primordial germ cells in culture
Resnick, J. L., Bixler, L. S., Cheng, L., & Donovan, P. J. (1992) · Nature · doi:10.1038/359550a0 · Cited by 871
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
Lee, G., Papapetrou, E. P., Kim, H., Chambers, S. M., Tomishima, M. J., Fasano, C. A., Ganat, Y. M., Menon, J., Shimizu, F., Viale, A., et al. (2009) · Nature · doi:10.1038/nature08320 · Cited by 867
A Brg1 Null Mutation in the Mouse Reveals Functional Differences among Mammalian SWI/SNF Complexes
Bultman, S., Gebuhr, T., Yee, D., La Mantia, C., Nicholson, J., Gilliam, A., Randazzo, F., Metzger, D., Chambon, P., Crabtree, G., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00127-1 · Cited by 823
Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells
Brambrink, T., Foreman, R., Welstead, G. G., Lengner, C. J., Wernig, M., Suh, H., & Jaenisch, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.004 · Cited by 821
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
Hawkins, R. D., Hon, G. C., Lee, L. K., Ngo, Q., Lister, R., Pelizzola, M., Edsall, L. E., Kuan, S., Luu, Y., Klugman, S., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.018 · Cited by 806
Nuclear reprogramming to a pluripotent state by three approaches
Yamanaka, S., & Blau, H. M. (2010) · Nature · doi:10.1038/nature09229 · Cited by 776
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells
Meissner, A., Wernig, M., & Jaenisch, R. (2007) · Nature Biotechnology · doi:10.1038/nbt1335 · Cited by 763
Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.009 · Cited by 720
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
Montgomery, R. L., Davis, C. A., Potthoff, M. J., Haberland, M., Fielitz, J., Qi, X., Hill, J. A., Richardson, J. A., & Olson, E. N. (2007) · Genes & Development · doi:10.1101/gad.1563807 · Cited by 712
Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells
Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711
Gli and hedgehog in cancer: tumours, embryos and stem cells
Ruiz i Altaba, A., Sánchez, P., & Dahmane, N. (2002) · Nature Reviews Cancer · doi:10.1038/nrc796 · Cited by 708
Global Transcription in Pluripotent Embryonic Stem Cells
Efroni, S., Duttagupta, R., Cheng, J., Dehghani, H., Hoeppner, D. J., Dash, C., Bazett-Jones, D. P., Le Grice, S., McKay, R. D. G., Buetow, K. H., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.021 · Cited by 698
Self-citationPatient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
Carvajal-Vergara, X., Sevilla, A., D’Souza, S. L., Ang, Y.-S., Schaniel, C., Lee, D.-F., Yang, L., Kaplan, A. D., Adler, E. D., Rozov, R., et al. (2010) · Nature · doi:10.1038/nature09005 · Cited by 690
Chromatin in pluripotent embryonic stem cells and differentiation
Meshorer, E., & Misteli, T. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1938 · Cited by 689
Self-citationA Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
Shi, Y., Tae Do, J., Desponts, C., Hahm, H. S., Schöler, H. R., & Ding, S. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.011 · Cited by 671
Kim, J., Woo, A. J., Chu, J., Snow, J. W., Fujiwara, Y., Kim, C. G., Cantor, A. B., & Orkin, S. H. (2010) · Cell · doi:10.1016/j.cell.2010.09.010 · Cited by 669
Zellsubstanz, Kern und Zelltheilung /
Flemming, W. (1882) · F.C.W. Vogel eBooks · doi:10.5962/bhl.title.168645 · Cited by 654
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., & Bergman, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1353 · Cited by 651
Role of the Murine Reprogramming Factors in the Induction of Pluripotency
Sridharan, R., Tchieu, J., Mason, M. J., Yachechko, R., Kuoy, E., Horvath, S., Zhou, Q., & Plath, K. (2009) · Cell · doi:10.1016/j.cell.2009.01.001 · Cited by 643
CHD7 cooperates with PBAF to control multipotent neural crest formation
Bajpai, R., Chen, D. A., Rada-Iglesias, A., Zhang, J., Xiong, Y., Helms, J., Chang, C.-P., Zhao, Y., Swigut, T., & Wysocka, J. (2010) · Nature · doi:10.1038/nature08733 · Cited by 616
Wen, B., Wu, H., Shinkai, Y., Irizarry, R. A., & Feinberg, A. P. (2009) · Nature Genetics · doi:10.1038/ng.297 · Cited by 614
The origin of the cancer stem cell: current controversies and new insights
Bjerkvig, R., Tysnes, B. B., Aboody, K. S., Najbauer, J., & Terzis, A. J. A. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1740 · Cited by 595
Kishigami, S., Mizutani, E., Ohta, H., Hikichi, T., Thuan, N. V., Wakayama, S., Bui, H.-T., & Wakayama, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.164 · Cited by 582
Sims, R. J., Millhouse, S., Chen, C.-F., Lewis, B. A., Erdjument-Bromage, H., Tempst, P., Manley, J. L., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.010 · Cited by 581
Ho, L., Ronan, J. L., Wu, J., Staahl, B. T., Chen, L., Kuo, A., Lessard, J., Nesvizhskii, A. I., Ranish, J., & Crabtree, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812889106 · Cited by 566
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Pasini, D., Cloos, P. A. C., Walfridsson, J., Olsson, L., Bukowski, J.-P., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J., & Helin, K. (2010) · Nature · doi:10.1038/nature08788 · Cited by 561
Nishioka, K., Chuikov, S., Sarma, K., Erdjument-Bromage, H., Allis, C. D., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.967202 · Cited by 557
Peng, J. C., Valouev, A., Swigut, T., Zhang, J., Zhao, Y., Sidow, A., & Wysocka, J. (2009) · Cell · doi:10.1016/j.cell.2009.12.002 · Cited by 530
Histone H3.3 is enriched in covalent modifications associated with active chromatin
McKittrick, E., Gafken, P. R., Ahmad, K., & Henikoff, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308092100 · Cited by 520
Genome-scale profiling of histone H3.3 replacement patterns
Mito, Y., Henikoff, J. G., & Henikoff, S. (2005) · Nature Genetics · doi:10.1038/ng1637 · Cited by 509
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Gaspar-Maia, A., Alajem, A., Polesso, F., Sridharan, R., Mason, M. J., Heidersbach, A., Ramalho-Santos, J., McManus, M. T., Plath, K., Meshorer, E., et al. (2009) · Nature · doi:10.1038/nature08212 · Cited by 509
Self-citationJarid2 and PRC2, partners in regulating gene expression
Li, G., Margueron, R., Ku, M., Chambon, P., Bernstein, B. E., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1886410 · Cited by 498
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
Trivedi, C. M., Luo, Y., Yin, Z., Zhang, M., Zhu, W., Wang, T., Floss, T., Goettlicher, M., Noppinger, P. R., Wurst, W., et al. (2007) · Nature Medicine · doi:10.1038/nm1552 · Cited by 468
Kimura, A., Umehara, T., & Horikoshi, M. (2002) · Nature Genetics · doi:10.1038/ng993 · Cited by 466
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
Epsztejn-Litman, S., Feldman, N., Abu-Remaileh, M., Shufaro, Y., Gerson, A., Ueda, J., Deplus, R., Fuks, F., Shinkai, Y., Cedar, H., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1476 · Cited by 456
The logic of chromatin architecture and remodelling at promoters
Cairns, B. R. (2009) · Nature · doi:10.1038/nature08450 · Cited by 452
Fouse, S. D., Shen, Y., Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., Jaenisch, R., & Fan, G. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.011 · Cited by 452
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
Loh, Y.-H., Zhang, W., Chen, X., George, J., & Ng, H.-H. (2007) · Genes & Development · doi:10.1101/gad.1588207 · Cited by 443
Fazzio, T. G., Huff, J. T., & Panning, B. (2008) · Cell · doi:10.1016/j.cell.2008.05.031 · Cited by 442
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
Wernig, M., Lengner, C. J., Hanna, J., Lodato, M. A., Steine, E., Foreman, R., Staerk, J., Markoulaki, S., & Jaenisch, R. (2008) · Nature Biotechnology · doi:10.1038/nbt1483 · Cited by 441
Kashyap, V., Rezende, N. C., Scotland, K. B., Shaffer, S. M., Persson, J. L., Gudas, L. J., & Mongan, N. P. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0113 · Cited by 436
Ho, L., Jothi, R., Ronan, J. L., Cui, K., Zhao, K., & Crabtree, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812888106 · Cited by 426
Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
Shen, X., Kim, W., Fujiwara, Y., Simon, M. D., Liu, Y., Mysliwiec, M. R., Yuan, G.-C., Lee, Y., & Orkin, S. H. (2009) · Cell · doi:10.1016/j.cell.2009.12.003 · Cited by 424
Sims, R. J., Chen, C.-F., Santos-Rosa, H., Kouzarides, T., Patel, S. S., & Reinberg, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500395200 · Cited by 422
Klochendler‐Yeivin, A., Fiette, L., Barra, J., Muchardt, C., Babinet, C., & Yaniv, M. (2000) · EMBO reports · doi:10.1093/embo-reports/kvd129 · Cited by 406
Myc influences global chromatin structure
Knoepfler, P. S., Zhang, X., Cheng, P. F., Gafken, P. R., McMahon, S. B., & Eisenman, R. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601152 · Cited by 383
Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Singhal, N., Graumann, J., Wu, G., Araúzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., & Schöler, H. R. (2010) · Cell · doi:10.1016/j.cell.2010.04.037 · Cited by 378
Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers
de la Serna, I. L., Ohkawa, Y., & Imbalzano, A. N. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1882 · Cited by 376
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
Kaji, K., Caballero, I. M., MacLeod, R., Nichols, J., Wilson, V. A., & Hendrich, B. (2006) · Nature Cell Biology · doi:10.1038/ncb1372 · Cited by 375
Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency
Chamberlain, S. J., Yee, D., & Magnuson, T. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0102 · Cited by 340
Gao, X., Tate, P., Hu, P., Tjian, R., Skarnes, W. C., & Wang, Z. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801802105 · Cited by 336
Hake, S. B., Garcia, B. A., Duncan, E. M., Kauer, M., Dellaire, G., Shabanowitz, J., Bazett-Jones, D. P., Allis, C. D., & Hunt, D. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509266200 · Cited by 333
Ng, R. K., & Gurdon, J. B. (2008) · Nature Cell Biology · doi:10.1038/ncb1674 · Cited by 329
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation
Dovey, O. M., Foster, C. T., & Cowley, S. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000478107 · Cited by 298
Global Chromatin Architecture Reflects Pluripotency and Lineage Commitment in the Early Mouse Embryo
Ahmed, K., Dehghani, H., Rugg-Gunn, P., Fussner, E., Rossant, J., & Bazett-Jones, D. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010531 · Cited by 264
Induction of Pluripotency in Adult Unipotent Germline Stem Cells
Ko, K., Tapia, N., Wu, G., Kim, J. B., Bravo, M. J. A., Sasse, P., Glaser, T., Ruau, D., Han, D. W., Greber, B., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.025 · Cited by 262
Zegerman, P., Canas, B., Pappin, D., & Kouzarides, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200045200 · Cited by 247
CHD1 Motor Protein Is Required for Deposition of Histone Variant H3.3 into Chromatin in Vivo
Konev, A. Y., Tribus, M., Park, S. Y., Podhraski, V., Lim, C. Y., Emelyanov, A. V., Vershilova, E., Pirrotta, V., Kadonaga, J. T., Lusser, A., et al. (2007) · Science · doi:10.1126/science.1145339 · Cited by 246
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns
Schnetz, M. P., Bartels, C. F., Shastri, K., Balasubramanian, D., Zentner, G. E., Balaji, R., Zhang, X., Song, L., Wang, Z., LaFramboise, T., et al. (2009) · Genome Research · doi:10.1101/gr.086983.108 · Cited by 245
Molecular control of pluripotency
Boyer, L. A., Mathur, D., & Jaenisch, R. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.009 · Cited by 244
Kidder, B. L., Palmer, S., & Knott, J. G. (2009) · Stem Cells · doi:10.1634/stemcells.2008-0710 · Cited by 242
Kaeser, M. D., Aslanian, A., Dong, M.-Q., Yates, J. R., & Emerson, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806061200 · Cited by 236
Walther Flemming: pioneer of mitosis research
Paweletz, N. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048077 · Cited by 209
PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping
Tiwari, V. K., McGarvey, K. M., Licchesi, J. D. F., Ohm, J. E., Herman, J. G., Schübeler, D., & Baylin, S. B. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060306 · Cited by 207
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
Nishiyama, M., Oshikawa, K., Tsukada, Y.-I., Nakagawa, T., Iemura, S.-I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I., & Nakayama, K. I. (2009) · Nature Cell Biology · doi:10.1038/ncb1831 · Cited by 202
Kim, J. K., Huh, S.-O., Choi, H., Lee, K.-S., Shin, D., Lee, C., Nam, J.-S., Kim, H., Chung, H., Lee, H. W., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7787-7795.2001 · Cited by 197
Chromatin Regulatory Mechanisms in Pluripotency
Lessard, J. A., & Crabtree, G. R. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-051809-102012 · Cited by 181
Hurd, E. A., Capers, P. L., Blauwkamp, M. N., Adams, M. E., Raphael, Y., Poucher, H. K., & Martin, D. M. (2007) · Mammalian Genome · doi:10.1007/s00335-006-0107-6 · Cited by 169
Yan, Z., Wang, Z., Sharova, L., Sharov, A. A., Ling, C., Piao, Y., Aiba, K., Matoba, R., Wang, W., & Ko, M. S. H. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0846 · Cited by 168
Molecular Analyses of Human Induced Pluripotent Stem Cells and Embryonic Stem Cells
Chin, M. H., Pellegrini, M., Plath, K., & Lowry, W. E. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.019 · Cited by 160
Schaniel, C., Ang, Y.-S., Ratnakumar, K., Cormier, C., James, T., Bernstein, E., Lemischka, I. R., & Paddison, P. J. (2009) · Stem Cells · doi:10.1002/stem.223 · Cited by 156
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Landry, J. W., Sharov, A. A., Piao, Y., Sharova, L. V., Xiao, H., Southon, E. A., Matta, J. L., Tessarollo, L., Zhang, Y. E., Ko, M. S. H., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000241 · Cited by 154
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression
Herceg, Z., Hulla, W., Gell, D. A., Cuenin, C., LLeonart, M. E., Jackson, S. P., & Wang, Z. (2001) · Nature Genetics · doi:10.1038/ng725 · Cited by 148
Cotterman, R. F., Jin, V. X., Krig, S. R., Lemen, J. M., Wey, A., Farnham, P., & Knoepfler, P. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1961 · Cited by 138
Chromatin plasticity and genome organization in pluripotent embryonic stem cells
Mattout, A., & Meshorer, E. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.02.001 · Cited by 134
Self-citationReduced Body Size and Decreased Intestinal Tumor Rates in HDAC2-Mutant Mice
Zimmermann, S., Kiefer, F., Prudenziati, M., Spiller, C., Hansen, J., Floß, T., Wurst, W., Minucci, S., & Göttlicher, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0312 · Cited by 132
Linking Heterochromatin Protein 1 (HP1) to cancer progression
Dialynas, G. K., Vitalini, M. W., & Wallrath, L. L. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.09.007 · Cited by 131
Venkatasubrahmanyam, S., Hwang, W. W., Meneghini, M. D., Tong, A. H. Y., & Madhani, H. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700914104 · Cited by 131
Functional Differentiation of SWI/SNF Remodelers in Transcription and Cell Cycle Control
Moshkin, Y. M., Mohrmann, L., van IJcken, W. F. J., & Verrijzer, C. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01257-06 · Cited by 131
Kirschmann, D. A., Lininger, R. A., Gardner, L. M., Seftor, E. A., Odero, V. A., Ainsztein, A. M., Earnshaw, W. C., Wallrath, L. L., & Hendrix, M. J. C. (2000) · PubMed · Cited by 124
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
Knoepfler, P. S. (2008) · Cell stem cell · doi:10.1016/j.stem.2007.12.004 · Cited by 122
Homozygous disruption of the tip60 gene causes early embryonic lethality
Hu, Y., Fisher, J. B., Koprowski, S. L., McAllister, D. M., Kim, M., & Lough, J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22110 · Cited by 121
Szutorisz, H., Georgiou, A., Tora, L., & Dillon, N. (2006) · Cell · doi:10.1016/j.cell.2006.10.045 · Cited by 119
Bhattacharya, D., Talwar, S., Mazumder, A., & Shivashankar, G. V. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.075 · Cited by 115
Frye, M., Fisher, A. G., & Watt, F. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000763 · Cited by 103
Mutation of the SNF2 family member Chd2 affects mouse development and survival
Marfella, C. G. A., Ohkawa, Y., Coles, A. H., Garlick, D. S., Jones, S. N., & Imbalzano, A. N. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20718 · Cited by 102
Shawlot, W., Deng, J. M., Fohn, L. E., & Behringer, R. R. (1998) · Transgenic Research · doi:10.1023/a:1008816308171 · Cited by 98
Azuara, V., Brown, K. E., Williams, R. R. E., Webb, N., Dillon, N., Festenstein, R., Buckle, V. J., Merkenschlager, M., & Fisher, A. G. (2003) · Nature Cell Biology · doi:10.1038/ncb1006 · Cited by 95
Genome‐wide reduction in H3K9 acetylation during human embryonic stem cell differentiation
Krejčí, J., Uhlířová, R., Galiová, G., Kozubek, S., Šmigová, J., & Bártová, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21714 · Cited by 77
MRG15 Regulates Embryonic Development and Cell Proliferation
Tominaga, K., Kirtane, B. M., Jackson, J. G., Ikeno, Y., Ikeda, T., Hawks, C. L., Smith, J. R., Matzuk, M. M., & Pereira‐Smith, O. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.2924-2937.2005 · Cited by 76
Common Themes of Dedifferentiation in Somatic Cell Reprogramming and CancerPreprint
Daley, G. Q. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.041 · Cited by 68
Fazzio, T. G., & Panning, B. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200908026 · Cited by 67
Park, S., Park, S. H., Kook, M., Kim, E., Park, S., & Lim, J. H. (2004) · Ultrastructural Pathology · doi:10.1080/01913120490515595 · Cited by 64
The establishment of gene silencing at single-cell resolution
Nishimura, E. O., Dudoit, S., & Rine, J. (2009) · Nature Genetics · doi:10.1038/ng.402 · Cited by 62
The emergence of definitive hematopoietic stem cells in the mammal
Dzierzak, E. A. (2005) · Current Opinion in Hematology · doi:10.1097/01.moh.0000160736.44726.0e · Cited by 59
Komashko, V., Acevedo, L. G., Squazzo, S. L., Iyengar, S., Rabinovich, A., O’Geen, H., Green, R., & Farnham, P. (2008) · Genome Research · doi:10.1101/gr.074609.107 · Cited by 56
Zhu, D., Fang, J., Li, Y., & Zhang, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007684 · Cited by 53
Recipient cell nuclear factors are required for reprogramming by nuclear transfer
Egli, D. M., & Eggan, K. C. (2010) · Development · doi:10.1242/dev.046151 · Cited by 41
Mutants in the Mouse NuRD/Mi2 Component P66α Are Embryonic Lethal
Marino, S., & Nusse, R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000519 · Cited by 28
iPS Cells: Insights into Basic Biology
Ramalho‐Santos, M. (2009) · Cell · doi:10.1016/j.cell.2009.08.012 · Cited by 21
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Metadata
- Authors
- Gaspar-Maia, A., Alajem, A., Meshorer, E., & Ramalho-Santos, M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-12-22
- Volume
- 12
- Issue
- 1
- Pages
- 36-47
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2095491090
- Cited by
- 573
- References
- 142
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- green
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.