Ciliogenesis: building the cell's antenna

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,617

Hedgehog signalling in the mouse requires intraflagellar transport proteins

Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425

Intraflagellar transport

Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423

A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis

Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384

The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

Singla, V., & Reiter, J. F. (2006) · Science · doi:10.1126/science.1124534 · Cited by 1,189

Chlamydomonas IFT 88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg 737, Are Required for Assembly of Cilia and Flagella

Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147

Proteomic analysis of a eukaryotic cilium

Pazour, G. J., Agrin, N., Leszyk, J., & Witman, G. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504008 · Cited by 1,025

A motility in the eukaryotic flagellum unrelated to flagellar beating.

Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007

Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons

Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898

HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890

The Molecular Architecture of Axonemes Revealed by Cryoelectron Tomography

Nicastro, D., Schwartz, C., Pierson, J., Gaudette, R., Porter, M. E., & McIntosh, J. R. (2006) · Science · doi:10.1126/science.1128618 · Cited by 879

Reconstructions of centriole formation and ciliogenesis in mammalian lungs

Sorokin, S. P. (1968) · Journal of Cell Science · doi:10.1242/jcs.3.2.207 · Cited by 824

Cilia and Hedgehog responsiveness in the mouse

Huangfu, D., & Anderson, K. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505328102 · Cited by 820

CENTRIOLES AND THE FORMATION OF RUDIMENTARY CILIA BY FIBROBLASTS AND SMOOTH MUSCLE CELLS

Sorokin, S. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.15.2.363 · Cited by 732

The Primary Cilium as a Complex Signaling Center

Berbari, N. F., O'Connor, A. K., Haycraft, C. J., & Yoder, B. K. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.025 · Cited by 621

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

Jin, H., White, S. R., Shida, T., Schulz, S., Aguiar, M., Gygi, S. P., Bazan, J. F., & Nachury, M. V. (2010) · Cell · doi:10.1016/j.cell.2010.05.015 · Cited by 605

The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.

Kozminski, K. G., Beech, P. L., & Rosenbaum, J. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1517 · Cited by 586

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney

Sun, Z., Amsterdam, A., Pazour, G. J., Cole, D. G., Miller, M. S., & Hopkins, N. (2004) · Development · doi:10.1242/dev.01240 · Cited by 528

Chapter Two Intraflagellar Transport (IFT)

Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

Hu, Q., Milenkovic, L., Jin, H., Scott, M. P., Nachury, M. V., Spiliotis, E. T., & Nelson, W. J. (2010) · Science · doi:10.1126/science.1191054 · Cited by 512

Decoding Cilia Function

Avidor-Reiss, T., Maer, A. M., Koundakjian, E., Polyanovsky, A., Keil, T., Subramaniam, S., & Zuker, C. S. (2004) · Cell · doi:10.1016/s0092-8674(04)00412-x · Cited by 505

The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly

Follit, J. A., Tuft, R. A., Fogarty, K. E., & Pazour, G. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0133 · Cited by 498

Foxj1 transcription factors are master regulators of the motile ciliogenic program

Yu, X., Ng, C. P., Habacher, H., & Roy, S. (2008) · Nature Genetics · doi:10.1038/ng.263 · Cited by 495

Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

Berbari, N. F., Lewis, J. S., Bishop, G. A., Askwith, C. C., & Mykytyn, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711027105 · Cited by 474

The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly

Pazour, G. J., Dickert, B. L., & Witman, G. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.473 · Cited by 471

Intraflagellar transport balances continuous turnover of outer doublet microtubules

Marshall, W. F., & Rosenbaum, J. L. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200106141 · Cited by 436

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Mukhopadhyay, S., Wen, X., Chih, B., Nelson, C. D., Lane, W. S., Scales, S. J., & Jackson, P. K. (2010) · Genes & Development · doi:10.1101/gad.1966210 · Cited by 435

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

May, S. R., Ashique, A. M., Karlen, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J., Ericson, J., & Peterson, A. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.050 · Cited by 428

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

Nachury, M. V., Seeley, E. S., & Jin, H. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113337 · Cited by 426

A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)

Pazour, G. J., Wilkerson, C. G., & Witman, G. B. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.979 · Cited by 425

Functional coordination of intraflagellar transport motors

Ou, G., E. Blacque, O., Snow, J. J., Leroux, M. R., & Scholey, J. M. (2005) · Nature · doi:10.1038/nature03818 · Cited by 411

Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons

Snow, J. J., Ou, G., Gunnarson, A. L., Walker, M. R. S., Zhou, H. M., Brust-Mascher, I., & Scholey, J. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1186 · Cited by 404

Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles

Deane, J. A., Cole, D. G., Seeley, E. S., Diener, D. R., & Rosenbaum, J. L. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00484-5 · Cited by 391

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

Craige, B., Tsao, C.-C., Diener, D. R., Hou, Y., Lechtreck, K.-F., Rosenbaum, J. L., & Witman, G. B. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006105 · Cited by 386

Cilia‐related diseases

Afzelius, B. (2004) · The Journal of Pathology · doi:10.1002/path.1652 · Cited by 378

Functional dissection of Rab GTPases involved in primary cilium formation

Yoshimura, S.-I., Egerer, J., Fuchs, E., Haas, A. K., & Barr, F. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703047 · Cited by 375

The biology of cilia and flagella

Sleigh, M. A. (1962) · Pergamon Press eBooks · doi:10.5962/bhl.title.4525 · Cited by 372

Bbs2 -null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin

Nishimura, D. Y., Fath, M., Mullins, R. F., Searby, C., Andrews, M., Davis, R., Andorf, J. L., Mykytyn, K., Swiderski, R. E., Yang, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405496101 · Cited by 366

The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

Lechtreck, K.-F., Johnson, E. C., Sakai, T., Cochran, D., Ballif, B. A., Rush, J., Pazour, G. J., Ikebe, M., & Witman, G. B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200909183 · Cited by 347

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

Blacque, O. E., Reardon, M. J., Li, C., McCarthy, J., Mahjoub, M. R., Ansley, S. J., Badano, J. L., Mah, A. K., Beales, P. L., Davidson, W. S., et al. (2004) · Genes & Development · doi:10.1101/gad.1194004 · Cited by 347

Intraflagellar transport (IFT) cargo

Qin, H., Diener, D. R., Geimer, S., Cole, D. G., & Rosenbaum, J. L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308132 · Cited by 342

Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly

Mykytyn, K., Mullins, R. F., Andrews, M., Chiang, A. P., Swiderski, R. E., Yang, B., Braun, T., Casavant, T., Stone, E. M., & Sheffield, V. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402354101 · Cited by 337

Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

Besschetnova, T. Y., Kolpakova-Hart, E., Guan, Y., Zhou, J., Olsen, B. R., & Shah, J. V. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.072 · Cited by 334

Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas

Porter, M. E., Bower, R., Knott, J. A., Byrd, P., & Dentler, W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.693 · Cited by 333

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

Tran, P. V., Haycraft, C. J., Besschetnova, T. Y., Turbe-Doan, A., Stottmann, R. W., Herron, B. J., Chesebro, A. L., Qiu, H., Scherz, P. J., Shah, J. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.105 · Cited by 322

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation

Loktev, A. V., Zhang, Q., Beck, J. S., Searby, C. C., Scheetz, T. E., Bazan, J. F., Slusarski, D. C., Sheffield, V. C., Jackson, P. K., & Nachury, M. V. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.11.001 · Cited by 316

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

Finetti, F., Paccani, S. R., Riparbelli, M. G., Giacomello, E., Perinetti, G., Pazour, G. J., Rosenbaum, J. L., & Baldari, C. T. (2009) · Nature Cell Biology · doi:10.1038/ncb1977 · Cited by 310

Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living Caenorhabditis elegans

Signor, D., Wedaman, K. P., Orozco, J. T., Dwyer, N. D., Bargmann, C. I., Rose, L. S., & Scholey, J. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.519 · Cited by 301

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia

Molla-Herman, A., Ghossoub, R., Blisnick, T., Meunier, A., Serres, C., Silbermann, F., Emmerson, C., Romeo, K., Bourdoncle, P., Schmitt, A., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.059519 · Cited by 298

FLAGELLAR REGENERATION IN PROTOZOAN FLAGELLATES

Rosenbaum, J. L., & Child, F. M. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.345 · Cited by 294

The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia

Gherman, A., Davis, E. E., & Katsanis, N. (2006) · Nature Genetics · doi:10.1038/ng0906-961 · Cited by 291

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

Dishinger, J. F., Kee, H. L., Jenkins, P. M., Fan, S., Hurd, T. W., Hammond, J. W., Truong, Y. N.-T., Margolis, B., Martens, J. R., & Verhey, K. J. (2010) · Nature Cell Biology · doi:10.1038/ncb2073 · Cited by 285

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

Geng, L., Okuhara, D., Yu, Z., Tian, X., Cai, Y., Shibazaki, S., & Somlo, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02818 · Cited by 282

Mutations in Hydin impair ciliary motility in mice

Lechtreck, K.-F., Delmotte, P., Robinson, M. L., Sanderson, M. J., & Witman, G. B. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710162 · Cited by 278

Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella

Piperno, G., & Mead, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4457 · Cited by 275

Functional Genomics of the Cilium, a Sensory Organelle

Blacque, O. E., Perens, E. A., Boroevich, K. A., Inglis, P. N., Li, C., Warner, A., Khattra, J., Holt, R. A., Ou, G., Mah, A. K., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.059 · Cited by 270

Novel heterotrimeric kinesin-related protein purified from sea urchin eggs

Cole, D. G., Chinn, S. W., Wedaman, K. P., Hall, K., Vuong, T., & Scholey, J. M. (1993) · Nature · doi:10.1038/366268a0 · Cited by 269

A knockin mouse model of the Bardet–Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity

Davis, R. E., Swiderski, R. E., Rahmouni, K., Nishimura, D. Y., Mullins, R. F., Agassandian, K., Philp, A. R., Searby, C. C., Andrews, M. P., Thompson, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708571104 · Cited by 259

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Mazelova, J., Astuto‐Gribble, L., Inoue, H., Tam, B. M., Schonteich, E., Prekeris, R., Moritz, O. L., Randazzo, P. A., & Deretic, D. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.267 · Cited by 244

Primary cilia of human endothelial cells disassemble under laminar shear stress

Iomini, C., Tejada, K., Mo, W., Vaananen, H., & Piperno, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312133 · Cited by 241

Protein Particles in Chlamydomonas Flagella Undergo a Transport Cycle Consisting of Four Phases

Iomini, C., Babaev-Khaimov, V., Sassaroli, M., & Piperno, G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.1.13 · Cited by 241

Flagellar Length Control System: Testing a Simple Model Based on Intraflagellar Transport and Turnover

Marshall, W. F., Qin, H., Brenni, M. R., & Rosenbaum, J. L. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0586 · Cited by 241

The Intraflagellar Transport Machinery of Chlamydomonas reinhardtii

Cole, D. G. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.t01-1-00103.x · Cited by 232

The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein.

Walther, Z., Vashishtha, M., & Hall, J. L. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.175 · Cited by 226

Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella

Hou, Y., Qin, H., Follit, J. A., Pazour, G. J., Rosenbaum, J. L., & Witman, G. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608041 · Cited by 226

Ciliary Targeting of Olfactory CNG Channels Requires the CNGB1b Subunit and the Kinesin-2 Motor Protein, KIF17

Jenkins, P. M., Hurd, T. W., Zhang, L., McEwen, D. P., Brown, R. L., Margolis, B., Verhey, K. J., & Martens, J. R. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.034 · Cited by 221

Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium

Jékely, G., & Arendt, D. (2006) · BioEssays · doi:10.1002/bies.20369 · Cited by 221

Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes

Stolc, V., Samanta, M. P., Tongprasit, W., & Marshall, W. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408358102 · Cited by 218

elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

Omori, Y., Zhao, C., Saras, A., Mukhopadhyay, S., Kim, W., Furukawa, T., Sengupta, P., Veraksa, A., & Malicki, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1706 · Cited by 218

Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells

Pitaval, A., Tseng, Q., Bornens, M., & Théry, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201004003 · Cited by 213

A Novel MAP Kinase Regulates Flagellar Length in Chlamydomonas

Berman, S. A., Wilson, N. F., Haas, N. A., & Lefebvre, P. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00415-9 · Cited by 208

Intraflagellar Transport Is Required for the Vectorial Movement of TRPV Channels in the Ciliary Membrane

Qin, H., Burnette, D. T., Bae, Y.-K., Forscher, P., Barr, M. M., & Rosenbaum, J. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.047 · Cited by 206

Electron-tomographic analysis of intraflagellar transport particle trains in situ

Pigino, G., Geimer, S., Lanzavecchia, S., Paccagnini, E., Cantele, F., Diener, D. R., Rosenbaum, J. L., & Lupetti, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200905103 · Cited by 204

Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model

Engel, B. D., Ludington, W. B., & Marshall, W. F. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200812084 · Cited by 203

The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation

Pathak, N., Obara, T., Mangos, S., Liu, Y., & Drummond, I. A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0537 · Cited by 203

Intraflagellar Transport Protein 27 Is a Small G Protein Involved in Cell-Cycle Control

Qin, H., Wang, Z., Diener, D., & Rosenbaum, J. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.040 · Cited by 201

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

Kubo, T., Yanagisawa, H.-A., Yagi, T., Hirono, M., & Kamiya, R. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.058 · Cited by 194

Distinct Mutants of Retrograde Intraflagellar Transport (IFT) Share Similar Morphological and Molecular Defects

Piperno, G., Siuda, E., Henderson, S., Segil, M., Vaananen, H., & Sassaroli, M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1591 · Cited by 194

Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella

Huang, K., Diener, D. R., Mitchell, A., Pazour, G. J., Witman, G. B., & Rosenbaum, J. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704069 · Cited by 192

Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors

Pan, X., Ou, G., Civelekoglu-Scholey, G., Blacque, O. E., Endres, N. F., Tao, L., Mogilner, A., Leroux, M. R., Vale, R. D., & Scholey, J. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606003 · Cited by 192

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

Wloga, D., Webster, D. M., Rogowski, K., Bré, M.-H., Levilliers, N., Jerka-Dziadosz, M., Janke, C., Dougan, S. T., & Gaertig, J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.04.008 · Cited by 186

Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes

Absalon, S., Blisnick, T., Kohl, L., Toutirais, G., Doré, G., Julkowska, D., Tavenet, A., & Bastin, P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0749 · Cited by 186

Mkks-null mice have a phenotype resembling Bardet–Biedl syndrome

Fath, M. A., Mullins, R. F., Searby, C., Nishimura, D. Y., Wei, J., Rahmouni, K., Davis, R. E., Tayeh, M. K., Andrews, M., Yang, B., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi123 · Cited by 185

Heterotrimeric Kinesin-II Is Required for the Assembly of Motile 9+2 Ciliary Axonemes on Sea Urchin Embryos

Morris, R. L., & Scholey, J. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.1009 · Cited by 184

Dissecting the Molecular Mechanisms of Intraflagellar Transport in Chlamydomonas

Pedersen, L. B., Geimer, S., & Rosenbaum, J. L. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.020 · Cited by 174

Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry

Ikegami, K., Sato, S., Nakamura, K., Ostrowski, L. E., & Setou, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002128107 · Cited by 173

Centriole Age Underlies Asynchronous Primary Cilium Growth in Mammalian Cells

Anderson, C. T., & Stearns, T. (2009) · Current Biology · doi:10.1016/j.cub.2009.07.034 · Cited by 169

Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

Suryavanshi, S., Eddé, B., Fox, L. A., Guerrero, S., Hard, R., Hennessey, T., Kabi, A., Malison, D., Pennock, D., Sale, W. S., et al. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.062 · Cited by 169

Transcriptional control of genes involved in ciliogenesis: a first step in making cilia

Thomas, J., Morlé, L., Soulavie, F., Laurençon, A., Sagnol, S., & Durand, B. (2010) · Biology of the Cell · doi:10.1042/bc20100035 · Cited by 169

An Aurora Kinase Is Essential for Flagellar Disassembly in Chlamydomonas

Pan, J., Wang, Q., & Snell, W. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00064-4 · Cited by 168

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

Follit, J. A., Li, L., Vucica, Y., & Pazour, G. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910096 · Cited by 168

Chlamydomonas IFT172 Is Encoded by FLA11, Interacts with CrEB1, and Regulates IFT at the Flagellar Tip

Pedersen, L. B., Miller, M. S., Geimer, S., Leitch, J. M., Rosenbaum, J. L., & Cole, D. G. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.037 · Cited by 164

ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

Ahmed, N. T., Gao, C., Lucker, B. F., Cole, D. G., & Mitchell, D. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802025 · Cited by 164

Gametogenesis and fertilization in Plasmodium yoelii nigeriensis : a transmission electron microscope study

Sinden, R. E., Canning, E. U., & Spain, B. (1976) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1976.0031 · Cited by 162

Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography

Sui, H., & Downing, K. H. (2006) · Nature · doi:10.1038/nature04816 · Cited by 158

Characterization of mouse IFT complex B

Follit, J. A., Xu, F., Keady, B. T., & Pazour, G. J. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20346 · Cited by 158

Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry

Kinzel, D., Boldt, K., Davis, E. E., Burtscher, I., Trümbach, D., Diplas, B. H., Attié‐Bitach, T., Wurst, W., Katsanis, N., Ueffing, M., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.005 · Cited by 152

Kinesin-13 Regulates Flagellar, Interphase, and Mitotic Microtubule Dynamics in Giardia intestinalis

Dawson, S. C., Sagolla, M. S., Mancuso, J. J., Woessner, D. J., House, S. A., Fritz‐Laylin, L. K., & Cande, W. Z. (2007) · Eukaryotic Cell · doi:10.1128/ec.00128-07 · Cited by 151

Intraflagellar transport molecules in ciliary and nonciliary cells of the retina

Sedmak, T., & Wolfrum, U. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911095 · Cited by 148

Sensory Ciliogenesis inCaenorhabditis elegans: Assignment of IFT Components into Distinct Modules Based on Transport and Phenotypic Profiles

Ou, G., Koga, M., Blacque, O. E., Murayama, T., Ohshima, Y., Schafer, J. C., Li, C., Yoder, B. K., Leroux, M. R., & Scholey, J. M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0805 · Cited by 145

Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival

Omori, Y., Chaya, T., Katoh, K., Kajimura, N., Sato, S., Muraoka, K., Ueno, S., Koyasu, T., Kondo, M., & Furukawa, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009437108 · Cited by 141

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

Hartman, T. R., Liu, D., Zilfou, J. T., Robb, V. A., Morrison, T. A., Watnick, T. J., & Henske, E. P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn325 · Cited by 137

The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly

Brazelton, W. J., Amundsen, C. D., Silflow, C. D., & Lefebvre, P. A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00485-7 · Cited by 136

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Evans, J. E., Snow, J. J., Gunnarson, A. L., Ou, G., Stahlberg, H., McDonald, K. L., & Scholey, J. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509115 · Cited by 135

Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas.

Piperno, G., Mead, K., & Henderson, S. C. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.2.371 · Cited by 134

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas

Piao, T., Luo, M., Wang, L., Guo, Y., Li, D., Li, P., Snell, W. J., & Pan, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808671106 · Cited by 133

The FLA3 KAP Subunit Is Required for Localization of Kinesin-2 to the Site of Flagellar Assembly and Processive Anterograde Intraflagellar Transport

Mueller, J. M., Perrone, C. A., Bower, R., Cole, D. G., & Porter, M. E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0931 · Cited by 132

A Novel Microtubule-Depolymerizing Kinesin Involved in Length Control of a Eukaryotic Flagellum

Blaineau, C., Tessier, M., Dubessay, P., Tasse, L., Crobu, L., Pagès, M., & Bastien, P. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.048 · Cited by 129

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3

Tammachote, R., Sieben, C. J., Sinders, R. M., Miller, C. A., Czarnecki, P. G., Leightner, A. C., Salisbury, J. L., Ward, C. J., Torres, V. E., Gattone, V. H., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp272 · Cited by 127

Retrograde Intraflagellar Transport Mutants Identify Complex A Proteins With Multiple Genetic Interactions inChlamydomonas reinhardtii

Iomini, C., Li, L., Esparza, J. M., & Dutcher, S. K. (2009) · Genetics · doi:10.1534/genetics.109.101915 · Cited by 125

A Dynein Light Intermediate Chain, D1bLIC, Is Required for Retrograde Intraflagellar Transport

Hou, Y., Pazour, G. J., & Witman, G. B. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0377 · Cited by 125

A CDK-related kinase regulates the length and assembly of flagella in Chlamydomonas

Tam, L., Wilson, N. F., & Lefebvre, P. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610022 · Cited by 124

Regulation of Flagellar Assembly by Glycogen Synthase Kinase 3 in Chlamydomonas reinhardtii

Wilson, N. F., & Lefebvre, P. A. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.5.1307-1319.2004 · Cited by 121

Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction

Ko, H. W., Norman, R. X., Tran, J., Fuller, K. P., Fukuda, M., & Eggenschwiler, J. T. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.014 · Cited by 113

Chlamydomonas Shortens Its Flagella by Activating Axonemal Disassembly, Stimulating IFT Particle Trafficking, and Blocking Anterograde Cargo Loading

Pan, J., & Snell, W. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.010 · Cited by 112

Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans

Mukhopadhyay, S., Lu, Y., Qin, H., Lanjuin, A., Shaham, S., & Sengupta, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601717 · Cited by 110

A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia

Fujiwara, M., Ishihara, T., & Katsura, I. (1999) · Development · doi:10.1242/dev.126.21.4839 · Cited by 109

Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas

Wang, Z., Fan, Z., Williamson, S. M., & Qin, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005384 · Cited by 104

Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation

Haycraft, C. J., Schafer, J. C., Zhang, Q., Taulman, P. D., & Yoder, B. K. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00089-7 · Cited by 101

Intraflagellar transport at a glance

Hao, L., & Scholey, J. M. (2009) · Journal of Cell Science · doi:10.1242/jcs.023861 · Cited by 99

Flagellar Protein Dynamics in Chlamydomonas

Song, L. Y., & Dentler, W. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103184200 · Cited by 94

Protein Kinase Involved in Flagellar-Length Control

Wiese, M., Kuhn, D., & Grünfelder, C. G. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.4.769-777.2003 · Cited by 92

At least one of the protofilaments in flagellar microtubules is not composed of tubulin

Nojima, D., Linck, R. W., & Egelman, E. H. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00037-6 · Cited by 83

Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway

DiBella, L. M., Park, A., & Sun, Z. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn384 · Cited by 83

Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

Bonnet, C. S., Aldred, M., von Ruhland, C., Harris, R., Sandford, R. N., & Cheadle, J. P. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp149 · Cited by 82

Chapter 4 Ciliary Tubulin and Its Post-Translational Modifications

Gaertig, J., & Włoga, D. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00804-1 · Cited by 80

IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation inCaenorhabditis elegans

Schafer, J. C., Winkelbauer, M. E., Williams, C. L., Haycraft, C. J., Desmond, R. A., & Yoder, B. K. (2006) · Journal of Cell Science · doi:10.1242/jcs.03187 · Cited by 79

ChlamydomonasIFT70/CrDYF-1 Is a Core Component of IFT Particle Complex B and Is Required for Flagellar Assembly

Fan, Z., Behal, R. H., Geimer, S., Wang, Z., Williamson, S. M., Zhang, H., Cole, D. G., & Qin, H. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0191 · Cited by 76

Loss of Bardet–Biedl syndrome proteins causes defects in peripheral sensory innervation and function

Tan, P. L., Barr, T. P., Inglis, P. N., Mitsuma, N., Huang, S. M., García-González, M. Á., Bradley, B. A., Coforio, S., Albrecht, P. J., Watnick, T. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706618104 · Cited by 75

Caenorhabditis elegansDYF-2, an Orthologue of Human WDR19, Is a Component of the Intraflagellar Transport Machinery in Sensory Cilia

Efimenko, E., Blacque, O. E., Ou, G., Haycraft, C. J., Yoder, B. K., Scholey, J. M., Leroux, M. R., & Swoboda, P. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0260 · Cited by 74

Synthesis and Turnover of Embryonic Sea Urchin Ciliary Proteins during Selective Inhibition of Tubulin Synthesis and Assembly

Stephens, R. E. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.11.2187 · Cited by 73

HA‐tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B

Lechtreck, K. F., Luro, S., Awata, J., & Witman, G. B. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20369 · Cited by 70

Tetrahymena IFT122A is not essential for cilia assembly but plays a role in returning IFT proteins from the ciliary tip to the cell body

Tsao, C.-C., & Gorovsky, M. A. (2008) · Journal of Cell Science · doi:10.1242/jcs.015826 · Cited by 67

Different Effects ofTetrahymena IFT172Domains on Anterograde and Retrograde Intraflagellar Transport

Tsao, C.-C., & Gorovsky, M. A. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0403 · Cited by 67

Cell Context-specific Effects of the β-Tubulin Glycylation Domain on Assembly and Size of Microtubular Organelles

Thazhath, R., Jerka‐Dziadosz, M., Duan, J., Włoga, D., Gorovsky, M. A., Frankel, J., & Gaertig, J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0247 · Cited by 65

The dyf-3 Gene Encodes a Novel Protein Required for Sensory Cilium Formation in Caenorhabditis elegans

Murayama, T., Toh, Y., Ohshima, Y., & Koga, M. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.005 · Cited by 65

Normal Ciliogenesis Requires Synergy between the Cystic Kidney Disease Genes MKS-3 and NPHP-4

Williams, C. L., Masyukova, S. V., & Yoder, B. K. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060597 · Cited by 64

Centrioles are freed from cilia by severing prior to mitosis

Parker, J., Hilton, L. K., Diener, D. R., Rasi, M. Q., Mahjoub, M. R., Rosenbaum, J. L., & Quarmby, L. M. (2010) · Cytoskeleton · doi:10.1002/cm.20454 · Cited by 61

Cystin Localizes to Primary Cilia via Membrane Microdomains and a Targeting Motif

Tao, B., Bu, S., Yang, Z., Siroky, B. J., Kappes, J. C., Kispert, A., & Guay‐Woodford, L. M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009020188 · Cited by 61

Flagellar Length Control in Chlamydomonas—A Paradigm for Organelle Size Regulation

Wemmer, K. A., & Marshall, W. F. (2007) · International review of cytology · doi:10.1016/s0074-7696(06)60004-1 · Cited by 57

Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis

Gao, C., Wang, G., Amack, J. D., & Mitchell, D. R. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22355 · Cited by 57

An Essential Role for DYF-11/MIP-T3 in Assembling Functional Intraflagellar Transport Complexes

Li, C., Inglis, P. N., Leitch, C. C., Efimenko, E., Zaghloul, N. A., Mok, C. A., Davis, E. E., Bialas, N. J., Healey, M. P., Héon, E., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000044 · Cited by 52

Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas

Tam, L., Dentler, W. L., & Lefebvre, P. A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200307143 · Cited by 49

The PKD protein qilin undergoes intraflagellar transport

Ou, G., Qin, H., Rosenbaum, J. L., & Scholey, J. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.044 · Cited by 48

Total Internal Reflection Fluorescence (TIRF) Microscopy of Chlamydomonas Flagella

Engel, B. D., Lechtreck, K. F., Sakai, T., Ikebe, M., Witman, G. B., & Marshall, W. F. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)93009-0 · Cited by 47

DYF-1 Is Required for Assembly of the Axoneme in Tetrahymena thermophila

Dave, D., Włoga, D., Sharma, N., & Gaertig, J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00378-08 · Cited by 34

Ciliogenesis in sea urchin embryos – a subroutine in the program of development

Stephens, R. E. (1995) · BioEssays · doi:10.1002/bies.950170409 · Cited by 32

Protofilament Ribbon Compartments of Ciliary and Flagellar Microtubules

Linck, R. W., & Norrander, J. M. (2003) · Protist · doi:10.1078/143446103322454086 · Cited by 27

Stochastic model of intraflagellar transport

Bressloff, P. C. (2006) · Physical Review E · doi:10.1103/physreve.73.061916 · Cited by 17

Functions and mechanics of dynein motor proteins

Roberts, A. J., Kon, T., Knight, P. J., Sutoh, K., & Burgess, S. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3667 · Cited by 537

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. A., et al. (2013) · Science · doi:10.1126/science.1240985 · Cited by 317

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69636 · Cited by 307

αTAT1 is the major α-tubulin acetyltransferase in mice

Kalebic, N., Sorrentino, S., Perlas, E., Bolasco, G., Martinez, C., & Heppenstall, P. A. (2013) · Nature Communications · doi:10.1038/ncomms2962 · Cited by 241

Stages of ciliogenesis and regulation of ciliary length

Avasthi, P., & Marshall, W. F. (2012) · Differentiation · doi:10.1016/j.diff.2011.11.015 · Cited by 234