Differential roles of monkey striatum in learning of sequential hand movement
Abstract
To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2x5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the anterior caudate and putamen, but not the middle-posterior putamen. The execution of well-learned sequences was disrupted after injections in the middle-posterior putamen and, less severely, after injections in the anterior caudate/putamen. These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements.
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Temporary inactivation of the sensorimotor striatum does not interfere with learning of new motor sequences but disrupts execution of previously-acquired sequences.
“Furthermore, temporary inactivation of the sensorimotor striatum does not interfere with the learning of new motor sequences, but it does disrupt the execution of previously-acquired sequences [18].”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [18]
Temporary inactivation of the associative striatum disrupts learning of new motor sequences but has less effect on execution of previously-acquired sequences.
“Evidence supporting a role for the associative striatum in behavioral acquisition was reported by Miyachi et al. [18], who found that temporary inactivation of the associative striatum disrupted learning of new motor sequences, but had less effect on the execution of previously-acquired sequences.”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [18]
These patterns can roughly be associated with social reasoning, motor control, learning and memory.
“and can roughly be associated with social reasoning, motor control, learning and memory [36–40].”
From Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution (2013) · cites this paper as [39]
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- Authors
- Miyachi, S., Hikosaka, O., Miyashita, K., Kárádi, Z., & Rand, M. K.
- Affiliations
- National Institute for Physiological Sciences (JP)
- Venue
- Experimental Brain Research
- Published
- 1997-06-16
- Volume
- 115
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0014-4819 (ISSN-L)
- OpenAlex
- W1977208975
- Cited by
- 374
- References
- 27
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 9 · 2015: 23 · 2014: 19 · 2013: 23 · 2012: 18
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- striatum, basal ganglia, putamen, muscimol inactivation, monkeys, GABAergic inhibition
- MeSH terms
- Animals, Hand, Injections, Learning, Macaca, Male, Memory, Movement, Muscimol, Neostriatum, GABA Agonists
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