Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health
Open accessAbstract
Neonatal gut microbiota establishment represents a crucial stage for gut maturation, metabolic and immunologic programming, and consequently short- and long-term health status. Human milk beneficially influences this process due to its dynamic profile of age-adapted nutrients and bioactive components and by providing commensal maternal bacteria to the neonatal gut. These include Lactobacillus spp., as well as obligate anaerobes such as Bifidobacterium spp., which may originate from the maternal gut via an enteromammary pathway as a novel form of mother-neonate communication. Additionally, human milk harbors a broad range of oligosaccharides that promote the growth and activity of specific bacterial populations, in particular, Bifidobacterium and Bacteroides spp. This review focuses on the diversity and origin of human milk bacteria, as well as on milk oligosaccharides that influence neonatal gut microbiota establishment. This knowledge can be used to develop infant formulae that more closely mimic nature's model and sustain a healthy gut microbiota.
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Breast milk contains more than 200 structurally different human milk oligosaccharides that cannot be digested by the infant but promote the growth of selected genera such as Bifidobacteria and Bacteroides.
“Breast milk also contains >200 structurally different human milk oligosaccharides (HMOs) (Jost et al., 2015), which cannot be digested by the infant, but rather promote the growth of selected genera, such as Bifidobacteria and Bacteroides (Marcobal et al., 2010), thought to promote the healthy development of the GI tract and immune system.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Jost et al., 2015
Microbial colonization of the intestinal tract is a successive process throughout the course of life.
“Microbial colonization of the intestinal tract is a successive process throughout the course of life.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [231]
In the first years of life the microbial community is dynamic and some bacteria that become part of the adult microbiota already colonize the gut during the first months of life.
“Especially in the first years of life the microbial community is dynamic and some bacteria that become part of the adult microbiota already colonize the gut during the first months of life (230-232).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [231]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review
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Irritable bowel syndrome, the microbiota and the gut-brain axis
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The developing gut microbiota and its consequences for health
Butel, M.-J., Waligora-Dupriet, A.-J., & Wydau-Dematteis, S. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000119 · Cited by 182 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Davis, E. C., Wang, M., & Donovan, S. M. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1278104 · Cited by 169 · see citing works
Factors influencing the gut microbiome in children: from infancy to childhood
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Li, S., Li, N., Wang, C., Zhao, Y., Cao, J., Li, X., Zhang, Z., Li, Y., Yang, X., Wang, X., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.798403 · Cited by 26 · see citing works
- Authors
- Jost, T., Lacroix, C., Braegger, C., & Chassard, C.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-15
- Volume
- 73
- Issue
- 7
- Pages
- 426-437
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2107978987
- Cited by
- 267
- References
- 132
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 18 · 2023: 29 · 2022: 30 · 2021: 39 · 2020: 31 · 2019: 26 · 2018: 28 · 2017: 19 · 2016: 21 · 2015: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Keywords
- breast milk, neonatal gut microbiota, human milk oligosaccharides, Lactobacillus, Bifidobacterium, Bacteroides, maternal-fetal communication, infant formula
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Bacteroides, Bifidobacterium, Humans, Infant, Lactobacillus, Milk, Human, Oligosaccharides, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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