Parvalbumin interneurons of hippocampus tune population activity at theta frequency
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Hippocampal theta rhythm arises from a combination of recently described intrinsic theta oscillators and inputs from multiple brain areas. Interneurons expressing the markers parvalbumin (PV) and somatostatin (SOM) are leading candidates to participate in intrinsic rhythm generation and principal cell (PC) coordination in distal CA1 and subiculum. We tested their involvement by optogenetically activating and silencing PV or SOM interneurons in an intact hippocampus preparation that preserves intrinsic connections and oscillates spontaneously at theta frequencies. Despite evidence suggesting that SOM interneurons are crucial for theta, optogenetic manipulation of these interneurons modestly influenced theta rhythm. However, SOM interneurons were able to strongly modulate temporoammonic inputs. In contrast, activation of PV interneurons powerfully controlled PC network and rhythm generation optimally at 8 Hz, while continuously silencing them disrupted theta. Our results thus demonstrate a pivotal role of PV but not SOM interneurons for PC synchronization and the emergence of intrinsic hippocampal theta.
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The frequency of theta oscillations can be experimentally manipulated by optogenetically activating pacemaker cells within the medial septum as well as local FS interneurons within the hippocampus.
“The frequency of theta oscillations can be experimentally manipulated by optogenetically activating pacemaker cells within the medial septum102 as well as local FS interneurons within the hippocampus103.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [103]
PV+ interneurons are the main effectors of intrinsic theta rhythm in the hippocampus.
“Optogenetic studies on the hippocampus have shown that parvalbumin (PV)+ interneurons are the main effectors of intrinsic theta rhythm”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [25]
SST+ interneurons modulate the entrainment of intrinsic theta by controlling external inputs to the hippocampus.
“while somatostatin (SST)+ interneurons modulate the entrainment of intrinsic theta by controlling external inputs to the hippocampus (25).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [25]
SST+ interneurons indirectly contribute to the entrainment of theta oscillations in the hippocampus.
“SST+ interneurons on the other hand have been demonstrated to indirectly contribute to the entrainment of theta oscillations in the hippocampus (25) and are responsible for preferentially driving beta (15–30 Hz) frequency oscillations in other brain regions (72).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [25]
GABAergic interneurons, especially the PV+ subtype, play an important role in the regulation of neuronal oscillations in the brain.
“GABAergic interneurons, especially the PV+ subtype, play an important role in the regulation of neuronal oscillations in the brain (24–27) and have also been implicated in neuropsychiatric disease (66; 67).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [25]
The CA1 circuit has an intrinsic ability to generate some form of theta waves even without rhythmic external inputs.
“Therefore, the latter studies suggest an intrinsic ability of the CA1 circuit to generate some form of theta waves even without rhythmic external inputs.”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Amilhon et al., 2015
Spontaneous theta-frequency LFP oscillations are present in the isolated whole CA1 preparation in vitro.
“recent reports indicate the presence of spontaneous theta-frequency LFP oscillations even in the isolated whole CA1 preparation in vitro (Goutagny et al., 2009; Amilhon et al., 2015).”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Amilhon et al., 2015
These results were in overall agreement with experimental data from the isolated CA1 preparation indicating that optogenetic silencing of PV+ cells, but not SOM+ cells such as the O-LM cells, caused a marked reduction in theta oscillations.
“Reassuringly, these results were in overall agreement with experimental data from the isolated CA1 preparation indicating that optogenetic silencing of PV+ cells, but not SOM+ cells such as the O-LM cells, caused a marked reduction in theta oscillations (Amilhon et al., 2015).”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Amilhon et al., 2015
These oscillations emerged from the network model without explicit encoding, rhythmic inputs or purposeful tuning of intra-CA1 parameters.
“Consistent with experimental results (Goutagny et al., 2009; Amilhon et al., 2015), these oscillations emerged from the network model without explicit encoding, rhythmic inputs or purposeful tuning of intra-CA1 parameters (all anatomical connectivity parameters were exactly as previously published in Bezaire and Soltesz (2013)).”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Amilhon et al., 2015
Experimental data on the isolated CA1 preparation were obtained from both rat and mouse.
“the experimental data on the isolated CA1 preparation were obtained from both rat (Goutagny et al., 2009) and mouse (Amilhon et al., 2015)”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Amilhon et al., 2015
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- Authors
- Amilhon, B., Huh, C. Y. L., Manseau, F., Ducharme, G., Nichol, H., Adamantidis, A., & Williams, S.
- Affiliations
- Douglas Mental Health University Institute (CA)
- University of Bern (CH)
- Corresponding author
- Amilhon, Bénédicte
- Williams, Sylvain
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 86
- Issue
- 5
- Pages
- 1277-1289
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1544607115
- Cited by
- 241
- References
- 39
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 16 · 2023: 28 · 2022: 26 · 2021: 22 · 2020: 27 · 2019: 22 · 2018: 24 · 2017: 24 · 2016: 13 · 2015: 2
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts Institute of Technology
- McGill University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- parvalbumin interneurons, somatostatin interneurons, hippocampal theta rhythm, optogenetic manipulation, CA1, subiculum, neural population activity
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Hippocampus, Interneurons, Organ Culture Techniques, Parvalbumins, Theta Rhythm, Mice
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