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Cited by 292

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Matrix viscoelasticity controls spatiotemporal tissue organization

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Elosegui-Artola, Alberto, Gupta, Anupam, Najibi, Alexander J., Seo, Bo Ri, Garry, Ryan, Tringides, Christina M., de Lázaro, Irene, Darnell, Max, Gu, Wei, Zhou, Qiao, Weitz, David A., Mahadevan, L., Mooney, David J.·2023·Nature Materials
DOI 10.1038/s41563-022-01400-4
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Abstract

Biomolecular and physical cues of the extracellular matrix environment regulate collective cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the matrix regulate collective cell spatial and temporal organization is not fully understood. Here we show that the passive viscoelastic properties of the matrix encapsulating a spheroidal tissue of breast epithelial cells guide tissue proliferation in space and in time. Matrix viscoelasticity prompts symmetry breaking of the spheroid, leading to the formation of invading finger-like protrusions, YAP nuclear translocation and epithelial-to-mesenchymal transition both in vitro and in vivo in a Arp2/3-complex-dependent manner. Computational modelling of these observations allows us to establish a phase diagram relating morphological stability with matrix viscoelasticity, tissue viscosity, cell motility and cell division rate, which is experimentally validated by biochemical assays and in vitro experiments with an intestinal organoid. Altogether, this work highlights the role of stress relaxation mechanisms in tissue growth dynamics, a fundamental process in morphogenesis and oncogenesis. Viscoelasticity is a universal mechanical feature of the extracellular matrix. Here the authors show that the extracellular matrix viscoelasticity guides tissue growth and symmetry breaking, a fundamental process in morphogenesis and oncogenesis.

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Metadata

Authors
Elosegui-Artola, A., Gupta, A., Najibi, A. J., Seo, B. R., Garry, R., Tringides, C. M., de Lázaro, I., Darnell, M., Gu, W., Zhou, Q., Weitz, D. A., Mahadevan, L., & Mooney, D. J.
Venue
Nature Materials
Publisher
Springer Science and Business Media LLC
Published
2022-12-01
Volume
22
Issue
1
Pages
117-127
ISSN
  • 1476-1122 (ISSN-L)
  • 1476-4660
DOI
10.1038/s41563-022-01400-4
OpenAlex
W4310496927
Cited by
292
References
9
FWCI
25.69
Type
journal article
Language
en
Open access
green
Licence

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CoChat. (2026). Citation check: Matrix viscoelasticity controls spatiotemporal tissue organization. https://app.cochat.ai/papers/10.1038/s41563-022-01400-4
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Elosegui-Artola, A., Gupta, A., Najibi, A. J., Seo, B. R., Garry, R., Tringides, C. M., de Lázaro, I., Darnell, M., Gu, W., Zhou, Q., Weitz, D. A., Mahadevan, L., & Mooney, D. J. (2023). Matrix viscoelasticity controls spatiotemporal tissue organization. Nature Materials. https://doi.org/10.1038/s41563-022-01400-4

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