Cited by 222T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationImmunotherapy and Immune Responses

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T cell regeneration after immunological injury

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Velardi, Enrico, Tsai, Jennifer J., van den Brink, Marcel R. M.·2021·Nature Reviews Immunology

DOI 10.1038/s41577-020-00457-zPMC PMC7583557

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Abstract

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, including prolonged immunosuppression, poor vaccine responses and increased risks of infections and malignancies. Thus, strategies that restore thymic function and enhance T cell reconstitution can provide considerable benefit to individuals whose immune system has been decimated in various settings. In this Review, we focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.

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See all 222

Authors: Velardi, E., Tsai, J. J., & van den Brink, M. R. M.
Affiliations: Bambino Gesù Children's Hospital (IT)
State University of New York (US)
Corresponding author: Velardi, Enrico
ORCID: Velardi, Enrico
Tsai, Jennifer J.
van den Brink, Marcel R. M.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2020-10-23
Volume: 21
Issue: 5
Pages: 277-291
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-020-00457-z
PMC: PMC7583557
OpenAlex: W3094124272
Cited by: 222
References: 282
Citations by year: 2026: 41 · 2025: 46 · 2024: 44 · 2023: 38 · 2022: 29 · 2021: 24
FWCI: 2.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Memorial Sloan-Kettering Cancer Center (P01-CA023766, CA008748, P30 CA008748)
Society of Memorial Sloan Kettering (P30-CA008748)
Parker Institute for Cancer Immunotherapy
Seres Therapeutics
Ministero della Salute
Associazione Italiana per la Ricerca sul Cancro
National Institutes of Health (1r01hl147584-01a1, 7r01ca228308-07)
National Institute on Aging (P01AG052359)
National Heart, Lung, and Blood Institute (HL123340, R01‐HL147584, R01HL123340, CA008748, R01HL125571)
National Cancer Institute (P01CA023766, R01‐CA228308, CA008748, R01CA228358, P30CA008748)
National Institute of Allergy and Infectious Diseases (AI124275, U01AI124275)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: T cell reconstitution, immune reconstitution, thymic function, T cell depletion, chemotherapy, radiotherapy, transplantation, infection, adaptive immunity, T cell diversity, immunosuppression, vaccine response
MeSH terms: Immunosenescence, Animals, B-Lymphocytes, Graft vs Host Disease, Humans, Immunotherapy, Lymphopenia, Regeneration, Stress, Physiological, T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Models, Immunological, Adaptive Immunity, Cellular Microenvironment

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