Molecular mechanisms of dietary restriction promoting health and longevity

Maximizing the intersection of human health and the health of the environment with regard to the amount and type of protein produced and consumed in the United States.

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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

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Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction

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Cryo-EM structure of human mTOR complex 2

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Patho-physiologic findings after chronic tryptophan deficiency in rats: A model for delayed growth and aging

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Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

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Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease

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Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span

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Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

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Consequences of growth hormone (GH) overexpression and GH resistance

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Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

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JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

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A word of caution against excessive protein intake

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Transgenic Mice Overexpressing Urokinase-Type Plasminogen Activator in the Brain Exhibit Reduced Food Consumption, Body Weight and Size, and Increased Longevity

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The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

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Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects

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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

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Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women

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The demography of slow aging in male and female Drosophila mutant for the insulin‐receptor substrate homologue chico

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Diet and the Suitability of the Male Fischer 344 Rat as a Model for Aging Research

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Tryptophan Predicts the Risk for Future Type 2 Diabetes

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Fasting and differential chemotherapy protection in patients

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Metabolism and the Epigenome: A Dynamic Relationship

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Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

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High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women

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Vitamin C and E supplementation blunts increases in total lean body mass in elderly men after strength training

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Caloric restriction may reverse age‐related autonomic decline in humans

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Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

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Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvements in glucose tolerance and mTORC 2 signaling

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Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

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The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

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The 3.2-Å resolution structure of human mTORC2

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Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

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An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function.

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Genomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

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Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

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Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

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Short‐term methionine deprivation improves metabolic health via sexually dimorphic, mTORCI‐independent mechanisms

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Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

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Influence of low tryptophan diet on survival and organ growth in mice

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m TORC 2‐ SGK ‐1 acts in two environmentally responsive pathways with opposing effects on longevity

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Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

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GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

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Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

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Regulation of metabolic health by essential dietary amino acids

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Dietary restriction involves NAD +‐dependent mechanisms and a shift toward oxidative metabolism

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A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

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SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.

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Histology and survival in age-delayed low-tryptophan-fed rats

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Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2‐isoprostanes: The CALERIE 2 randomized clinical trial

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Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

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Effects of Caloric Intake Timing on Insulin Resistance and Hyperandrogenism in Lean Women with Polycystic Ovary Syndrome

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Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

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Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

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Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

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The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids

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Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila

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GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

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Intermittent fasting increases energy expenditure and promotes adipose tissue browning in mice

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TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

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Diminished mTOR signaling: a common mode of action for endocrine longevity factors

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Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

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Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

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Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution

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Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

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Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice

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Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine

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The general control nonderepressible‐2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in C aenorhabditis elegans

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Metabotyping of Long-Lived Mice using 1H NMR Spectroscopy

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Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

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Hypothalamic mTORC2 is essential for metabolic health and longevity

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Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study

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Effects of Soy-derived Diets on Plasma and Liver Lipids, Glucose Tolerance, and Longevity in Normal, Long-lived and Short-lived Mice

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The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase

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Dietary Regulation of Adult Stem Cells

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Alternate-day fasting protects the livers of mice against high-fat diet–induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling

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SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

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Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

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Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys

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Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

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