Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial
Open accessAbstract
Several phase II studies have demonstrated that psilocybin-assisted therapy shows therapeutic potential across a spectrum of neuropsychiatric conditions, including major depressive disorder (MDD). However, the mechanisms underlying its often persisting beneficial effects remain unclear. Observational research suggests that improvements in psychological flexibility may mediate therapeutic effects. However, no psychedelic trials to date have substantiated this finding in a clinical sample. In an exploratory placebo-controlled, within-subject, fixed-order study, individuals with moderate to severe MDD were administered placebo (n = 19) followed by psilocybin (0.3 mg/kg) (n = 15) 4 weeks later. Dosing sessions were embedded within a manualized psychotherapy that incorporated principles of Acceptance and Commitment Therapy. Depression severity, psychological flexibility, mindfulness, and values-congruent living were measured over a 16-weeks study period. Psychological flexibility, several facets of mindfulness, and values-congruent living significantly improved following psilocybin and were maintained through week 16. Additionally, improvements in psychological flexibility and experiential acceptance were strongly associated with reductions in depression severity following psilocybin. These findings support the theoretical premise of integrating psilocybin treatment with psychotherapeutic platforms that target psychological flexibility and add to emerging evidence that increasing psychological flexibility may be an important putative mechanism of change in psilocybin-assisted therapy for MDD and potentially, other mental health conditions.
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Specific traits of the psychedelic experience, such as acceptance-related experiences, mystical experiences, or reappraisal of negative emotion, are relevant mediators of the therapeutic outcomes of psychedelic-assisted psychotherapy.
“Current research points toward specific traits of the psychedelic experience as relevant mediators of the therapeutic outcomes of PAP, such as acceptance-related experiences, the presence of mystical experiences, or the reappraisal of negative emotion (52–55).”
From Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol (2025) · cites this paper as [53]
The Introduction (page unavailable) reports that mystical-type experiences have correlated with or partially mediated outcomes in some psilocybin studies, and identifies experiential acceptance as a potential mechanism. The Discussion (page unavailable) links increased acceptance with reduced depression severity, but cautions that the association does not establish causation and says the parent trial found no significant mystical-experience correlation. The paper does not address reappraisal of negative emotion as a mediator. (LLM, conf=0.86)
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A systematic review and meta-analysis of the success of blinding in antidepressant RCTs
Scott, A. J., Sharpe, L., & Colagiuri, B. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114297 · Cited by 42 · see citing works
A Systematic Review of Study Design and Placebo Controls in Psychedelic Research
Wen, A. Q., Singhal, N., Jones, B. D. M., Zeifman, R. J., Mehta, S. H., Shenasa, M. A., Blumberger, D. M., Daskalakis, Z. J., & Weissman, C. R. (2023) · Psychedelic Medicine · doi:10.1089/psymed.2023.0028 · Cited by 36 · cited 1× · see citing works
“This issue remains ubiquitous across psychedelic research 72 and is likely a problem more broadly within psychiatry (e.g., see 73 ).”
BackgroundKiraga, M. K., Kuypers, K. P. C., Uthaug, M. V., Ramaekers, J. G., & Mason, N. L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.883869 · Cited by 26 · cited 3× · see citing works
“Within non-clinical samples, several studies have observed increases in facets of mindfulness (most consistently the facets of experiential acceptance/non-judgmental awareness) following use/administration of classic psychedelics 22,42–49 , including psilocybin 50–52 (for a review, see 53 ).”
BackgroundPsychedelics and mindfulness: A systematic review and meta-analysis
Radakovic, C., Radaković, R., Peryer, G., & Geere, J. (2022) · Journal of Psychedelic Studies · doi:10.1556/2054.2022.00218 · Cited by 24 · see citing works
Kangaslampi, S. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05703-9 · Cited by 21 · cited 1× · see citing works
“Furthermore, findings from the present study cannot firmly establish a causal effect of psilocybin therapy on psychological flexibility (for further discussion, see 67 ).”
BackgroundZeifman, R. J., Spriggs, M. J., Kettner, H., Lyons, T., Rosas, F. E., Mediano, P. A. M., Erritzøe, D., & Carhart-Harris, R. L. (2022) · doi:10.31234/osf.io/w8j6t · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS)
Zeifman, R. J., Spriggs, M. J., Kettner, H., Lyons, T., Rosas, F. E., Mediano, P. A. M., Erritzøe, D., & Carhart-Harris, R. L. (2025) · Scientific Reports · doi:10.1038/s41598-023-28111-3 · Cited by 54 · see citing works
The science of psychedelic medicine
Siegel, J. S., Liston, C. M., Nicol, G. E., Carhart-Harris, R. L., & Bogenschutz, M. P. (2026) · Nature Medicine · doi:10.1038/s41591-025-04194-5 · Cited by 24 · see citing works
“During this time, clinicians may help patients to integrate insights from their psychedelic experience or adopt behavioral changes 99,102–106 .”
Jensen, M. E., Stenbæk, D. S., Messell, C., Poulsen, E. D., Varga, T. V., Fisher, P. M., Nielsen, M. K. K., Johansen, S. S., Volkow, N. D., Knudsen, G. M., et al. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251319457 · Cited by 21 · see citing works
“Other psychological effects have been proposed to be involved in the therapeutic effects of psilocybin, including mindfulness (Heuschkel and Kuypers, 2020; Søndergaard et al., 2022) and psychological flexibility (Davis et al., 2020b; Sloshower et al., 2024).”
Zou, Y., Wang, R., Xiong, X., Bian, C., Yan, S., & Zhang, Y. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07067-w · Cited by 23 · see citing works
Kurzbaum, E., Páleníček, T., Sharchaton, A., Azerrad, S., & Dekel, Y. (2025) · Journal of Fungi · doi:10.3390/jof11020099 · Cited by 15 · see citing works
Lewis, B. R., Hendrick, J., Byrne, K., Odette, M. M., Wu, C., & Garland, E. L. (2025) · PLoS Medicine · doi:10.1371/journal.pmed.1004519 · Cited by 18 · see citing works
“While interventions such as MBSR and psilocybin may specifically target individual resilience and psychological flexibility [43,44], they do not necessarily address other possible factors mediating burnout, such as adjusting workload demands, time management skills, and conflict resolution skills.”
Schenberg, E. E. (2025) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70097 · Cited by 14 · see citing works
“Finally, some PAT clinical studies showed that qualitative and phenomenological aspects of lived experiences [107–111] and interpersonal relationships [112] correlated with treatment outcomes, which can corroborate causal claims that these are part of the therapeutic mechanism of action, or support…”
Psilocybin or Nicotine Patch for Smoking Cessation
Johnson, M. W., Naudé, G. P., Hendricks, P. S., & Garcia‐Romeu, A. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.0972 · Cited by 14 · see citing works
Acceptance as a possible link between past psychedelic experiences and psychological flexibility
Krabbe, A., Sikka, P., & Jylkkä, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-75595-8 · Cited by 13 · see citing works
“Most earlier studies on psychological flexibility and psychedelic use have considered low scores on the AAQ-II to indicate greater psychological flexibility 7,8,14,16 .”
BackgroundResultInfluentialThe Emergence of Psilocybin in Psychiatry and Neuroscience
Omidian, H., & Omidian, A. (2025) · Pharmaceuticals · doi:10.3390/ph18040555 · Cited by 12 · see citing works
“Existing models such as ACT and CFT have demonstrated the potential to enhance core therapeutic processes, including emotional regulation, psychological flexibility, and self-compassion [49–51].”
InfluentialHealing, Harms, and Humility: Expanding the Scope of Psychedelic-Assisted Psychotherapy Research
O’Donnell, K. C., Grigsby, J., & Grob, C. S. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230785 · Cited by 11 · see citing works
Zeng, J., & Wang, H. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1616925 · Cited by 9 · see citing works
RetractedPsilocybin induces sex- and context-specific recruitment of the stress axis
Cook, S. G., Lee, S., Ference, E., Shi, Y., Baimoukhametova, D. V., Rojas‐Carvajal, M., Hen, R., Bains, J. S., Turi, G. F., & Füzesi, T. (2025) · Current Biology · doi:10.1016/j.cub.2025.11.031 · Cited by 9 · see citing works
Knock, E., Siefried, K. J., Bedi, G., Albert, S., Day, R. O., Ezard, N., Ross, M., Liknaitzky, P., & Brett, J. (2025) · Addiction · doi:10.1111/add.70187 · Cited by 9 · see citing works
Gonçalves, K. T. D. C., Tavares, V. D. D. O., Barros, M. L. D. M., de Brito, A. J. C., Cavalcanti-Ribeiro, P., Palhano-Fontes, F., Falchi-Carvalho, M., Arcoverde, E., SANTOS, R. G. D., Hallak, J. E. C., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01925-6 · Cited by 7 · see citing works
Irrmischer, M., Puxty, D. J., Yıldırım, B. O., Deijen, J. B., & Engelbregt, H. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06733-3 · Cited by 6 · see citing works
“…impacting an individual’s ability to address the trauma (Ehlers and Clark 2000), while psychedelics actually increase psychological flexibility (Agin-Liebes et al. 2022; Close et al. 2020), also in the presence of depression (Doss et al. 2021; Sloshower et al. 2024) and anxiety (Davis et al. 2020).”
Brakha, T. A., Buchard, A., Mabilais, C., Alaux, S., Amberger, C., Furtado, L., Seragnoli, F., Briefer, J.-F., Thorens, G., Sabé, M., et al. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.116992 · Cited by 6 · see citing works
“These findings converge with models positing that changes in psychological flexibility and emotion regulation may mediate reduction in depression and anxiety following psychedelic-assisted therapy [24-27].”
Sabucedo, P., Andión, O., Neimeyer, R. A., Soto-Angona, O., Javkin, J., Haro, J. M., Farré, M., & González, D. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1484736 · Cited by 6 · see citing works
The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders
Kim, V., Wilson, S. M., & Woesner, M. E. (2024) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001941 · Cited by 5 · see citing works
Pilot study of psilocybin in patients with post-treatment lyme disease
Garcia‐Romeu, A., Naudé, G. P., Rebman, A. W., So, S., Yaffe, A., Geithner, I., Kozero, E. A., Yang, T., Soloski, M. J., & Aucott, J. N. (2026) · Scientific Reports · doi:10.1038/s41598-026-38091-9 · Cited by 5 · see citing works
Psychedelics for the treatment of end-of-life distress in patients with a life-threatening disease
Tap, S. C., Bostoen, T., Breeksema, J. J., & Schoevers, R. A. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.03.001 · Cited by 4 · see citing works
Exploring serotonergic psychedelics as a treatment for personality disorders
Carrithers, B. M., Roberts, D. E., Weiss, B., King, J. D., Carhart-Harris, R. L., Gordon, A. R., Pagni, B. A., Moreau, M., Ross, S., & Zeifman, R. J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110413 · Cited by 4 · see citing works
Lewis, B. R., Hendrick, J., Byrne, K., Odette, M. M., Wu, C., & Garland, E. L. (2025) · medRxiv · doi:10.1101/2024.12.31.24319806 · Cited by 4 · see citing works
From molecules to meaning: unpacking the antidepressant mechanisms of psychedelic drugs
Acero, V. P., Flatt, T. A., Gooch, P. M., Gaughan, S. J., Levin, A. W., & Davis, A. K. (2025) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2025.2515866 · Cited by 4 · see citing works
Modlin, N., Williamson, V., Maggio, C., Stubley, J., Kirlić, N., Cleare, A., & Rucker, J. J. (2025) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253251342319 · Cited by 3 · see citing works
Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome
Mauney, E. E., King, F., Murray, H. B., & Kuo, B. (2025) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002149 · Cited by 3 · see citing works
“41 Psychological fl exibility, a core concept in acceptance and commitment therapy (ACT) — a therapeutic approach on which many PAT therapy manuals are based 42,43 — refers to the ability to adapt to challenges by balancing and changing behaviors, thoughts, and emotions in the face of stress.”
Beesley, V. L., Kennedy, T., Maccallum, F., Ross, M., Harvey, R., Rossell, S., Sarris, J., Perkins, D., Neale, R. E., Bennett-levy, J., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-095992 · Cited by 2 · see citing works
Kerr‐Gaffney, J., Myrtle, S., Askari, F., Bird, C., Modlin, N. L., Young, A. H., & Rucker, J. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811251408769 · Cited by 3 · see citing works
“In those with depression, a past study did not find that improvements in cognitive flexibility were related to improvements in depression (Doss et al., 2021), whilst another study found strong associations between the two (Sloshower et al., 2024).”
Positive psychology 4.0: a science of consequence for a world that can no longer wait
van Zyl, L. E. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1726065 · Cited by 2 · see citing works
“More research is starting to emerge as to the use of psychedelics as a means to help manage psychopathology but also to help people find more meaning and purpose in their lives (Rupiński et al., 2025; Sloshower et al., 2024).”
InfluentialKoning, E., Chaves, C., Kirkpatrick, R. H., & Brietzke, E. M. (2024) · Journal of Eating Disorders · doi:10.1186/s40337-024-01185-8 · Cited by 2 · see citing works
Is there a place for psychedelics in sports practice?
Portes, M. A. M., Werle, I., & Bertoglio, L. J. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2025.13 · Cited by 2 · see citing works
Singh, A. N. A., & de Assis, G. L. (2025) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-025-00368-7 · Cited by 3 · see citing works
“…psychological flexibility improved and were maintained to week 16, with greater gains significantly associated with larger depression reductions after psilocybin [76]; and group “communitas” predicted enduring improvements at 4 weeks in well-being and social connectedness ( r = 0.22–0.25; [77]).”
InfluentialExploring Factors Affecting Psychological Flexibility After Psychedelic Experiences
Roméo, B., Kervadec, E., Fauvel, B., Strika-Bruneau, L., Amirouche, A., Verroust, V., Piolino, P., & Benyamina, A. (2025) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2025.2495937 · Cited by 1 · see citing works
Mehmood, M., Bremler, R., Spriggs, M. J., Kettner, H., Roseman, L., Damgaard, L., Carhart-Harris, R. L., Erritzøe, D., & Zeifman, R. J. (2025) · Psychedelic Medicine · doi:10.1177/28314425251392251 · Cited by 2 · see citing works
Psilocybin-assisted cognitive behavioral therapy for major depressive disorder: A pilot trial
Weintraub, M. J., Jeffrey, J. K., Ichinose, M. C., Bergman, R. L., Shapiro, B., Barnett, G., Artin, H., Lynn, M., Salimian, A., Grody, S., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121423 · Cited by 1 · see citing works
Psychological support in psychedelic-assisted therapy clinical trials: A systematic review
Brusky, B., M’Baïlara, K., Alla, F., & Barrault, M. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261424204 · Cited by 1 · see citing works
“…mediate outcomes, including oceanic boundlessness and ego dissolution; emotional regulation; psychological flexibility; rumination and thought suppression; and experiential avoidance (Barba et al., 2022; Roseman et al., 2018; Sloshower et al., 2024; Van Der Kolk et al., 2024; Zeifman et al., 2023).”
Therapist-rated predictors of response to psychedelic-assisted therapy
Viljoen, G., Bendau, A., Walter, H., Mertens, L. J., Evens, R., Wolff, M., Herwig, U., Johnson, M. W., Seynaeve, M., Koslowski, M., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00642-4 · Cited by 1 · see citing works
“…in therapeutic improvement following psy-chedelic experiences, including increased self-compassion 16 , increased Article https://doi.org/10.1038/s44220-026-00642-4 mindfulness 17 , reductions in experiential avoidance 18 , increases in psychological flexibility 19,20 and enhanced empathy 21 .”
InfluentialBolcont, R., Palhano-Fontes, F., Barros, H., Laborde, S., Amorim, D., Falchi-Carvalho, M., Coelho, N. L. G., Wießner, I., & de Araújo, D. B. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261465005 · Cited by 1 · see citing works
“…with depression and existential distress related to life-threatening illnesses, where reductions in anxiety co-occurred with increases in life satisfaction, meaning in life, and psychological flexibility (Goodwin et al., 2023; Griffiths et al., 2016; Raison et al., 2023; Sloshower et al., 2024).”
Systems-based psychiatry: insights from psychedelic research on mechanisms of healing
Shannon, S., & Weil, A. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1789902 · Cited by 1 · see citing works
Experience, plasticity, and context: Beyond single-level models of antidepressant action
Eckert, D. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261473402 · Cited by 1 · see citing works
Strika-Bruneau, L., Elhssaini, C., Fauvel, B., Kervadec, E., Bezo, A., Amirouche, A., Benyamina, A., & Roméo, B. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261473436 · Cited by 1 · see citing works
Protecting Patient Autonomy in Psychedelic-Assisted Psychotherapy: A Nursing Ethics Perspective
Tustison, J., Niemi, C. A., & Choi, K. R. (2025) · Issues in Mental Health Nursing · doi:10.1080/01612840.2025.2514624 · Cited by 1 · see citing works
“Recent research suggests that psychological flexibility may be a key mechanism of change in psilocybin-assisted therapy for depression (Sloshower et al., 2024).”
Potencial terapéutico de la psilocibina en neuropsiquiatría: una revisión narrativa
Faccini-Durán, G. (2025) · Acta neurológica colombiana · doi:10.22379/anc.v41i3.1922
Reuter, T. K., Sears, F., & Gezon, L. L. (2025) · Anthropology of Consciousness · doi:10.1111/anoc.70026
The interplay of psychedelic use and meditation in shaping psychological well-being
Krabbe, A., Sikka, P., & Jylkkä, J. (2025) · Consciousness and Cognition · doi:10.1016/j.concog.2025.103977
“Additionally, we included a multidimensional measure of psychological flexibility and inflexi-bility, given evidence that improvements in psychological flexibility may mediate the therapeutic effects of psychedelics (Davis et al., 2020; Sloshower et al., 2024).”
Brett, J., Lea, T., Knock, E., Albert, S. M., Acheson, L. S., Siefried, K. J., & Job, S. (2025) · Addiction · doi:10.1111/add.70284
Psychological Flexibility Scale: Validity and Reliability Study
Bozkurt, E. G., & KARDAŞ, F. (2025) · Adıyaman Üniversitesi Eğitim Bilimleri Dergisi · doi:10.17984/adyuebd.1660097
Psilocibina en depresión: mecanismos neurobiológicos y cambios cognitivos
Arias, A. V., Ramírez, M. C., López, A. H., & Becerra-Hernández, L. V. (2026) · Acta neurológica colombiana · doi:10.22379/anc.v42i1.1926
Predictors of the Effectiveness of Psychedelics in Treating Depression—A Scoping Review
Chmiel, J., & Rybakowski, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052202 · Cited by 1 · see citing works
“…more after psilocybin than placebo and tracked symptom change with exceptional precision—QIDS improvement correlated ρ = 0.88 ( p < 0.001) with AAQ-II gains and ρ = − 0.64 ( p = 0.014) with increased “accept without judgment”; these mind–symptom couplings were absent in the placebo condition [67].”
InfluentialInserra, A., VanderZwaag, J., Campanale, A., Murray, C. J., & Szabo, A. J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27340-7.00008-5
Gu, E. Y., Irvine, N. M., Miller, M. J., Ramirez, E., Santaella-Tenorio, J., Lippincott, T., Bogenschutz, M. P., Bunting, A. M., Meacham, M. C., & Krawczyk, N. (2026) · Journal of Psychedelic Studies · doi:10.1556/2054.2026.00487
Low, Z. X. B. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111717
Geller, J. A., Pacilio, R. M., Downey, A. E., Ragnhildstveit, A., Raymond‐Flesch, M., Knatz-Peck, S., & Gukasyan, N. (2026) · Current Psychiatry Reports · doi:10.1007/s11920-026-01679-z
Psilocybin and Mental Health Outcomes: Scoping Review with ☸SAIMSARA
SAIMSARA (2026) · SAIMSARA Journal · doi:10.62487/saimsara7a54f680
Retreat from racism: A psychedelic group experience for racial stress and trauma
Rosal, S. R. P., Faber, S. C., MacIntyre, M., & Williams, M. T. (2026) · Psychedelics · doi:10.1016/j.psyche.2026.100031
Back, A. L., & Bosnak, R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1895181
Oliveira, P. D., Meunier, H., Breton, A., & Dambrun, M. (2026) · Neuroscience of Consciousness · doi:10.1093/nc/niag022
“2021, Sloshower et al .”
Simon, G., Hopper, J. W., Cherniak, A. D., Cassidy, E. K., Skragge, M., & Granqvist, P. (2026) · Neuroethics · doi:10.1007/s12152-026-09672-2
Mathai, D. S., Pilecki, B. C., Zaki, H., Morris, T., Morris, M., & Garcia‐Romeu, A. (2026) · Psychedelics · doi:10.1016/j.psyche.2026.100046
Szarpak, Ł., Pruc, M., Jablonska-Moczulo, D., Niewiadomska, I., Rybczynski, B., & Cubała, W. J. (2026) · Therapeutics · doi:10.3390/therapeutics3040021
Clinical Evidence on Psilocybin and Its Representation in Media Reporting
Madden, K., Flood, B., Kashir, I., Ahmad, R., Ali, H., Petranker, R., MacKillop, J., & Adili, A. F. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.38843
Treatment expectation is associated with willingness to participate in a psychedelic clinical trial
Payton, A. P., Flohr, J., Heifets, B. D., & Sikka, P. (2026) · Journal of Psychedelic Studies · doi:10.1556/2054.2026.00498
- Authors
- Sloshower, J., Zeifman, R. J., Guss, J., Krause, R., Safi-Aghdam, H., Pathania, S., Pittman, B., & D’Souza, D. C.
- Affiliations
- Yale University (US)
- NYU Langone Health (US)
- New York University (US)
- Corresponding author
- Sloshower, Jordan
- ORCID
- Venue
- Scientific Reports
- Published
- 2024-04-17
- Volume
- 14
- Issue
- 1
- Pages
- 8833-8833
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC11024097
- OpenAlex
- W4394886406
- Cited by
- 65
- References
- 71
- Citations by year
- 2026: 31 · 2025: 30 · 2024: 4
- FWCI
- 32.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Heffter Research Institute
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- psilocybin-assisted therapy, major depressive disorder, psychological flexibility, mechanisms of change, acceptance and commitment therapy, mindfulness, experiential acceptance, psychedelic therapy, depression severity
- MeSH terms
- Depression, Major Depressive Disorder, Hallucinogens, Humans, Psilocybin, Acceptance and Commitment Therapy
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