Cited by 514Stress Responses and CortisolChild Abuse and TraumaTreatment of Major Depression

The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Heim, Christine, Plotsky, Paul M, Nemeroff, Charles B·2004·Neuropsychopharmacology

Open this paper in CoChat — free account

Abstract

Almost four decades of intensive research have sought to elucidate the neurobiological bases of depression. Epidemiological studies have revealed that both genetic and environmental factors contribute to the risk for depression. Adverse early-life experiences influence neurobiological systems within genetic limits, leading to the neurobiological and behavioral manifestations of depression. We summarize the burgeoning evidence concerning a pre-eminent role of early adverse experience in the pathogenesis of depression. The available data suggest that (1) early adverse experience contributes to the pathophysiology of depression, (2) there are neurobiologically different subtypes of depression depending on the presence or absence of early adverse experience, likely having confounded previous research on the neurobiology of depression, and (3) early adverse experience likely influences treatment response in depression. Classification of depression based on developmental and neurobiological features will likely considerably improve future research in the field of depression, and might lead to optimized treatment strategies that directly target different neurobiological pathways to depression.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300397

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Self-citation
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Self-citation
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Self-citation
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Self-citation
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Self-citation
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437
Self-citation
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Self-citation
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352

Flagged first, then by citations

Show all 88 references

Research works printed but not linked: 1

Plotsky PM, Sánchez MM, Levine S (2001). Intrinsic and extrinsic factors modulating physiological coping systems during development. In: Broom DM (ed). Coping with Challenge. Dahlem University Press: Berlin. pp 169–196.

Sorted by citations

Items 101–200 of 513

HPA axis and sleep: Identifying subtypes of major depression
Antonijevic, I. A., & Antonijevic, I. A. (2008) · Stress · doi:10.1080/10253890701378967 · Cited by 140
Learning under stress in the adult rat is differentially affected by ‘juvenile’ or ‘adolescent’ stress
Tsoory, M., & Richter‐Levin, G. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006255 · Cited by 134
Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in Life
Schepanski, S. N., Buß, C., Hanganu‐Opatz, I. L., & Arck, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02186 · Cited by 137
Interaction between Oxytocin Genotypes and Early Experience Predicts Quality of Mothering and Postpartum Mood
Mileva‐Seitz, V. R., Steiner, M. S., Atkinson, L. R., Meaney, M. J., Levitan, R. D., Kennedy, J. L., Sokolowski, M. B., & Fleming, A. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061443 · Cited by 134
Interrelated and interdependent
Diamond, A. D. (2006) · Developmental Science · doi:10.1111/j.1467-7687.2007.00578.x · Cited by 137
Stress during Adolescence Increases Novelty Seeking and Risk-Taking Behavior in Male and Female Rats
Toledo-Rodriguez, M., & Sandi, C. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00017 · Cited by 126
Foundations of posttraumatic stress disorder: Does early life trauma lead to adult posttraumatic stress disorder?
Pratchett, L. C., & Yehuda, R. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000186 · Cited by 142
Childhood maltreatment is associated with a sex‐dependent functional reorganization of a brain inhibitory control network
Elton, A., Tripathi, S. P., Mletzko, T., Young, J., Cisler, J. M., James, G. A., & Kilts, C. D. (2014) · Human Brain Mapping · doi:10.1002/hbm.22280 · Cited by 119
Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., Zimmermann, U. S., Schmidt, M. H., Esser, G., Rietschel, M., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009875 · Cited by 127
Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome
Eede, F. V. D., Moorkens, G. H., Houdenhove, B. V., Cosyns, P. R., & Claes, S. J. (2007) · Neuropsychobiology · doi:10.1159/000104468 · Cited by 125
Early child adversity and psychopathology in adulthood: HPA axis and cognitive dysregulations as potential mechanisms.
Raymond, C., Marin, M.-F., Majeur, D., & Lupien, S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.015 · Cited by 120
Depressive Symptoms in Adults Separated from Their Parents as Children: A Natural Experiment during World War II
Pesonen, A., Räikkönen, K., Heinonen, K., Kajantie, E., Forsén, T., & Eriksson, J. G. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm254 · Cited by 118
Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences
Claessens, S. E. F., Daskalakis, N. P., van der Veen, R., Oitzl, M. S., de Kloet, E. R., & Champagne, D. L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2118-y · Cited by 123
Long-term effects of early life deprivation on brain glia in Fischer rats
Leventopoulos, M., Rüedi‐Bettschen, D., Knuesel, I., Feldon, J., Pryce, C. R., & Opacka‐Juffry, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.039 · Cited by 125
The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles
Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115
HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
Binder, E. B., Kunzel, H. E., Nickel, T., Kern, N., Pfennig, A., Majer, M., Uhr, M., Ising, M., & Holsboer, F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.018 · Cited by 118
Enriched Environment Experience Overcomes Learning Deficits and Depressive-Like Behavior Induced by Juvenile Stress
Ilin, Y., & Richter‐Levin, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004329 · Cited by 116
Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: Why depression feels so bad and what addicts really want
Zellner, M. R., Watt, D. F., Solms, M., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.003 · Cited by 112
Stress load during childhood affects psychopathology in psychiatric patients
Weber, K., Rockstroh, B. S., Borgelt, J., Awiszus, B., Popov, T. G., Hoffmann, K. K. P., Schonauer, K., Watzl, H., & Pröpster, K. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-63 · Cited by 112
Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration
Jonas, W., Mileva‐Seitz, V. R., Girard, A. W., Bisceglia, R., Kennedy, J. L., Sokolowski, M. B., Meaney, M. J., Fleming, A. S., & Steiner, M. S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12069 · Cited by 111
Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury
Reichl, C., Heyer, A., Brunner, R. M., Parzer, P., Völker, J. M., Resch, F., & Kaess, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.011 · Cited by 112
Early Social Adversity, Altered Brain Functional Connectivity, and Mental Health
Holz, N. E., Berhe, O., Sacu, S., Schwarz, E., Tesarz, J., Heim, C. C., & Tost, H. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.019 · Cited by 114
Self-citation
Stress reactivity in war-exposed young children with and without posttraumatic stress disorder: Relations to maternal stress hormones, parenting, and child emotionality and regulation
Feldman, R., Vengrober, A., Eidelman-Rothman, M., & Zagoory‐Sharon, O. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000291 · Cited by 109
The Rise in Cortisol in Family Day Care: Associations With Aspects of Care Quality, Child Behavior, and Child Sex
Gunnar, M. R., Kryzer, E. M., Ryzin, M. J. V., & Phillips, D. A. (2010) · Child Development · doi:10.1111/j.1467-8624.2010.01438.x · Cited by 109
Depression research and treatment: Are we skating to where the puck is going to be?
Luyten, P., Blatt, S. J., Houdenhove, B. V., & Corveleyn, J. M. T. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.12.003 · Cited by 115
Psychostimulant withdrawal as an inducing condition in animal models of depression
Barr, A. M., & Markou, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.012 · Cited by 112
Stress before Puberty Exerts a Sex- and Age-Related Impact on Auditory and Contextual Fear Conditioning in the Rat
Toledo‐Rodriguez, M., & Sandi, C. (2007) · Neural Plasticity · doi:10.1155/2007/71203 · Cited by 109
The impact of life stress on adult depression and anxiety is dependent on gender and timing of exposure
Herbison, C. E., Allen, K. L., Robinson, M., Newnham, J. P., & Pennell, C. E. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000372 · Cited by 106
Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats
Schwetz, I., McRoberts, J. A., Coutinho, S. V., Bradesi, S., Gale, G. D., Fanselow, M. S., Million, M., Ohning, G., Taché, Y., Plotsky, P. M., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00498.2004 · Cited by 109
Self-citation
Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models
Kehne, J. H., & Cain, C. K. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.011 · Cited by 106
Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects
Bondar, N. P., Lepeshko, A. A., & Reshetnikov, V. V. (2018) · Behavioural Neurology · doi:10.1155/2018/1538931 · Cited by 115
The Neurobiological Bases of Memory Formation: From Physiological Conditions to Psychopathology
Bisaz, R., Travaglia, A., & Alberini, C. M. (2014) · Psychopathology · doi:10.1159/000363702 · Cited by 124
Long-term effects of early life stress exposure: Role of epigenetic mechanisms
Silberman, D. M., Acosta, G. B., & Zubilete, M. A. Z. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.033 · Cited by 114
Prevalence of exposure to potentially traumatic events in a healthy birth cohort of very young children in the northeastern United States
Briggs‐Gowan, M. J., Ford, J. D., Fraleigh, L., McCarthy, K., & Carter, A. S. (2010) · Journal of Traumatic Stress · doi:10.1002/jts.20593 · Cited by 125
Effects of neonatal handling on social memory, social interaction, and number of oxytocin and vasopressin neurons in rats
Todeschin, A. S., Duarte, E. C. W., Jacob, M., Aranda, B. C. C., Jacobs, S., Fernandes, M. D. C., Ribeiro, M. F. M., Sanvitto, G. L., & Lucion, A. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.006 · Cited by 103
Effects of early stress on behavioral syndromes: An integrated adaptive perspective
Sih, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.015 · Cited by 106
The international society for developmental psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development
Sullivan, R. M., Wilson, D. A., Feldon, J., Yee, B. K., Meyer, U., Richter‐Levin, G., Avital, A., Tsoory, M., Gruß, M., Bock, J., et al. (2006) · Developmental Psychobiology · doi:10.1002/dev.20170 · Cited by 102
Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats
Rüedi-Bettschen, D., Pedersen, E.-M., Feldon, J., & Pryce, C. R. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.001 · Cited by 97
Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent
Chen, Y., Fenoglio, K. A., Dubé, C. M., Grigoriadis, D. E., & Baram, T. Z. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001863 · Cited by 98
Cerebrospinal Fluid Corticotropin-Releasing Factor Concentration is Associated with Pain but not Fatigue Symptoms in Patients with Fibromyalgia
McLean, S. A., Williams, D. A., Stein, P. K., Harris, R. E., Lyden, A. K., Whalen, G., Park, K. M., Liberzon, I., Sen, A., Gracely, R. H., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301200 · Cited by 101
Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory
McClelland, S., Kőrösi, A., Cope, J. L., Ivy, A. S., & Baram, T. Z. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.008 · Cited by 101
Early life abuse and risk of endometriosis
Harris, H. R., Wieser, F. A., Vitonis, A. F., Rich-Edwards, J. W., Boynton‐Jarrett, R., Bertone‐Johnson, E. R., & Missmer, S. A. (2018) · Human Reproduction · doi:10.1093/humrep/dey248 · Cited by 97
Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats
Levant, B., Ozias, M. K., Davis, P. F., Winter, M. K., Russell, K. L., Carlson, S. E., Reed, G. A., & McCarson, K. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.06.012 · Cited by 102
Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment.
Vivinetto, A. L., Suárez, M. M., & Rivarola, M. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.014 · Cited by 103
The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset
Pryce, C. R., Aubert, Y., Maier, C., Pearce, P. C., & Fuchs, E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1989-2 · Cited by 94
Rumination as a Mediator between Childhood Trauma and Adulthood Depression/Anxiety in Non-clinical Participants
Kim, J. S., Jin, M. J., Jung, W., Hahn, S., & Lee, S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01597 · Cited by 110
The pathways from mother's love to baby's future
Kőrösi, A. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.027.2009 · Cited by 95
Self-reported symptoms of depressed mood, trait anxiety and aggressive behavior in post-pubertal adolescents: Associations with diurnal cortisol profiles
den Bergh, B. R. H. V., CALSTER, B. V., Puissant, S. P., & Huffel, S. V. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.03.015 · Cited by 94
Early life stress and novelty seeking behavior in adolescent monkeys
Parker, K. J., Rainwater, K. L., Buckmaster, C. L., Schatzberg, A. F., Lindley, S. E., & Lyons, D. M. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.008 · Cited by 89
Developmental origins of flatter cortisol rhythms: socioeconomic status and adult cortisol activity
DeSantis, A. S., Kuzawa, C. W., & Adam, E. K. (2015) · American Journal of Human Biology · doi:10.1002/ajhb.22668 · Cited by 86
Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders
Tsoory, M., Guterman, A., & Richter‐Levin, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301397 · Cited by 88
Impact of Psychosocial Adversity on Alcohol Intake in Young Adults: Moderation by the LL Genotype of the Serotonin Transporter Polymorphism
Laucht, M., Treutlein, J., Schmid, B., Blomeyer, D., Becker, K., Buchmann, A. F., Schmidt, M. H., Esser, G., Jennen-Steinmetz, C., Rietschel, M., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.010 · Cited by 90
Early-life stress and recurrent psychological distress over the lifecourse predict divergent cortisol reactivity patterns in adulthood
Goldman-Mellor, S. J., Hamer, M., & Steptoe, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.010 · Cited by 88
Long-term consequences of parental death in childhood: Psychological and physiological manifestations.
Luecken, L. J. (2008) · Handbook of bereavement research and practice: Advances in theory and intervention. · doi:10.1037/14498-019 · Cited by 89
Changes in cortical thickness across the lifespan in major depressive disorder
Truong, W., Minuzzi, L., Soares, C. N., Frey, B. N., Evans, A. C., MacQUEEN, G. M., & Hall, G. B. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.09.003 · Cited by 85
Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome
Rajeevan, M. S., Smith, A. K., Dimulescu, I. M., Unger, E. R., Vernon, S. D., Heim, C. C., & Reeves, W. C. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00244.x · Cited by 78
Self-citation
From stress to postpartum mood and anxiety disorders: How chronic peripartum stress can impair maternal adaptations
Hillerer, K. M., Neumann, I. D., & Slattery, D. A. (2012) · Neuroendocrinology · doi:10.1159/000330445 · Cited by 82
Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression
Hornung, O. P., & Heim, C. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00014 · Cited by 85
Self-citation
Post-weaning isolation promotes food intake and body weight gain in rats that experienced neonatal maternal separation
Ryu, V., Yoo, S. B., Kang, D. W., Lee, J.-H., & Jahng, J. W. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.006 · Cited by 83
Corticosteroid effects on cellular physiology of limbic cells
Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.036 · Cited by 77
Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
Post, R. M., Altshuler, L. L., Leverich, G. S., Frye, M. A., Suppes, T. M., McElroy, S. L., Keck, P. E., Nolen, W. A., Kupka, R., Grunze, H., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.020 · Cited by 76
The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure
Dammering, F., Martins, J., Dittrich, K., Czamara, D., Rex‐Haffner, M., Overfeld, J., de Punder, K., Buß, C., Entringer, S., Winter, S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100394 · Cited by 81
Self-citation
A Model for the Involvement of Neural Cell Adhesion Molecules in Stress-Related Mood Disorders
Sandi, C., & Bisaz, R. (2007) · Neuroendocrinology · doi:10.1159/000101535 · Cited by 76
Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling
Duchesne, A., Dufresne, M. M., & Sullivan, R. M. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.11.012 · Cited by 75
Plasticity of the stress response early in life: Mechanisms and significance
Kőrösi, A., & Baram, T. Z. (2010) · Developmental Psychobiology · doi:10.1002/dev.20490 · Cited by 78
Early deprivation leads to altered behavioural, autonomic and endocrine responses to environmental challenge in adult Fischer rats
Rüedi‐Bettschen, D., Zhang, W., Russig, H., Ferger, B., Weston, A. A., Pedersen, E., Feldon, J., & Pryce, C. R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05158.x · Cited by 79
The Serotonin Transporter and Early Life Stress: Translational Perspectives
Houwing, D. J., Buwalda, B., van der Zee, E. A., de Boer, S. F., & Olivier, J. D. A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00117 · Cited by 83
Mood and malignancy: head and neck cancer and depression
Archer, J. A., Hutchison, I. L., & Korszun, A. (2008) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2008.00635.x · Cited by 72
Gender, Traumatic Events, and Mental Health Disorders in a Rural Asian Setting
Axinn, W. G., Ghimire, D. J., Williams, N. E., & Scott, K. M. (2013) · Journal of Health and Social Behavior · doi:10.1177/0022146513501518 · Cited by 76
Eye movement desensitization and reprocessing ( EMDR ) therapy in the treatment of depression: a matched pairs study in an inpatient setting
Hase, M., Balmaceda, U. M., Hase, A., Lehnung, M., Tumani, V., Huchzermeier, C., & Hofmann, A. (2015) · Brain and Behavior · doi:10.1002/brb3.342 · Cited by 72
Early Adverse Care, Stress Neurobiology, and Prevention Science: Lessons Learned
Bruce, J., Gunnar, M. R., Pears, K. C., & Fisher, P. A. (2013) · Prevention Science · doi:10.1007/s11121-012-0354-6 · Cited by 75
The centrality of personal relationships in the creation and amelioration of mental health problems: the current interdisciplinary case
Pilgrim, D. M., Rogers, A. E., & Bentall, R. P. (2009) · Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine · doi:10.1177/1363459308099686 · Cited by 69
Therapeutic Alliance as Active Inference: The Role of Therapeutic Touch and Synchrony
McParlin, Z., Cerritelli, F., Friston, K. J., & Esteves, J. E. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.783694 · Cited by 76
An animal model of eating disorders associated with stressful experience in early life
Jahng, J. W. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.11.010 · Cited by 73
The Interplay of Familial Depression Liability and Adverse Events in Predicting the First Onset of Depression During a 10-Year Follow-up
Zimmermann, P., Brückl, T. M., Lieb, R., Nocon, A., Ising, M., Beesdo‐Baum, K., & Wïttchen, H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.020 · Cited by 67
The relationship between fibromyalgia and major depressive disorder: a comprehensive review
Pae, C., Luyten, P., Marks, D. M., Han, C., Park, S., Patkar, A. A., Masand, P. S., & Houdenhove, B. V. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802288338 · Cited by 70
A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression
Zaninotto, L., Solmi, M., Veronese, N., Guglielmo, R., Ioime, L., Camardese, G., & Serretti, A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.039 · Cited by 70
Long‐term colonic hypersensitivity in adult rats induced by neonatal unpredictable vs predictable shock
Tyler, K., Moriceau, S., Sullivan, R. M., & Greenwood‐van Meerveld, B. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00955.x · Cited by 63
Using animal models to study post‐partum psychiatric disorders
Perani, C. V., & Slattery, D. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12640 · Cited by 62
The Effects of Maltreatment and Neuroendocrine Regulation on Memory Performance
Cicchetti, D., Rogosch, F. A., Howe, M. L., & Toth, S. L. (2010) · Child Development · doi:10.1111/j.1467-8624.2010.01488.x · Cited by 73
Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats
Jones, N. C., Kumar, G., O'Brien, T. J., Morris, M. J., Rees, S. M., & Salzberg, M. R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.023 · Cited by 61
Variations of maternal care alter offspring levels of behavioural defensiveness in adulthood: Evidence for a threshold model
MENARD, J., & Hakvoort, R. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.014 · Cited by 62
Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats
Glover, M. E., Pugh, P. C., Jackson, N., Cohen, J. L., Fant, A. D., Akil, H., & Clinton, S. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.044 · Cited by 64
Quality of early mother–child interaction associated with depressive psychopathology in the offspring: A prospective study from infancy to adulthood
Schmid, B., Blomeyer, D., Buchmann, A. F., Trautmann‐Villalba, P., Zimmermann, U. S., Schmidt, M. H., Esser, G., Banaschewski, T., & Laucht, M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.05.010 · Cited by 67
High novelty-seeking rats are resilient to negative physiological effects of the early life stress
Clinton, S. M., Watson, S. J., & Akil, H. (2013) · Stress · doi:10.3109/10253890.2013.850670 · Cited by 62
Relationship Between Childhood Physical Maltreatment and Migraine in Adolescents
Fuh, J., Wang, S., Juang, K., Lu, S., Liao, Y., & Chen, S. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01639.x · Cited by 59
Dysregulation of the cortisol diurnal rhythm following prenatal alcohol exposure and early life adversity
McLachlan, K., Rasmussen, C., Oberlander, T. F., Loock, C., Pei, J. R., Andrew, G., Reynolds, J. N., & Weinberg, J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.03.003 · Cited by 62
Iatrogenic opioid use disorder, chronic pain and psychiatric comorbidity: A systematic review
van Rijswijk, S. M., Beek, M. H. C. T. V., Schoof, G. M., Schene, A. H., Steegers, M. A. H., & Schellekens, A. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.04.008 · Cited by 63
Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: Are we there yet?
Adam, E. K., Sutton, J. M., Doane, L. D., & Mineka, S. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000461 · Cited by 63
Anxious attachment style and salivary cortisol dysregulation in healthy female children and adolescents
Oskis, A., Loveday, C., Hucklebridge, F. H., Thorn, L., & Clow, A. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02296.x · Cited by 58
The impact of childhood residential mobility on mental health outcomes in adolescence and early adulthood: a record linkage study
Tseliou, F., Maguire, A., Donnelly, M., & O’Reilly, D. (2015) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2015-206123 · Cited by 61
HISTORY OF CHILDHOOD ABUSE AND MOTHER-INFANT INTERACTION: A SYSTEMATIC REVIEW OF OBSERVATIONAL STUDIES
Vaillancourt, K., Pawlby, S. J., & Fearon, P. R. M. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21634 · Cited by 69
Interrelationship of childhood trauma, neuroticism, and depressive phenotype
Moskvina, V., FARMER, A. E., Swainson, V., O'Leary, J., Gunasinghe, C., Owen, M., Craddock, N. J., McGuffin, P., & Korszun, A. (2006) · Depression and Anxiety · doi:10.1002/da.20216 · Cited by 58
Daytime Cortisol Secretion in 6-Month-Old Twins: Genetic and Environmental Contributions as a Function of Early Familial Adversity
Ouellet‐Morin, I., Dionne, G., Pérusse, D., LUPIEN, S. J., Arseneault, L., Barr, R. G., Tremblay, R. E., & Boivin, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.003 · Cited by 57
Hyperphagia and depression‐like behavior by adolescence social isolation in female rats
Jahng, J. W., Yoo, S. B., Ryu, V., & Lee, J. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.10.001 · Cited by 56
Behavioral effects of environmental enrichment during gestation in WKY and Wistar rats
Rosenfeld, A., & Weller, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.006 · Cited by 55
Childhood trauma and basal cortisol in people with personality disorders
Flory, J. D., Yehuda, R., Grossman, R., New, A. S., Mitropoulou, V., & Siever, L. J. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.05.007 · Cited by 54
Pathogenic involvement of neuropeptides in anxiety and depression
Alldredge, B. (2010) · Neuropeptides · doi:10.1016/j.npep.2009.12.014 · Cited by 56
Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study.
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A., Schmidt, M., Esser, G., Jennen-Steinmetz, C., Rietschel, M., & Banaschewski, T. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.002 · Cited by 46
Early-life events. Effects on aging
Kajantie, E. (2008) · HORMONES · doi:10.1007/bf03401501 · Cited by 55

Authors: Heim, C., Plotsky, P. M., & Nemeroff, C. B.
Affiliations: Emory University (US)
Corresponding author: Nemeroff, Charles B
ORCID: Heim, Christine
Nemeroff, Charles B
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2004-03-03
Volume: 29
Issue: 4
Pages: 641-648
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300397
OpenAlex: W2329414057
Cited by: 514
References: 88
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 12 · 2019: 16 · 2018: 15 · 2017: 24 · 2016: 31 · 2015: 23 · 2014: 28 · 2013: 32 · 2012: 27
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (R01MH042088, P50MH058922, MH58922, MH42088)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: childhood adversity, depression, neurobiology of depression, depression pathogenesis, genetic and environmental risk factors, depression subtypes, treatment response, developmental origins of mental disorders, depression classification
MeSH terms: Animals, Depression, Environment, Humans, Hypothalamo-Hypophyseal System, Life Change Events, Neurobiology, Pituitary-Adrenal System, Stress, Physiological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks