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In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks
Abstract
In vivo acute toxicity of high doses of nanoparticles of three different porous iron(III) carboxylate Metal–Organic Frameworks (nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.
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Citations
Cites
Functional Porous Coordination Polymers
Kitagawa, S., Kitaura, R., & Noro, S. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200300610 · Cited by 11,071
Hybrid porous solids: past, present, future
Férey, G. (2008) · Chem. Soc. Rev. · doi:10.1039/b618320b · Cited by 5,822
Eddaoudi, M., Moler, D. B., Li, H., Chen, B., Reineke, T. M., O'Keeffe, M., & Yaghi, O. M. (2001) · Accounts of Chemical Research · doi:10.1021/ar000034b · Cited by 5,180
Horcajada, P., Chalati, T., Serre, C., Gillet, B., Sebrie, C., Baati, T., Eubank, J. F., Heurtaux, D., Clayette, P., Kreuz, C., et al. (2010) · Nature Materials · doi:10.1038/nmat2608 · Cited by 4,260
Self-citationMetal–Organic Frameworks in Biomedicine
Horcajada, P., Gref, R., Baati, T., Allan, P. K., Maurin, G., Couvreur, P., Férey, G., Morris, R. E., & Serre, C. (2012) · Chemical Reviews · doi:10.1021/cr200256v · Cited by 4,168
Self-citationLong-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,515
LXXIII.—Oxidation of tartaric acid in presence of iron
Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,920
Self-citationThe catalytic decomposition of hydrogen peroxide by iron salts
Haber, F., & Weiss, J. (1934) · Proceedings of the Royal Society of London. Series A - Mathematical and Physical Sciences · doi:10.1098/rspa.1934.0221 · Cited by 2,571
Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery
Della Rocca, J., Liu, D., & Lin, W. (2011) · Accounts of Chemical Research · doi:10.1021/ar200028a · Cited by 2,087
Metal–Organic Frameworks as Efficient Materials for Drug Delivery
Horcajada, P., Serre, C., Vallet‐Regí, M., Sebban, M., Taulelle, F., & Férey, G. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601878 · Cited by 2,024
Self-citationFérey, G., & Serre, C. (2009) · Chemical Society Reviews · doi:10.1039/b804302g · Cited by 1,654
Self-citationSynthesis and catalytic properties of MIL-100(Fe), an iron(iii) carboxylate with large pores
Horcajada, P., Surblé, S., Serre, C., Hong, D.-Y., Seo, Y.-K., Chang, J.-S., Grenèche, J.-M., Margiolaki, I., & Férey, G. (2007) · Chem. Commun. · doi:10.1039/b704325b · Cited by 1,538
Self-citationTaylor-Pashow, K. M. L., Della Rocca, J., Xie, Z., Tran, S., & Lin, W. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906198y · Cited by 1,522
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Role of metals in oxygen radical reactions
Aust, S. D., Morehouse, L. A., & Thomas, C. E. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90025-x · Cited by 1,145
Infinite polymeric frameworks consisting of three dimensionally linked rod-like segments
Hoskins, B. F., & Robson, R. (1989) · Journal of the American Chemical Society · doi:10.1021/ja00197a079 · Cited by 1,100
Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework
An, J., Geib, S. J., & Rosi, N. L. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902972w · Cited by 1,076
Singh, R., Pantarotto, D., Lacerda, L., Pastorin, G., Klumpp, C., Prato, M., Bianco, A., & Kostarelos, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509009103 · Cited by 1,043
Nanoscale Metal−Organic Frameworks as Potential Multimodal Contrast Enhancing Agents
Rieter, W. J., Taylor, K. M. L., An, H., Lin, W., & Lin, W. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0627444 · Cited by 891
Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery
Rieter, W. J., Pott, K. M., Taylor, K. M. L., & Lin, W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803383k · Cited by 803
Nanotoxicity: the growing need for in vivo study
Fischer, H. C., & Chan, W. C. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.11.008 · Cited by 717
Bassett, M. L., Halliday, J. W., & Powell, L. W. (1986) · Hepatology · doi:10.1002/hep.1840060106 · Cited by 664
Manganese-Based Nanoscale Metal−Organic Frameworks for Magnetic Resonance Imaging
Taylor, K. M. L., Rieter, W. J., & Lin, W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803777x · Cited by 657
[60]Fullerene is a Powerful Antioxidant in Vivo with No Acute or Subacute Toxicity
Gharbi, N., Pressac, M., Hadchouel, M., Szwarc, H., Wilson, S. R., & Moussa, F. (2005) · Nano Letters · doi:10.1021/nl051866b · Cited by 656
Why hybrid porous solids capture greenhouse gases?
Férey, G., Serre, C., Devic, T., Maurin, G., Jobic, H., Llewellyn, P. L., De Weireld, G., Vimont, A., Daturi, M., & Chang, J.-S. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00040j · Cited by 652
Self-citationYoon, J. W., Seo, Y., Hwang, Y. K., Chang, J., Leclerc, H., Wuttke, S., Bazin, P., Vimont, A., Daturi, M., Bloch, E., et al. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201001230 · Cited by 634
Self-citationAssessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles
Mahmoudi, M., Hofmann, H., Rothen-Rutishauser, B., & Petri-Fink, A. (2012) · Chemical Reviews · doi:10.1021/cr2002596 · Cited by 617
Yu, M. K., Jeong, Y. Y., Park, J., Park, S., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 615
Kupffer cells are central in the removal of nanoparticles from the organism
Sadauskas, E., Wallin, H., Stoltenberg, M., Vogel, U., Doering, P., Larsen, A., & Danscher, G. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-10 · Cited by 607
The granulomatous inflammatory response. A review.
Adams, D. O. (1976) · PubMed · Cited by 550
Nanoscale metal–organic materials
Carné, A., Carbonell, C., Imaz, I., & Maspoch, D. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00042f · Cited by 524
Brain barrier systems: a new frontier in metal neurotoxicological research
Zheng, W., Aschner, M., & Ghersi-Egea, J.-F. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00251-5 · Cited by 507
Horcajada, P., Salles, F., Wuttke, S., Devic, T., Heurtaux, D., Maurin, G., Vimont, A., Daturi, M., David, O., Magnier, E., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja206936e · Cited by 504
Self-citationChiral Nanoporous Metal‐Organic Frameworks with High Porosity as Materials for Drug Delivery
Sun, C., Qin, C., Wang, C., Su, Z., Wang, S., Wang, X., Yang, G., Shao, K., Lan, Y., & Wang, E. (2011) · Advanced Materials · doi:10.1002/adma.201102538 · Cited by 429
Metal–biomolecule frameworks (MBioFs)
Imaz, I., Rubio-Martínez, M., An, J., Solé-Font, I., Rosi, N. L., & Maspoch, D. (2011) · Chemical Communications · doi:10.1039/c1cc11202c · Cited by 426
McKinlay, A. C., Xiao, B., Wragg, D. S., Wheatley, P. S., Megson, I. L., & Morris, R. E. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801997r · Cited by 417
Seo, Y., Yoon, J. W., Lee, J. S., Hwang, Y. K., Jun, C., Chang, J., Wuttke, S., Bazin, P., Vimont, A., Daturi, M., et al. (2012) · Advanced Materials · doi:10.1002/adma.201104084 · Cited by 362
Self-citationLong term in vivo biotransformation of iron oxide nanoparticles
Levy, M., Luciani, N., Alloyeau, D., Elgrabli, D., Deveaux, V., Pechoux, C., Chat, S., Wang, G., Vats, N., Gendron, F., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.031 · Cited by 361
Optimisation of the synthesis of MOF nanoparticles made of flexible porous iron fumarate MIL-88A
Chalati, T., Horcajada, P., Gref, R., Couvreur, P., & Serre, C. (2011) · J. Mater. Chem. · doi:10.1039/c0jm03563g · Cited by 360
Self-citationLiu, T., Li, L., Teng, X., Huang, X., Liu, H., Chen, D., Ren, J., He, J., & Tang, F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.035 · Cited by 357
Lipidosis induced by amphiphilic cationic drugs
Lüllmann, H., Lüllmann‐Rauch, R., & Wassermann, O. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90435-5 · Cited by 352
Iron, oxidative stress and human health
Puntarulo, S. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.07.001 · Cited by 348
Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems
Sharma, A., Madhunapantula, S. V., & Robertson, G. P. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.637916 · Cited by 242
Unusual copper-induced sensitization of the biological damage due to superoxide radicals.
Samuni, A., Chevion, M., & Czapski, G. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42937-7 · Cited by 237
NO-Releasing Zeolites and Their Antithrombotic Properties
Wheatley, P. S., Butler, A. R., Crane, M. S., Fox, S., Xiao, B., Rossi, A. G., Megson, I. L., & Morris, R. E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0503579 · Cited by 235
Briley-Saebo, K., Bj�rnerud, A., Grant, D., Ahlstrom, H., Berg, T., & Kindberg, G. M. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0884-8 · Cited by 235
Yu, T., Greish, K., McGill, L. D., Ray, A., & Ghandehari, H. (2012) · ACS Nano · doi:10.1021/nn2043803 · Cited by 213
The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene
Baati, T., Bourasset, F., Gharbi, N., Njim, L., Abderrabba, M., Kerkeni, A., Szwarc, H., & Moussa, F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.036 · Cited by 191
Self-citationMaes, M., Trekels, M., Boulhout, M., Schouteden, S., Vermoortele, F., Alaerts, L., Heurtaux, D., Seo, Y., Hwang, Y. K., Chang, J., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100050 · Cited by 187
Self-citationDrug delivery to brain via the blood–brain barrier
Scherrmann, J.-M. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(02)00202-1 · Cited by 184
Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells
Huxford, R. C., deKrafft, K. E., Boyle, W. S., Liu, D., & Lin, W. (2012) · Chem. Sci. · doi:10.1039/c1sc00499a · Cited by 177
Liver copper storage and transport during development: implications for cytotoxicity
Luza, S., & Speisky, H. (1996) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.812 · Cited by 171
Pisoni, R. L., Acker, T. L., Lisowski, K. M., Lemons, R. M., & Thoene, J. G. (1990) · The Journal of cell biology · doi:10.1083/jcb.110.2.327 · Cited by 162
Hyaluronic Acid−Quantum Dot Conjugates for In Vivo Lymphatic Vessel Imaging
Bhang, S. H., Won, N., Lee, T., Jin, H., Nam, J., Park, J., Chung, H., Park, H., Sung, Y., Hahn, S. K., et al. (2009) · ACS Nano · doi:10.1021/nn900138d · Cited by 157
Metallothionein protects against oxidative stress-induced lysosomal destabilization
Baird, S. K., Kurz, T., & Brunk, U. T. (2006) · Biochemical Journal · doi:10.1042/bj20051143 · Cited by 145
Nagy, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132258 · Cited by 144
Pawelczyk, E., Arbab, A. S., Pandit, S., Hu, E. S., & Frank, J. A. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1038 · Cited by 125
Chalati, T., Horcajada, P., Couvreur, P., Serre, C., Yahia, M. B., Maurin, G., & Gref, R. (2011) · Nanomedicine · doi:10.2217/nnm.11.69 · Cited by 123
Self-citationBiodegradation of magnetite dextran nanoparticles in the rat. A histologic and biophysical study.
Okon, E. E., Pouliquen, D., Okon, P., Zv, K., Tp, S., Sg, L., Kudryavtsev, B. N., & JALLET, P. (1994) · PubMed · Cited by 117
Cytochrome P450: new nomenclature and clinical implications.
Cupp, M. J., & Tracy, T. S. (1998) · PubMed · Cited by 116
Kedziorek, D., Muja, N., Walczak, P., Ruíz-Cabello, J., Gilad, A. A., Jie, C., & Bulte, J. W. M. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22290 · Cited by 106
Ferritin and hemosiderin in pathological tissues
Iancu, T. C. (1992) · Electron Microscopy Reviews · doi:10.1016/0892-0354(92)90011-e · Cited by 97
Ananthoji, R., Eubank, J. F., Nouar, F., Mouttaki, H., Eddaoudi, M., & Harmon, J. P. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm11075f · Cited by 74
Vaisman, B. L., Fibach, E., & Konijn, A. M. (1997) · Blood · doi:10.1182/blood.v90.2.831 · Cited by 72
Haemosiderin and tissue damage
Weir, M., Gibson, J. F., & Peters, T. J. (1984) · Cell Biochemistry and Function · doi:10.1002/cbf.290020402 · Cited by 70
Mráz, J., Jheeta, P., Gescher, A., Hyland, R., Thummel, K. E., & Threadgill, M. D. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00032a009 · Cited by 62
Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke
Mehta, S. H., Webb, R. C., Ergul, A., Tawak, A., & Dorrance, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2002 · Cited by 60
Lin, H.-L., & Hollenberg, P. F. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0001979 · Cited by 51
Miyawaki, H. (1965) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/34.5.601 · Cited by 51
Elbarbry, F., Wilby, K. J., & Alcorn, J. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.02.006 · Cited by 50
Baâti, T., Horcajada, P., Gref, R., Couvreur, P., & Serre, C. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.07.011 · Cited by 45
Self-citationGonzález‐Jasso, E. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00337-5 · Cited by 44
Hemochromatosis: How Much Iron Is Too Much?
Tavill, A. S., & Bacon, B. R. (1986) · Hepatology · doi:10.1002/hep.1840060128 · Cited by 26
Okada, S. (1998) · International Journal of Clinical Oncology · doi:10.1007/bf02489833 · Cited by 14
Baâti, T., Horcajada, P., Gref, R., Couvreur, P., & Serre, C. (2012) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2012.05.006 · Cited by 11
Self-citationBaâti, T., Horcajada, P., Gref, R., Couvreur, P., & Serre, C. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.06.020 · Cited by 8
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Metadata
- Authors
- Baati, T., Njim, L., Neffati, F., Kerkeni, A., Bouttemi, M., Gref, R., Najjar, M. F., Zakhama, A., Couvreur, P., Serre, C., & Horcajada, P.
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 4
- Issue
- 4
- Pages
- 1597
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- OpenAlex
- W2135465393
- Cited by
- 405
- References
- 77
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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