Per- and polyfluoroalkyl substances and fluorine mass balance in cosmetic products from the Swedish market: implications for environmental emissions and human exposure
Open accessAbstract
Occurrence of PFASs, total fluorine and extractable organic fluorine in cosmetic products and their importance to human and environmental exposure.
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Written from the paper’s full text.
TL;DR
Thirty-one Swedish cosmetic products were analyzed for 39 PFASs by LC-MS/MS and for extractable organic fluorine (EOF) and total fluorine (TF) by combustion ion chromatography. Foundations and powders contained multiple PFASs, especially polyfluoroalkyl phosphate esters (PAPs), but known PFASs explained only a small fraction of EOF and TF, indicating unidentified fluorinated substances.
Key findings
- 16 of 31 products contained measurable concentrations of at least one targeted PFAS; foundations and powders contained up to 25 of 39 monitored PFASs above detection limits, while creams, pencil and shaving foams did not contain detectable concentrations of the 39 targeted PFASs.
- PAPs dominated in three foundations: Σ14 PAP concentrations ranged from <LOD to 471 mg g⁻¹, with 6:2/6:2 diPAP at 256, 63.7 and 405 mg g⁻¹ and 6:2 monoPAP at 55.5, 50.4 and 62.0 mg g⁻¹; Σ39 PFAS concentrations in those samples were 319, 229 and 479 mg g⁻¹.
- Σ10 PFCA concentrations ranged from <LOD to 9220 ng g⁻¹ in foundations and from <LOD to 679 ng g⁻¹ in powders and eye shadows; the most frequently detected PFASs were short-chain PFCAs (PFHpA 39%, PFBA 35%, PFHxA 32%, PFPeA 29%).
- EOF accounted for 0–55% of TF, averaging 9%; in FOUN01–FOUN03, ΣC_F_PFAS accounted for 11, 10 and 28% of C_F_EOF, while C_F_EOF accounted for 55, 48 and 41% of C_F_TF. Estimated daily PFOA exposure from the analyzed cosmetics was <0.006–3.1 ng per kg per day, with higher-end values exceeding Swedish dietary PFOA intake of 0.04–0.7 ng per kg per day.
Methods
- Thirty-one cosmetic products from five categories (cream, foundation, pencil, powder, shaving foam) were purchased from the Swedish market in 2016–2017; 24 listed 9 different PFASs as ingredients and 7 did not list PFASs and served as controls.
- Samples were analyzed for 39 PFASs by LC-MS/MS and for EOF and TF by combustion ion chromatography (CIC); fluorine mass balance calculations converted measured PFAS concentrations to fluorine equivalents and compared them with EOF and TF.
- QA/QC included spike/recovery experiments, certified reference material for TF, triplicate measurements for TF/EOF, procedural blanks, and an inter-laboratory comparison of 18 samples for 11 PFASs.
Limitations
- Stated: some listed fluorinated ingredients (e.g., fluorinated silanes and polymeric substances) were not quantified due to lack of MS-based methods and/or authentic standards, so the mass balance gap may partly reflect the active ingredient.
- Stated: PAP concentrations in FOUN01–FOUN03 were not corrected for procedural losses, and when internal standards were added to extracts rather than samples, losses during extraction were not tracked.
- Evident from the text: the study covers a small set of Swedish products, many extractable organic fluorine components remained unidentified, and dermal absorption coefficients for a wider range of PFASs and application conditions are lacking.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
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Cites
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Claims the paper makes
0 of 27 cited sources checked · 0 supported · 0 flagged
- Findingown data
Σ14 PAP concentrations up to 470 mg g−1 were measured in products listing mixtures of PAPs as an ingredient.
“S 14 PAP concentrations up to 470 mg g À1 were measured in products listing mixtures of PAPs as an ingredient.”
Quote in the paperSubstantial claim - Findingown data
CIC revealed high to moderate TF content in creams, pencil and shaving foams.
“CIC revealed high to moderate TF content.”
Quote in the paperSubstantial claim - Findingown data
For all samples, Σ39 PFAS concentrations explained only a small fraction of the EOF and TF.
“For all samples, S 39 PFAS concentrations only explained a small fraction of the EOF and TF”
Quote in the paperSubstantial claim- Rests on an assumption: The 39 targeted PFASs account for all known PFASs present in the samples, so that any remaining EOF/TF is due to unknown fluorinated substances.
- Findingown data
The highest detection frequency was observed for short-chain PFCAs: PFHpA 39%, PFBA 35%, PFHxA 32%, PFPeA 29%.
“The highest detection frequency was observed for short-chain PFCAs (PFHpA 39%, PFBA 35%, PFHxA 32%, PFPeA 29%).”
Quote in the paperNot a substantial claim - Findingown data
No perfluoroether carboxylic acids, PFSAs or related precursors were detected above LODs in any sample.
“No peruoroether carboxylic acids, PFSAs or related precursors were detected above LODs in any sample.”
Quote in the paperNot a substantial claim
- Findingown data
Pencil and shaving foams displayed lower TF concentrations (438 and <LOD-837 mg/kg, respectively).
“Pencil and shaving foams displayed lower TF concentrations (438 and <LOD -837 mg g À1 , respectively).”
Quote in the paperNot a substantial claim - Findingown data
TF and EOF content showed high variability within each product category.
“Overall, TF and EOF content showed high variability within each product category.”
Quote in the paperNot a substantial claim - Findingown data
The highest EOF concentrations were measured in foundation samples (1.29-1720 mg/kg).
“In contrast to TF concentrations, the highest EOF concentrations were measured in foundation samples (1.29-1720 mg g À1 ).”
Quote in the paperNot a substantial claim - Findingown data
In total, 16 out of 31 samples contained measurable concentrations of at least one PFAS.
“In total, 16 out of 31 samples contained measurable concentrations of at least one PFAS (see Fig. 2, Tables S7 and S8 † for a full list of concentrations).”
Quote in the paperSubstantial claim - Findingown data
Samples of cream, pencil and shaving foam did not contain detectable concentrations of targeted PFASs.
“whereas samples of cream, pencil and shaving foam did not contain detectable concentrations of targeted PFASs.”
Quote in the paperSubstantial claim - Findingreasoning
The finding of PAPs in FOUN01, FOUN02 and FOUN03 is in agreement with the ingredients lists, which specify ammonium C6-16 perfluoroalkylethyl phosphate (FOUN01 and FOUN03) and C9-15 fluoroalcohol phosphate (FOUN02) as intentionally added components.
“The nding of PAPs in these samples is in agreement with the ingredients lists, which specify ammonium C6-16 per-uoroalkylethyl phosphate (FOUN01 and FOUN03) and C9-15 uoroalcohol phosphate (FOUN02) as intentionally added components (INCI nomenclature).”
Quote in the paperNot a substantial claim - Findingown data
Creams, pencil and shaving foams did not contain measurable concentrations of any of the 39 targeted PFASs.
“While creams, pencil and shaving foams did not contain measurable concentrations of any of the 39 PFASs targeted here”
Quote in the paperNot a substantial claim - Findingown data
Three samples (FOUN01, FOUN02 and FOUN03) contained particularly high concentrations of PAPs and PFCAs, with Σ39 PFAS concentrations of 319, 229 and 479 mg g−1, respectively.
“Three samples (FOUN01, FOUN02 and FOUN03) contained particularly high concentrations of PAPs and PFCAs (see Fig. 2), with S 39 PFAS concentrations of 319, 229 and 479 mg g À1 , respectively.”
Quote in the paperSubstantial claim - Findingown data
Samples not listing fluorinated ingredients were below LOD for all PFASs.
“Samples not listing uorinated ingredients were below LOD for all PFASs.”
Quote in the paperSubstantial claim - Findingown data
Foundation and powder products contained up to 25 out of 39 monitored PFASs above detection limits.
“Foundation and powder products contained up to 25 out of 39 monitored PFASs above detection limits”
Quote in the paperSubstantial claim - Findingnone given
PAPs were present in 100-fold higher concentrations compared to PFCAs in the analyzed cosmetic products.
“It should also be noted that these calculations do not consider indirect exposure to PFOA via metabolism of PAPs, which were present in 100-fold higher concentrations compared to PFCAs, or other potential precursors that contributed to the EOF fraction.”
Quote in the paperSubstantial claim - Findingreasoning
The estimated daily exposure to PFOA from the cosmetic products analyzed in this study would be in the range <0.006-3.1 ng per kg per day.
“the estimated daily exposure to PFOA from CPs analyzed in this study would be in the range <0.006-3.1 ng per kg per day.”
Quote in the paperSubstantial claim - Premisecitation
To the authors' knowledge, the only study that has quantified PFASs in cosmetic products was Fujii et al. (2013).
“In fact, to our knowledge the only study which has quantied PFASs in CPs was that of Fujii et al. (2013)”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [22] source
Not checked in the free run.
- Premisecitation
PFASs are used in cosmetic products that come into contact with the skin.
“One of the lesser known uses for PFASs is in cosmetics products (CPs) which come into contact with the skin (e.g.hair products, powders, sunblocks, etc.).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17]
Not checked in the free run.
- Interpretationreasoning
The co-occurrence of PFCAs and FTSAs in FOUN01, FOUN02 and FOUN03 is more likely due to impurities in the technical mixture of PAPs or degradation of the active ingredients, since they are found in relatively low concentrations.
“The co-occurrence of PFCAs (S 10 PFCA concentrations 4890, 9220 and 8480 ng g À1 respectively) and FTSAs (S 3 FTSA concentrations of 21.9, 288 and 60.6 ng g À1 , respectively) in these samples is, however, more likely due to impurities in the technical mixture of PAPs or degradation of the active ingredients, since they are found in relatively low concentrations.”
Quote in the paperNot a substantial claim - Study design and conductown data
Procedural blanks prepared and processed independently along with all samples did not show detectable contamination for any target PFAS.
“The procedural blanks that were prepared and processed independently along with all samples did not show detectable contamination for any target PFAS.”
Quote in the paperSubstantial claim - Study design and conductown data
Method accuracy, assessed through spike/recovery experiments, ranged from 71 to 126% for most PFASs.
“Method accuracy, as assessed through spike/recovery experiments, ranged from 71 to 126% for most PFASs (Table S4 †).”
Quote in the paperSubstantial claim - Premisereasoning
When paired with targeted PFAS analysis, fluorine mass balance calculations can assess the fraction of TF and EOF explained by known PFASs and the fraction of as-of-yet unidentified PFASs.
“When paired with targeted PFAS analysis using e.g.LC-MS/MS, uorine mass balance calculations can be used to assess the fraction of TF and EOF explained by known PFASs, but also the fraction of as-of-yet unidentied PFASs.”
Quote in the paperSubstantial claim - Interpretationown data
The unexplained fraction of EOF and TF indicates the presence of unknown organic and/or inorganic fluorinated substances, including polymers.
“pointing to the presence of unknown organic and/or inorganic fluorinated substances, including polymers.”
Quote in the paperSubstantial claim- Rests on an assumption: The 39 targeted PFASs account for all known PFASs present in the samples, so that any remaining EOF/TF is due to unknown fluorinated substances.
- Premisecitation
Early applications of CIC and PIGE in firefighting foams, biota and textiles have revealed that only a small fraction of the organic fluorine content can be accounted for by known PFASs.
“Early applications of CIC and PIGE in reghting foams, biota and textiles have revealed that only a small fraction of the organic uorine content can be accounted for by known PFASs.31,33,37”
Quote in the paperSubstantial claim0 of 3 sources checked - Interpretationown data
PTFE is not extracted with methanol.
“All samples listing PTFE as ingredient had high TF concentrations (n ¼ 9, 837-19 200 mg g À1 ), whereas EOF could only be detected in 5 of the PTFE-containing samples in low concentrations (<LOD -12.3 mg g À1 ), suggesting that PTFE is not extracted with methanol.”
Quote in the paperSubstantial claim - Study design and conductreasoning
For samples FOUN01, FOUN02 and FOUN03, the reported PAP concentrations are not corrected for procedural losses.
“Therefore, the concentrations reported for PAPs in those three samples are not corrected for procedural losses.”
Quote in the paperSubstantial claim - Interpretationown data
PFCAs of various chain-lengths are present in cosmetic products as impurities or degradation products of other PFASs which are added as active ingredients.
“This study demonstrates that PFCAs of various chain-lengths are present in CPs as impurities or degradation products of other PFASs which are added as active ingredients.”
Quote in the paperSubstantial claim - Interpretationcitation
The homologue pattern of PFASs in cosmetics appears to follow the same trend as treated textiles and papers, where recent studies typically report the highest concentrations and detection frequency for C6 compounds.
“Thus, the homologue pattern of PFASs in cosmetics appear to follow the same trend as treated textiles and papers where recent studies typically report the highest concentrations and detection frequency for C6 compounds.”
Quote in the paperNot a substantial claim0 of 3 sources checked - Interpretationown data
Swedish cosmetic products contain large quantities of both known and as-of-yet unidentified PFASs.
“this study demonstrates that Swedish cosmetic products contain large quantities of both known and as-of-yet unidentied PFASs.”
Quote in the paperSubstantial claim- Rests on an assumption: The 39 targeted PFASs account for all known PFASs present in the samples, so that any remaining EOF/TF is due to unknown fluorinated substances.
- Interpretationreasoning
Because all PFAS concentrations were adjusted for extraction losses while EOF concentrations were not, the gap between C_F_EOF and ΣC_F_PFAS (C_F_extr.unknown) should be considered conservative (i.e. underestimated).
“As in these cases all PFAS concentrations were adjusted for extraction losses while EOF concentrations are not, the gap between C F_EOF and SC F_PFAS (C F_extr.unknown ) should be considered conservative (i.e.underestimated).”
Quote in the paperSubstantial claim - Study design and conductown data
Inter-laboratory comparison on a subset of 18 unfortified samples revealed good agreement between labs, with a coefficient of determination of 0.9605 for 11 targeted PFAS measurements.
“Results of the inter-laboratory comparison on a subset of 18 samples (unfortied) revealed good agreement between labs, with a coefficient of determination of 0.9605 for 11 targeted PFAS measurements (Fig. S1 †).”
Quote in the paperNot a substantial claim - Premisecitation
Combustion ion chromatography (CIC) and particle induced gamma ray emission (PIGE) have recently been introduced for indirect quantification of total and extractable organic fluorine in samples.
“combustion ion chromatography (CIC) [25][26][27][28][29][30][31][32][33][34][35][36] and particle induced gamma ray emission (PIGE) 28,37,38 have recently been introduced for indirect quan-tication of total and extractable organic uorine (TF and EOF, respectively) in samples.”
Quote in the paperSubstantial claim0 of 3 sources checked - Study design and conductown data
Most substances displayed good precision (average RSD of 24%) at both fortification levels.
“Nevertheless, most substances displayed good precision (average RSD of 24%) at both fortication levels (Table S4 †).”
Quote in the paperNot a substantial claim - Interpretationnone given
There may be environmental risks associated with PFASs in cosmetic products which enter waste streams following use.
“In addition to the potential for human exposure, there may be environmental risks associated with PFASs in CPs which enter waste streams following use.”
Quote in the paperSubstantial claim - Premisecitation
DiPAPs, which are among the known ingredients in some cosmetic products, contributed a major proportion (63%) to the ΣPFAS concentrations in sludge samples.
“Notably, diPAPs, which are among the known ingredients in some CPs, contributed a major proportion (63%) to the SPFAS concentrations in sludge samples.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [57]
Not checked in the free run.
- Study design and conductnone given
For FOUN01, FOUN02 and FOUN03, concentrations of PAPs (which represented the major fraction of characterized EOF) were not corrected for procedural losses.
“Here it is germane to note that for these three samples, concentrations of PAPs (which represented the major fraction of characterized EOF) were not corrected for procedural losses (see explanation in Methods section).”
Quote in the paperSubstantial claim - Study design and conductreasoning
The exposure calculations do not consider indirect exposure to PFOA via metabolism of PAPs or other potential precursors that contributed to the EOF fraction.
“It should also be noted that these calculations do not consider indirect exposure to PFOA via metabolism of PAPs, which were present in 100-fold higher concentrations compared to PFCAs, or other potential precursors that contributed to the EOF fraction.”
Quote in the paperSubstantial claim - Premisereasoning
These exposure assessments have not considered the potential contribution of cosmetic products towards dermal uptake due to the lack of measurement data.
“However, these exposure assessments have not considered the potential contribution of CPs towards dermal uptake due to the lack of measurement data.”
Quote in the paperSubstantial claim0 of 2 sources checked
- May combine two claims. 22
- Classified as probably not a substantial claim. 19
- The quote only partly states this claim. 1
May combine two claims.
Findingown dataThe highest TF concentrations were found in powders (547-19200 mg/kg), closely followed by creams (<LOD-11100 mg/kg) and foundations (326-3120 mg/kg).
“The highest TF concentrations were found in powders (547-19 200 mg g À1 ), closely followed by creams (<LOD -11 100 mg g À1 ) and foundations (326-3120 mg g À1 ).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe major PFASs in FOUN01, FOUN02 and FOUN03 were 6:2/6:2 diPAP (256, 63.7 and 405 mg g−1, respectively) and 6:2 monoPAP (55.5, 50.4 and 62.0 mg g−1, respectively), accounting for 98% (FOUN01 and FOUN03) and 50% (FOUN02) of Σ39 PFAS.
“The major PFASs in these samples were 6:2/6:2 diPAP (256, 63.7 and 405 mg g À1 , respectively) and 6:2 monoPAP (55.5, 50.4 and 62.0 mg g À1 , respectively), accounting for 98% (FOUN01 and FOUN03) and 50% (FOUN02) of S 39 PFAS.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor the remaining samples, the fraction of C_F_EOF accounted for by ΣC_F_PFAS was negligible (≤1.3%), with remaining C_F_extr.unknown of up to 552 mg/kg.
“For the remaining samples, the fraction of C F_EOF accounted for by SC F_PFAS was negligible (#1.3%), with remaining C F_extr.unknown of up to 552 mg g À1 .”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenThe Japanese products displayed a slightly different homologue pattern.
“However, the Japanese products displayed a slightly different homologue pattern”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataFOUN01, FOUN02 and FOUN03, which displayed the highest Σ39 PFAS concentrations, also showed high TF (3120, 2900 and 2570 mg/kg respectively) and EOF concentrations (1720, 1380 and 1050 mg/kg respectively).
“FOUN01, FOUN02 and FOUN03, which displayed the highest S 39 PFAS concentrations, also showed high TF (3120, 2900 and 2570 mg g À1 respectively) and EOF concentrations (1720, 1380 and 1050 mg g À1 respectively).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSix long-chain PFCA homologues were detected above the LOD, in order of decreasing detection frequency: PFUnDA > PFOA = PFDA = PFDoDA > PFNA > PFTrDA.
“Six long-chain PFCA homologues were detected above the LOD (in order of decreasing detection frequency: PFUnDA > PFOA ¼ PFDA ¼ PFDoDA > PFNA > PFTrDA).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSome mono- and diPAPs were detected in far higher concentrations than PFCAs, up to 405 mg g−1.
“Although PFCAs were the most frequently detected compounds, some mono-and diPAPs were detected in far higher concentrations (up to 405 mg g À1 ).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown data6:2 and 8:2 FTSA were detected in three (FOUN01, FOUN02 and FOUN03; 21.9 to 132 ng g−1) and one (FOUN03, 156 ng g−1) foundation products, respectively.
“Additionally, 6:2 and 8:2 FTSA were detected in three (FOUN01, FOUN02 and FOUN03; 21.9 to 132 ng g À1 ) and one (FOUN03, 156 ng g À1 ) foundation products, respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataΣ14 PAP concentrations ranged from <LOD to 471 mg g−1 for foundations and from <LOD to 282 ng g−1 for powders and eye shadows.
“S 14 PAP concentrations ranged from <LOD to 471 mg g À1 for foundations and from <LOD to 282 ng g À1 for powders and eye shadows.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataComparatively low EOF concentrations were observed in powders (<LOD-296 mg/kg), creams (<LOD-31.9 mg/kg) and shaving foams (<LOD-3.53 mg/kg).
“Comparatively low EOF concentrations were observed in powders (<LOD -296 mg g À1 ), creams (<LOD -31.9 mg g À1 ) and shaving foams (<LOD -3.53 mg g À1 ).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe dominant chain lengths for PAPs were 6:2 and 8:2, although homologues from 4:2 up to 12:2 were also detected.
“The dominant chain lengths for PAPs were 6:2 and 8:2, albeit homologues from 4:2 up to 12:2 were also detected.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataΣ10 PFCA concentrations ranged from <LOD to 9220 ng g−1 for foundations and from <LOD to 679 ng g−1 for powders and eye shadows.
“S 10 PFCA concentrations ranged from <LOD to 9220 ng g À1 for foundations and from <LOD to 679 ng g À1 for powders and eye shadows.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataIn FOUN01, FOUN02 and FOUN03, ΣC_F_PFAS accounted for 11, 10 and 28% of C_F_EOF respectively, which in turn accounted for 55, 48 and 41% of C_F_TF.
“In these samples, SC F_PFAS accounted for 11, 10 and 28% of C F_EOF respectively, which in turn accounted for 55, 48 and 41% of C F_TF (Fig. 3).”
Quote in the paperSubstantial claimMay combine two claims. The quote only partly states this claim.
Findingown dataAll samples listing PTFE as ingredient had high TF concentrations (n = 9, 837-19200 mg/kg), whereas EOF could only be detected in 5 of the PTFE-containing samples in low concentrations (<LOD-12.3 mg/kg).
“All samples listing PTFE as ingredient had high TF concentrations (n ¼ 9, 837-19 200 mg g À1 ), whereas EOF could only be detected in 5 of the PTFE-containing samples in low concentrations (<LOD -12.3 mg g À1 ), suggesting that PTFE is not extracted with methanol.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataNo EOF was detected in the pencil sample.
“No EOF was detected in the pencil sample.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataFoundations and powders contained 25 different PFASs, with the most frequently detected being perfluorinated carboxylic acids (perfluoroheptanoic acid and perfluorohexanoic acid) and polyfluoroalkyl phosphate esters (PAPs).
“Foundations and powders contained 25 different PFASs with the most frequently detected being perfluorinated carboxylic acids (perfluoroheptanoic acid and perfluorohexanoic acid) and polyfluoroalkyl phosphate esters (PAPs).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
FindingcitationOur findings of PFCAs in cosmetics were in good agreement with Fujii et al. (2013), who reported Σ9 PFCA concentrations of up to 5900 ng g−1 in foundations collected from the Japanese market in 2009 and 2011.
“Our ndings of PFCAs in cosmetics were in good agreement with a previous study by Fujii et al. (2013) who reported S 9 PFCA concentrations of up to 5900 ng g À1 in foundations collected from the Japanese market in 2009 and 2011.22”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [22] source
Not checked in the free run.
May combine two claims.
PremisecitationA recent survey of ingredients confirmed the presence of 59 different PFAS-containing cosmetic products on the Swedish market, but their concentrations remain unknown.
“While a recent survey of ingredients conrmed the presence of 59 different PFAS-containing CPs on the Swedish market, their concentrations remain unknown.21”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [21] source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationIn Fujii et al. (2013), more than 87% of products sampled from Japan, Korea, France and the United States contained PFCAs.
“in which >87% of products sampled from Japan, Korea, France and the United States contained PFCAs. 22”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [22] source
Not checked in the free run.
May combine two claims.
Study design and conductown dataIntra-sample variability, assessed via triplicate measurements of 20% of samples, averaged 10% for TF and 3% for EOF measurements.
“Finally, intra-sample variability (assessed via triplicate measurements of 20% of samples) averaged 10% for TF and 3% for EOF measurements.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataAs a final validation, 18 unfortified samples were re-analyzed for 11 PFASs by IVL Swedish Environmental Institute and compared to results generated by SU.
“As a nal validation of the method, 18 unfortied samples were re-analyzed for 11 PFASs by IVL Swedish Environmental Institute (IVL) and compared to results generated by SU.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductreasoningBecause native and/or isotopically labelled standards were unavailable for some PFASs, the study defined three levels of data quality.
“Since native and/or isotopically labelled standards were unavailable for some PFASs, we dened three levels of data quality.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenThree extraction blanks were processed along with every batch, and QC standard and blank injections were performed intermittently to assess instrument drift and carryover.
“In addition to the aforementioned method validation, three extraction blanks were processed along with every batch, and QC standard and blank injections were performed intermittently to assess instrument dri and carryover, respectively (both LC-MS/MS and CIC).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataIntra-sample variability of TF and EOF was assessed by analyzing 20% of samples in triplicate by CIC.
“Intra-sample variability of TF and EOF was assessed by analyzing 20% of samples in triplicate (CIC).”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationcitationPFASs used in cosmetic products may fly under the radar of both EU and North American cosmetics regulation and REACH, either because there are no data on their risks to human health or because they are used in relatively small quantities.
“Thus, PFASs used in CPs may y under the radar of both EU and North American Cosmetics regulation and REACH, either because there are no data on their risk(s) to human health or because they are used in relatively small quantities.17”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17]
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductown dataQA/QC experiments served to evaluate whether inorganic fluorine (NaF) was removed during the extraction procedure.
“In addition to assessing accuracy and precision of the method for EOF, these experiments served to evaluate whether inorganic uorine (NaF) was removed during the extraction procedure.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenTo the authors' knowledge, this is the first fluorine mass balance study on cosmetic products.
“To our knowledge this is the rst uorine mass balance study on CPs.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningThe addition of internal standards to the extracts accounts for matrix effects in quantification, but losses during the extraction procedure are not tracked by this approach.
“The addition of internal standards to the extracts (versus to the sample) accounts for matrix effects in the quantication; however, losses during the extraction procedure are not tracked by this approach.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningThe larger intra-sample variability for TF compared to EOF measurements may be attributed in part to the uncertainty of weighing small amounts of neat product material and potential heterogeneity of the small aliquots.
“The larger intra-sample variability for TF compared to EOF measurements may be attributed in part to the uncertainty of weighing small amounts of neat product material and potential heterogeneity of the small aliquots.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAll EOF concentrations were blank corrected.
“All EOF concentrations were blank corrected.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningThe not-corrected PAP concentrations for FOUN01, FOUN02 and FOUN03 are directly comparable to EOF concentrations and can be used directly for mass balance calculations.
“Thus, these not-corrected concentrations are directly comparable to EOF concentrations, which also return concentrations in the sample extract rather than in the neat sample, and can be used directly for mass balance calculations.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationSeveral other studies have demonstrated the presence of PFCAs as impurities in products treated with fluorotelomer-based substances.
“Several other studies have demonstrated the presence of PFCAs as impurities in products treated with uorotelomer-based substances.[41][42][43][44][45]”
Quote in the paperNot a substantial claim0 of 3 sources checkedClassified as probably not a substantial claim.
Study design and conductown dataAccuracy and precision of TF measurements were assessed through triplicate combustions of a certified reference material (BCR®-461, fluorine in clay).
“The accuracy and precision of TF measurements were assessed through triplicate combustions of a certied reference material (CRM) (BCR®-461, uorine in clay).”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationDermal exposure to PFCAs has, thus far, been considered negligible relative to contributions from dietary intake, drinking water and ingestion of house dust according to current human exposure assessments.
“Dermal exposure to PFCAs has, thus far, been considered negligible relative to contributions from dietary intake, drinking water and ingestion of house dust according to current human exposure assessments.”
Quote in the paperSubstantial claim0 of 2 sources checkedClassified as probably not a substantial claim.
PremisereasoningBecause CIC and PIGE are fluorine-specific, a standard of any fluorinated substance may be used for quantification.
“As these approaches are uorine-specic, a standard of any uorinated substance may be used for quantication.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataTF method blanks were below 1% of sample concentrations, and therefore TF measurements were not blank-corrected.
“TF method blanks were below 1% of sample concentrations, and therefore TF measurements were not blank-corrected.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationcitationThe results from this study on PFASs in cosmetic products, in combination with more recent dermal permeability studies of PFOA, underscore the need to revisit the potential contribution of dermal exposure.
“Thus, the results from this study on PFASs in CPs in combination with more recent dermal permeability studies of PFOA underscore the need to revisit the potential contribution of dermal exposure.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [50] source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationJapanese cosmetic products displayed a slightly different homologue pattern with consistently higher concentrations of PFOA compared to PFHxA.
“However, the Japanese products displayed a slightly different homologue pattern with consistently higher concentrations of PFOA compared to PFHxA.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [22] source
Not checked in the free run.
The paper relies on this without support.
The 39 targeted PFASs account for all known PFASs present in the samples, so that any remaining EOF/TF is due to unknown fluorinated substances.
“The total concentration of unidentied, extractable organic uorine (C F_extr.unknown ; ng F per g) can then be determined by subtracting SC F_PFAS from the total extractable organic uorine concentration (C F_EOF ; ng F per g) as measured directly by CIC, according to eqn (2).”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The EOF assay using CIC was most recently applied to detect PFAS in cosmetics.
“Most recently, the technique was applied to detect PFAS in cosmetics [98].”
From Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment (2019) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Individual FTSA detections conflict with reported sample totals
MinorThe text says 8:2 FTSA was detected only in FOUN03 at 156 ng g À1, but later gives the sum of all three FTSAs in FOUN03 as just 60.6 ng g À1. It also gives FOUN02 an FTSA sum of 288 ng g À1, exceeding the stated maximum of 132 ng g À1 for 6:2 FTSA, the only FTSA reported there.
“Additionally, 6:2 and 8:2 FTSA were detected in three (FOUN01, FOUN02 and FOUN03; 21.9 to 132 ng g À1 ) and one (FOUN03, 156 ng g À1 ) foundation products, respectively.”
“S 3 FTSA concentrations of 21.9, 288 and 60.6 ng g À1 , respectively”
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“1 ng/kg/d, with the high end exceeding dietary exposure in Sweden (Schultes et al. 2018).”
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Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
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“In another study, 39 PFAS in 31 cosmetic products available on the Swedish market were analyzed using LC–MS/MS and combustion ion chromatography (CIC) (Schultes et al. 2018).”
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“There are more than 4700 known PFAS chemicals and this number continues to grow as new chemicals are invented in industry [12].”
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“…dermal absorption through direct contact with these products a possible source of exposure (EFSA CONTAM Panel, 2020; Kotthoff et al., 2015; Be � canov � a et al., 2016; Schultes et al., 2018; Whitehead et al., 2021; van der Veen et al., 2020; Harris et al., 2022; Ragnarsd � ottir et al., 2022).”
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Self-citationPFAS removal from water using quaternary amine functionalized porous polymers
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- Authors
- Schultes, L., Vestergren, R., Volkova, K., Westberg, E., Jacobson, T., & Benskin, J. P.
- Affiliations
- Stockholm University (SE)
- IVL Swedish Environmental Research Institute (CN)
- Swedish Society for Nature Conservation (SE)
- Corresponding author
- Schultes, Lara
- Vestergren, Robin
- Benskin, Jonathan P.
- Venue
- Environmental Science: Processes & Impacts
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 20
- Issue
- 12
- Pages
- 1680-1690
- ISSN
- 2050-7887 (ISSN-L)
- 2050-7895
- OpenAlex
- W2898732378
- Cited by
- 193
- References
- 47
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 35 · 2023: 41 · 2022: 29 · 2021: 21 · 2020: 17 · 2019: 11
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Environmental Science Processes & Impacts (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Svenska Forskningsrådet Formas (2013-00794)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- per- and polyfluoroalkyl substances, PFASs, cosmetics, fluorine mass balance, extractable organic fluorine, total fluorine, perfluorinated carboxylic acids, perfluorohexanoic acid, human exposure, environmental emissions, hair care products, sunscreen
- MeSH terms
- Caproates, Chromatography, Liquid, Cosmetics, Environmental Exposure, Environmental Pollutants, Fluorine, Fluorocarbons, Heptanoic Acids, Humans, Sweden
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