Cited by 514Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactFluoride Effects and Removal

Estimating Consumer Exposure to PFOS and PFOA

Trudel, David, Horowitz, Lea, Wormuth, Matthias, Scheringer, Martin, Cousins, Ian T., Hungerbühler, Konrad·2008·Risk Analysis

Abstract

Perfluorinated compounds have been used for more than 50 years as process aids, surfactants, and for surface protection. This study is a comprehensive assessment of consumer exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) from a variety of environmental and product-related sources. To identify relevant pathways leading to consumer exposure to PFOS and PFOA a scenario-based approach has been applied. Scenarios represent realistic situations where age- and gender-specific exposure occurs in the everyday life of consumers. We find that North American and European consumers are likely to experience ubiquitous and long-term uptake doses of PFOS and PFOA in the range of 3 to 220 ng per kg body weight per day (ng/kg(bw)/day) and 1 to 130 ng/kg(bw)/day, respectively. The greatest portion of the chronic exposure to PFOS and PFOA is likely to result from the intake of contaminated foods, including drinking water. Consumer products cause a minor portion of the consumer exposure to PFOS and PFOA. Of these, it is mainly impregnation sprays, treated carpets in homes, and coated food contact materials that may lead to consumer exposure to PFOS and PFOA. Children tend to experience higher total uptake doses (on a body weight basis) than teenagers and adults because of higher relative uptake via food consumption and hand-to-mouth transfer of chemical from treated carpets and ingestion of dust. The uptake estimates based on scenarios are within the range of values derived from blood serum data by applying a one-compartment pharmacokinetic model.

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Crossref · 10.1111/j.1539-6924.2008.01017.x

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Authors
Trudel, D., Horowitz, L., Wormuth, M., Scheringer, M., Cousins, I. T., & Hungerbühler, K.
Affiliations
  • ETH Zurich (CH)
  • Stockholm University (SE)
Corresponding author
Scheringer, Martin
Venue
Risk Analysis
Publisher
Wiley
Published
2008-04
Volume
28
Issue
2
Pages
251-269
ISSN
  • 0272-4332 (ISSN-L)
  • 1539-6924
OpenAlex
W2038447616
Cited by
514
References
79
Citations by year
2026: 24 · 2025: 32 · 2024: 40 · 2023: 30 · 2022: 36 · 2021: 38 · 2020: 31 · 2019: 29 · 2018: 26 · 2017: 25 · 2016: 21 · 2015: 21 · 2014: 24 · 2013: 24 · 2012: 23
FWCI
21.90
Type
journal article
Language
en
Open access
closed
Locations
  • Risk Analysis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesamt für Gesundheit
  • Health Canada
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
Keywords
PFOS, perfluorooctanoic acid, perfluorinated compounds, consumer exposure, exposure assessment, food contamination, drinking water contamination, consumer goods, food contact materials, children's exposure, dust ingestion, one-compartment model
MeSH terms
Adolescent, Adult, Caprylates, Child, Child, Preschool, Dust, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Female, Fluorocarbons, Humans, Infant, Male, Water Pollutants, Chemical, Air Pollution, Indoor, Alkanesulfonic Acids

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