The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications
Abstract
This review systematically summarizes the cutting-edge methods for preparing engineered exosomes through cell engineering and exosome engineering, as well as the latest advancements of engineered exosomes in therapeutic applications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Exosome surface modification techniques have evolved from basic chemical methods to more advanced genetic and physical approaches, significantly enhancing their targeting capabilities, stability, and functionality.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [39]
Citations
Cites
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications
Zheng, Y., Ley, S. H., & Hu, F. B. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.151 · Cited by 5,697
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899
Engineering exosomes for targeted drug delivery
Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547
Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323
Self-citationLiang, Y., Xu, X., Li, X., Xiong, J., Li, B., Duan, L., Wang, D., & Xia, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c10458 · Cited by 391
Zha, Y., Li, Y., Lin, T., Chen, J., Zhang, S., & Wang, J. (2021) · Theranostics · doi:10.7150/thno.50741 · Cited by 232
Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles
Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79
Sun, W., Xing, C., Zhao, L., Zhao, P., Yang, G., & Yuan, L. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.03.016 · Cited by 62
Flagged first, then by citations
Research works printed but not linked: 168
- Zhang, 2023, Int. J. Nanomed., 18, 209, 10.2147/IJN.S388916 · DOI
- Wolf, 1967, Br. J. Haematol., 13, 269, 10.1111/j.1365-2141.1967.tb08741.x · DOI
- Tang, 2023, Proc. Natl. Acad. Sci. U. S. A., 120, e2303822120, 10.1073/pnas.2303822120 · DOI
- Kalluri, 2020, Science, 367, eaau6977, 10.1126/science.aau6977 · DOI · Paper page
- Nowak, 2023, Int. J. Mol. Sci., 24, 10267, 10.3390/ijms241210267 · DOI
- Tian, 2018, ACS Nano, 12, 671, 10.1021/acsnano.7b07782 · DOI
- Poon, 2019, J. Extracell. Vesicles, 8, 1608786, 10.1080/20013078.2019.1608786 · DOI
- Stefańska, 2023, Cells, 12, 356, 10.3390/cells12030356 · DOI
- Omrani, 2023, Mol. Cell. Biochem., 1
- Dimik, 2023, Drug Delivery Transl. Res., 13, 473, 10.1007/s13346-022-01225-3 · DOI
- Huda, 2021, ACS Biomater. Sci. Eng., 7, 2106, 10.1021/acsbiomaterials.1c00217 · DOI
- Li, 2022, J. Oncol., 2022, 9356807
- Jadli, 2020, Mol. Cell. Biochem., 467, 77, 10.1007/s11010-020-03703-z · DOI
- Elsharkasy, 2020, Adv. Drug Delivery Rev., 159, 332, 10.1016/j.addr.2020.04.004 · DOI
- Peng, 2022, J. Extracell. Vesicles, 11, e12187, 10.1002/jev2.12187 · DOI
- Usman, 2018, Nat. Commun., 9, 2359, 10.1038/s41467-018-04791-8 · DOI · Paper page
- Chu, 2022, Stem Cell Rev. Rep., 18, 2152, 10.1007/s12015-022-10398-w · DOI
- Zhao, 2023, Stem Cell Res. Ther., 14, 62, 10.1186/s13287-023-03270-2 · DOI
- Sandfeld-Paulsen, 2016, J. Thorac. Oncol., 11, 1701, 10.1016/j.jtho.2016.05.034 · DOI
- Wang, 2015, Oncol. Lett., 10, 71, 10.3892/ol.2015.3155 · DOI
- Tkach, 2017, EMBO J., 36, 3012, 10.15252/embj.201696003 · DOI
- Jayasinghe, 2023, ACS Nano, 17, 21639, 10.1021/acsnano.3c06803 · DOI
- Pak, 2023, J. Gastroenterol. Hepatol., 38, 539, 10.1111/jgh.16110 · DOI
- Muthu, 2021, Stem Cell Invest., 8, 7, 10.21037/sci-2020-037 · DOI
- Mathivanan, 2012, Nucleic Acids Res., 40, D1241, 10.1093/nar/gkr828 · DOI
- Jiang, 2021, Mol. Cancer, 20, 117, 10.1186/s12943-021-01411-w · DOI
- Bhadresha, 2022, Sci. Rep., 12, 20258, 10.1038/s41598-022-24443-8 · DOI
- You, 2019, QJM, 112, 581, 10.1093/qjmed/hcz093 · DOI
- Raposo, 2013, J. Cell Biol., 200, 373, 10.1083/jcb.201211138 · DOI · Paper page
- Pooresmaeil, 2023, Ther. Delivery, 14, 775, 10.4155/tde-2023-0131 · DOI
- Liang, 2020, J. Nanobiotechnol., 18, 10, 10.1186/s12951-019-0563-2 · DOI · Paper page
- Huang, 2023, ACS Omega, 8, 43374, 10.1021/acsomega.3c04479 · DOI
- Xu, 2021, Theranostics, 11, 8926, 10.7150/thno.62330 · DOI · Paper page
- Lin, 2022, J. Nanobiotechnol., 20, 432, 10.1186/s12951-022-01636-x · DOI · Paper page
- Lee, 2023, Biomater. Res., 27, 81, 10.1186/s40824-023-00418-2 · DOI
- Chen, 2023, Front. Bioeng. Biotechnol., 11, 1254356, 10.3389/fbioe.2023.1254356 · DOI
- Dong, 2018, Theranostics, 8, 1243, 10.7150/thno.22856 · DOI
- Yan, 2023, Int. J. Biol. Sci., 19, 625, 10.7150/ijbs.79875 · DOI
- Rashidi, 2022, Front. Genet., 13, 1009338, 10.3389/fgene.2022.1009338 · DOI
- Luan, 2017, Acta Pharmacol. Sin., 38, 754, 10.1038/aps.2017.12 · DOI
- Jiang, 2022, Curr. Med. Chem., 29, 3111, 10.2174/0929867328666210902142015 · DOI
- Toffoli, 2015, Nanomedicine, 10, 2963, 10.2217/nnm.15.118 · DOI
- Bonomi, 2015, Cytotherapy, 17, 1687, 10.1016/j.jcyt.2015.09.005 · DOI · Paper page
- Kalimuthu, 2018, Front. Pharmacol., 9, 1116, 10.3389/fphar.2018.01116 · DOI
- Mortezaee, 2023, Med. Oncol., 40, 128, 10.1007/s12032-023-01995-x · DOI
- Patton, 2020, J. Cell. Biochem., 121, 828, 10.1002/jcb.29328 · DOI
- Debbi, 2022, Biotechnol. Adv., 59, 107983, 10.1016/j.biotechadv.2022.107983 · DOI
- Logozzi, 2018, Cancers, 10, 370, 10.3390/cancers10100370 · DOI
- Erwin, 2023, Pharm. Res., 40, 833, 10.1007/s11095-022-03420-w · DOI
- Dooley, 2021, Mol. Ther., 29, 1729, 10.1016/j.ymthe.2021.01.020 · DOI
- Kooijmans, 2016, J. Extracell. Vesicles, 5, 31053, 10.3402/jev.v5.31053 · DOI
- Zheng, 2023, Anal. Chim. Acta, 1263, 341319, 10.1016/j.aca.2023.341319 · DOI
- Alvarez-Erviti, 2011, Nat. Biotechnol., 29, 341, 10.1038/nbt.1807 · DOI · Paper page
- Wang, 2022, J. Nanobiotechnol., 20, 247, 10.1186/s12951-022-01462-1 · DOI
- Levy, 2021, Front. Mol. Biosci., 8, 680580, 10.3389/fmolb.2021.680580 · DOI
- Lyu, 2023, Pharm. Res., 40, 927, 10.1007/s11095-022-03400-0 · DOI
- Antimisiaris, 2018, Pharmaceutics, 10, 218, 10.3390/pharmaceutics10040218 · DOI
- Rahbarghazi, 2019, Cell Commun. Signaling, 17, 73, 10.1186/s12964-019-0390-y · DOI
- Tamura, 2017, Acta Biomater., 57, 274, 10.1016/j.actbio.2017.05.013 · DOI
- Nakase, 2015, Sci. Rep., 5, 10112, 10.1038/srep10112 · DOI
- Qi, 2016, ACS Nano, 10, 3323, 10.1021/acsnano.5b06939 · DOI · Paper page
- Wang, 2017, ACS Appl. Mater. Interfaces, 9, 27441, 10.1021/acsami.7b06464 · DOI
- Zuo, 2020, Nat. Commun., 11, 1790, 10.1038/s41467-020-15569-2 · DOI
- Kanchanapally, 2019, Int. J. Nanomed., 14, 531, 10.2147/IJN.S191313 · DOI
- Kim, 2016, Nanomedicine, 12, 655, 10.1016/j.nano.2015.10.012 · DOI · Paper page
- Ahmed, 2022, Mol. Pharm., 19, 763, 10.1021/acs.molpharmaceut.1c00182 · DOI
- Haney, 2015, J. Controlled Release, 207, 18, 10.1016/j.jconrel.2015.03.033 · DOI · Paper page
- Gebeyehu, 2021, Crit. Rev. Ther. Drug Carrier Syst., 38, 53, 10.1615/CritRevTherDrugCarrierSyst.2021036301 · DOI
- Kumar, 2023, AAPS PharmSciTech, 24, 166, 10.1208/s12249-023-02624-6 · DOI
- Chen, 2022, Mol. Med. Rep., 25, 213, 10.3892/mmr.2022.12729 · DOI
- Du, 2021, Theranostics, 11, 8185, 10.7150/thno.59121 · DOI
- Alvarez-Erviti, 2011, Nat. Biotechnol., 29, 341, 10.1038/nbt.1807 · DOI · Paper page
- He, 2022, Theranostics, 12, 1816, 10.7150/thno.69885 · DOI
- Kooijmans, 2013, J. Controlled Release, 172, 229, 10.1016/j.jconrel.2013.08.014 · DOI · Paper page
- Lennaárd, 2021, Pharmaceutics, 14, 38, 10.3390/pharmaceutics14010038 · DOI
- Shao, 2023, Int. J. Pharm., 641, 123090, 10.1016/j.ijpharm.2023.123090 · DOI
- Shi, 2022, Curr. Pharm. Biotechnol., 23, 1072, 10.2174/1389201022666210820114236 · DOI
- Wang, 2021, J. Controlled Release, 329, 894, 10.1016/j.jconrel.2020.10.020 · DOI
- Li, 2023, Asian J. Pharm. Sci., 18, 100797, 10.1016/j.ajps.2023.100797 · DOI
- Tian, 2018, Biomaterials, 150, 137, 10.1016/j.biomaterials.2017.10.012 · DOI · Paper page
- Zhang, 2022, Bioact. Mater., 18, 1
- Kim, 2018, Nanomedicine, 14, 195, 10.1016/j.nano.2017.09.011 · DOI · Paper page
- Pham, 2021, J. Extracell. Vesicles, 10, e12057, 10.1002/jev2.12057 · DOI · Paper page
- Zhupanyn, 2020, J. Controlled Release, 319, 63, 10.1016/j.jconrel.2019.12.032 · DOI
- Xu, 2022, Acta Biomater., 154, 23, 10.1016/j.actbio.2022.10.007 · DOI
- Lee, 2016, ACS Appl. Mater. Interfaces, 8, 6790, 10.1021/acsami.6b01315 · DOI
- Huang, 2023, Regen. Ther., 22, 90, 10.1016/j.reth.2022.12.007 · DOI
- Salunkhe, 2020, J. Controlled Release, 326, 599, 10.1016/j.jconrel.2020.07.042 · DOI
- Zhan, 2020, Theranostics, 10, 7889, 10.7150/thno.45028 · DOI · Paper page
- Lin, 2018, Adv. Sci., 5, 1700611, 10.1002/advs.201700611 · DOI · Paper page
- Liu, 2023, BMEMat, 1, e12025, 10.1002/bmm2.12025 · DOI
- Lin, 2020, Small, 16, e1903916, 10.1002/smll.201903916 · DOI
- Coughlan, 2020, Curr. Protoc. Cell Biol., 88, e110, 10.1002/cpcb.110 · DOI
- Ayala-Mar, 2019, Electrophoresis, 40, 3036, 10.1002/elps.201800526 · DOI
- Coumans, 2017, Circ. Res., 120, 1632, 10.1161/CIRCRESAHA.117.309417 · DOI
- Kim, 2015, PLoS One, 10, e0129760, 10.1371/journal.pone.0129760 · DOI
- Mohammadi, 2021, Biosens. Bioelectron., 183, 113176, 10.1016/j.bios.2021.113176 · DOI
- Navajas, 2019, Methods Mol. Biol., 1959, 39, 10.1007/978-1-4939-9164-8_3 · DOI
- Ding, 2021, Small, 17, e2007174, 10.1002/smll.202007174 · DOI
- Gao, 2022, Plast. Reconstr. Surg., 149, 638, 10.1097/PRS.0000000000008830 · DOI
- Lane, 2017, Methods Mol. Biol., 1660, 111, 10.1007/978-1-4939-7253-1_10 · DOI
- Greening, 2015, Methods Mol. Biol., 1295, 179, 10.1007/978-1-4939-2550-6_15 · DOI
- Song, 2020, Molecules, 25, 5585, 10.3390/molecules25235585 · DOI
- Rai, 2021, Methods Mol. Biol., 2261, 105, 10.1007/978-1-0716-1186-9_9 · DOI
- Jiang, 2014, Lab Chip, 14, 671, 10.1039/C3LC50977J · DOI
- Wu, 2017, Proc. Natl. Acad. Sci. U. S. A., 114, 10584, 10.1073/pnas.1709210114 · DOI
- Gu, 2021, Sci. Adv., 7, eabc0467, 10.1126/sciadv.abc0467 · DOI
- Li, 2020, Biotechnol. J., 15, e1900225, 10.1002/biot.201900225 · DOI
- Kim, 2024, Adv. Healthcare Mater., e2303782, 10.1002/adhm.202303782 · DOI
- Ramnauth, 2023, Sensors, 23, 8292, 10.3390/s23198292 · DOI
- Ko, 2023, ACS Appl. Mater. Interfaces, 15, 26069, 10.1021/acsami.3c00446 · DOI
- Back, 2023, Anal. Biochem., 673, 115161, 10.1016/j.ab.2023.115161 · DOI
- Wang, 2020, Lab Chip, 20, 4632, 10.1039/D0LC00677G · DOI
- Guo, 2020, Biosens. Bioelectron., 164, 112292, 10.1016/j.bios.2020.112292 · DOI
- Zhang, 2021, Talanta, 221, 121571, 10.1016/j.talanta.2020.121571 · DOI
- Suwatthanarak, 2021, Lab Chip, 21, 597, 10.1039/D0LC00899K · DOI
- Tay, 2021, Lab Chip, 21, 2511, 10.1039/D1LC00333J · DOI
- Liu, 2021, Adv. Mater., 33, e2008493, 10.1002/adma.202008493 · DOI
- Cizmar, 2017, Methods Mol. Biol., 1660, 221, 10.1007/978-1-4939-7253-1_18 · DOI
- Szatanek, 2017, Int. J. Mol. Sci., 18, 1153, 10.3390/ijms18061153 · DOI
- Benmoussa, 2017, J. Extracell. Vesicles, 6, 1401897, 10.1080/20013078.2017.1401897 · DOI
- Khodakov, 2016, Adv. Drug Delivery Rev., 105, 3, 10.1016/j.addr.2016.04.005 · DOI
- Cheng, 2014, J. Extracell. Vesicles, 3, 3, 10.3402/jev.v3.23743 · DOI · Paper page
- Zhang, 2023, Signal Transduction Targeted Ther., 8, 124, 10.1038/s41392-023-01382-y · DOI
- You, 2018, Am. J. Cancer Res., 8, 1332
- Zhu, 2022, Biomater. Sci., 10, 2154, 10.1039/D2BM00161F · DOI
- Yu, 2023, J. Mol. Med., 101, 1209, 10.1007/s00109-023-02357-w · DOI
- Hade, 2021, Cells, 10, 1959, 10.3390/cells10081959 · DOI
- Yuan, 2023, Adv. Healthcare Mater., 12, e2202959, 10.1002/adhm.202202959 · DOI
- Ayyar, 2021, Front. Pharmacol., 12, 658505, 10.3389/fphar.2021.658505 · DOI
- Ji, 2024, Int. J. Nanomed., 19, 3943, 10.2147/IJN.S452184 · DOI
- Huang, 2022, Mol. Cancer, 21, 45, 10.1186/s12943-022-01515-x · DOI
- Zhou, 2021, Cancer Cell Int., 21, 485, 10.1186/s12935-021-02157-7 · DOI
- Limoni, 2019, Appl. Biochem. Biotechnol., 187, 352, 10.1007/s12010-018-2813-4 · DOI
- Huang, 2022, J. Controlled Release, 343, 107, 10.1016/j.jconrel.2022.01.026 · DOI · Paper page
- Bai, 2020, Asian J. Pharm. Sci., 15, 461, 10.1016/j.ajps.2019.04.002 · DOI
- Liu, 2023, Adv. Mater., 35, e2303660, 10.1002/adma.202303660 · DOI
- Si, 2012, Diabetes, 61, 1616, 10.2337/db11-1141 · DOI
- Li, 2021, J. Endocrinol. Invest., 44, 1193, 10.1007/s40618-020-01405-3 · DOI
- Wang, 2024, ACS Nano, 18, 4871, 10.1021/acsnano.3c09814 · DOI
- Sun, 2018, ACS Nano, 12, 7613, 10.1021/acsnano.7b07643 · DOI
- Davidson, 2018, J. Cell. Mol. Med., 22, 141, 10.1111/jcmm.13302 · DOI
- Nilforoushzadeh, 2023, Arch. Dermatol. Res., 315, 147, 10.1007/s00403-022-02326-2 · DOI
- Huldani, 2023, Tissue Cell, 85, 102252, 10.1016/j.tice.2023.102252 · DOI
- Huang, 2021, Adv. Clin. Chem., 103, 47, 10.1016/bs.acc.2020.08.006 · DOI
- Youn, 2019, Antioxidants, 8, 18, 10.3390/antiox8010018 · DOI
- Khan, 2015, Circ. Res., 117, 52, 10.1161/CIRCRESAHA.117.305990 · DOI
- de Abreu, 2020, Nat. Rev. Cardiol., 17, 685, 10.1038/s41569-020-0389-5 · DOI
- Kishore, 2016, Circ. Res., 118, 330, 10.1161/CIRCRESAHA.115.307654 · DOI
- Lai, 2010, Stem Cell Res., 4, 214, 10.1016/j.scr.2009.12.003 · DOI · Paper page
- Gray, 2015, Circ. Res., 116, 255, 10.1161/CIRCRESAHA.116.304360 · DOI
- Zhu, 2021, J. Nanobiotechnol., 19, 61, 10.1186/s12951-021-00808-5 · DOI
- Wang, 2024, Colloid Interface Sci., 59, 100775, 10.1016/j.colcom.2024.100775 · DOI
- Bei, 2021, Small, 17, e2101741, 10.1002/smll.202101741 · DOI
- Kim, 2020, Biotechnol. J., 15, e2000082, 10.1002/biot.202000082 · DOI
- Tienda-Vázquez, 2023, Cells, 12, 1625, 10.3390/cells12121625 · DOI
- Gao, 2023, Photochem. Photobiol. Sci., 22, 135, 10.1007/s43630-022-00304-1 · DOI
- Roe, 2021, Scand. J. Immunol., 93, e12970, 10.1111/sji.12970 · DOI
- Xie, 2019, J. Agric. Food Chem., 67, 9477, 10.1021/acs.jafc.9b02925 · DOI
- Bu, 2021, Theranostics, 11, 9988, 10.7150/thno.64229 · DOI
- Wang, 2018, J. Am. Heart Assoc., 7, e008737, 10.1161/JAHA.118.008737 · DOI
- Teng, 2018, Cell Host Microbe, 24, 637, 10.1016/j.chom.2018.10.001 · DOI · Paper page
- Rezaie, 2022, Cell Commun. Signaling, 20, 145, 10.1186/s12964-022-00959-4 · DOI
- Xu, 2019, Clin. Immunol., 205, 116, 10.1016/j.clim.2019.06.006 · DOI
- Deng, 2023, J. Controlled Release, 354, 635, 10.1016/j.jconrel.2023.01.017 · DOI
- Wang, 2023, Adv. Mater., 35, e2302503, 10.1002/adma.202302503 · DOI
- Jiang, 2024, Int. Immunopharmacol., 129, 111677, 10.1016/j.intimp.2024.111677 · DOI
- Meng, 2020, BMC Musculoskeletal Disord., 21, 150, 10.1186/s12891-020-3159-y · DOI
Cited by
Sorted by citations
Emerging role of exosomes in cancer therapy: progress and challenges
Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297
Metadata
- Authors
- Fan, X., Zhang, Y., Liu, W., Shao, M., Gong, Y., Wang, T., Xue, S., & Nian, R.
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2024
- Volume
- 12
- Issue
- 14
- Pages
- 3500-3521
- ISSN
- 2047-4830
- 2047-4849
- Cited by
- 50
- References
- 9
- Language
- en
- Funders
- Natural Science Foundation of Shandong Province (ZR2022QB122, ZR2022MH123, ZR2022MB062)
- Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences (QIBEBT ICP 202302)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review