The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.
Relationship Between Hepatic/Visceral Fat and Hepatic Insulin Resistance in Nondiabetic and Type 2 Diabetic Subjects
Open accessAbstract
Background and aims Abdominal fat accumulation (visceral/hepatic) has been associated with hepatic insulin resistance (IR) in obesity and type 2 diabetes (T2DM). We examined the relationship between visceral/hepatic fat accumulation and hepatic IR/accelerated gluconeogenesis (GNG).Methods In 14 normal glucose tolerant (NGT) (body mass index [BMI] = 25 +/- 1 kg/m(2)) and 43 T2DM (24 nonobese, BMI = 26 +/- 1; 19 obese, BMI = 32 +/- 1 kg/m(2)) subjects, we measured endogenous (hepatic) glucose production (3-(3)H-glucose) and GNG ((2)H(2)O) in the basal state and during 240 pmol/m(2)/min euglycemic-hyperinsulinemic clamp, and liver (LF) subcutaneous (SAT)/visceral (VAT) fat content by magnetic resonance spectroscopy/magnetic resonance imaging.Results LF was increased in lean T2DM compared with lean NGT (18% +/- 3% vs 9% +/- 2%, P < .03), but was similar in lean T2DM and obese T2DM (18% +/- 3% vs 22% +/- 3%; P = NS). Both VAT and SAT increased progressively from lean NGT to lean T2DM to obese T2DM. T2DM had increased basal endogenous glucose production (EGP) (NGT, 15.1 +/- 0.5; lean T2DM, 16.3 +/- 0.4; obese T2DM, 17.2 +/- 0.6 micromol/min/kg(ffm); P = .02) and basal GNG flux (NGT, 8.6 +/- 0.4; lean T2DM, 9.6 +/- 0.4; obese T2DM, 11.1 +/- 0.6 micromol/min/kg(ffm); P = .02). Basal hepatic IR index (EGP x fasting plasma insulin) was increased in T2DM (NGT, 816 +/- 54; lean T2DM, 1252 +/- 164; obese T2DM, 1810 +/- 210; P = .007). In T2DM, after accounting for age, sex, and BMI, both LF and VAT, but not SAT, were correlated significantly (P < .05) with basal hepatic IR and residual EGP during insulin clamp. Basal percentage of GNG and GNG flux were correlated positively with VAT (P < .05), but not with LF. LF, but not VAT, was correlated with fasting insulin, insulin-stimulated glucose disposal, and impaired FFA suppression by insulin (all P < .05).Conclusions Abdominal adiposity significantly affects both lipid (FFA) and glucose metabolism. Excess VAT primarily increases GNG flux. Both VAT and LF are associated with hepatic IR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In small groups of diabetic patients, insulin clearance has reported to be normal, 16 -18 decreased, 19,20 or even increased.21”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [17]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“Except for a recent study of Gastaldelli et al, 17 who found no difference in insulin clearance between lean normal subjects and lean or obese type 2 diabetic patients, there are no studies in which carefully matched groups of type 2 diabetic patients and nondiabetic subjects would have been compared with respect to liver fat, hepatic insulin sensitivity, and insulin clearance.”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
Belfort, R., Harrison, S. A., Brown, K., Darland, C., Finch, J., Hardies, J., Balas, B., Gastaldelli, A., Tio, F., Pulcini, J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060326 · Cited by 1,827
Association of nonalcoholic fatty liver disease with insulin resistance
Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,570
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322
Insulin resistance: a metabolic pathway to chronic liver disease
Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900
Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method
Steele, R., Wall, J. S., de Bodo, R. C., & Altszuler, N. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.15 · Cited by 816
Groop, L. C., Bonadonna, R. C., DelPrato, S., Ratheiser, K., Zyck, K., Ferrannini, E., & DeFronzo, R. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114142 · Cited by 812
Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S., Ponti, V., Pagano, G., Ferrannini, E., & Rizzetto, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1682-x · Cited by 770
Research works printed but not linked: 1
- Matsuda, 1997, Relationship between insulin sensitivity in adipose tissue, liver, muscle and components of the insulin resistance syndrome, Diabetes, 46, 68A
Cited by
Sorted by citations
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
Yki‐Järvinen, H. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70032-4 · Cited by 1,296
Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164
A position statement on NAFLD/NASH based on the EASL 2009 special conference
Ratziu, V., Bellentani, S., Cortez‐Pinto, H., Day, C., & Marchesini, G. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.04.008 · Cited by 1,083
Cusi, K., Isaacs, S., Barb, D., Basu, R., Caprio, S., Garvey, W. T., Kashyap, S., Mechanick, J. I., Mouzaki, M., Nadolsky, K., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.03.010 · Cited by 1,021
Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 940
Bolinder, J., Ljunggren, Ö., Kullberg, J., Johansson, L., Wilding, J., Langkilde, A. M., Sugg, J., & Parikh, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2260 · Cited by 867
Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R. A., Bugianesi, E., & Gastaldelli, A. (2013) · Nutrients · doi:10.3390/nu5051544 · Cited by 849
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
Chondronikola, M., Volpi, E., Børsheim, E., Porter, C. C., Annamalai, P., Enerbäck, S., Lidell, M. E., Saraf, M. K., Labbé, S. M., Hurren, N. M., et al. (2014) · Diabetes · doi:10.2337/db14-0746 · Cited by 803
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO) (2016) · Diabetologia · doi:10.1007/s00125-016-3902-y · Cited by 695
Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.038 · Cited by 631
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631
Kanwal, F., Shubrook, J. H., Adams, L. A., Pfotenhauer, K., Wai-Sun Wong, V., Wright, E., Abdelmalek, M. F., Harrison, S. A., Loomba, R., Mantzoros, C. S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.07.049 · Cited by 618
Korenblat, K. M., Fabbrini, E., Mohammed, B. S., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.075 · Cited by 592
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535
A Global View of the Interplay between Non-Alcoholic Fatty Liver Disease and Diabetes
Stefan, N., & Cusi, K. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00003-1 · Cited by 593
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
Saponaro, C., Gaggini, M., Carli, F., & Gastaldelli, A. (2015) · Nutrients · doi:10.3390/nu7115475 · Cited by 558
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
European Association for the Study of the Liver (EASL), E. A. F. T. S. O. D. (. (2016) · Obesity Facts · doi:10.1159/000443344 · Cited by 531
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
Tilg, H., Adolph, T. E., Dudek, M., & Knolle, P. A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00501-9 · Cited by 539
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500
From the metabolic syndrome to NAFLD or vice versa?
Vanni, E., Bugianesi, E., Kotronen, A., Minicis, S. D., Yki‐Järvinen, H., & Svegliati‐Baroni, G. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.01.016 · Cited by 500
Taylor, R. (2013) · Diabetes Care · doi:10.2337/dc12-1805 · Cited by 485
Insulin resistance, inflammation, and non-alcoholic fatty liver disease
Tilg, H., & Moschen, A. R. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.005 · Cited by 484
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance
Gaggini, M., Carli, F., Rosso, C., Buzzigoli, E., Marietti, M., Latta, V. D., Ciociaro, D., Abate, M. L., Gambino, R., Cassader, M., et al. (2017) · Hepatology · doi:10.1002/hep.29465 · Cited by 476
Neeland, I. J., Lim, S., Tchernof, A., Gastaldelli, A., Rangaswami, J., Ndumele, C. E., Powell-Wiley, T. M., & Després, J.-P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00563-5 · Cited by 463
Lomonaco, R., Ortiz‐Lopez, C., Orsak, B., Webb, A., Hardies, J., Darland, C., Finch, J., Gastaldelli, A., Harrison, S. A., Tio, F. O., et al. (2011) · Hepatology · doi:10.1002/hep.25539 · Cited by 460
From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
Gastaldelli, A., & Cusi, K. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.07.002 · Cited by 455
Self-citationMetabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
Masoodi, M., Gastaldelli, A., Hyötyläinen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00502-9 · Cited by 451
Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
Marra, F., Gastaldelli, A., Svegliati‐Baroni, G., Tell, G., & Tiribelli, C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.003 · Cited by 427
Svegliati‐Baroni, G., Saccomanno, S., Rychlicki, C., Agostinelli, L., De Minicis, S., Candelaresi, C., Faraci, G., Pacetti, D., Vivarelli, M., Nicolini, D., et al. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02462.x · Cited by 405
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382
Ridderstråle, M., Andersen, K. R., Zeller, C., Kim, G., Woerle, H. J., & Broedl, U. C. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70120-2 · Cited by 385
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
ter Horst, K. W., & Serlie, M. J. M. (2017) · Nutrients · doi:10.3390/nu9090981 · Cited by 379
Swainson, M. G., Batterham, A. M., Tsakirides, C., Rutherford, Z. H., & Hind, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177175 · Cited by 370
Gastaldelli, A., Gaggini, M., & DeFronzo, R. A. (2017) · Diabetes · doi:10.2337/db16-1167 · Cited by 344
Self-citationPoirier, P., Cornier, M.-A., Mazzone, T., Stiles, S., Cummings, S., Klein, S., McCullough, P. A., Ren Fielding, C., & Franklin, B. A. (2011) · Circulation · doi:10.1161/cir.0b013e3182149099 · Cited by 339
Kotronen, A., Juurinen, L., Tiikkainen, M., Vehkavaara, S., & Yki–Järvinen, H. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.021 · Cited by 339
Resolving the paradox of hepatic insulin resistance
Santoleri, D., & Titchenell, P. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.016 · Cited by 336
“In addition, both obese and diabetic human beings show a higher prevalence of NAFLD than lean ones.(7) Isotope labeling experiments in subjects with NAFLD showed that subjects with increased hepatic steatosis had 2fold higher rates of de novo lipogenesis and increased plasma levels of free fatty acids (FFAs) and insul…”
BackgroundChamorro-García, R., Sahu, M. B., Abbey, R. J., Laude, J., Pham, N., & Blumberg, B. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205701 · Cited by 339
du Plessis, J., van Pelt, J. F., Korf, H., Mathieu, C., der Schueren, B. V., Lannoo, M., Oyen, T., Topal, B., Fetter, G., Nayler, S., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.044 · Cited by 337
Pathogenesis and Prevention of Hepatic Steatosis.
Nassir, F., Rector, R. S., Hammoud, G. M., & Ibdah, J. A. (2015) · PubMed Central · Cited by 317
Hepatic lipid metabolism and non-alcoholic fatty liver disease
Tessari, P., Coracina, A., Cosma, A., & Tiengo, A. (2009) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.12.015 · Cited by 314
A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease
Chen, Z., Yu, R., Xiong, Y., Du, F.-T., & Zhu, S. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0572-9 · Cited by 325
Targher, G., & Byrne, C. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3093 · Cited by 299
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
Yki-Järvinen, H., Luukkonen, P. K., Hodson, L., & Moore, J. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00472-y · Cited by 294
Gastaldelli, A., Harrison, S. A., Belfort-Aguilar, R., Hardies, L. J., Balas, B., Schenker, S., & Cusi, K. (2009) · Hepatology · doi:10.1002/hep.23116 · Cited by 285
Understanding the mechanisms of reversal of type 2 diabetes
Taylor, R., Al-Mrabeh, A., & Sattar, N. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30076-2 · Cited by 299
Fabbrini, E., Cella, M., McCartney, S. A., Fuchs, A. G., Abumrad, N. A., Pietka, T., Chen, Z., Finck, B. N., Han, D. H., Magkos, F., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.010 · Cited by 290
Cusi, K. J., Chang, Z., Harrison, S., Lomonaco, R., Bril, F., Orsak, B., Ortiz‐Lopez, C., Hecht, J., Feldstein, A. E., Webb, A., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.042 · Cited by 272
Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis
Cusi, K. J. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.009 · Cited by 270
Ortiz‐Lopez, C., Lomonaco, R., Orsak, B., Finch, J., Chang, Z., Kochunov, V., Hardies, J., & Cusi, K. J. (2012) · Diabetes Care · doi:10.2337/dc11-1849 · Cited by 258
Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I., & Yki‐Järvinen, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922344117 · Cited by 261
Measuring and estimating insulin resistance in clinical and research settings
Gastaldelli, A. (2022) · Obesity · doi:10.1002/oby.23503 · Cited by 244
Self-citationNonalcoholic Fatty Liver Disease and Metabolic Syndrome
Kim, D., Touros, A., & Kim, W. R. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.08.010 · Cited by 239
Heyens, L. J. M., Busschots, D., Koek, G. H., Robaeys, G., & Francque, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.615978 · Cited by 258
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
Mashek, D. G. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101115 · Cited by 247
Rosso, C., Kazankov, K., Younes, R., Esmaili, S., Marietti, M., Sacco, M., Carli, F., Gaggini, M., Salomone, F., Møller, H. J., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.06.031 · Cited by 217
Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
D’Adamo, E., Cali, A. M. G., Weiss, R., Santoro, N., Pierpont, B. M., Northrup, V. S., & Caprio, S. (2010) · Diabetes Care · doi:10.2337/dc10-0284 · Cited by 218
How to Measure Adipose Tissue Insulin Sensitivity
Søndergaard, E., Ycaza, A. E. E. D., Morgan-Bathke, M. E., & Jensen, M. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00047 · Cited by 207
Yu, J., Marsh, S., Hu, J., Feng, W., & Wu, C. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2862173 · Cited by 199
Guiu, B., Petit, J., Loffroy, R., Salem, D. B., Aho, S., Masson, D., Hillon, P., Krause, D., & Cercueil, J. (2008) · Radiology · doi:10.1148/radiol.2493080217 · Cited by 192
Iacono, A., Raso, G. M., Canani, R. B., Calignano, A., & Meli, R. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.002 · Cited by 197
Cellular and molecular mechanisms in liver fibrogenesis
Novo, E., Cannito, S., Paternostro, C., Bocca, C., Miglietta, A., & Parola, M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.02.015 · Cited by 194
Lessons from Mouse Models of High-Fat Diet-Induced NAFLD
Nakamura, A., & Terauchi, Y. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121240 · Cited by 196
Nonalcoholic fatty liver disease
Krawczyk, M. J., Bonfrate, L., & Portincasa, P. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.08.005 · Cited by 193
Nonalcoholic fatty liver disease in type 2 diabetes mellitus
Cusi, K. J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283293015 · Cited by 190
Localization of fat depots and cardiovascular risk
Gruzdeva, O. V., Borodkinа, D. A., Учасова, Е. Г., Dyleva, Y. A., & Барбараш, О. Л. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0856-8 · Cited by 195
Erion, D. M., Yonemitsu, S., Nie, Y., Nagai, Y., Gillum, M. P., Hsiao, J. J., Iwasaki, T., Stark, R., Weismann, D., Yu, X. X., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812931106 · Cited by 180
Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease
Chao, H., Chao, S.-W., Lin, H., Ku, H., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020298 · Cited by 192
What lipodystrophies teach us about the metabolic syndrome
Mann, J. P., & Savage, D. B. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129190 · Cited by 185
Bril, F., Lomonaco, R., Orsak, B., Ortiz‐Lopez, C., Webb, A., Tio, F. O., Hecht, J., & Cusi, K. J. (2013) · Hepatology · doi:10.1002/hep.26988 · Cited by 173
Steven (2016) · doi:10.2337/dc15-0750 · Cited by 171
Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
Valenti, L., Bugianesi, E., Pajvani, U., & Targher, G. (2016) · Liver International · doi:10.1111/liv.13185 · Cited by 171
Pathophysiology of Non Alcoholic Fatty Liver Disease
Petta, S., Gastaldelli, A., Rebelos, E., Bugianesi, E., Messa, P., Miele, L., Svegliati‐Baroni, G., Valenti, L. V. C., & Bonino, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122082 · Cited by 182
Increased risk of cardiovascular disease and chronic kidney disease in NAFLD
Bonora, E., & Targher, G. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.79 · Cited by 171
Glucose dysregulation and hepatic steatosis in obese adolescents
Cali, A. M. G., de Oliveira, A. M., Kim, H.-J., Chen, S., Reyes‐Múgica, M., Escalera, S., Dziura, J., Taksali, S. E., Kursawe, R., Shaw, M. M., et al. (2009) · Hepatology · doi:10.1002/hep.22858 · Cited by 163
ter Horst, K. W., Gilijamse, P. W., Versteeg, R. I., Ackermans, M. T., Nederveen, A. J., la Fleur, S. E., Romijn, J. A., Nieuwdorp, M., Zhang, D., Samuel, V. T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.035 · Cited by 166
Zhu, Y., Sidell, M. A., Arterburn, D. E., Daley, M. F., DESAI, J. R., Fitzpatrick, S. L., Horberg, M. A., Koebnick, C., McCormick, E. V., Oshiro, C. E. S., et al. (2019) · Diabetes Care · doi:10.2337/dc19-0532 · Cited by 170
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss
Al-Mrabeh, A. H., Zhyzhneuskaya, S. V., Peters, C. N., Barnes, A. C., Melhem, S., Jesuthasan, A., Aribisala, B. S., Hollingsworth, K. G., Lietz, G., Mathers, J. C., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.018 · Cited by 164
The Emerging Role of Glucagon-like Peptide-1 Receptor Agonists for the Management of NAFLD
Chavez, C. P., Cusi, K. J., & Kadiyala, S. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab578 · Cited by 165
Ectopic fat and cardiovascular disease: What is the link?
Gastaldelli, A., & Basta, G. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.05.005 · Cited by 164
Simon, T. G., King, L. Y., Chong, D. Q., Nguyen, L. H., Ma, Y., VoPham, T., Giovannucci, E. L., Fuchs, C. S., Meyerhardt, J. A., Corey, K. E., et al. (2018) · Hepatology · doi:10.1002/hep.29660 · Cited by 160
Park, S. K., Seo, M. H., Shin, H. C., & Ryoo, J. (2012) · Hepatology · doi:10.1002/hep.26183 · Cited by 159
Vanni, E., Abate, M. L., Gentilcore, E., Hickman, I. J., Gambino, R., Cassader, M., Smedile, A., Ferrannini, E., Rizzetto, M., Marchesini, G., et al. (2009) · Hepatology · doi:10.1002/hep.23031 · Cited by 158
Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
Yki‐Järvinen, H. (2015) · Nutrients · doi:10.3390/nu7115454 · Cited by 155
Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes
Lomonaco, R., Bril, F., Portillo-Sánchez, P., Ortiz‐Lopez, C., Orsak, B., Biernacki, D., Lo, M. C., Suman, A., Weber, M. H., & Cusi, K. J. (2016) · Diabetes Care · doi:10.2337/dc15-1876 · Cited by 151
Oh, S., So, R., Shida, T., Matsuo, T., Kim, B., Akiyama, K., Isobe, T., Okamoto, Y., Tanaka, K., & Shoda, J. (2017) · Scientific Reports · doi:10.1038/srep43029 · Cited by 146
Bonnet, F., Ducluzeau, P., Gastaldelli, A., Laville, M., Anderwald, C. H., Konrad, T., Mari, A., Balkau, B., & for the RISC Study Group (2011) · Diabetes · doi:10.2337/db10-1806 · Cited by 145
Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD)
Syed‐Abdul, M. M. (2023) · Metabolites · doi:10.3390/metabo14010012 · Cited by 166
Petäjä, E. M., & Yki‐Järvinen, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050633 · Cited by 144
Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., & Ciaula, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115640 · Cited by 167
Obesity, Abdominal Obesity, and Insulin Resistance
Westphal, S. A. (2008) · Clinical cornerstone · doi:10.1016/s1098-3597(08)60025-3 · Cited by 146
Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: Common Pathophysiologic Mechanisms
Saponaro, C., Gaggini, M., & Gastaldelli, A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0607-4 · Cited by 145
Cuthbertson, D. J., Shojaee-Moradie, F., Sprung, V. S., Jones, H., Pugh, C. J. A., Richardson, P., Kemp, G. J., Barrett, M., Jackson, N. C., Thomas, E. L., et al. (2016) · Clinical Science · doi:10.1042/cs20150447 · Cited by 138
Gastaldelli, A. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70015-8 · Cited by 138
Meli, R., Mattace Raso, G., & Calignano, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00177 · Cited by 137
Takeshita, Y., Takamura, T., Honda, M., Kita, Y., Zen, Y., Kato, K., Misu, H., Ota, T., Nakamura, M., Yamada, K., et al. (2014) · Diabetologia · doi:10.1007/s00125-013-3149-9 · Cited by 137
Hepatic glucose metabolism in the steatotic liver
Scoditti, E., Sabatini, S., Carli, F., & Gastaldelli, A. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00888-8 · Cited by 134
Is There a Paradox in Obesity?
Goyal, A., Nimmakayala, K. R., & Zonszein, J. (2014) · Cardiology in Review · doi:10.1097/crd.0000000000000004 · Cited by 132
Metadata
- Authors
- Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., & DeFronzo, R. A.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Istituto di Fisiologia Clinica (IT)
- University of Pisa (IT)
- Corresponding author
- Gastaldelli, Amalia
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 133
- Issue
- 2
- Pages
- 496-506
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2136226749
- Cited by
- 629
- References
- 43
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 33 · 2023: 40 · 2022: 40 · 2021: 40 · 2020: 27 · 2019: 41 · 2018: 36 · 2017: 47 · 2016: 34 · 2015: 26 · 2014: 39 · 2013: 37 · 2012: 33
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 24092)
- National Center for Research Resources (M01RR01346, M01RR001346)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- hepatic insulin resistance, visceral fat, liver fat, abdominal fat accumulation, type 2 diabetes, obesity, hepatic glucose production, gluconeogenesis, hepatic steatosis, hyperinsulinemic-euglycemic clamp, subcutaneous adipose tissue, hepatic lipid accumulation, hepatic lipogenesis, hepatic lipolysis
- MeSH terms
- Adult, Aging, Blood Glucose, Diabetes Mellitus, Type 2, Female, Gluconeogenesis, Humans, Insulin, Insulin Resistance, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Magnetic Resonance Spectroscopy, Obesity, Glucose Clamp Technique, Body Mass Index, Abdominal Fat, Glycogenolysis, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
