The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice
Open accessAbstract
Background & aims Abnormal delivery of bile acids (BAs) to the colon as a result of disease or therapy causes constipation or diarrhea by unknown mechanisms. The G protein-coupled BA receptor TGR5 (or GPBAR1) is expressed by enteric neurons and endocrine cells, which regulate motility and secretion.Methods We analyzed gastrointestinal and colon transit, as well as defecation frequency and water content, in wild-type, knockout, and transgenic mice (trg5-wt, tgr5-ko, and tgr5-tg, respectively). We analyzed colon tissues for contractility, peristalsis, and transmitter release.Results Deoxycholic acid inhibited contractility of colonic longitudinal muscle from tgr5-wt but not tgr5-ko mice. Application of deoxycholic acid, lithocholic acid, or oleanolic acid (a selective agonist of TGR5) to the mucosa of tgr5-wt mice caused oral contraction and caudal relaxation, indicating peristalsis. BAs stimulated release of the peristaltic transmitters 5-hydroxytryptamine and calcitonin gene-related peptide; antagonists of these transmitters suppressed BA-induced peristalsis, consistent with localization of TGR5 to enterochromaffin cells and intrinsic primary afferent neurons. tgr5-ko mice did not undergo peristalsis or transmitter release in response to BAs. Mechanically induced peristalsis and transmitter release were not affected by deletion of tgr5. Whole-gut transit was 1.4-fold slower in tgr5-ko than tgr5-wt or tgr5-tg mice, whereas colonic transit was 2.2-fold faster in tgr5-tg mice. Defecation frequency was reduced 2.6-fold in tgr5-ko and increased 1.4-fold in tgr5-tg mice compared with tgr5-wt mice. Water content in stool was lower (37%) in tgr5-ko than tgr5-tg (58%) or tgr5-wt mice (62%).Conclusions The receptor TGR5 mediates the effects of BAs on colonic motility, and deficiency of TGR5 causes constipation in mice. These findings might mediate the long-known laxative properties of BAs, and TGR5 might be a therapeutic target for digestive diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“ECs were shown to express TGR5, and administration of deoxycholic acid increased 5-HT secretion in colonic tissue of the wild-type, but not Tgr5 transgenic mice (Alemi et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Alemi et al., 2013
Experimental — accuracy not yet measuredIn the citing paper
“Prokinetic effects of bile acids can be mediated by the G protein-coupled bile acid receptor TGR5 (or GPBAR1), expressed by enteric neurons and enteroendocrine cells based on findings from animal models55.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [55]
In the citing paper
“Secondary BAs, produced by gut bacteria, have a unique signaling profile in the GI tract as compared with primary bile moieties.”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Alemi et al., 2013
In the citing paper
“For example, secondary BAs were shown to activate colonic motility by stimulating the release of intestinal 5-HT and CGRP (Alemi et al., 2013).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Alemi et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
Self-citationTGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885
Self-citationRole of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Identification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993
Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics
Hofmann, A. F., & Hagey, L. R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7568-6 · Cited by 873
Katsuma, S., Hirasawa, A., & Tsujimoto, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.139 · Cited by 789
TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading
Pols, T. W. H., Nomura, M., Harach, T., Sasso, G. L., Oosterveer, M. H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.006 · Cited by 643
Self-citationWang, Y., Chen, W., Yu, D. D., FORMAN, B. M., & Huang, W. (2011) · Hepatology · doi:10.1002/hep.24525 · Cited by 496
Cipriani, S., Mencarelli, A., Chini, M. G., Distrutti, E., Renga, B., Bifulco, G., Baldelli, F., Donini, A., & Fiorucci, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025637 · Cited by 382
Flagged first, then by citations
1 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D., & Patterson, A. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00805-x · Cited by 1,214
Pleiotropic Roles of Bile Acids in Metabolism
de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.013 · Cited by 1,209
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine
Kayama, H., Okumura, R., & Takeda, K. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115104 · Cited by 784
Bile acid receptors as targets for drug development
Schaap, F. G., Trauner, M., & Jansen, P. L. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.151 · Cited by 696
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 568
New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond
Beuers, U., Trauner, M., Jansen, P., & Poupon, R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.023 · Cited by 537
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481
Self-citationBile acid nuclear receptor FXR and digestive system diseases
Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.004 · Cited by 477
The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468
Bile Acids as Metabolic Regulators and Nutrient Sensors
Chiang, J. Y. L., & Ferrell, J. M. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124344 · Cited by 456
Camilleri, M., Ford, A. C., Mawe, G. M., Dinning, P. G., Rao, S. S., Chey, W. D., Simrén, M., Lembo, A., Young-Fadok, T. M., & Chang, L. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.95 · Cited by 411
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration
Sorrentino, G., Perino, A., Yıldız, E., Alam, G. E., Sleiman, M. S. B., Gioiello, A., Pellicciari, R., & Schoonjans, K. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.067 · Cited by 415
Self-citationRelationship between the gut microbiome and brain function
Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy009 · Cited by 376
The microbiota–gut–brain axis and neurodevelopmental disorders
Wang, Q., Yang, Q., & Liu, X. (2023) · Protein & Cell · doi:10.1093/procel/pwad026 · Cited by 429
Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364
Hofmann, A. F., & Hagey, L. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r049437 · Cited by 365
Kastl, A., Terry, N. A., Wu, G. D., & Albenberg, L. G. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.07.006 · Cited by 381
Advancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 349
Ge, X., Ding, C., Zhao, W., Xu, L., Tian, H., Gong, J., Zhu, M., Li, J., & Li, N. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1105-4 · Cited by 274
Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 286
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
Hegyi, P., Maléth, J., Walters, J. R., Hofmann, A. F., & Keely, S. J. (2018) · Physiological Reviews · doi:10.1152/physrev.00054.2017 · Cited by 269
The diverse metabolic roles of peripheral serotonin
Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261
Bile acids and their receptors in metabolic disorders
Fiorucci, S., Distrutti, E., Carino, A., Zampella, A., & Biagioli, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101094 · Cited by 264
Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253
Bile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy
Camilleri, M. (2015) · Gut and Liver · doi:10.5009/gnl14397 · Cited by 243
Copple, B. L., & Li, T. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.007 · Cited by 238
Ge, X., Zhao, W., Ding, C., Tian, H., Xu, L., Wang, H., Ni, L., Jiang, J., Gong, J., Zhu, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00612-y · Cited by 232
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation
Perino, A., Pols, T. W. H., Nomura, M., Stein, S., Pellicciari, R., & Schoonjans, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76289 · Cited by 233
Self-citationBile Acid Signaling in Inflammatory Bowel Diseases
Fiorucci, S., Carino, A., Baldoni, M., Santucci, L., Costanzi, E., Graziosi, L., Distrutti, E., & Biagioli, M. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06715-3 · Cited by 243
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221
Dong, S., Zhu, M., Wang, K., Zhao, X., Hu, L., Jing, W., Lu, H., & Wang, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105767 · Cited by 210
Dey, N., Wagner, V. E., Blanton, L. V., Cheng, J., Fontana, L., Haque, R., Ahmed, T., & Gordon, J. I. (2015) · Cell · doi:10.1016/j.cell.2015.08.059 · Cited by 195
Qi, Y., Jiang, C., Cheng, J., Krausz, K. W., Li, T., Ferrell, J. M., Gonzalez, F. J., & Chiang, J. Y. L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.04.008 · Cited by 209
Signalling from the periphery to the brain that regulates energy homeostasis
Kim, K., Seeley, R. J., & Sandoval, D. A. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.8 · Cited by 188
Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis
Zhang, P., Zheng, L., Duan, Y., Gao, Y., Gao, H., Mao, D., & Luo, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126707 · Cited by 171
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163
Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea
Camilleri, M., Sellin, J. H., & Barrett, K. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.014 · Cited by 165
Meixiong, J., Vasavda, C., Snyder, S. H., & Dong, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903316116 · Cited by 164
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
Perino, A., & Schoonjans, K. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 157
Self-citationBile acids and the metabolic syndrome
McGlone, E. R., & Bloom, S. R. (2018) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563218817798 · Cited by 157
Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149
Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson’s Disease
Li, P., Killinger, B. A., Ensink, E., Beddows, I., Yilmaz, A., Lubben, N., Lamp, J., Schilthuis, M., Vega, I. E., Woltjer, R., et al. (2021) · Metabolites · doi:10.3390/metabo11010029 · Cited by 146
Microbiota–neuroepithelial signalling across the gut–brain axis
Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147
Enteric nervous system: the bridge between the gut microbiota and neurological disorders
Geng, Z.-H., Zhu, Y., Li, Q.-L., Zhao, C., & Zhou, P.-H. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.810483 · Cited by 144
Lajczak, N., Porru, E., Fallon, C. M., Smyth, J. S., Curley, C. E., McCarron, P. A., Tambuwala, M. M., Roda, A., & Keely, S. J. (2020) · Physiological Reports · doi:10.14814/phy2.14456 · Cited by 146
Effect of different bile acids on the intestine through enterohepatic circulation based on FXR
Xiang, J., Zhang, Z., Xie, H., Zhang, C., Bai, Y., Cao, H., Che, Q., Guo, J., & Su, Z. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949095 · Cited by 142
Understanding bile acid signaling in diabetes: From pathophysiology to therapeutic targets
Ferrell, J. M., & Chiang, J. Y. L. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0043 · Cited by 139
Bushyhead, D. W., & Quigley, E. M. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.002 · Cited by 151
Carino, A., Cipriani, S., Marchianò, S., Biagioli, M., Santorelli, C., Donini, A., Zampella, A., Monti, M. C., & Fiorucci, S. (2017) · Scientific Reports · doi:10.1038/srep42801 · Cited by 135
Bile acid receptors and gastrointestinal functions
Ticho, A. L., Malhotra, P., Dudeja, P. K., Gill, R. K., & Alrefai, W. A. (2019) · Liver Research · doi:10.1016/j.livres.2019.01.001 · Cited by 138
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
Ferrebee, C. B., & Dawson, P. A. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.001 · Cited by 131
Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies
Waclawiková, B., Codutti, A., Alim, K., & Aidy, S. E. (2022) · Gut Microbes · doi:10.1080/19490976.2021.1997296 · Cited by 134
Bala, V., Rajagopal, S., Kumar, D. P., Nalli, A. D., Mahavadi, S., Sanyal, A. J., Grider, J. R., & Murthy, K. S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00420 · Cited by 124
Self-citationBile acids and their receptors in regulation of gut health and diseases
Lin, S., Wang, S., Wang, P., Tang, C., Wang, Z., Chen, L., Luo, G., Chen, H., Liu, Y., Feng, B., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101210 · Cited by 126
Effect of Increased Bile Acid Synthesis or Fecal Excretion in Irritable Bowel Syndrome-Diarrhea
Camilleri, M., Busciglio, I., Acosta, A., Shin, A., Carlson, P., Burton, D., Ryks, M., Rhoten, D., Lamsam, J., Lueke, A., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.215 · Cited by 114
Camilleri, M., Acosta, A. J., Busciglio, I. A., Boldingh, A., Dyer, R. B., Zinsmeister, A. R., Lueke, A. J., Gray, A., & Donato, L. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13065 · Cited by 115
Pathophysiological connections between gallstone disease, insulin resistance, and obesity
Cortés, V., Francisco Barrera, M., & Nervi, F. O. (2019) · Obesity Reviews · doi:10.1111/obr.12983 · Cited by 118
Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
Doden, H. L., & Ridlon, J. M. (2021) · Microorganisms · doi:10.3390/microorganisms9030469 · Cited by 113
Direct and indirect mechanisms by which the gut microbiota influence host serotonin systems
Legan, T. B., Lavoie, B. A., & Mawe, G. M. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14346 · Cited by 124
Mechanisms controlling hormone secretion in human gut and its relevance to metabolism
Martin, A. M., Sun, E. W. L., & Keating, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0399 · Cited by 117
Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract
Bunnett, N. W. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.271155 · Cited by 110
Self-citationReview article: bile acid diarrhoea – pathogenesis, diagnosis and management
Mottacki, N., Simrén, M., & Bajor, A. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13570 · Cited by 114
Han, B., Lv, X., Liu, G., Li, S., Fan, J., Chen, L., Huang, Z., Lin, G., Xu, X., Huang, Z., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2232143 · Cited by 127
The Role of Bile Acids in Chronic Diarrhea
Camilleri, M., & Vijayvargiya, P. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000696 · Cited by 111
The Microbiota and the Gut–Brain Axis in Controlling Food Intake and Energy Homeostasis
Romaní‐Pérez, M., Bullich‐Vilarrubias, C., López‐Almela, I., Liébana-García, R., Olivares, M., & Sanz, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115830 · Cited by 117
Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy
Walters, J. R. F. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.32 · Cited by 104
New insights into the pathogenesis and treatment of irritable bowel syndrome
Oświęcimska, J. M., Szymlak, A., Roczniak, W., Girczys-Połedniok, K., & Kwiecień, J. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2016.11.001 · Cited by 113
The Multifaceted Role of Serotonin in Intestinal Homeostasis
Koopman, N., Katsavelis, D., ten Hove, A. S., Brul, S., de Jonge, W. J., & Seppen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179487 · Cited by 112
Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota
Settanni, C. R., Bibbò, S., Ianiro, G., Rinninella, E., Cintoni, M., Mele, M. C., Cammarota, G., & Gasbarrini, A. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1869938 · Cited by 98
Critical roles of bile acids in regulating intestinal mucosal immune responses
Sun, R., Xu, C., Feng, B., Gao, X., & Liu, Z. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211018098 · Cited by 105
Okumura, R., & Takeda, K. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01026-5 · Cited by 109
Bile Acid Malabsorption in Inflammatory Bowel Disease
Vı́tek, L. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000193 · Cited by 105
Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors
Keitel, V., Stindt, J., & Häussinger, D. (2019) · Handbook of Experimental Pharmacology · doi:10.1007/164_2019_230 · Cited by 98
Physiological underpinnings of irritable bowel syndrome: neurohormonal mechanisms
Camilleri, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.270892 · Cited by 98
Elobixibat and its potential role in chronic idiopathic constipation
Acosta, A., & Camilleri, M. (2014) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x14528269 · Cited by 91
A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation
Zhang, C., Yu, L., Ma, C., Jiang, S., Zhang, Y., Wang, S., Tian, F., Xue, Y., Zhao, J., Zhang, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.10.011 · Cited by 98
Jensen, D. D., Godfrey, C. B., Niklas, C., Canals, M., Kočan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.455774 · Cited by 91
Self-citationRole of gut microbiota-derived signals in the regulation of gastrointestinal motility
Zheng, Z., Tang, J., Hu, Y., & Zhang, W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.961703 · Cited by 94
The microbiota-gut-brain axis: Focus on the fundamental communication pathways
Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 91
Therapeutic targeting of bile acids
Camilleri, M., & Gores, G. J. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2015 · Cited by 85
Immunology of bile acids regulated receptors
Fiorucci, S., Marchianò, S., Urbani, G., Giorgio, C. D., Distrutti, E., Zampella, A., & Biagioli, M. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101291 · Cited by 86
Regional differences in nutrient‐induced secretion of gut serotonin
Martin, A. M., Lumsden, A. L., Young, R. L., Jessup, C. F., Spencer, N. J., & Keating, D. J. (2017) · Physiological Reports · doi:10.14814/phy2.13199 · Cited by 83
Iyer, N. R., & Corr, S. C. (2021) · Nutrients · doi:10.3390/nu13124259 · Cited by 83
Castro, J., Harrington, A. M., Lieu, T., Garcia‐Caraballo, S., Maddern, J., Schober, G., O’Donnell, T. A., Grundy, L., Lumsden, A. L., Miller, P. E., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131712 · Cited by 78
Self-citationHolzer, P. D., & Holzer‐Petsche, U. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.820006 · Cited by 78
The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon
Martin, A. M., Lumsden, A. L., Young, R. L., Jessup, C. F., Spencer, N. J., & Keating, D. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13046 · Cited by 74
Sonne, D. P., Hansen, M., & Knop, F. K. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0154 · Cited by 75
Manipulation of epithelial integrity and mucosal immunity by host and microbiota‐derived metabolites
Kayama, H., & Takeda, K. (2020) · European Journal of Immunology · doi:10.1002/eji.201948478 · Cited by 76
Chemotherapy-induced gastrointestinal toxicity: Pathogenesis and current management
He, Y., Zheng, J., Ye, B., Dai, Y., & Nie, K. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115787 · Cited by 77
Gut Microbiota‐Bile Acid Crosstalk in Diarrhea‐Irritable Bowel Syndrome
Zhan, K., Zheng, H., Jian-qing, L., Wu, H., Qin, S., Luo, L., & Huang, S. (2020) · BioMed Research International · doi:10.1155/2020/3828249 · Cited by 72
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, C. B., Trammell, S. A. J., Albrechtsen, N. J. W., Schoonjans, K., Albrechtsen, R., Gillum, M. P., Kuhre, R. E., & Holst, J. J. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00010.2019 · Cited by 69
Self-citationYu, L., Hu, X., Xu, R., Zhao, Y., Xiong, L., Ai, J., Wang, X., Chen, X., Ba, Y., Xing, Z., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117628 · Cited by 79
Zhou, A., Yuan, Y., Yang, M., Huang, Y., Li, X., Li, S., Yang, S., & Tang, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.832672 · Cited by 71
The role of bile acids in functional GI disorders
Appleby, R., & Walters, J. R. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12370 · Cited by 66
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 68
The Farnesoid X Receptor: Good for BAD
Keely, S. J., & Walters, J. R. F. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.08.004 · Cited by 61
Metadata
- Authors
- Alemi, F., Poole, D. P., Chiu, J., Schoonjans, K., Cattaruzza, F., Grider, J. R., Bunnett, N. W., & Corvera, C. U.
- Affiliations
- University of California, San Francisco (US)
- The University of Melbourne (AU)
- École Polytechnique Fédérale de Lausanne (CH)
- Virginia Commonwealth University (US)
- Monash University (AU)
- San Francisco VA Medical Center (US)
- Corresponding author
- Bunnett, Nigel W.
- Corvera, Carlos U.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 144
- Issue
- 1
- Pages
- 145-154
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC6054127
- OpenAlex
- W2003525898
- Cited by
- 362
- References
- 44
- Citations by year
- 2026: 38 · 2025: 25 · 2024: 32 · 2023: 24 · 2022: 46 · 2021: 45 · 2020: 22 · 2019: 22 · 2018: 23 · 2017: 20 · 2016: 16 · 2015: 16 · 2014: 24 · 2013: 9
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Northern California Institute for Research and Education
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (125487)
- Monash University
- National Institutes of Health (DK39957, DK-34153, DK43207)
- Medical Research Council
- National Health and Medical Research Council (63303)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK034153, DK-39957, R37DK039957, DK 57840, DK 43207, R01DK057840, R01DK043207, R56DK034153, DK-34153, R01DK039957, R56DK043207)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- TGR5, bile acids, colonic motility, peristalsis, defecation, constipation, deoxycholic acid, enterochromaffin cells, serotonin, calcitonin gene-related peptide, colonic transit, laxative effect, enteric neurons, G protein-coupled receptors, stool water content
- MeSH terms
- Animals, Colon, Defecation, Deoxycholic Acid, Enterochromaffin Cells, Feces, Gastrointestinal Transit, Intestinal Mucosa, Lithocholic Acid, Mice, Inbred C57BL, Mice, Transgenic, Muscle Contraction, Muscle Relaxation, Neurons, Afferent, Oleanolic Acid, Peristalsis, Serotonin, Water, Calcitonin Gene-Related Peptide, Mice, Knockout, Receptors, G-Protein-Coupled, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
