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Cited by 953

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Open access
Zhang, Yanqiao, Lee, Florence Ying, Barrera, Gabriel, Lee, Hans, Vales, Charisse, Gonzalez, Frank J., Willson, Timothy M., Edwards, Peter A.·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0506982103
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Abstract

Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose metabolism. Activation of FXR by the synthetic agonist GW4064 or hepatic overexpression of constitutively active FXR by adenovirus-mediated gene transfer significantly lowered blood glucose levels in both diabetic db/db and wild-type mice. Consistent with these data, FXR null mice exhibited glucose intolerance and insulin insensitivity. We further demonstrate that activation of FXR in db/db mice repressed hepatic gluconeogenic genes and increased hepatic glycogen synthesis and glycogen content by a mechanism that involves enhanced insulin sensitivity. In view of its central roles in coordinating regulation of both glucose and lipid metabolism, we propose that FXR agonists are promising therapeutic agents for treatment of diabetes mellitus.

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Metadata

Authors
Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-01-12
Volume
103
Issue
4
Pages
1006-1011
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0506982103
OpenAlex
W2045223517
Cited by
953
References
9
FWCI
17.83
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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