The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Early evolution of animal cell signaling and adhesion genes
Open accessAbstract
In stark contrast to the rapid morphological radiation of eumetazoans during the Cambrian explosion, the simple body plan of sponges (Phylum Porifera) emerged from the Cambrian relatively unchanged. Although the genetic and developmental underpinnings of these disparate evolutionary outcomes are unknown, comparisons between modern sponges and eumetazoans promise to reveal the extent to which critical genetic factors were present in their common ancestors. Two particularly interesting classes of genes in this respect are those involved in cell signaling and adhesion. These genes help guide development and morphogenesis in modern eumetazoans, but the timing and sequence of their origins is unknown. Here, we demonstrate that the sponge Oscarella carmela , one of the earliest branching animals, expresses core components of the Wnt, transforming growth factor β, receptor tyrosine kinase, Notch, Hedgehog, and Jak/Stat signaling pathways. Furthermore, we identify sponge homologs of nearly every major eumetazoan cell-adhesion gene family, including those that encode cell-surface receptors, cytoplasmic linkers, and extracellular-matrix proteins. From these data, we infer that key signaling and adhesion genes were in place early in animal evolution, before the divergence of sponge and eumetazoan lineages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gene Regulatory Networks and the Evolution of Animal Body Plans
Davidson, E. H., & Erwin, D. H. (2006) · Science · doi:10.1126/science.1113832 · Cited by 1,207
Unexpected complexity of the Wnt gene family in a sea anemone
Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599
The New View of Animal Phylogeny
Halanych, K. M. (2004) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev.ecolsys.35.112202.130124 · Cited by 489
Precambrian Sponges with Cellular Structures
Li, C.-W., Chen, J.-Y., & Hua, T.-E. (1998) · Science · doi:10.1126/science.279.5352.879 · Cited by 489
The evolution of signalling pathways in animal development
Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466
Medina, M., Collins, A. G., Silberman, J. D., & Sogin, M. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171316998 · Cited by 395
Peterson, K. J., & Butterfield, N. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503660102 · Cited by 361
Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians
Technau, U., Rudd, S., Maxwell, P., Gordon, P. M. K., Saina, M., Grasso, L. C., Hayward, D. C., Sensen, C. W., Saint, R., Holstein, T. W., et al. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.09.007 · Cited by 337
The last common bilaterian ancestor
Erwin, D. H., & Davidson, E. H. (2002) · Development · doi:10.1242/dev.129.13.3021 · Cited by 320
Fossils, molecules and embryos: new perspectives on the Cambrian explosion
Valentine, J. W., Jablonski, D., & Erwin, D. H. (1999) · Development · doi:10.1242/dev.126.5.851 · Cited by 300
Cited by
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
Carroll, S. B. (2008) · Cell · doi:10.1016/j.cell.2008.06.030 · Cited by 2,067
The Amphimedon queenslandica genome and the evolution of animal complexity
Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049
The Trichoplax genome and the nature of placozoans
Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., Kuo, A., Mitros, T., Salamov, A., Carpenter, M. L., et al. (2008) · Nature · doi:10.1038/nature07191 · Cited by 889
The Multiple Origins of Complex Multicellularity
Knoll, A. H. (2011) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.031208.100209 · Cited by 562
Co-evolution of eukaryotes and ocean oxygenation in the Neoproterozoic era
Lenton, T. M., Boyle, R. A., Poulton, S. W., Shields-Zhou, G. A., & Butterfield, N. J. (2014) · Nature Geoscience · doi:10.1038/ngeo2108 · Cited by 424
The Capsaspora genome reveals a complex unicellular prehistory of animals
Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3325 · Cited by 317
Rokas, A., & Carroll, S. B. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040352 · Cited by 315
A Post-Synaptic Scaffold at the Origin of the Animal Kingdom
Sakarya, O., Armstrong, K. A., Adamska, M., Adamski, M., Wang, I.-F., Tidor, B., Degnan, B. M., Oakley, T. H., & Kosik, K. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000506 · Cited by 291
“Other gene families such as the cadherins and tyrosine kinases also appeared before the metazoa/choanozoa split and laid the ground work for rapid expansion of these families within metazoan lineages [18].”
BackgroundRiesgo, A., Farrar, N., Windsor, P. J., Giribet, G., & Leys, S. P. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu057 · Cited by 266
Niehrs, C. (2010) · Development · doi:10.1242/dev.039651 · Cited by 283
Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257
Profiling cellular diversity in sponges informs animal cell type and nervous system evolution
Musser, J. M., Schippers, K. J., Nickel, M., Mizzon, G., Kohn, A. B., Pape, C., Ronchi, P., Papadopoulos, N., Tarashansky, A. J., Hammel, J. U., et al. (2021) · Science · doi:10.1126/science.abj2949 · Cited by 242
The Genomic and Cellular Foundations of Animal Origins
Richter, D. J., & King, N. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133456 · Cited by 196
Self-citationNewman, S. A., & Bhat, R. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072481sn · Cited by 208
Origins of neurogenesis, a cnidarian view
Galliot, B., Quiquand, M., Ghila, L., de Rosa, R., Miljkovic-Licina, M., & Chera, S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.563 · Cited by 168
The Evolutionary History of YAP and the Hippo/YAP Pathway
Hilman, D., & Gat, U. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr065 · Cited by 166
Deep Phylogeny and Evolution of Sponges (Phylum Porifera)
Wörheide, G., Dohrmann, M., Erpenbeck, D., Larroux, C., Maldonado, M., Voigt, O., Borchiellini, C., & Lavrov, D. V. (2012) · Advances in Marine Biology · doi:10.1016/b978-0-12-387787-1.00007-6 · Cited by 166
Intrinsically disordered proteins and multicellular organisms
Dunker, A. K., Bondos, S. E., Huang, F., & Oldfield, C. J. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.09.025 · Cited by 150
Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139
The Physiology and Molecular Biology of Sponge Tissues
Leys, S. P., & Hill, A. (2012) · Advances in Marine Biology · doi:10.1016/b978-0-12-394283-8.00001-1 · Cited by 128
Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115
Embryogenesis and larval differentiation in sponges
Leys, S. P., & Ereskovsky, A. V. (2006) · Canadian Journal of Zoology · doi:10.1139/z05-170 · Cited by 100
Nickel, M. (2010) · Invertebrate Biology · doi:10.1111/j.1744-7410.2010.00193.x · Cited by 93
PETERSON, K. J., SUMMONS, R. E., & DONOGHUE, P. C. J. (2007) · Palaeontology · doi:10.1111/j.1475-4983.2007.00692.x · Cited by 93
Müller, W. E. G., Li, J., Schröder, H. C., Qiao, L., & Wang, X. (2007) · Biogeosciences · doi:10.5194/bg-4-219-2007 · Cited by 78
Adams, E. D. M., Goss, G. G., & Leys, S. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015040 · Cited by 74
Degnan, S. M., & Degnan, B. M. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0248 · Cited by 71
Voigt, O., Adamski, M., Sluzek, K., & Adamska, M. (2014) · BMC Evolutionary Biology · doi:10.1186/s12862-014-0230-z · Cited by 63
What sponges can tell us about the evolution of developmental processes
Adamska, M., Degnan, B. M., Green, K., & Zwafink, C. (2011) · Zoology · doi:10.1016/j.zool.2010.10.003 · Cited by 65
Evolutionary insights into premetazoan functions of the neuronal protein homer
Burkhardt, P., Grønborg, M., McDonald, K., Sulur, T., Wang, Q., & King, N. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu178 · Cited by 56
Self-citationThe mouth, the anus, and the blastopore—open questions about questionable openings
Hejnol, A., & Martindale, M. Q. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0004 · Cited by 37
Marshal, C. R., & Valentine, J. W. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00908.x · Cited by 30
Origin of Metazoan Developmental Toolkits and Their Expression in the Fossil Record
Tweedt, S. M., & Erwin, D. H. (2015) · Advances in Marine Genomics · doi:10.1007/978-94-017-9642-2_3 · Cited by 27
Genomic, phylogenetic, and cell biological insights into metazoan origins
Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24
Self-citation
Metadata
- Authors
- Nichols, S. A., Dirks, W., Pearse, J. S., & King, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-08-15
- Volume
- 103
- Issue
- 33
- Pages
- 12451-12456
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2013204587
- Cited by
- 327
- References
- 14
- FWCI
- 30.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
