The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
Open accessAbstract
Inflammation involves a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanisms. Recent studies have shown that microRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide noncoding RNAs, contribute to the regulation of inflammation by repressing gene expression at the posttranscriptional level. In this study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after TLR4 activation. miR-9 is also induced by TLR2 and TLR7/8 agonists and by the proinflammatory cytokines TNF-alpha and IL-1beta, but not by IFNgamma. Among the 3 different genes encoding miR-9 precursors in humans, we show that LPS selectively induces the transcription of miR-9-1 located in the CROC4 locus, in a MyD88- and NF-kappaB-dependent manner. In PMN and monocytes, LPS regulates NFKB1 at both the transcriptional and posttranscriptional levels, and a conserved miR-9 seed sustained a miR-9-dependent inhibition of the NFKB1 transcript. Overall, these data suggest that TLR4-activated NF-kappaB rapidly increases the expression of miR-9 that operates a feedback control of the NF-kappaB-dependent responses by fine tuning the expression of a key member of the NF-kappaB family.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It was shown that NF-κB, upon its activation in response to LPS, initiates transcription of miR-9-1, which subsequently downregulates NF-κB [112].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [112]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
Requirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Research works printed but not linked: 31
- 10.1016/j.cell.2006.02.015 · DOI
- 10.1016/j.coi.2005.11.012 · DOI
- 10.1189/jlb.1003473 · DOI
- 10.1016/S0092-8674(04)00045-5 · DOI
- 10.1016/j.ceb.2008.01.006 · DOI
- 10.4049/jimmunol.180.8.5689 · DOI · Paper page
- 10.1073/pnas.0610731104 · DOI · Paper page
- 10.4049/jimmunol.179.8.5082 · DOI · Paper page
- 10.4049/jimmunol.181.9.6563 · DOI
- 10.1006/mcne.2000.0866 · DOI
- 10.1016/j.molimm.2007.10.035 · DOI
- 10.1371/journal.pbio.0020363 · DOI · Paper page
- 10.1016/S0092-8674(03)01018-3 · DOI · Paper page
- 10.1038/nature05992 · DOI
- 10.1038/nrg1328 · DOI
- 10.1016/j.immuni.2007.02.005 · DOI
- 10.1016/j.cell.2005.09.023 · DOI · Paper page
- 10.1038/ncb1613 · DOI · Paper page
- 10.1016/j.cell.2007.07.021 · DOI
- 10.1084/jem.20050572 · DOI
- 10.1126/science.1141229 · DOI
- 10.1038/nn.2115 · DOI · Paper page
- 10.1074/jbc.M601225200 · DOI · Paper page
- 10.2353/ajpath.2008.080009 · DOI
- 10.4049/jimmunol.178.11.7344 · DOI
- 10.1016/j.biocel.2007.05.004 · DOI
- 10.1074/jbc.M602222200 · DOI
- 10.1146/annurev.immunol.16.1.225 · DOI
- 10.1158/0008-5472.CAN-06-1867 · DOI
- 10.1038/nprot.2007.528 · DOI
- 10.4049/jimmunol.167.4.2312 · DOI
Cited by
Sorted by citations
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
“miRNAs have emerged as regulators of phagocyte activation and function (34, 139), but their role in macrophage polarization needs to be further defined.”
Self-citationNeutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159
“More recent evidence highlights that de novo induction of microRNAs might be part of the crucial regulatory circuits that control neutrophil gene expressio”
BackgroundSelf-citationThe complexity of NF-κB signaling in inflammation and cancer
Hoesel, B., & Schmid, J. A. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-86 · Cited by 3,277
“Several miRNAs have been shown to be transcriptional targets of NF-κB including miR-9, miR-21, miR-143, miR-146 and miR-224 [145-150].”
BackgroundMolecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
Wang, N., Liang, H., & Zen, K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00614 · Cited by 2,086
Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
Neutrophils, from Marrow to Microbes
Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,679
“MiR-9 is induced in LPS and TNF-a-stimulated neutrophils by NF-kB and exerts a feedback inhibition on NF-kB translation (Bazzoni et al., 2009).”
BackgroundEndotoxin tolerance: new mechanisms, molecules and clinical significance
Biswas, S. K., & Lopez-Collazo, E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.009 · Cited by 1,318
MicroRNAs: the fine-tuners of Toll-like receptor signalling
O'Neill, L. A. J., Sheedy, F. J., & McCoy, C. E. (2011) · Nature reviews. Immunology · doi:10.1038/nri2957 · Cited by 881
“More recently, the TLR-responsive miRNA miR-9 was shown to directly target NFKB1 mRN”
BackgroundSheedy, F. J., Palsson-McDermott, E., Hennessy, E. J., Martin, C., O'Leary, J. J., Ruan, Q., Johnson, D. S., Chen, Y., & O'Neill, L. A. J. (2010) · Nature Immunology · doi:10.1038/ni.1828 · Cited by 1,005
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Boldin, M. P., Taganov, K. D., Rao, D. S., Yang, L., Zhao, J. L., Kalwani, M., Garcia-Flores, Y., Luong, M., Devrekanli, A., Xu, J., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101823 · Cited by 861
“We identified three miRNA genes (miR-146a, miR-132, and miR-155) whose expression is sharply upregulated in response to LPS, and this list was later expanded further to include miR-9, miR-21, and miR-147 through the work of others (Bazzoni et al., 2009; Liu et al., 2009; Sheedy et al., 2010).”
BackgroundmicroRNAs and the immune response
Tsitsiou, E., & Lindsay, M. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.05.003 · Cited by 358
“Studies into the mechanism of LPS-induced miR9, miR-146a and miR-155 expression demonstrate a central role of the pro-inflammatory transcription factor nuclear factor (NF)-kB [8 ,11,13].”
BackgroundMacrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673
“In addition, epigenetic modifications with involvement of miRNAs, histone methylation and acetylation have emerged as regulators of phagocyte activation and function [5, 198–201].”
BackgroundNeutrophil-derived cytokines: facts beyond expression
Tecchio, C., Micheletti, A., & Cassatella, M. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00508 · Cited by 699
“For instance, miR9 was for the first time demonstrated to inhibit NFKB1/p50 transcripts in human neutrophils exposed to pro-inflammatory signals, operating in this manner as a feedback control for NFKB1/p50dependent responses (29).”
BackgroundSelf-citationInflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
Schetter, A. J., Heegaard, N. H. H., & Harris, C. C. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp272 · Cited by 671
Resolution of Inflammation: What Controls Its Onset?
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00160 · Cited by 638
“Bazzoni and colleagues suggest that miR-9 induction probably acts as a tuning mechanism to prevent negative regulation by p50 homodimers, as occurs in monocytes in systemic anti-inflammatory response syndrome (SIRS) (109).”
BackgroundCell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis
Mussbacher, M., Salzmann, M., Brostjan, C., Hoesel, B., Schoergenhofer, C., Datler, H., Hohensinner, P., Basílio, J., Petzelbauer, P., Assinger, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00085 · Cited by 596
“While NF-κB is known to exert a negative feedback regulation by inducing transcription of its inhibitor IκBα, an additional feedback mechanism has been identified in neutrophils: Expression of miR-9 is controlled by NF-κB and serves to inhibit the NFκB1 transcript (193).”
BackgroundMa, X., Becker Buscaglia, L. E., Barker, J. R., & Li, Y. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr007 · Cited by 542
“miR-9 is another miRNA induced by LPS via MyD88 and NF-kB (Bazzoni et al., 2009).”
InfluentialMicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
Dai, R., & Ahmed, S. A. (2011) · Translational research · doi:10.1016/j.trsl.2011.01.007 · Cited by 450
Mattes, J., Collison, A., Plank, M. W., Phipps, S., & Foster, P. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905063106 · Cited by 431
“This study also supports emerging data that miRNA expression and function are linked to innate immune responses (35, 37, 38).”
ResultmiR-146a Is Critical for Endotoxin-induced Tolerance
Nahid, M. A., Pauley, K. M., Satoh, M., & Chan, E. K. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056317 · Cited by 423
Macrophage polarization and plasticity in health and disease
Biswas, S. K., Chittezhath, M., Shalova, I. N., & Lim, J.-Y. (2012) · Immunologic Research · doi:10.1007/s12026-012-8291-9 · Cited by 406
Macrophage polarization and allergic asthma
Saradna, A., Do, D. C., Kumar, S. A., Fu, Q.-L., & Gao, P. (2017) · Translational research · doi:10.1016/j.trsl.2017.09.002 · Cited by 441
Zhou, X., Ren, Y., Moore, L. M., Mei, M., You, Y., Xu, P., Wang, B., Wang, G., Jia, Z., Pu, P., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2009.126 · Cited by 363
“5 Subsequently, miRNAs have been shown to have important roles in many physiological processes of mammalian systems by influencing cell apoptosis, proliferation, differentiation, development, and metabolism through regulation of critical signaling molecules including cytokines, growth factors, transcription factors, a…”
BackgroundIdentifying Functional MicroRNAs in Macrophages with Polarized Phenotypes
Graff, J. W., Dickson, A. M., Clay, G., McCaffrey, A. P., & Wilson, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327031 · Cited by 367
Becker, H., Marcucci, G., Maharry, K. S., Radmacher, M. D., Mrózek, K., Margeson, D., Whitman, S. P., Wu, Y.-Z., Schwind, S., Paschka, P., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.1496 · Cited by 346
“Also overexpressed were members of the let-7 family, which target oncogenes RAS and MYC(63); miR-100, upregulated in t(15;17)-positive AML(64,65); and miR-9, which targets NF B and can be hypermethylated in cancer.(66,67) Downregulated were miR-126, the expression of which we recently positively correlated with MN1 ex…”
BackgroundA trio of microRNAs that control Toll-like receptor signalling
Quinn, S. R., & O'Neill, L. A. (2011) · International Immunology · doi:10.1093/intimm/dxr034 · Cited by 314
Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment
Tahamtan, A., Teymoori‐Rad, M., Nakstad, B., & Salimi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01377 · Cited by 368
“Other Anti-inflammatory miRNAs miR-9 expression increases in human monocytes and neutrophils upon NF-κB activation and acts as a feedback control of the NF-κB-dependent responses (133).”
BackgroundMicroRNA in TLR signaling and endotoxin tolerance
Nahid, M. A., Satoh, M., & Chan, E. K. L. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.26 · Cited by 299
Molecular mechanisms of innate memory and tolerance to LPS
Seeley, J. J., & Ghosh, S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0316-118rr · Cited by 381
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298
Molecular and epigenetic basis of macrophage polarized activation
Porta, C., Riboldi, E., Ippolito, A., & Sica, A. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.003 · Cited by 334
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension
Parikh, V. N., Jin, R. C., Rabello, S., Gulbahce, N., White, K., Hale, A., Cottrill, K. A., Shaik, R. S., Waxman, A. B., Zhang, Y., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.060269 · Cited by 264
Negative regulation of Toll-like receptor 4 signaling by IL-10–dependent microRNA-146b
Curtale, G., Mirolo, M., Renzi, T. A., Rossato, M., Bazzoni, F., & Locati, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219852110 · Cited by 289
“TLRs have been shown to regulate a distinct panel of miR in monocytes, including miR-155 andmiR-146a (15-17).”
BackgroundSelf-citationmicroRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus
Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B. T., Kauppinen, S., & Lund, A. H. (2013) · Scientific Reports · doi:10.1038/srep02535 · Cited by 257
Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 293
“miR-9 suppresses the proinflammatory activity of NF-κB directly [98], whereas miR-21 indirectly suppresses this activity via PDCD4 [99].”
BackgroundKalla, R., Ventham, N. T., Kennedy, N. A., Quintana, J. F., Nimmo, E. R., Buck, A. H., & Satsangi, J. (2014) · Gut · doi:10.1136/gutjnl-2014-307891 · Cited by 281
MicroRNAs in Immune Response and Macrophage Polarization
Liu, G., & Abraham, E. H. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300068 · Cited by 249
Murphy, A., Guyre, P., & Pioli, P. (2010) · Journal of Immunology · doi:10.4049/jimmunol.0903463 · Cited by 255
Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9523 · Cited by 257
microRNAs and the immune response
Lindsay, M. A. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.04.004 · Cited by 475
The role of Toll-like receptors in rheumatoid arthritis
Huang, Q., & Pope, R. M. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0051-z · Cited by 253
“These pathways include the induction of A20 that suppresses NF-κB activation [34], ATF3 that attenuates activation by NF-κB and C/EBPδ [35], and induction of the microRNA miR- 9, which is induced by TLR2 and TLR7/8 agonists and provides feedback suppression of NF-κB activation [ 36 ].”
BackgroundProinflammatory Role for let-7 MicroRNAS in Experimental Asthma
Polikepahad, S., Knight, J. M., Naghavi, A. O., Oplt, T., Creighton, C. J., Shaw, C. A., Benham, A. L., Kim, J. K., Soibam, B., Harris, R. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145698 · Cited by 244
Targeting the NFκB Signaling Pathways for Breast Cancer Prevention and Therapy
Wang, W., Nag, S. A., & Zhang, R. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141106124315 · Cited by 287
“Several miRNAs are known to be transcriptional targets of NFκB, including miR-143, miR-146, miR-224, miR-9, and miR-21 [212,213].”
BackgroundMiR-146a in Immunity and Disease
Rusca, N., & Monticelli, S. (2011) · Molecular Biology International · doi:10.4061/2011/437301 · Cited by 231
Important aspects of Toll-like receptors, ligands and their signaling pathways
Chang, Z. L. (2010) · Inflammation Research · doi:10.1007/s00011-010-0208-2 · Cited by 228
MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways
He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238
“For example, miR-9 expression is directly induced by LPS via the TLR4-MyD88-NF-κB-dependent pathway in human monocytes and neutrophils [58].”
BackgroundInfluentialSaha, B., Momen-Heravi, F., Kodys, K., & Szabo, G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.694133 · Cited by 229
Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients
Ji, Q., Ji, Y., Peng, J., Zhou, X., Chen, X., Zhao, H., Xu, T., Chen, L., & Xu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163645 · Cited by 241
MicroRNAs, new effectors and regulators of NF‐κB
Boldin, M. P., & Baltimore, D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01089.x · Cited by 199
“Apparently, miR-9 upregulation in response to LPS depends on NF-jB signaling (36).”
InfluentialNahid, M. A., Satoh, M., & Chan, E. K. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002311 · Cited by 213
MicroRNAs in inflammation and immune responses
Contreras, J., & Rao, D. S. (2011) · Leukemia · doi:10.1038/leu.2011.356 · Cited by 237
Rossato, M., Curtale, G., Tamassia, N., Castellucci, M., Mori, L., Gasperini, S., Mariotti, B., De Luca, M., Mirolo, M., Cassatella, M. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209100109 · Cited by 215
“In our previous work we described the involvement of miRNAs in the regulation of monocyte activation after TLR engagement (12).”
BackgroundMethodInfluentialSelf-citationSonkoly, E., & Pivarcsi, A. (2009) · International Reviews of Immunology · doi:10.3109/08830180903208303 · Cited by 216
Role of microRNAs in the immune system, inflammation and cancer
Raisch, J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i20.2985 · Cited by 215
Zhou, R., Hu, G., Liu, J., Gong, A.-Y., Drescher, K. M., & Chen, X. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000681 · Cited by 212
“In addition, miR-146b, miR-155, and miR-9 have been reported to be NF-kB-dependent miRNAs in monocytes or neutrophils [15,47,48].”
BackgroundOlivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2012) · AGE · doi:10.1007/s11357-012-9440-8 · Cited by 206
Brain, O., Owens, B. M. J., Pichulik, T., Allan, P., Khatamzas, E., Leslie, A. J., Steevels, T. A. M., Sharma, S., Mayer, A., Catuneanu, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.035 · Cited by 201
“…of miRNA expression induced through TLR stimulation have demonstrated that they function as negative regulators of innate immune responses by targeting key signaling proteins and cytokines (Ceppi et al., 2009; Taganov et al., 2006; Bazzoni et al., 2009; Sheedy et al., 2010; Tili et al., 2007).”
BackgroundMicroRNAs linking inflamm-aging, cellular senescence and cancer
Olivieri, F., Rippo, M. R., Monsurrò, V., Salvioli, S., Capri, M., Procopio, A. D., & Franceschi, C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.001 · Cited by 210
The mammalian microRNA response to bacterial infections
Eulálio, A., Schulte, L. N., & Vogel, J. (2012) · RNA Biology · doi:10.4161/rna.20018 · Cited by 197
Pattern recognition receptors in fungal immunity
Patin, E. C., Thompson, A., & Orr, S. J. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.003 · Cited by 236
Ottman, R., Nguyen, C., Lorch, R., & Chakrabarti, R. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-1 · Cited by 167
“Despite this association, an increase in NF-kB1 expression could be predicted in treated -104S cells, as NF-kB1 is a direct target of the down-regulated miRNA miR-9 [133].”
BackgroundWu, S., He, L., Li, Y., Wang, T., Feng, L., Jiang, L., Zhang, P., & Huang, X. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.05.003 · Cited by 173
MicroRNA-mediated control of macrophages and its implications for cancer
Squadrito, M. L., Etzrodt, M., Palma, M. D., & Pittet, M. J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.003 · Cited by 190
“miR-9 [54], miR-21 [55] and miR-147 [56] can all be induced by several TLR agonists in a MyD88 and NF-kB-dependent manner and, like miR-146, are thought to inhibit proinflammatory responses in monocytes/macrophages by suppressing NF-kB activation through a negative feedback loop mechanism.”
Expression profiles of miRNAs in polarized macrophages
ZHANG, Y., ZHANG, M., ZHONG, M., SUO, Q., & LV, K. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1260 · Cited by 181
“By contrast, the alternative M2 form of macrophage activation is a generic name used for various forms of non-classically activated macrophages resulting from cell exposure to IL-4 or IL-13, immune complexes, IL-10, glucocorticoid, or secosteroid (vitamin D3) (3,9,11).”
Qi, J., Qiao, Y., Wang, P., Li, S., Zhao, W., & Gao, C. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.011 · Cited by 170
MicroRNAs in autoimmunity and inflammatory bowel disease: Crucial regulators in immune response
Iborra, M., Bernuzzi, F., Invernizzi, P., & Danese, S. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.07.002 · Cited by 181
Interplay between DNA repair and inflammation, and the link to cancer
Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 191
“Macrophage inflammatory responses to infection involve the upregulation of several miRNAs including miR-21 (Bazzoni et al., 2009; Liu et al., 2009; Sheedy et al., 2010).”
BackgroundTranscriptional Regulation of Macrophages Polarization by MicroRNAs
Li, H., Jiang, T., Li, M., Zheng, X., & Zhao, G.-J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01175 · Cited by 212
“The important roles of miR-9 in innate immune and antiinflammatory response have been described (35, 36).”
BackgroundNeurimmiRs: microRNAs in the neuroimmune interface
Soreq, H., & Wolf, Y. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.009 · Cited by 162
A guide to miRNAs in inflammation and innate immune responses
Nejad, C., Stunden, H. J., & Gantier, M. P. (2018) · FEBS Journal · doi:10.1111/febs.14482 · Cited by 199
Circulating inflamma-miRs in aging and age-related diseases
Olivieri, F., Rippo, M. R., Procopio, A. D., & Fazioli, F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00121 · Cited by 184
MicroRNAs as Molecular Switches in Macrophage Activation
Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 193
“More recently, miR-322 was also reported as a negative regulator of NF-κB1 expression (110, 113).”
BackgroundSelf-citationA miR-19 regulon that controls NF-κB signaling
Gantier, M. P., Stunden, H. J., McCoy, C. E., Behlke, M. A., Wang, D., Kaparakis‐Liaskos, M., Sarvestani, S. T., Yang, Y. H., Xu, D., Corr, S. C., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks521 · Cited by 176
“For instance, miR-9 is canonically induced by NF-kB following Toll-like receptor (TLR) 4 activation in human neutrophils and monocytes, and acts to repress NF-kB signaling through direct targeting of p50 mRNA (8).”
BackgroundInfluentialTLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes
Philippe, L., Alsaleh, G., Suffert, G., Meyer, A., Georgel, P., Sibilia, J., Wachsmann, D., & Pfeffer, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102348 · Cited by 178
MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?
Miranda, R. C., Pietrzykowski, A. Z., Tang, Y., Sathyan, P., Mayfield, D., Keshavarzian, A., Sampson, W., & Hereld, D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01126.x · Cited by 180
“For example, a recent report (Bazzoni et al., 2009) showed that miR9 was up-regulated in human neutrophils and monocytes, when stimulated by TLR4 or the proinflammatory cytokines, TNF-a and interleukin-1b.”
BackgroundInhibitory feedback control of NF-κB signalling in health and disease
Prescott, J. A., Mitchell, J. P., & Cook, S. J. (2021) · Biochemical Journal · doi:10.1042/bcj20210139 · Cited by 198
OmicsNet: a web-based tool for creation and visual analysis of biological networks in 3D space
Zhou, G., & Xia, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky510 · Cited by 175
“Sp1 is a transcription factor involved in the regulation of Il-10 (44), a key effector in regulatory T cell response that mediates helminth-mediated immunoregulation (45), while the miRNA-9 family is involved in the regulation of the immune response (46,47).”
BackgroundEmerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
Khoshnam, S. E., Winlow, W., Farbood, Y., Moghaddam, H. F., & Farzaneh, M. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01368 · Cited by 156
The Clinical Application of MicroRNAs in Infectious Disease
Drury, R. E., O’Connor, D., & Pollard, A. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01182 · Cited by 172
MicroRNAs in inflammatory lung disease - master regulators or target practice?
Oglesby, I. K., McElvaney, N. G., & Greene, C. M. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-148 · Cited by 147
“miR-155, -146, -9 and -21 to name a few, which were shown to target SHIP1, IRAK1/TRAF6, NF- B1, and tumor suppressor PDCD4 respectively [54-57].”
Transcriptional firing helps to drive NETosis
Khan, M. A., & Palaniyar, N. (2017) · Scientific Reports · doi:10.1038/srep41749 · Cited by 175
MiR-9 promotes microglial activation by targeting MCPIP1
Yao, H., Ma, R., Yang, L., Hu, G., Chen, X., Duan, M., Kook, Y., Niu, F., Liao, K., Fu, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5386 · Cited by 158
Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40
Xue, X., Feng, T., Yao, S., Wolf, K. J., Liu, C., Liu, X., Elson, C. O., & Cong, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100535 · Cited by 156
MicroRNA Dysregulation in the Spinal Cord following Traumatic Injury
Yunta, M., Nieto-Díaz, M., Esteban, F. J., Caballero-López, M., Navarro-Ruíz, R., Reigada, D., Pita-Thomas, D. W., Águila, Á. D., Muñoz-Galdeano, T., & Maza, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034534 · Cited by 122
MicroRNAs in the immune response
Pedersen, I. M., & David, M. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.016 · Cited by 139
miRNAs reshape immunity and inflammatory responses in bacterial infection
Zhou, X., Li, X., & Wu, M. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0006-9 · Cited by 190
Zeng, Z., Gong, H., Li, Y., Jie, K., Ding, C., Shao, Q., Liu, F., Zhan, Y., Nie, C., Zhu, W., et al. (2013) · Experimental Lung Research · doi:10.3109/01902148.2013.808285 · Cited by 128
microRNAs in Inflammatory Bowel Disease
Pekow, J., & Kwon, J. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21691 · Cited by 141
“Similarly, miR-9 is induced by TLR4 activated nuclear factor kappa B (NF-jB) in polymorphonuclear cells and monocytes, and miR-9 is involved in inhibitory feedback at the level of NFKB1, a gene that contributes to NF-jB protein expression.(30) In addition to miR-146a and miR-9, miR-155 plays in integral role in the im…”
BackgroundInterplay Between Reactive Oxygen Species and MicroRNAs in Cancer
He, J., & Jiang, B. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0051-4 · Cited by 146
Perry, M. M., Williams, A. E., Tsitsiou, E., Larner-Svensson, H., & Lindsay, M. A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.038 · Cited by 116
Moffatt, C. E., & Lamont, R. J. (2011) · Infection and Immunity · doi:10.1128/iai.00082-11 · Cited by 136
“Human monocytes exposed to lipopolysaccharide (LPS) upregulate miRNA-146a (miR-146a) and miR-9, resulting in the downregulation of cytokines involved in the innate immune response (5, 54).”
BackgroundMicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics
Nieto‐Díaz, M., Esteban, F. J., Reigada, D., Muñoz‐Galdeano, T., Yunta, M., Caballero-López, M. J., Navarro-Ruíz, R., del Águila, Á., & Maza, R. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00053 · Cited by 137
“In particular, downregulation of miR-9 and miR-199 (Yunta et al., 2012) may induce the overexpression of the NF-κB pathway genes p50NFkB and ikkb (Chen et al., 2008; Bazzoni et al., 2009; Wang et al., 2011).”
BackgroundGao, F., Zhao, Z.-L., Zhao, W.-T., Fan, Q., Wang, S.-C., Li, J., Zhang, Y.-Q., Shi, J.-W., Lin, X.-L., Yang, S., et al. (2013) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2012.12.097 · Cited by 133
Cerella, C., Sobolewski, C., Dicato, M., & Diederich, M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.050 · Cited by 129
MicroRNAs in the regulation of TLR and RIG-I pathways
Li, Y., & Shi, X. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.55 · Cited by 127
MicroRNA regulation of innate immune responses in epithelial cells
Zhou, R., O’Hara, S. P., & Chen, X. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.19 · Cited by 111
“26 Additionally, LPS directly induces miR-9 expression via the myeloid differentiation primary response gene 88 (MyD88)/NF-kB-dependent pathway in human neutrophils, monocytes and macrophages”
BackgroundMicroRNAs as regulators of death receptors signaling
Garofalo, M., Condorelli, G. L., Croce, C. M., & Condorelli, G. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.105 · Cited by 121
Teruel, R., Pérez‐Sánchez, C., Corral, J., Herranz, M., Pérez-Andreu, V., Sáiz, E., García‐Barberá, N., Martínez‐Martínez, I., Roldán, V., Vicente, V., et al. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04451.x · Cited by 119
Wu, X., Dai, Y., Yang, Y., Huang, C. Z., Meng, X., Wu, B., & Li, J. (2016) · Immunology · doi:10.1111/imm.12608 · Cited by 116
The emerging role of micro RNA s in regulating immune and inflammatory responses in the lung
Foster, P. S., Plank, M. W., Collison, A., Tay, H. L., Kaiko, G. E., Li, J., Johnston, S. L., Hansbro, P. M., Kumar, R. K., Yang, M., et al. (2013) · Immunological Reviews · doi:10.1111/imr.12058 · Cited by 110
“Let-7a 4 Up KBRAS2 Positive regulator of NF-jB signaling (25) Let-7e 4 Up TLR4 Negative regulator of TLR4 signaling (26) Mir-9 2, 4, 7, 8 Up NFKB1 Negative regulator of NF-jB signaling (14) Mir-21 4 Up PDCD4 Negative regulator of TLR4 signaling (6) Mir-125b 4 Down IRF4, KBRAS2 and TNF Positive regulation of TNF-a resp…”
Background
Metadata
- Authors
- Bazzoni, F., Rossato, M., Fabbri, M., Gaudiosi, D., Mirolo, M., Mori, L., Tamassia, N., Mantovani, A., Cassatella, M. A., & Locati, M.
- Affiliations
- University of Verona (IT)
- Humanitas University (IT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-03-31
- Volume
- 106
- Issue
- 13
- Pages
- 5282-5287
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2664036
- OpenAlex
- W2020932061
- Cited by
- 548
- References
- 40
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 17 · 2023: 14 · 2022: 18 · 2021: 25 · 2020: 33 · 2019: 33 · 2018: 38 · 2017: 38 · 2016: 35 · 2015: 36 · 2014: 46 · 2013: 65 · 2012: 50
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondazione Cariplo
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
- Università degli Studi di Verona
- Alleanza Contro il Cancro
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- miR-9, microRNA, monocytes, neutrophils, lipopolysaccharide, TLR4, TLR2, TLR7/8, NF-κB, NFKB1, MyD88, post-transcriptional regulation, inflammation, TNF-α, IL-1β, feedback regulation
- MeSH terms
- Humans, Inflammation, Lipopolysaccharides, Monocytes, Neutrophils, Transcriptional Activation, Cytokines, NF-kappa B, Inflammation Mediators, Gene Expression Profiling, MicroRNAs, Toll-Like Receptors, Toll-Like Receptor 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
