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NeurimmiRs: microRNAs in the neuroimmune interface

Soreq, Hermona, Wolf, Yochai·2011·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2011.06.009
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Abstract

Recent reports of microRNA (miR) modulators of both neuronal and immune processes (here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels in diseases affecting both the immune system and higher brain functions, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and anxiety-related disorders. In our opinion, NeurimmiRs that function within both the nervous and the immune systems, such as miR-132 and miR-124, may act as 'negotiators' between these two interacting compartments. We suggest that NeurimmiRs primarily target transcriptional or other regulatory genes, which enables modulation of both immune and cognitive processes through direct or indirect alterations of neuron-glia and/or brain-to-body signaling. Thus, manipulating NeurimmiR control over the immune contributions to cognitive pathways may offer new therapeutic targets.

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Metadata

Authors
Soreq, H., & Wolf, Y.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2011-10
Volume
17
Issue
10
Pages
548-555
ISSN
1471-4914
DOI
10.1016/j.molmed.2011.06.009
Cited by
162
References
8
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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