Cited by 303Autism Spectrum Disorder ResearchFunctional Brain Connectivity StudiesNeural dynamics and brain function

Local and long-range functional connectivity is reduced in concert in autism spectrum disorders

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Khan, Sheraz, Gramfort, Alexandre, Shetty, Nandita R., Kitzbichler, Manfred G., Ganesan, Santosh, Moran, Joseph M., Lee, Su Mei, Gabrieli, John D. E. +5 more·2013·Proceedings of the National Academy of Sciences

Abstract

Long-range cortical functional connectivity is often reduced in autism spectrum disorders (ASD), but the nature of local cortical functional connectivity in ASD has remained elusive. We used magnetoencephalography to measure task-related local functional connectivity, as manifested by coupling between the phase of alpha oscillations and the amplitude of gamma oscillations, in the fusiform face area (FFA) of individuals diagnosed with ASD and typically developing individuals while they viewed neutral faces, emotional faces, and houses. We also measured task-related long-range functional connectivity between the FFA and the rest of the cortex during the same paradigm. In agreement with earlier studies, long-range functional connectivity between the FFA and three distant cortical regions was reduced in the ASD group. However, contrary to the prevailing hypothesis in the field, we found that local functional connectivity within the FFA was also reduced in individuals with ASD when viewing faces. Furthermore, the strength of long-range functional connectivity was directly correlated to the strength of local functional connectivity in both groups; thus, long-range and local connectivity were reduced proportionally in the ASD group. Finally, the magnitude of local functional connectivity correlated with ASD severity, and statistical classification using local and long-range functional connectivity data identified ASD diagnosis with 90% accuracy. These results suggest that failure to entrain neuronal assemblies fully both within and across cortical regions may be characteristic of ASD.

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  • Electrophysiological source imaging has been used to map spatiotemporal responses underlying sensory processing, object recognition, disrupted visual processing in autistic patients, attention and consciousness, visual rivalry, visuomotor coordination, and speech recognition.

    “To name a few, ESI has been used to map the spatiotemporal responses underlying sensory processing, object recognition (64), disrupted visual processing in autistic patients (65), attention and consciousness (66), visual rivalry (67–69), visuomotor coordination (11), and speech recognition (70).”

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Authors
Khan, S., Gramfort, A., Shetty, N. R., Kitzbichler, M. G., Ganesan, S., Moran, J. M., Lee, S. M., Gabrieli, J. D. E., Tager-Flusberg, H. B., Joseph, R. M., Herbert, M. R., Hämäläinen, M. S., & Kenet, T.
Affiliations
  • Harvard University (US)
  • Boston University (US)
Venue
Proceedings of the National Academy of Sciences
Published
2013-01-14
Volume
110
Issue
8
Pages
3107-3112
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1965183327
Cited by
303
References
62
Citations by year
2026: 8 · 2025: 12 · 2024: 27 · 2023: 21 · 2022: 16 · 2021: 18 · 2020: 33 · 2019: 29 · 2018: 22 · 2017: 22 · 2016: 29 · 2015: 24 · 2014: 23 · 2013: 19
FWCI
17.37
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
  • National Institutes of Health (1s10rr031599-01)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB009048)
  • National Center for Research Resources (P41-RR-14075, P41RR014075, S10-RR031599)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
autism spectrum disorder, local functional connectivity, long-range functional connectivity, fusiform face area, face processing, ASD severity, neural entrainment, magnetoencephalography
MeSH terms
Adolescent, Adult, Child, Child Development Disorders, Pervasive, Electroencephalography, Humans, Magnetoencephalography, Young Adult

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