Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments
Open accessAbstract
Significance: Outside of permafrost, no contiguous DNA sequences have been generated from material older than ∼120,000 y. By improving our ability to sequence very short DNA fragments, we have recovered the mitochondrial genome sequence of a >300,000-y-old cave bear from Sima de los Huesos, a Spanish cave site that is famous for its rich collection of Middle Pleistocene human fossils. This finding demonstrates that DNA can survive for hundreds of thousands of years outside of permafrost and opens the prospect of making more samples from this time period accessible to genetic studies.
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- Authors
- Dabney, J., Knapp, M., Glocke, I., Gansauge, M.-T., Weihmann, A., Nickel, B., Valdiosera, C., García, N., Pääbo, S., Arsuaga, J.-L., & Meyer, M.
- Affiliations
- Max Planck Institute for Evolutionary Anthropology (DE)
- Bangor University (GB)
- Universidad Complutense de Madrid (ES)
- Centro de Investigación Sobre la Evolución y Comportamiento Humanos, Universidad Complutense de Madrid–Instituto de Salud Carlos III, 28029 Madrid, Spain;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-09-09
- Volume
- 110
- Issue
- 39
- Pages
- 15758-15763
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3785785
- OpenAlex
- W2050254973
- Cited by
- 1,443
- References
- 48
- Citations by year
- 2026: 128 · 2025: 163 · 2024: 113 · 2023: 117 · 2022: 137 · 2021: 153 · 2020: 161 · 2019: 129 · 2018: 95 · 2017: 96 · 2016: 60 · 2015: 50 · 2014: 34 · 2013: 5
- FWCI
- 32.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Library Open Repository (Universidad Complutense Madrid) (submittedVersion, other-oa)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- cave bear, Ursus deningeri, mitochondrial genome, ancient DNA, single-stranded DNA library preparation, Sima de los Huesos, Middle Pleistocene, phylogenetic relationships
- MeSH terms
- Animals, Base Sequence, Ursidae, DNA, Molecular Sequence Data, Phylogeny, Time Factors, Genome, Mitochondrial, Caves
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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