The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study
Open accessAbstract
Stress over the lifespan is thought to promote accelerated aging and early disease. Telomere length is a marker of cell aging that appears to be one mediator of this relationship. Telomere length is associated with early adversity and with chronic stressors in adulthood in many studies. Although cumulative lifespan adversity should have bigger impacts than single events, it is also possible that adversity in childhood has larger effects on later life health than adult stressors, as suggested by models of biological embedding in early life. No studies have examined the individual vs. cumulative effects of childhood and adulthood adversities on adult telomere length. Here, we examined the relationship between cumulative childhood and adulthood adversity, adding up a range of severe financial, traumatic, and social exposures, as well as comparing them to each other, in relation to salivary telomere length. We examined 4,598 men and women from the US Health and Retirement Study. Single adversities tended to have nonsignificant relations with telomere length. In adjusted models, lifetime cumulative adversity predicted 6% greater odds of shorter telomere length. This result was mainly due to childhood adversity. In adjusted models for cumulative childhood adversity, the occurrence of each additional childhood event predicted 11% increased odds of having short telomeres. This result appeared mainly because of social/traumatic exposures rather than financial exposures. This study suggests that the shadow of childhood adversity may reach far into later adulthood in part through cellular aging.
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“When broken down by life period, childhood adversity had a significant effect on proinflammatory gene expression (Levine et al., 2015), as well as telomere length (Puterman et al., 2016), both potential mechanisms of disease development.”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Puterman et al., 2016
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Shonkoff, J. P., Garner, A. S., THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, C. O. E. C., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., McGuinn, L., Pascoe, J., & Wood, D. L. (2012) · Pediatrics · doi:10.1542/peds.2011-2663 · Cited by 5,164
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
Self-citationValidity of adult retrospective reports of adverse childhood experiences: review of the evidence
Hardt, J., & Rutter, M. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00218.x · Cited by 2,827 · cited 3×
“(60, 61) concluded that recall bias, however, should have little effect in studies with clearly defined adverse experiences, which is the case with the rest of the selected adverse experiences in the current study (i.”
BackgroundShonkoff, J. P., Boyce, W. T., & McEwen, B. S. (2009) · JAMA · doi:10.1001/jama.2009.754 · Cited by 2,326
BOYCE, W. T., & ELLIS, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050145 · Cited by 2,078
Manuscripts Accepted for Publication
(2005) · Child Development · doi:10.1111/j.1467-8624.2005.00876.x · Cited by 2,051
Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761
MCEWEN, B. S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.001 · Cited by 1,638
Glickman, M. E., Rao, S. R., & Schultz, M. R. (2014) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.03.012 · Cited by 1,561
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434
Telomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,395
Avison, W. R., Brown, G. W., & Harris, T. (1990) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2072630 · Cited by 1,148
Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856
Dube, S. R., Williamson, D. F., Thompson, T., Felitti, V. J., & Anda, R. F. (2004) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2003.08.009 · Cited by 660
Miller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591
Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Sanders, J. L., & Newman, A. B. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs008 · Cited by 556
Shalev, I., Moffitt, T. E., Sugden, K., Williams, B., Houts, R. M., Danese, A., Mill, J., Arseneault, L., & Caspi, A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.32 · Cited by 489
The association of telomere length and cancer: a meta-analysis
Wentzensen, I. M., Mirabello, L., Pfeiffer, R. M., & Savage, S. A. (2011) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0005 · Cited by 458
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400
Self-citationGoing against the grain: chemotaxis and infection in Vibrio cholerae
Butler, S. M., & Camilli, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1207 · Cited by 397
Racial Disparities in Child Adversity in the U.S
Slopen, N., Shonkoff, J. P., Albert, M. A., Yoshikawa, H., Jacobs, A., Stoltz, R., & Williams, D. R. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.06.013 · Cited by 382
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., Svenson, U., Roos, G., Hosgood, H. D., Shen, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020466 · Cited by 376 · cited 1×
“Other recent meta-analyses support the concurrent associations between short telomeres and diabetes (8) and several cancers (9, 10).”
ResultMacDonald, K. S., Thomas, M. L., Sciolla, A., Schneider, B., Pappas, K., Bleijenberg, G., Bohus, M., Bradley, B., Carpenter, L. L., Carr, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146058 · Cited by 374
The roles of senescence and telomere shortening in cardiovascular disease
Fyhrquist, F., Saijonmaa, O. J., & Strandberg, T. E. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.30 · Cited by 373
Shonkoff, J. P., & Fisher, P. A. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000813 · Cited by 362
Axis of ageing: telomeres, p53 and mitochondria
Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 345
Telomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339
Needham, B. L., Adler, N. E., Gregorich, S. E., Rehkopf, D. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.023 · Cited by 332
Self-citationHunt, S. C., Chen, W., Gardner, J. P., Kimura, M., Srinivasan, S. R., Eckfeldt, J. H., Berenson, G. S., & Aviv, A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00397.x · Cited by 309
Telomere length predicts survival independent of genetic influences
Bakaysa, S. L., Mucci, L. A., Slagboom, P. E., Boomsma, D. I., McClearn, G. E., Johansson, B. E. A., & Pedersen, N. L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00340.x · Cited by 304
Technical Description of the Health and Retirement Study Sample Design
Heeringa, S. G. (1995) · doi:10.7826/isr-um.06.585031.001.05.0001.1995 · Cited by 301
Rode, L., Nordestgaard, B. G., & Bojesen, S. E. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv074 · Cited by 297
Retrospective Reporting of Childhood Adversity: Issues in Assessing Long-Term Recall
Maughan, B., & Rutter, M. (1997) · Journal of Personality Disorders · doi:10.1521/pedi.1997.11.1.19 · Cited by 292
Social disadvantage, genetic sensitivity, and children's telomere length
Mitchell, C., Hobcraft, J., McLanahan, S. S., Siegel, S. R., Berg, A., Brooks-Gunn, J., Garfinkel, I., & Notterman, D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404293111 · Cited by 281
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins
Kimura, M., Hjelmborg, J., Gardner, J. P., Bathum, L., Brimacombe, M. B., Lu, X., Christiansen, L., Vaupel, J. W., Aviv, A., & Christensen, K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm380 · Cited by 277
Njajou, O. T., Hsueh, W.-C., Blackburn, E. H., Newman, A. B., Wu, S.-H., Li, R., Simonsick, E. M., Harris, T. B., Cummings, S., & Cawthon, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp061 · Cited by 249
Epel, E. S., Merkin, S. S., Cawthon, R., Blackburn, E. H., Adler, N. E., Pletcher, M. J., & Seeman, T. E. (2008) · Aging · doi:10.18632/aging.100007 · Cited by 236
Self-citationAssociation between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis
Zhao, J., Miao, K., Wang, H., Ding, H., & Wang, D. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079993 · Cited by 220
Race/ethnicity and telomere length in the Multi‐Ethnic Study of Atherosclerosis
Roux, A. V. D., Ranjit, N., Jenny, N. S., Shea, S., Cushman, M., Fitzpatrick, A. L., & Seeman, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00470.x · Cited by 220
Can We Trust Older People’s Statements on Their Childhood Circumstances? Evidence from SHARELIFE
Havari, E., & Mazzonna, F. (2011) · European Journal of Population / Revue européenne de Démographie · doi:10.1007/s10680-014-9332-y · Cited by 212
Gutierrez‐Rodrigues, F., Santana-Lemos, B. A. A., Scheucher, P. S., Alves‐Paiva, R. M., & Calado, R. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113747 · Cited by 203
Oliveira, B. S., Zunzunegui, M. V., Quinlan, J., Fahmi, H., Tu, M. T., & Guerra, R. O. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.006 · Cited by 167
Reconstructing childhood health histories
Smith, J. P. (2009) · Demography · doi:10.1353/dem.0.0058 · Cited by 160
O’Donovan, A., Tomiyama, A. J., Lin, J., Puterman, E. M., Adler, N. E., Kemeny, M. E., Wolkowitz, O. M., Blackburn, E. H., & Epel, E. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.01.007 · Cited by 155
Self-citationPuterman, E., Lin, J., Krauss, J., Blackburn, E. H., & Epel, E. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.70 · Cited by 150
Self-citationGenetics of leukocyte telomere length and its role in atherosclerosis
Aviv, A. (2012) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.05.001 · Cited by 143
Seeman, T. E., Gruenewald, T. L., Karlamangla, A. S., Sidney, S., Liu, K., McEwen, B. S., & Schwartz, J. E. (2009) · American Journal of Human Biology · doi:10.1002/ajhb.21018 · Cited by 136
Brown, G. W. (1989) · Cited by 136
Is Socioeconomic Status Associated With Biological Aging as Measured by Telomere Length?
Robertson, T., Batty, G. D., Der, G., Fenton, C., Shiels, P. G., & Benzeval, M. (2012) · Epidemiologic Reviews · doi:10.1093/epirev/mxs001 · Cited by 119
Sequelae of Prospective versus Retrospective Reports of Adverse Childhood Experiences
Hardt, J., Vellaisamy, P., & Schoon, I. (2010) · Psychological Reports · doi:10.2466/02.04.09.10.16.21.pr0.107.5.425-440 · Cited by 116
Surtees, P. G., Wainwright, N. W. J., Pooley, K. A., Luben, R., Khaw, K., Easton, D. F., & Dunning, A. M. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr112 · Cited by 115
Telomere Length Shortening and Alzheimer Disease—A Mendelian Randomization Study
Zhan, Y., Song, C., Karlsson, R., Tillander, A., Reynolds, C. A., Pedersen, N. L., & Hägg, S. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1513 · Cited by 111 · cited 2×
“They showed that common sequence variants of seven genes that directly regulate telomere maintenance, summed as a genetic risk score, significantly increase risks for cardiovascular, pulmonary (23), and Alzheimer’s diseases (24).”
BackgroundPérez‐Rivero, G., Ruiz‐Torres, M. P., Rivas‐Elena, J. V., Jerkić, M., Díez-Marqués, M. L., López-Novoa, J. M., Blasco, M. A., & Rodrı́guez-Puyol, D. (2006) · Circulation · doi:10.1161/circulationaha.105.611111 · Cited by 109
Childhood and later life stressors and increased inflammatory gene expression at older ages
Levine, M. E., Cole, S. W., Weir, D. R., & Crimmins, E. M. (2015) · Social Science & Medicine · doi:10.1016/j.socscimed.2015.01.030 · Cited by 106
Self-citationPuterman, E., & Epel, E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00465.x · Cited by 106
Self-citationWork-Related Exhaustion and Telomere Length: A Population-Based Study
Ahola, K., Sirén, I., Mika Kivimaki, B., Ripatti, S., Aromaa, A., Lönnqvist, J. K., & Hovatta, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040186 · Cited by 104
Telomere shortening in formerly abused and never abused women.
Humphreys, J., Epel, E. S., Cooper, B. A., Lin, J., Blackburn, E. H., & Lee, K. A. (2012) · Biological Research For Nursing · doi:10.1177/1099800411398479 · Cited by 97
Self-citationDeelen, J., Beekman, M., Codd, V., Trompet, S., Broer, L., Hägg, S., Fischer, K., Thijssen, P. E., Suchiman, H. E. D., Postmus, I., et al. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt267 · Cited by 97
Reliability of Retrospective Assessments of Childhood Experiences in Germany
Hardt, J., Sidor, A., Bracko, M., & Egle, U. T. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000235789.79491.1b · Cited by 95
The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length
Verhoeven, J. E., van Oppen, P., Puterman, E. M., Elzinga, B. M., & Penninx, B. W. J. H. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000226 · Cited by 87
Self-citationLongitudinal Changes in Leukocyte Telomere Length and Mortality in Humans
Bendix, L., Thinggaard, M., Fenger, M., Kølvraa, S., Avlund, K., Linneberg, A. R., & Osler, M. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt153 · Cited by 83
Change in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors
Duggan, C. R., Risques, R. A., Alfano, C. M., Prunkard, D. E., Imayama, I., Holte, S., Baumgartner, K. B., Baumgartner, R., Bernstein, L., Ballard-Barbash, R. R., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju035 · Cited by 70
No association between mean telomere length and life stress observed in a 30 year birth cohort
Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097102 · Cited by 62
Telomeres, Atherosclerosis, and Human Longevity
Aviv, A., Kark, J. D., & Susser, E. (2015) · Epidemiology · doi:10.1097/ede.0000000000000280 · Cited by 60
Litzelman, K., Witt, W. P., Gangnon, R. E., Nieto, F. J., Engelman, C. D., Seltzer, M. M., & Skinner, H. G. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu066 · Cited by 57
Leukocyte telomere length is not associated with mortality in older men
Svensson, J., Karlsson, M. K., Ljunggren, Ö., Tivesten, Å., Mellström, D., & Movérare‐Skrtic, S. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.04.013 · Cited by 52
Fujishiro, K., Roux, A. V. D., Landsbergis, P. A., Jenny, N. S., & Seeman, T. E. (2013) · Occupational and Environmental Medicine · doi:10.1136/oemed-2012-101296 · Cited by 34
Shorter Ends, Faster End? Leukocyte Telomere Length and Mortality Among Older Taiwanese
Glei, D. A., Goldman, N., Weinstein, M., & Risques, R. A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu191 · Cited by 24
Ala‐Mursula, L., Buxton, J. L., Ek, E., Koiranen, M., Taanila, A. M., Blakemore, A. I. F., & Järvelin, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080094 · Cited by 15
Schaefer, C. A., Sciortino, S., Kvale, M. N., Lapham, K., Ranatunga, D. K., Rowell, S., Sadler, M., Ludwig, D., Walter, L., Eeden, S. K. V. D., et al. (2013) · Clinical Medicine & Research · doi:10.3121/cmr.2013.1176.b4-3 · Cited by 13
B4-1: An Overview of Kaiser Permanente's Research Program on Genes, Environment, and Health
Schaefer, C. A., Rowell, S., Henderson, M., Walter, L., Sadler, M., Miles, S., Schaffer, D., Croen, L., Jorgenson, E., Kushi, L. H., et al. (2013) · Clinical Medicine & Research · doi:10.3121/cmr.2013.1176.b4-1 · Cited by 2
Research works printed but not linked: 1
- JE Verhoeven, P van Oppen, E Puterman, B Elzinga, BWJH Penninx, The association of early and recent psychosocial life stress with leukocyte telomere length. Psychosom Med 77, 882–891 (2015). · DOI
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Metadata
- Authors
- Puterman, E., Gemmill, A., Karasek, D., Weir, D., Adler, N. E., Prather, A. A., & Epel, E. S.
- Affiliations
- University of British Columbia (CA)
- University of California, Berkeley (US)
- University of Michigan (US)
- University of California, San Francisco (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-10-03
- Volume
- 113
- Issue
- 42
- Pages
- E6335-E6342
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5081642
- OpenAlex
- W2529798465
- Cited by
- 165
- References
- 77
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 11 · 2023: 18 · 2022: 19 · 2021: 13 · 2020: 15 · 2019: 34 · 2018: 25 · 2017: 13
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- HHS | NIH | National Heart, Lung, and Blood Institute (R00 HL 109247, K08 HL 112961)
- Canada Research Chairs (950-230617)
- HHS | NIH | National Institute on Aging (T32-AG000246)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- telomere length, cumulative adversity, childhood adversity, biological embedding, cellular aging, accelerated aging, salivary biomarkers, financial hardship, traumatic events, social adversity
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Longevity, Male, Middle Aged, Risk Factors, Stress, Psychological, United States, Multivariate Analysis, Odds Ratio, Telomere, Cellular Senescence, Telomere Shortening, Public Health Surveillance
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