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Axis of ageing: telomeres, p53 and mitochondria

Sahin, Ergün, DePinho, Ronald A.·2012·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3352PMC PMC3718675
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  • Reduced efficiency of mitochondrial bioenergetics with aging may result from reduced biogenesis, for instance as a consequence of telomere attrition in telomerase-deficient mice with subsequent p53-mediated repression of PGC-1α and PGC-1β.

    “The reduced efficiency of mitochondrial bioenergetics with aging may result from multiple converging mechanisms including reduced biogenesis of mitochondria, for instance as a consequence of telomere attrition in telomerase-deficient mice, with subsequent p53-mediated repression of PGC-1α and PGC-1β”

    From The Hallmarks of Aging (2013) · cites this paper as Sahin and Depinho, 2012

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Metadata

Authors
Sahin, E., & DePinho, R. A.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-05-16
Volume
13
Issue
6
Pages
397-404
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm3352
PMC
PMC3718675
Cited by
345
References
53
Language
en
Licence
www.springer.com/tdm (tdm)

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