Cited by 647Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

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Kempadoo, Kimberly A., Mosharov, Eugene V., Choi, Se Joon, Sulzer, David, Kandel, Eric R.·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1616515114PMC PMC5187750

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Abstract

Dopamine neurotransmission in the dorsal hippocampus is critical for a range of functions from spatial learning and synaptic plasticity to the deficits underlying psychiatric disorders such as attention-deficit hyperactivity disorder. The ventral tegmental area (VTA) is the presumed source of dopamine in the dorsal hippocampus. However, there is a surprising scarcity of VTA dopamine axons in the dorsal hippocampus despite the dense network of dopamine receptors. We have explored this apparent paradox using optogenetic, biochemical, and behavioral approaches and found that dopaminergic axons and subsequent dopamine release in the dorsal hippocampus originate from neurons of the locus coeruleus (LC). Photostimulation of LC axons produced an increase in dopamine release in the dorsal hippocampus as revealed by high-performance liquid chromatography. Furthermore, optogenetically induced release of dopamine from the LC into the dorsal hippocampus enhanced selective attention and spatial object recognition via the dopamine D1/D5 receptor. These results suggest that spatial learning and memory are energized by the release of dopamine in the dorsal hippocampus from noradrenergic neurons of the LC. The present findings are critical for identifying the neural circuits that enable proper attention selection and successful learning and memory.

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Authors: Kempadoo, K. A., Mosharov, E. V., Choi, S. J., Sulzer, D., & Kandel, E. R.
Affiliations: Columbia University (US)
New York State Psychiatric Institute (US)
Howard Hughes Medical Institute (US)
ORCID: Kempadoo, Kimberly A.
Mosharov, Eugene V.
Choi, Se Joon
Sulzer, David
Kandel, Eric R.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-12-07
Volume: 113
Issue: 51
Pages: 14835-14840
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1616515114
PMC: PMC5187750
OpenAlex: W2560490590
Cited by: 647
References: 38
Citations by year: 2026: 57 · 2025: 79 · 2024: 95 · 2023: 76 · 2022: 67 · 2021: 70 · 2020: 62 · 2019: 59 · 2018: 61 · 2017: 19
FWCI: 29.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund (n/a)
HHS | National Institutes of Health (T32 MH015174-37, R01 DA07418, R01 DA010154)
HHS | NIH | National Institute of Neurological Disorders and Stroke (R01 NS07522)
Parkinson's Disease Foundation (n/a)
Howard Hughes Medical Institute (n/a)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine release, locus coeruleus, dorsal hippocampus, spatial learning and memory, noradrenergic neurons, ventral tegmental area, dopamine D1/D5 receptors, selective attention, optogenetic stimulation, dopamine signaling
MeSH terms: Animals, Axons, Behavior, Animal, Dopamine, Hippocampus, Locus Coeruleus, Male, Memory, Mice, Inbred C57BL, Synaptic Transmission, Neurons, Mice, Optogenetics, Spatial Learning

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Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

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