Cited by 1,294

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

Open access

Hai, T, Curran, T·1991·Proceedings of the National Academy of Sciences

Open this paper in CoChat — free account

Abstract

The Fos/Jun and ATF/CREB families of transcription factors function in coupling extracellular signals to alterations in expression of specific target genes. Like many eukaryotic transcription factors, these proteins bind to DNA as dimers. Dimerization is mediated by a structure known as the "leucine-zipper" motif. Although Fos/Jun and ATF/CREB were previously thought to interact preferentially with different DNA regulatory elements (the AP-1/TRE and ATF/CRE sites, respectively), we find that members of these two families form selective cross-family heterodimers. The resulting heterodimers display distinguishable DNA binding specificities from each other and from their parental homodimers. These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.88.9.3720

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321

Show all 1 references

The integrated stress response
Pakos‐Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., & Gorman, A. M. (2016) · The EMBO Reports · doi:10.15252/embr.201642195 · Cited by 2,659
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959
Invited review c-Fos as a transcription factor: a stressful (re)view from a functional map
Kovács, K. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00023-0 · Cited by 740
Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.
Xanthoudakis, S., & Curran, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05097.x · Cited by 708
Self-citation
CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642
Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus
Impey, S., Mark, M., Villacres, E. C., Poser, S., Chavkin, C., & Storm, D. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80120-8 · Cited by 593
Heterodimer formation of cJun and ATF‐2 is responsible for induction of c‐jun by the 243 amino acid adenovirus E1A protein.
van Dam, H., Duyndam, M., Rottier, R., Bosch, A., de Vries‐Smits, L., Herrlich, P., Zantema, A., Angel, P., & van der Eb, A. J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05680.x · Cited by 375
The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB
Wang, J.-M., Chao, J.-R., Chen, W., Kuo, M.-L., Yen, J. J.-Y., & Yang-Yen, H.-F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6195 · Cited by 357
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
Li, Y., & Jaiswal, A. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42151-5 · Cited by 353
Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer
Ku, H.-C., & Cheng, C.-F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00556 · Cited by 345
Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design.
Vinson, C. R., Hai, T., & Boyd, S. M. (1993) · Genes & Development · doi:10.1101/gad.7.6.1047 · Cited by 336
Self-citation
A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity
Inoue, F., Kircher, M., Martin, B., Cooper, G. M., Witten, D. M., McManus, M. T., Ahituv, N., & Shendure, J. (2017) · Genome Research · doi:10.1101/gr.212092.116 · Cited by 331
A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions.
Krylov, D., Mikhailenko, I., & Vinson, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06579.x · Cited by 269
Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I
Tabuchi, A., Sakaya, H., Kisukeda, T., Fushiki, H., & Tsuda, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204784200 · Cited by 209
Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems
Smolen, P., Baxter, D. A., & Byrne, J. H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c531 · Cited by 185
The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors
Antinore, M. J., Birrer, M. J., Patel, D., Nader, L., & McCance, D. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00546.x · Cited by 165
Activating Transcription Factor 3 and the Nervous System
Hunt, D., Raivich, G., & Anderson, P. N. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00007 · Cited by 162
“c-Jun co-immunoprecipitates with ATF3 in extracts of reticulocytes (Hai and Curran, 1991), PC12 cells (Nakagomi et al.”
Background
Single-cell transcriptomics for the assessment of cardiac disease
Miranda, A. M. A., Janbandhu, V., Maatz, H., Kanemaru, K., Cranley, J., Teichmann, S. A., Hübner, N., Schneider, M. D., Harvey, R. P., & Noseda, M. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00805-7 · Cited by 117
Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory
Pasini, S., Corona, C., Liu, J., Greene, L. A., & Shelanski, M. L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.025 · Cited by 116
C/EBPα:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBPα homodimers or AP-1
Cai, D. H., Wang, D., Keefer, J., Yeamans, C., Hensley, K., & Friedman, A. D. (2008) · Oncogene · doi:10.1038/sj.onc.1210940 · Cited by 96
Characterization of Keratinocyte Differentiation Induced by Ascorbic Acid: Protein Kinase C Involvement and Vitamin C Homeostasis11The authors declared not to have a conflict of interest.
Savini, I., Rossi, A., Duranti, G., Avigliano, L., Catani, M. V., & Melino, G. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01624.x · Cited by 91
Induction of ATF3 Gene Network by Triglyceride-Rich Lipoprotein Lipolysis Products Increases Vascular Apoptosis and Inflammation
Aung, H. H., Lame, M. W., Gohil, K., An, C.-I., Wilson, D. W., & Rutledge, J. C. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.301375 · Cited by 86
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
Gazon, H., Lemasson, I., Polakowski, N., Césaire, R., Matsuoka, M., Barbeau, B., Mesnard, J.-M., & Peloponese, J.-M. (2012) · Journal of Virology · doi:10.1128/jvi.00661-12 · Cited by 73
Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes
Mollinedo, F., Gajate, C., Tugores, A., Flores, I., & Naranjo, J. R. (1993) · Biochemical Journal · doi:10.1042/bj2940137 · Cited by 63
Redox Regulation of Ap-1
Xanthoudakis, S., & Curran, T. (1996) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-9480-9_10 · Cited by 63
Self-citation
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Huang, Y., Li, L., An, G., Yang, X., Cui, M., Song, X., Lin, J., Zhang, X., Yao, Z., Wan, C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01232-7 · Cited by 59
Group A streptococcal pharyngitis: immune responses involved in bacterial clearance and GAS-associated immunopathologies.
Soderholm, A. T., Barnett, T. C., Sweet, M. J., & Walker, M. J. (2018) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0617-227rr · Cited by 51
Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A
Lee, J.-S., Zhang, X., & Shi, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17666 · Cited by 48
Drosophila Activating Transcription Factor-2 Is Involved in Stress Response via Activation by p38, but Not c-Jun NH2-Terminal Kinase
Sano, Y., Akimaru, H., Okamura, T., Nagao, T., Okada, M., & Ishii, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1008 · Cited by 42
PIAS3 Interacts with ATF1 and Regulates the Human Ferritin H Gene through an Antioxidant-responsive Element
Iwasaki, K., Hailemariam, K., & Tsuji, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701477200 · Cited by 41
Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program
Baresic, M., Salatino, S., Kupr, B., van Nimwegen, E., & Handschin, C. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01710-13 · Cited by 40
Activation of the Ferritin H Enhancer, FER-1, by the Cooperative Action of Members of the AP1 and Sp1 Transcription Factor Families
Tsuji, Y., Torti, S. V., & Torti, F. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2984 · Cited by 36
AP-1 targets in the brain
Rylski, M. (2004) · Frontiers in Bioscience · doi:10.2741/1207 · Cited by 33
Activating Transcription Factor 1 and Cyclic AMP Response Element Modulator Can Modulate the Activity of the Immunoglobulin κ 3′ Enhancer
Pongubala, J. M. R., & Atchison, M. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10304 · Cited by 31
A broad bean cDNA clone encoding a DNA-binding protein resembling mammalian CREB in its sequence specificity and DNA methylation sensitivity
Ehrlich, K. C., Cary, J. W., & Ehrlich, M. (1992) · Gene · doi:10.1016/0378-1119(92)90726-6 · Cited by 30
Characterization and phosphorylation of CREB-like proteins in Aplysia central nervous system
Dash, P. K., & Moore, A. N. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00350-2 · Cited by 27
The genetic architecture of protein interaction affinity and specificity
Bendel, A. M., Faure, A. J., Klein, D., Shimada, K., Lyautey, R., Schiffelholz, N., Kempf, G., Cavadini, S., Lehner, B., & Diss, G. (2024) · Nature Communications · doi:10.1038/s41467-024-53195-4 · Cited by 22

Authors: Hai, T., & Curran, T.
Venue: Proceedings of the National Academy of Sciences
Publisher: Proceedings of the National Academy of Sciences
Published: 1991-05
Volume: 88
Issue: 9
Pages: 3720-3724
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.88.9.3720
OpenAlex: W2023666553
Cited by: 1,294
References: 1
FWCI: 23.21
Type: journal article
Language: en
Open access: green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources