Cited by 177Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsLysosomal Storage Disorders Research

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Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

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Ji, Zhong-Sheng, Miranda, R. Dennis, Newhouse, Yvonne M., Weisgraber, Karl H., Huang, Yadong, Mahley, Robert W.·2002·Journal of Biological Chemistry

DOI 10.1074/jbc.m112109200

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Abstract

We assessed the isoform-specific effects of apolipoprotein (apo) E on the response of Neuro-2a cells to the amyloid beta peptide (Abeta1-42). As determined by the intracellular staining pattern and the release of beta-hexosaminidase into the cytosol, apoE4-transfected cells treated with aggregated Abeta1-42 showed a greater tendency toward lysosomal leakage than neo- or apoE3-transfected cells. Abeta1-42 caused significantly greater cell death and more than 2-fold greater DNA fragmentation in apoE4-secreting than in apoE3-secreting or control cells. H2O2 or staurosporine enhanced cell death and apoptosis in apoE4-transfected cells but not in apoE3-transfected cells. A caspase-9 inhibitor abolished the potentiation of Abeta1-42-induced apoptosis by apoE4. Similar results were obtained with conditioned medium from cells secreting apoE3 or apoE4. Cells preincubated for 4 h with a source of apoE3 or apoE4, followed by removal of apoE from the medium and from the cell surface, still exhibited the isoform-specific response to Abeta1-42, indicating that the potentiation of apoptosis required intracellular apoE, presumably in the endosomes or lysosomes. Studies of phospholipid (dimyristoylphosphatidylcholine) bilayer vesicles encapsulating 5-(and-6)-carboxyfluorescein dye showed that apoE4 remodeled and disrupted the phospholipid vesicles to a greater extent than apoE3 or apoE2. In response to Abeta1-42, vesicles containing apoE4 were disrupted to a greater extent than those containing apoE3. These findings are consistent with apoE4 forming a reactive molecular intermediate that avidly binds phospholipid and may insert into the lysosomal membrane, destabilizing it and causing lysosomal leakage and apoptosis in response to Abeta1-42.

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Authors: Ji, Z.-S., Miranda, R. D., Newhouse, Y. M., Weisgraber, K. H., Huang, Y., & Mahley, R. W.
Affiliations: University of California, San Francisco (US)
Corresponding author: Mahley, Robert W.
ORCID: Huang, Yadong
Mahley, Robert W.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-06
Volume: 277
Issue: 24
Pages: 21821-21828
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m112109200
OpenAlex: W2043090568
Cited by: 177
References: 115
Citations by year: 2026: 8 · 2025: 8 · 2024: 9 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 11
FWCI: 5.40
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6719 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01hl047660-10)
National Heart, Lung, and Blood Institute (HL-47660)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
Keywords: APOE ε4, apolipoprotein E isoforms, amyloid-beta, amyloid-beta 42, apoptosis, N2a cells, caspase-9, DNA fragmentation, lysosomal membrane destabilization, endosomes, Alzheimer's disease
MeSH terms: Animals, Apolipoproteins E, Dimyristoylphosphatidylcholine, Enzyme Inhibitors, Humans, Hydrogen Peroxide, Lysosomes, Microscopy, Fluorescence, Neurons, Time Factors, Transfection, Tumor Cells, Cultured, Amyloid beta-Peptides, Apoptosis, Staurosporine, Protein Isoforms, Mice, Apolipoprotein E4, DNA Fragmentation

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Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

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