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Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells
Open accessAbstract
We assessed the isoform-specific effects of apolipoprotein (apo) E on the response of Neuro-2a cells to the amyloid beta peptide (Abeta1-42). As determined by the intracellular staining pattern and the release of beta-hexosaminidase into the cytosol, apoE4-transfected cells treated with aggregated Abeta1-42 showed a greater tendency toward lysosomal leakage than neo- or apoE3-transfected cells. Abeta1-42 caused significantly greater cell death and more than 2-fold greater DNA fragmentation in apoE4-secreting than in apoE3-secreting or control cells. H2O2 or staurosporine enhanced cell death and apoptosis in apoE4-transfected cells but not in apoE3-transfected cells. A caspase-9 inhibitor abolished the potentiation of Abeta1-42-induced apoptosis by apoE4. Similar results were obtained with conditioned medium from cells secreting apoE3 or apoE4. Cells preincubated for 4 h with a source of apoE3 or apoE4, followed by removal of apoE from the medium and from the cell surface, still exhibited the isoform-specific response to Abeta1-42, indicating that the potentiation of apoptosis required intracellular apoE, presumably in the endosomes or lysosomes. Studies of phospholipid (dimyristoylphosphatidylcholine) bilayer vesicles encapsulating 5-(and-6)-carboxyfluorescein dye showed that apoE4 remodeled and disrupted the phospholipid vesicles to a greater extent than apoE3 or apoE2. In response to Abeta1-42, vesicles containing apoE4 were disrupted to a greater extent than those containing apoE3. These findings are consistent with apoE4 forming a reactive molecular intermediate that avidly binds phospholipid and may insert into the lysosomal membrane, destabilizing it and causing lysosomal leakage and apoptosis in response to Abeta1-42.
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Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Self-citationAssociation of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,292
Flagged first, then by citations
2 of the 115 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Slooter, 1997, J. Am. Med. Assoc., 277, 818, 10.1001/jama.1997.03540340052032 · DOI
- Wisniewski, 1994, Am. J. Pathol., 145, 1030
- Kaback, 1977, Prog. Clin. Biol. Res., 18, 267
- Morrow, 2000, Protein Sci., 9 Suppl. 1, 101
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BackgroundPasternak, S., Callahan, J. W., & Mahuran, D. J. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6107 · Cited by 127
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QUINN, C. M., KÅGEDAL, K., TERMAN, A., STROIKIN, U., BRUNK, U. T., JESSUP, W., & GARNER, B. (2004) · Biochemical Journal · doi:10.1042/bj20031352 · Cited by 36
Kar, S., Poirier, J., Guevara, J., Dea, D., Hawkes, C. A., Robitaille, Y., & Quirion, R. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.005 · Cited by 44
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Leduc, V., Domenger, D., Beaumont, L. D., Lalonde, D., Jasmin, S. B., & Poirier, J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/974361 · Cited by 46
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Tanaka, M., Vedhachalam, C., Sakamoto, T., Dhanasekaran, P., Phillips, M. C., Lund-Katz, S., & Saito, H. (2006) · Biochemistry · doi:10.1021/bi060023b · Cited by 43
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Persson, T., Lattanzio, F., Calvo‐Garrido, J., Rimondini, R., Rubio-Rodrigo, M., Sundström, E., Maioli, S., Matton, A., & Cedazo-Mı́nguez, Á. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150738 · Cited by 44
Kauffman, M. A., Consalvo, D., Morón, D. G., Lereis, V. P., & Kochen, S. S. (2010) · Epilepsy Research · doi:10.1016/j.eplepsyres.2010.05.007 · Cited by 40
Thai, C., Lim, Y. Y., Villemagne, V. L., Laws, S. M., Ames, D. J., Ellis, K. A., Rainey‐Smith, S. R., Martins, R. N., Masters, C. L., Rowe, C. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139082 · Cited by 40
Goodchild, S. C., Sheynis, T., Thompson, R. F., Tipping, K. W., Xue, W., Ranson, N. A., Beales, P. A., Hewitt, E. W., & Radford, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104492 · Cited by 38
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Self-citationMerritt, V. C., Clark, A. L., Sorg, S. F., Evangelista, N. D., Werhane, M. L., Bondi, M. W., Schiehser, D. M., & Delano‐Wood, L. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1508555 · Cited by 38
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Schmukler, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0892-4 · Cited by 35
Metadata
- Authors
- Ji, Z.-S., Miranda, R. D., Newhouse, Y. M., Weisgraber, K. H., Huang, Y., & Mahley, R. W.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Mahley, Robert W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 277
- Issue
- 24
- Pages
- 21821-21828
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2043090568
- Cited by
- 177
- References
- 115
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 11
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01hl047660-10)
- National Heart, Lung, and Blood Institute (HL-47660)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Keywords
- APOE ε4, apolipoprotein E isoforms, amyloid-beta, amyloid-beta 42, apoptosis, N2a cells, caspase-9, DNA fragmentation, lysosomal membrane destabilization, endosomes, Alzheimer's disease
- MeSH terms
- Animals, Apolipoproteins E, Dimyristoylphosphatidylcholine, Enzyme Inhibitors, Humans, Hydrogen Peroxide, Lysosomes, Microscopy, Fluorescence, Neurons, Time Factors, Transfection, Tumor Cells, Cultured, Amyloid beta-Peptides, Apoptosis, Staurosporine, Protein Isoforms, Mice, Apolipoprotein E4, DNA Fragmentation
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