Cited by 286Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and related disorders

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Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep

Cajochen, Christian, Münch, Mirjam, Knoblauch, Vera, Blatter, Katharina, Wirz‐Justice, Anna·2006·Chronobiology International

DOI 10.1080/07420520500545813

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Abstract

The reduction of electroencephalographic (EEG) slow-wave activity (SWA) (EEG power density between 0.75-4.5 Hz) and spindle frequency activity, together with an increase in involuntary awakenings during sleep, represent the hallmarks of human sleep alterations with age. It has been assumed that this decrease in non-rapid eye movement (NREM) sleep consolidation reflects an age-related attenuation of the sleep homeostatic drive. To test this hypothesis, we measured sleep EEG characteristics (i.e., SWA, sleep spindles) in healthy older volunteers in response to high (sleep deprivation protocol) and low sleep pressure (nap protocol) conditions. Despite the fact that the older volunteers had impaired sleep consolidation and reduced SWA levels, their relative SWA response to both high and low sleep pressure conditions was similar to that of younger persons. Only in frontal brain regions did we find an age-related diminished SWA response to high sleep pressure. On the other hand, we have clear evidence that the circadian regulation of sleep during the 40 h nap protocol was changed such that the circadian arousal signal in the evening was weaker in the older study participants. More sleep occurred during the wake maintenance zone, and subjective sleepiness ratings in the late afternoon and evening were higher than in younger participants. In addition, we found a diminished melatonin secretion and a reduced circadian modulation of REM sleep and spindle frequency-the latter was phase-a…

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Authors: Cajochen, C., Münch, M., Knoblauch, V., Blatter, K., & Wirz‐Justice, A.
Affiliations: Universitäre Psychiatrische Kliniken Basel (CH)
Corresponding author: Cajochen, Christian
ORCID: Cajochen, Christian
Münch, Mirjam
Blatter, Katharina
Wirz‐Justice, Anna
Venue: Chronobiology International
Publisher: Informa UK Limited
Published: 2006-01
Volume: 23
Issue: 1-2
Pages: 461-474
ISSN: 0742-0528 (ISSN-L)
1525-6073
DOI: 10.1080/07420520500545813
OpenAlex: W1966147077
Cited by: 285
References: 59
Citations by year: 2026: 10 · 2025: 7 · 2024: 12 · 2023: 20 · 2022: 14 · 2021: 20 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 17 · 2016: 18 · 2015: 19 · 2014: 15 · 2013: 16 · 2012: 27
FWCI: 6.12
Type: journal article
Language: en
Open access: closed
Locations: Chronobiology International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: aging, sleep, circadian regulation, sleep homeostasis, slow-wave activity, sleep spindles, sleep deprivation, NAP, sleep pressure, melatonin, REM sleep, circadian phase, subjective sleepiness, older adults
MeSH terms: Adult, Aged, Aging, Biological Clocks, Circadian Rhythm, Electroencephalography, Homeostasis, Humans, Melatonin, Middle Aged, Physiological Phenomena, Sleep, Sleep Stages, Wakefulness

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Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep

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