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Cited by 1,172

The DOI matches its Crossref record.

The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells

Open access
Steinman, Ralph M., Turley, Shannon, Mellman, Ira, Inaba, Kayo·2000·The Journal of Experimental Medicine
DOI 10.1084/jem.191.3.411
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Abstract

What makes a protein immunogenic, particularly for strong T cell-mediated immunity?To a first approximation, this determination seems to be made by dendritic cells (DCs).Immature DCs, as in skin (1-4), lung ( 5), blood (6, 7), and spleen (7, 8), take up proteins, immune complexes, microbes, and dying cells.However, in order to use these antigens to stimulate a T cell response, the DCs must undergo a characteristic process of terminal differentiation called "maturation."The known stimuli for DC maturation are numerous and include inflammatory cytokines, CD40 ligand (CD40L), viral and microbial constituents such as doublestranded RNA and LPS, and certain CpG oligonucleotides. DC Maturation as a Control Point in the Initiation of ImmunityMaturation changes DCs in many ways that help explain their potent immunogenicity.Examples include de novo expression of T cell costimulatory molecules like CD86 (9, 10); the capacity to produce 12) and resist immunosuppression by IL-10 (13); the development of a new repertoire of chemokine receptors, especially CCR7 (14-17), that guide entry into lymphatics and migration to the T cell areas (18); the production of DC survival and stimulatory molecules like CD40 and TNF-related activation-induced cytokine receptor (TRANCE-R) (19,20); and a redistribution of MHC class II molecules from lysosomes to the cell surface (21,22).

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Metadata

Authors
Steinman, R. M., Turley, S., Mellman, I., & Inaba, K.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2000-02-07
Volume
191
Issue
3
Pages
411-416
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.191.3.411
OpenAlex
W2100446366
Cited by
1,172
References
0
FWCI
37.47
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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