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Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
Open accessAbstract
Alzheimer’s disease (AD) is characterized by extracellular aggregates of amyloid β peptides, intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of microglia. Because variants of genes expressed in microglia correlate with AD risk, microglial response to pathology plausibly impacts disease course. In mouse AD models, single-cell RNA sequencing (scRNA-seq) analyses delineated this response as progressive conversion of homeostatic microglia into disease-associated microglia (DAM); additional reactive microglial populations have been reported in other models of neurodegeneration and neuroinflammation. We review all of these microglial signatures, highlighting four fundamental patterns: DAM, IFN–microglia, MHC-II microglia, and proliferating microglia. We propose that all reported microglia populations are either just one or a combination, depending on the clustering strategy applied and the disease model. We further review single-nucleus RNA sequencing (snRNA-seq) data from human AD specimens and discuss reasons for parallels and discrepancies between human and mouse transcriptional profiles. Finally, we outline future directions for delineating the microglial impact in AD pathogenesis.
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“Many disease-associated microglial programs are spatially enriched around plaques, which suggests that microglial state transitions are not only disease-stage-dependent but also anatomically localized.”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [46]
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“They can express molecules associated with antigen presentation, including MHC class II–related genes and co-stimulatory ligands such as CD80 or CD86, especially under inflammatory conditions.”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [46]
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“Single-cell and single-nucleus studies have repeatedly identified Alzheimer ’s-associated microglial states enriched for immune activation, antigen-presentation genes, lipid-processing pathways, and inflammatory mediators.”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [46]
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“Instead, microglia in Alzheimer’s disease appear to acquire hybrid programs: they remain tissue-resident myeloid cells, but they can express genes normally associated with professional antigen presentation, immune communication, and inflammatory coordination.”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [46]
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“This microglial subset is characterized by reduced expression of homeostatic genes (e.g., Tmem119, P2ry12, Cx3cr1) and increased expression of inflammatory genes (e.g., Clec7a, Apoe, Trem2) including Ch25h (Chen and Colonna, 2021).”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Chen and Colonna, 2021
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“The recent finding therefore suggests that at least some plaque-associated microglia may borrow elements of lymphoid signaling logic rather than merely presenting antigen to lymphocytes [44,45,46].”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [46]
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Metadata
- Authors
- Chen, Y., & Colonna, M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Colonna, Marco
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-07-22
- Volume
- 218
- Issue
- 9
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC8302448
- OpenAlex
- W3185694768
- Cited by
- 339
- References
- 92
- Citations by year
- 2026: 65 · 2025: 60 · 2024: 85 · 2023: 75 · 2022: 47 · 2021: 6
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (RF1 AG051485, R21 AG059176, RF1 AG059082)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- Alzheimer's disease, microglia, disease-associated microglia, microglial activation, single-cell RNA sequencing, single-nucleus RNA sequencing, microglial proliferation, neuroinflammation, amyloid-beta, tau pathology
- MeSH terms
- Aging, Alzheimer Disease, Animals, Histocompatibility Antigens Class II, Disease Models, Animal, Humans, Interferon Type I, Neurons, Gene Expression, Microglia, Mice, Single-Cell Analysis
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